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Nematode serine protease inhibitor SPI-I8 negatively regulates host NF-κB signalling by hijacking MKRN1-mediated polyubiquitination of RACK1
Published 2025-03-01“…Considering the structural and functional conservation of SPI-I8s among Strongylida nematodes and the conservation of interactive mediators (i.e., MKRN1 and RACK1) among mammals, our findings provide insights into the host-parasite interface where parasitic roundworms secret molecules to suppress host inflammatory responses. …”
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983
Single-cell RNA sequencing reveals SLC31A1-mediated M2 polarization of macrophages promotes malignant progression in triple-negative breast cancer
Published 2025-05-01“…Abstract Background Among the various types of breast cancer that endanger women’s lives, triple-negative breast cancer (TNBC) stands out due to its extreme heterogeneity, aggressive nature, and high likelihood of recurrence. …”
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984
Targeting PRDX2 to inhibit tumor growth and metastasis in triple-negative breast cancer: the role of FN1 and the PI3K/AKT/SP1 pathway
Published 2025-04-01“…Abstract Background Triple-negative breast cancer (TNBC) is characterized by high invasiveness, high potential for metastasis, easy recurrence, and poor prognosis. …”
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985
Current instability phenomena in a tunnel diode and electron self-organization processes
Published 2019-06-01“… In the article the mechanisms of electric instability in semiconductors are considered. The origin of negative differential conductivity of different types are described. …”
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986
Impact of self-identity on social anxiety among college students: a moderated mediation model
Published 2025-07-01“…BackgroundSocial anxiety is a prevalent and impairing condition among college students, often interfering with academic performance, emotional wellbeing, and social functioning.ObjectiveThis study aimed to test a moderated mediation model in which self-identity predicts social anxiety, with fear of negative evaluation (FNE) serving as a mediator and perceived social support acting as a moderator in the latter part of the pathway.MethodsA total of 328 college students (Mage = 19.48, SD = 1.02; 43.29% male) completed standardized self-report measures of self-identity, FNE, social anxiety, and perceived social support. …”
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987
Unraveling Abnormal Thermal Quenching of Sub‐Gap Emission in β‐Ga2O3
Published 2025-01-01“…One channel is the nsnp‐ns2 transition of Sn2+, the other is donor‐acceptor pair recombination via (2VGa‐Sni)2− complex, which is energetically favorable as evidenced by density functional theory calculations. The semi‐classical quantum theory models fitting proves the transition from green to UV emissions with elevated temperature. …”
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988
Altered structural and functional homotopic connectivity associated with cognitive changes in SLE
Published 2024-10-01“…Correlation analysis demonstrated that the increased VMHC values in insula was negatively correlated with decreased orientation function and positively correlated with decreased attention function. …”
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989
THE EFFECT OF BLADDER PAIN SYNDROME/INTERSTITIAL CYSTITIS ON PARTNER SEXUAL FUNCTIONS
Published 2022-01-01“…Objective: Bladder pain syndrome/Interstitial cystitis (BPS/IC) negatively affects both women’s social life and sexual functions. …”
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990
A time for sex: circadian regulation of mammalian sexual and reproductive function
Published 2025-01-01“…Evidence supporting the importance of proper clock function on fertility comes from several lines of work demonstrating that misalignment of biological rhythms or disrupted function of the body’s master clock, such as occurs from repeated shift work or chronic jet lag, negatively impacts reproduction by interfering with both male and female fertility. …”
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991
Sex differences in the association between lipids and cognitive function in older adults
Published 2024-12-01“…Background: It is well known that cognitive function is associated with gender differences. However, the effect of sex differences on the relationship between lipids fractions and cognitive function in older adults has been contentious. …”
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Mediating effect of frailty on social isolation and cognitive function among the elderly
Published 2025-01-01“…Mediating effect analysis showed that social isolation affected cognitive function directly and negatively with the effect value of -0.773 (95%CI: -0.899 to -0.647), and also affected cognitive function by frailty indirectly and negatively with the effect value of -0.147 (95%CI: -0.188 to -0.110), with the mediating effect contributed 15.98% of the total effect. …”
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993
Cognitive function, sleep characteristics and their relationship in older adults with insomnia and anxiety
Published 2025-08-01“…The wake time after sleep (WASO) monitored by polysomnography was significantly longer than that in patients with simple insomnia disorder, and the duration of N3 and N3% were significantly shorter than that in patients with simple sleep disorder, with statistical significance (P < 0.05). Executive function was positively correlated with N3 duration and N3%, naming function was negatively correlated with N1 duration and N1%, and memory was negatively correlated with wake time after sleep (WASO) in insomnia patients with anxiety, (P < 0.05). …”
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Age-related changes in vascular structure and function among obese women
Published 2008-08-01“…The study aimed at investigating age-related changes in vascular structure and function among obese women. In total, 83 obese females and 45 women with normal weight were divided into four age subgroups. …”
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The moderating role of aerobic exercise in the relationship between stress and cognitive functions
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996
Hyperbranched Polyethylene Ionomers Containing Quaternary Ammonium Ions and Their Functionalization of Nanomaterials
Published 2025-03-01“…With their unique hydrophobic hyperbranched polyethylene backbone, this class of ionomers enables the successful functionalization of negatively surface-charged nanomaterials, thus improving the processing and application of the latter. …”
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Diagnosis of Functional Gastrointestinal Disorders and Choice of Treatment Regimen in Constipation Patients
Published 2021-10-01“…Functional constipation commonly afflicts different ages and negatively impacts the quality of life. …”
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Attentional and electrophysiological associations with executive function ability in young autistic children
Published 2025-07-01“…Abstract Difficulties in executive functioning (EF) have been consistently reported in autistic individuals, but less is known about the attentional and neural mechanisms driving these difficulties. …”
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The Impact of Changing Ground-Floor Functions on Sidewalk Accessibility in Urban Spaces
Published 2025-07-01“…Changing functions of ground-floor units and their increasing outdoor expansions negatively impact sidewalk accessibility. …”
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Remembering the romantic past: Autobiographical memory functions and romantic relationship quality.
Published 2021-01-01“…In contrast, the social function served by the relationship events was positively associated, and the directive function was negatively associated with intimacy and relationship satisfaction. …”
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