Transcriptome remodelling and changes in growth and cardiometabolic phenotype result following Grb10a knockdown in the early life of the zebrafish by Bridget L. Evans, Terence Garner, Chiara De Leonibus, Lily Wright, Megan Sharps, Oliver H. Wearing, Daniel M. Ripley, Holly A. Shiels, Adam F. L. Hurlstone, Peter E. Clayton, Adam Stevens

“…Abstract Embryonic growth trajectory is a risk factor for chronic metabolic and cardiovascular disorders. Grb10 is a negative regulator of the main pathways driving embryonic growth. …”
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A scoping review on human-centered design approaches and considerations in the design of technologies for loneliness and social isolation in older adults by Freya Probst, John Ratcliffe, Erika Molteni, Nikitia Mexia, Jessica Rees, Faith Matcham, Michela Antonelli, Anthea Tinker, Yu Shi, Sebastien Ourselin, Wei Liu

“…Loneliness and social isolation are prevalent concerns among older adults and can lead to negative health consequences and a reduced lifespan. …”
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The C/C Genotype of rs1231760 in <i>RGS2</i> Is a Risk Factor for the Progression of <i>H. pylori</i>-Positive Atrophic Gastritis by Increasing <i>RGS2</i> Expression by Naoyuki Yamaguchi, Takuki Sakaguchi, Jing-Jing Wei, Yuna Tazoe, Tatsuo Inamine, Daisuke Fukuda, Ken Ohnita, Tatsuro Hirayama, Hajime Isomoto, Kayoko Matsushima, Kazuhiro Tsukamoto

“…Then, with in silico analysis using HaploReg v4.1 and JASPAR (Matrix ID: MA0113.3), we extracted rs1231760 of <i>RGS2</i> as a key single-nucleotide polymorphism (SNP) that could be involved in the functional change in the candidate gene. A correlation analysis between the selected SNP and AG in 200 <i>H. pylori</i>-positive and 302 <i>H. pylori</i>-negative participants was conducted. …”
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Mitigation of chemotherapy-induced gut dysbiosis and diarrhea by supplementation with heat-killed Bacteroides fragilis by Xinwen Yan, Xinlong Lin, Jianhua Wu, Lijun Zheng, Yangyang Liu, Fang Wu, Ying Lin, Yishi Lu, Chongyang Huang, Binhai Shen, Hongbin Liu, Ruo Huang, Fengyi Hou, Qian Zhou, Mengyao Song, Ke Liu, Fangqing Zhu, Sheng Li, Yuqing Lin, Wei Wang, Ping Li, Wangjun Liao, Fachao Zhi

“…Fecal samples from eligible participants underwent shotgun metagenomic sequencing to comprehensively profile the gut microbiome composition and function. To evaluate probiotic efficacy and mechanisms, we utilized 6–8-week-old male BALB/c and C57BL/6 mice in established 5-FU- or CPT-11-induced CID models. …”
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Artificial intelligence for the understanding of electrolyte chemistry and electrode interface in lithium battery by Chen Yawei, Liu Yue, He Zixu, Xu Liang, Yu Peiping, Sun Qintao, Li Wanxia, Jie Yulin, Cao Ruiguo, Cheng Tao, Jiao Shuhong

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Multi-Objective Optimal Scheduling of Water Transmission and Distribution Channel Gate Groups Based on Machine Learning by Yiying Du, Chaoyue Zhang, Rong Wei, Li Cao, Tiantian Zhao, Wene Wang, Xiaotao Hu

“…The NSGA-II multi-objective optimisation algorithm is used to minimise the water distribution error and the water level deviation before the gate as the objective function in order to achieve global optimisation of the regulation of the complex canal system. …”
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Transcriptome analysis of early embryonic development in a mouse model of polycystic ovary syndrome by Shan Han, Shan Han, Jiale Lv, Xuedong Sun, Yanqiu Xie, Yuhua Shi, Yuhua Shi, Yuhua Shi

“…We subsequently evaluated the reproductive phenotype and fertility of the PCOS-like mice, focusing on ovarian function and embryo developmental potential. Smart-seqII RNA sequencing was performed on blastocysts to obtain the RNA expression profile of preimplantation embryos from PCOS mice. …”
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Sustainable Packaging Solutions: Food Engineering and Biodegradable Materials by Kai-Chao Yao, Hsi-Huang Hsieh, Kuo-Yi Li, Jing-Ran Xu, Wei-Sho Ho, Wei-Lun Huang, Shu-Hua Huang, Yu-Hsiang Liao, Ying-Ju Tseng

“…Through a systematic innovation design process, this research proposes a biodegradable food container capable of decomposing entirely into particles and water within one month, blending naturally with the soil without compromising functionality. Moreover, the container incorporates a quick-alignment mechanism and an intuitive sealing design that ensures airtightness and spill prevention. …”
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FGF21 protects against HFpEF by improving cardiac mitochondrial bioenergetics in mice by Ke Zhang, Jing Gan, Baile Wang, Wei Lei, Dong Zhen, Jie Yang, Ningrui Wang, Congcong Wen, Xiaotang Gao, Xiaokun Li, Aimin Xu, Xinguang Liu, Yulin Li, Fan Wu, Zhuofeng Lin

“…Here, we show that elevated circulating FGF21 levels are negatively associated with cardiac diastolic function in patients with HFpEF. …”
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The influence of environmental factors on woman's reproductive health by I. A. Zhirnov, K. A. Nazmieva, A. I. Khabibullina, L. A. Ilyasova, N. S. Saidmursalova, R. R. Demisheva, P. E. Alikhadzhieva, A. Kh. Soltagereeva, A. A. Golovnya, A. V. Kakhramonova, I. M. Dzhalilov, U. U. Galimova

“…Fertility experimental and epidemiological studies showed that environmental factors such as climate, temperature, seasonality, radiation, air pollution, diet and energy balance, working environment, bad habits (e.g. smoking), EDC (plasticizers, heavy metals, parabens, pesticides, industrial chemicals and their by-products, medicines, perfluorochemicals, antibacterial agents) may be associated with impaired female reproductive function.Conclusion. Environmental factors, including EDC, have a significant impact on women's reproductive health and can negatively affect fertility. …”
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Gut Microbiota and Neurovascular Patterns in Amnestic Mild Cognitive Impairment by Alexis B. Kazen, Laura Glass Umfleet, Fatima A. Aboulalazm, Alexander D. Cohen, Scott Terhune, Lilly Mason, Shawn Obarski, Malgorzata Franczak, Tammy Lyn Kindel, Yang Wang, John R. Kirby

“…<b>Background/Objectives:</b> The interplay between the gut microbiome (GMB) and neurovascular function in neurodegeneration is unclear. The goal of this proof-of-concept, cross-sectional study is to identify relationships between the GMB, neurovascular functioning, and cognition in amnestic mild cognitive impairment (aMCI), the prototypical prodromal symptomatic stage of Alzheimer’s disease (AD). …”
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Impact of Salinity on Sugar Composition and Partitioning in Relation to Flower Fertility in <i>Solanum lycopersicum</i> and <i>Solanum chilense</i> by Servane Bigot, Juan Pablo Martínez, Stanley Lutts, Muriel Quinet

“…Salinity negatively affects flower production and fertility in tomato but the underlying mechanisms are not fully understood. …”
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Characterization of the aryl hydrocarbon receptor as a potential candidate to improve cancer T cell therapies by Valentine De Castro, Oumaïma Abdellaoui, Barbara Dehecq, Babacar Ndao, Patricia Mercier-Letondal, Alexandra Dauvé, Francine Garnache-Ottou, Olivier Adotévi, Romain Loyon, Yann Godet

“…Multiple studies, particularly in murine models, have demonstrated the capacity of the aryl hydrocarbon receptor (AHR) to negatively regulate antitumor T cell functions. AHR is a cytoplasmic receptor and transcription factor that was originally identified as a xenobiotic sensor, but has since been shown to play a significant role in the gene regulation of various immune cells, including T cells. …”
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Analysis of Th17 and Tc17 Frequencies and Antiviral Defenses in Gut-Associated Lymphoid Tissue of Chronic HIV-1 Positive Patients by Gabriella d’Ettorre, Giancarlo Ceccarelli, Mauro Andreotti, Carla Selvaggi, Noemi Giustini, Sara Serafino, Ivan Schietroma, Giuseppe Nunnari, Guido Antonelli, Vincenzo Vullo, Carolina Scagnolari

“…These data indicate that prolonged antiretroviral treatment improves GALT immune function despite the persistence of immune activation and type I IFN response in chronic HIV-1 positive patients.…”
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Rehabilitation and physical activity during treatment of various types of cancer by Weronika Woźniak, Monika Gaszyńska, Antonina Drzewiecka, Artur Drzewiecki, Wiktor Korczak, Maria Anna Madejska, Aleksandra Rudzka, Wojciech Falkowski, Anna Krysińska, Jakub Magielski

“…Through their analysis, it is possible to demonstrate the impact of rehabilitation and physical activity on the functioning of patients during cancer treatment. Keywords: rehabilitation, exercise cancer, breast cancer, lung cancer, gastrointestinal cancer Brief description of state of the art: The negative effects of treatment can affect any system in the human body, so rehabilitation is necessary to assist the patient in the process of cancer therapy, which can have a significant positive impact on treatment. …”
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Involvement of WNT Signaling in the Regulation of Gestational Age-Dependent Umbilical Cord-Derived Mesenchymal Stem Cell Proliferation by Sota Iwatani, Akemi Shono, Makiko Yoshida, Keiji Yamana, Khin Kyae Mon Thwin, Jumpei Kuroda, Daisuke Kurokawa, Tsubasa Koda, Kosuke Nishida, Toshihiko Ikuta, Kazumichi Fujioka, Masami Mizobuchi, Mariko Taniguchi-Ikeda, Ichiro Morioka, Kazumoto Iijima, Noriyuki Nishimura

“…Although the cell proliferation and differentiation of BM-derived MSCs is known to decline with age, the functional difference between preterm and term UC-MSCs is poorly characterized. …”
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Spinel oxide enables high-temperature self-lubrication in superalloys by Zhengyu Zhang, Eitan Hershkovitz, Qi An, Liping Liu, Xiaoqing Wang, Zhifei Deng, Garrett Baucom, Wenbo Wang, Jing Zhao, Ziming Xin, Lowell Moore, Yi Yao, Md Rezwan Ul Islam, Xin Chen, Bai Cui, Ling Li, Hongliang Xin, Lin Li, Honggyu Kim, Wenjun Cai

“…By integrating high-temperature tribological testing, advanced materials characterization, and computations, we show that the formation of spinel-based oxide layers on superalloy promotes sustained self-lubrication due to their lower shear strength and more negative formation and cohesive energy compared to other surface oxides. …”
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Angiogenesis in rheumatoid Arthritis: Pathological characterization, pathogenic mechanisms, and nano-targeted therapeutic strategies by Fang Zhao, Zeyu Hu, Gejing Li, Min Liu, Qiong Huang, Kelong Ai, Xiong Cai

“…Herein, this review provides an in-depth description of the unique structural and functional aspects of pathological angiogenesis in RA and its negative consequences. …”
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Reelin-LRP8 signaling mediates brain dissemination of breast cancer cells via abluminal migration by Haofeng Huang, Min Zhang, Enyu Huang, Yongfang Zhao, Xiaoyu Li, Pu Qiu, Cairui Li, Jiahua Tao, Yuanqi Zhang, Lianxiang Luo, Guozhu Ning, Ceshi Chen, Jingjing Zhang

“…Our findings revealed that LRP8, an apolipoprotein E receptor, is upregulated in BC patients with brain metastasis. Functional studies demonstrated that LRP8 knockdown significantly inhibited proliferation, migration, and invasion of triple-negative breast cancer (TNBC) cells both in vitro and in vivo. …”
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Fe(II)-loaded goat manure biochar efficiently activated peroxymonosulfate for tetracycline degradation in groundwater by Lianjie Fan, Lianjie Fan, Lianjie Fan, Qinglin Xie, Yanhong Li, Shengzhang Zou, Shengzhang Zou, Haiping Lu, Haiping Lu, Su Ling Li, Su Ling Li, Xiaoxiao Li

“…Recently, the excessive discharge of goat manure has resulted in groundwater environmental challenges and negative impacts. It is of practical significance that such wastes can be converted into functional materials to promote the resource utilization of waste and reduce the risk of antibiotic contamination. …”
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