Dentin sialophosphoprotein (DSPP) gene-silencing inhibits key tumorigenic activities in human oral cancer cell line, OSC2. by Rajeshree Joshi, Amany Tawfik, Nneka Edeh, Veronica McCloud, Stephen Looney, Jill Lewis, Stephen Hsu, Kalu U E Ogbureke

“…<h4>Conclusions/significance</h4>DSPP-silencing in OSC2 cell decreased salient hallmarks of oral tumorigenesis and provides the first functional evidence of a potential key role for DSPP in oral cancer biology. …”
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Optimized Design of Cultural Space in Wuhan Metro: Analysis and Reflection Based on Multi-Source Data by Zhengcong Wei, Yangxue Hu, Yile Chen, Tianjia Wang

“…The main findings are as follows: (1) The metro cultural space is an important window for the public to perceive the city culture, and the public in general shows positive perception of emotions: among the 16,316 data samples, 47.7% are positive comments, 17.8% are neutral comments, and 34.5% are negative comments. (2) Based on the frequency of content in the sample data for metro station exit and entrance space, metro train space, metro concourse and platform space, they are ranked as weak cultural spaces (18%), medium cultural spaces (33%), and strong cultural spaces (49%) in terms of the public’s perception of urban culture. (3) At present, there are certain deficiencies in Wuhan metro cultural space: the circulation paths in concourses and platforms are overly dominant, leaving little space for rest or interaction; the cultural symbols of metro train space are fragmented; the way of articulation between cultural and functional space in the metro station exit and entrance space is weak, and the space is single in form. (4) Wuhan metro cultural space needs to be based on locality landscape expression, functional zoning reorganization, innovative scene creation to optimize the visual symbol system and behavioral symbol system in the space, to establish a good image of the space, and to strengthen the public’s cultural identity and emotional resonance.…”
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Metabolomic profiling of rectal microorganisms in Tibetan sheep across cold and warm seasons by Qi-Tala An, Zhipeng Zhao, Yaxiong Ren, Xia Liu, Liangwei Yao, Siyuan Chen, Zhikuan Yuan, Peijian Feng, Wenhao Li, Xiaohua Du

“…The current study sought to investigate the characteristics of alterations in rectal metabolites and their functional implications during the cold and warm seasons in Tibetan sheep. …”
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Analysis of dynamic network reconfiguration in HIV patients with cognitive impairment based multilayer network by Xingyuan Jiang, Juming Ma, Chuanke Hou, Hongjun Li

“…Our study aims to evaluate changes in the dynamic activity patterns of functional brain communities in the early stages of HIV infection by comparing time-varying multilayer network metrics. …”
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Use of a multifocal electroretinogram to evaluate the therapeutic effect of a single intravitreal dexamethasone implant, Ozurdex®, for refractory diabetic macular oedema by Aya Refaat Ali Mohammed, Mohamed Farouk Sayed Othman, Yehia Mahmoud Khairat, Amr Ahmed Mohamed Abdelrahman

“…Abstract Aim To evaluate the therapeutic effect of a single intravitreal dexamethasone implant (Ozurdex®) in eyes with refractory diabetic macular oedema (DME) anatomically via optical coherence tomography (OCT) and functionally via best corrected visual acuity (BCVA) and multifocal electroretinography (mfERG). …”
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Internet use patterns and their relationship with frailty in older Japanese adults by Yaya Li, Kayo Godai, Michiko Kido, Susumu Komori, Ryoichi Shima, Kei Kamide, Mai Kabayama

“…The K-means cluster analysis identified three internet use patterns: “less use” (n = 478), “social use” (n = 261), and “functional use” (n = 169). Logistic regressions with less use as a reference showed a negative relationship between social use and frailty (adjusted OR, 0.54; 95% CI, 0.35–0.84). …”
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Climate change distress and impairment in Germany by Lars König, Lars König, Priska Breves, Gesa Alena Linnemann, Tim Hamer, Ralf Suhr, Ralf Suhr

“…It is important, however, to differentiate between the affective experience of distress over climate change and the functional impairments associated with climate change. …”
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Values of the apparent diffusion coefficient in the differential diagnosis of tumors of the posterior fossa in the pediatric population of Colombia by Andrés Fernando López-Cadena, Luz Ángela Moreno-Gómez, Diego Armando Guerrero-Gómez

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Sentinel lymph node biopsy in patients with breast cancer. Experience in implementing at the regional level. Priority issues by A. Yu. Vorontsov, A. N. Volodin, M. A. Kurochkina, V. V. Radovskiy, T. V. Burova, S. V. Gamayunov

“…This study included 500 patients with invasive (T1–2) breast cancer with clinically negative sentinel lymph nodes of all immunohistochemical subtypes that had undergone SLNB and histological examination. …”
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Enrichment of galets with innovative plant components and their spectroscopic quality assessment by N. M. Stukalska, S. I. Litvynchuk, O. S. Bohdan

“…This also applies to the field of nutrition, since nutrition is one of the main and most effective methods of reducing the negative impact of the environment on the body. In order to increase the positive impact of food products on the body, actions are often taken to improve them by adding the latest ingredients to the classic recipe, which help to give the products new functional properties and increase their biological value. …”
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Barriers and facilitators of recovery in drug users under addiction treatment: A qualitative study by Hananeh Abdi, Azam Farah-Bijari, Batul Ahadi, Roshanak Khodabakhsh-Pirkalani

“…Internal stimuli were divided into three organizing categories: negative personality-emotional characteristics, weak cognitive functions, and skill weaknesses, and external stimuli were divided into three organizing categories: family injuries, traumatic socio-economic issues, and obstacles related to treatment. …”
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A pilot randomized trial comparing face-to-face and internet-based unified transdiagnostic treatment for adolescents with anxiety and depressive disorders in Iran by Nasim Mousavi, Fereshteh Momeni, Abbas Pourshahbaz, Hamid Poursharifi, Zahra Daneshian, Gerhard Andersson, Gerhard Andersson

“…A Mixed-model Analysis of Variance was used for data analysis.ResultsBoth face-to-face and internet-based transdiagnostic treatments demonstrated similar efficacy in reducing anxiety and depression symptoms, improving functioning, decreasing negative affect, and reducing avoidance in adolescents. …”
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Association Between Frailty Scoring and Cardiopulmonary Exercise Testing: A Retrospective Cohort Study by Alex Hunter, Matthew Roche, Moheb Robeel, Luke Hodgson

“…<b>Introduction:</b> Cardiopulmonary exercise testing (CPET) is the gold-standard assessment of functional capacity and predicts postoperative outcomes in major abdominal and thoracic surgery, as well as in older individuals undergoing elective surgery for colorectal cancer. …”
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The relationship between physical activity and Internet addiction among Chinese adolescents: exploring latent profile analysis and multi-level mediating mechanisms by Jiamin Zhu, Yutong Zhai, Xiaotong Yuan, Zhiyong Zhang, Xiaoping Meng, Xiaoping Meng

“…LPA supported a three-class solution—Functional Use (31.2%), At-Risk Use (49.5%), and Addicted Use (19.3%)—and multi-group SEM indicated that the magnitude of both indirect pathways varied across these typologies, with the strongest mediation observed in the At-Risk group. …”
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Green synthesis of silver nanoparticles using Keratinase from Pseudomonas aeruginosa-C1M, characterization and applications as novel multifunctional biocatalyst by Marium Saba, Safia Farooq, Abdulrahman H. Alessa, Kadriye Inan Bektas, Ali Osman Belduz, Alam Zeb Khan, Aamer Ali Shah, Malik Badshah, Samiullah Khan

“…The study further investigates the structural, morphological, and functional properties of these AgNPs, particularly their antibacterial activity and their potential role in azo dye decontamination. …”
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RELIABILITY, VALIDITY AND SENSITIVITY OF RUSSIAN VERSIONS OF PEDSQL GENERIC CORE SCALE AND PEDSQL RHEUMATOLOGY MODULE QUESTIONNAIRES by R.V. Denisova, E.I. Alexeeva, V.Yu. Al'bitsky, I.V. Vinyarskaya, S.I. Valieva, T.M. Bzarova, A.O. Lisitsin, E.Yu. Gudkova

“…Significant inverse negative relationship of functional insufficiency index reflects validity of Russian versions of PedsQL RM and PedsQL GCS questionnaires. …”
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Collective Trauma- Psychosocial consequences of war in northern Sri Lanka 10 years on, a mixed methods study by Umaharan Thamotharampillai, Ruwanthi Perera, Rajitha Wickremasinghe, Shehan Williams, Thedsanamoorthy Vijayasangar, Balasubramaniam Sivatharsan, Vanceline Hilbert, Daya Somasundaram

“…The observed social capital and collective efficacy changes, dysfunctional family units, negative changes in the functional dynamics of the community, higher rates of coping efforts and high prevalence of individual level effects of trauma are manifestations of collective trauma.…”
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Some Peculiarities of Psycho-Emotional Changes in Patients with Renal Encephalopathy by Shevaga V., Payenok A., Zadorozhnyj A., Zadorozhna B.

“…Today, doctors in general practice observe the steady growth of chronic diseases of the internal organs, which lead to violations of the normal functioning of the central nervous system with the gradual emergence of encephalopathy. …”
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UC-MSCs Secretome Induces Proliferation of CD4+ T Cells, CD8+ T Cells, NK Cells, and Increases sPD-1 Levels in Severe COVID-19’s Whole Blood by Winna Soleha, Heri Wibowo, Murdani Abdullah, Saraswati Pradipta, Lucky Novita Syari, Isabella Kurnia Liem, Arleni Bustami, Anna Rozaliyan

“…The secretome released by MSC functions similarly to the cells themselves as an immunomodulator, offering potential advantages in terms of safety and cost-effectiveness. …”
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Comprehensive Analysis of a circRNA-miRNA-mRNA Network to Reveal Potential Inflammation-Related Targets for Gastric Adenocarcinoma by YunXia Liu, YeFeng Xu, Feng Xiao, JianFeng Zhang, YiQing Wang, YongWei Yao, JieWen Yang

“…The regulatory network contained 26 circRNAs, 10 miRNAs, and 1459 mRNAs. Functional enrichment analysis revealed that the selected 33 DEGs were involved in negative regulation of fat cell differentiation, response to wounding, extracellular matrix- (ECM-) receptor interaction, and regulation of cell growth pathways. …”
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