A map of human cancer signaling by Qinghua Cui, Yun Ma, Maria Jaramillo, Hamza Bari, Arif Awan, Song Yang, Simo Zhang, Lixue Liu, Meng Lu, Maureen O'Connor‐McCourt, Enrico O Purisima, Edwin Wang

“…We find that cancer mutated genes are enriched in positive signaling regulatory loops, whereas the cancer‐associated methylated genes are enriched in negative signaling regulatory loops. We further characterized an overall picture of the cancer‐signaling architectural and functional organization. …”
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Contribution of two-component response regulator OmpR to virulence, motility, exopolysaccharide production, and osmotic stress in Pseudomonas syringae pv. actinidiae by Lei Zhang, Xiaoxi Chang, Ke Zhang, Qian Wang, Min Fu, Lili Huang, Lixin Zhang

“…The EnvZ/OmpR two-component system (TCS) has been confirmed to regulate virulence and mediate environmental stress responses in Gram-negative bacteria. However, the functional role of EnvZ/OmpR in Psa has not been fully clarified. …”
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Stimulation of the anterior thalamus modulates behavior in multiple cognitive domains by Ha Neul Song, Yu Jin Rah, Ik Hyun Ryu, Jung Han Shin, Seunghoon Lee, Young-Min Shon, Sang Ah Lee

“…Despite the fact that the ATN plays a crucial role in various cognitive functions, including emotional processing, memory, and spatial navigation, there is limited understanding of the effects of ATN-DBS across multiple cognitive domains. …”
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The “most bothersome symptom” construct: A qualitative study of Australians living with endometriosis by Alice M. Mitchell, Danushi Rajapakse, Michelle Peate, K. Jane Chalmers, Steven J. Kamper, Helena Frawley, Claudia Cheng, Martin Healey, Sarah Lensen

“…This term more appropriately captured the broad ways in which endometriosis symptoms impair daily functioning.…”
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A biopsychosocial approach to improving multidimensional frailty status in community-dwelling older adults: a protocol for a cluster randomized controlled trial by Jiao Jiao, David Wai-kwong Man, Sonia Lippke, Holger Hassel, Bjorn Tsz-king Tam, Connie Hoi-man Chan, Yuen-ling Ng, Kenneth Ka-hei Lo

“…Abstract Background Frailty is a significant clinical syndrome affecting aging populations, leading to increased risks of negative outcomes such as falls, disability, hospitalization, and premature mortality. …”
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Target-specific peptides for BK virus agnoprotein identified through phage display screening: advancing antiviral therapeutics by Xiaofei Xing, Jingxian Han, Keke Wang, Fuyun Tian, CuiXia Jiang, Wei Liang, Lin Qi, Xin Yue, Yinhang Wen, Yuwei Hu, Hui Qiao

“…Abstract BK virus is implicated in polyomavirus-associated nephropathy (PVAN) and hemorrhagic cystitis, particularly in kidney transplant recipients, affecting the functionality of the transplanted kidney and posing a risk of graft loss. …”
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Outcomes of temporalis muscle-based facial reanimation surgery: A systematic review and meta-analysis by Zhen Yu Wong, Frank W. de Jongh, Koen J.A.O. Ingels, Niels van Heerbeek, Sjaak Pouwels

“…Significant improvement was reported across the validated rating scales of symmetry, functional outcomes, aesthetic outcomes and patient-reported outcomes whereas the superiority compared to other procedures remained inconclusive. …”
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Viroscope™: a universal solution for plant virus and viroid diagnostics using HTS and cloud-based analysis by Verónica Morgante, Juan Cristóbal Jiménez, Claudio Ponce, Cristóbal Urrutia, Fernanda Vera, Camila Farías, Rocío Camps de la Maza, Valentina Caro, Marco Muñoz, Bernardo Pollak

“…Comparative analysis with RT-qPCR confirmed that Viroscope™ results exhibited a high degree of correlation with current methods and furthermore, Viroscope™ was able to detect viruses in samples which yielded negative RT-qPCR results. Universally applicable across plant tissue, Viroscope™ detects all known viruses and viroids in public databases while employing innovative metrics for functional assessment. …”
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Comprehensive analysis of faecal metagenomic and serum metabolism revealed the role of gut microbes and related metabolites in detecting colorectal lateral spreading tumours by Hao Lin, Yudai Chen, Ming Zhou, Hongli Wang, Lichun Chen, Li Zheng, Zhixin Wang, Xiaoling Zheng, Shiyun Lu

“…Colorectal lateral spreading tumours (LST), early-stage lesions of colorectal cancer (CRC), are associated with gut microbiota dysbiosis. However, the functional alterations in gut microbiota and their metabolic pathways remain inadequately understood. …”
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TRAF1-C5 Affects Quality of Life in Patients with Primary Biliary Cirrhosis by Joanna Raszeja-Wyszomirska, Ewa Wunsch, Agnieszka Kempinska-Podhorodecka, Daniel S. Smyk, Dimitrios P. Bogdanos, Malgorzata Milkiewicz, Piotr Milkiewicz

“…GG homozygotes of rs3761847 had lower vitality (P<0.05), mental health (P<0.05), mental component summary score (P<0.05) and impairment of social functioning (P<0.01). Allelic analysis has shown that T allele of rs2900180 and G allele of rs3761847 related to SF-36’s vitality (P<0.05 and P<0.01), social functioning (P<0.05 and P<0.05), mental health (P<0.01 and P<0.05), and mental component summary score (P<0.01 and P<0.05), respectively. …”
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Decoding the Molecular Grammar of TIA1-Dependent Stress Granules in Proteostasis and Welander Distal Myopathy Under Oxidative Stress by Isabel Alcalde-Rey, Beatriz Ramos Velasco, José Alcalde, José M. Izquierdo

“…Collectively, these findings illustrate a characteristic molecular grammar of TIAR- and TIA1-dependent SGs under oxidative conditions, suggesting a gain of versatility between two structurally and functionally highly conserved/related proteins.…”
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Impact of multiple educational technologies on well-being: the mediating role of digital cognitive load by Rasha Kadri Ibrahim, Yusraa Ahmed Al Marar, Modhi Salman, Shahed Jehad, Mariam Gaber Hamza, Ahmed Samir Abouelnasr, Sally Mohammed Farghaly Abdelaliem, Shorok Hamed Alahmedi, Abdelaziz Hendy

“…Self-administered questionnaires functioned as the principal instruments for data collection. …”
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The Personalized Approach to the Chronic Central Serous Chorioretinopathy Treatment Based on the Navigated Micropulse Laser Technology by P. L. Volodin, A. V. Doga, E. V. Ivanova, V. A. Pismenskaya, Iu. I. Kukharskaya, E. S. Khrisanfova

“…Results. 1 month after treatment the positive dynamics of functional and anatomical results in all patients was observed. …”
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Upregulation of transferrin receptor-1 induces cholangiocarcinoma progression via induction of labile iron pool by Wassana Jamnongkan, Raynoo Thanan, Anchalee Techasen, Nisana Namwat, Watcharin Loilome, Piyapharom Intarawichian, Attapol Titapun, Puangrat Yongvanit

“…Additionally, the levels of labile iron pool and the functions of transferrin receptor-1 on cholangiocarcinoma development were also identified. …”
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Diversity of mast cell subpopulations in the tumor microenvironment of colorectal cancer and their prognostic implications by Tianyu Qiao, Chao Ding, Songtao Yu, Wenyang Li, Yonghou Zhao, Guiyu Wang

“…Conclusion This study reveals the functional heterogeneity of mast cell subpopulations in the CRC tumor microenvironment and their differential roles in tumor progression. …”
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In silico analysis of L- and G-type lectin receptor kinases in tomato: evolution, diversity, and abiotic responses by Makarim Elfadil M. Osman, Rieham Sallah H. Osman, Sara A. A. Elmubarak, Mohanad A. Ibrahim, Hana Badreldin Mohamed Abakar, Amina I. Dirar, Emadeldin Hassan E. Konozy

“…These duplicated genes showed evidence of both purifying and negative selection, suggesting functional conservation and sub-functionalization. …”
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АSSOCIATION BETWEEN OXIDATIVE-ANTIOXIDANT MODIFICATIONS OF LOW-DENSITY LIPOPROTEINS AND CORONARY HEART DISEASE IN A MALE POPULATION OF NOVOSIBIRSK by Yu. I. Ragino, A. S. Krivchun, Ya. V. Polonskaya, L. V. Sherbakova, E. V. Sadovskyi, M. I. Voevoda

“…The participants underwent a questionnaire survey, a standard cardiologic survey, anthropometry, blood pressure measurement, and electrocardiography. “Definite CHD” (Functional Class II–IV stable effort angina) was registered in 223 men (21,8%), according to validated epidemiologic, clinical, and functional criteria. …”
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Personal Characteristics and Adaptation Mechanisms of Patients with Arterial Hypertension and Chronic Heart Failure by E. V. Efremova, A. M. Shutov, E. V. Petrova

“…Objective: to study the characteristics of adaptation and mental functioning of patients with hypertension and heart failure with comorbidity (the patient has concomitant diseases). …”
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FEATURES OF FREE RADICAL OXIDATION AND ANTIOXIDANT PROTECTION IN CHILDREN WITH SUGAR DIABETES OF THE FIRST TYPE by I. M. Bykov, L. G. Ivchenko, D. A. Domenyuk, N. Yu. Kostyukova, A. P. Storozhuk, D. M. Ilijev

“…Assessment of the state of lipid peroxidation, antioxidant defense and oxidative stress indicators on the model of functional activity of neutrophil granulocytes of blood in children with type 1 diabetes mellitus depending on the stage of endocrinopathy compensation.Materials and methods. …”
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A Novel Pyrazinone Derivative with Anti-MRSA Activity, Produced by <i>Streptomyces anulatus</i> Isolated from the Rhizosphere of <i>Malus trilobata</i> in Lebanon by Dany Abi Chahine, Bassel Awada, Ghada Derbaj, Aya Hanna, Antoine Abou Fayad, Mireille Kallassy Awad

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