Prevotella copri-mediated caffeine metabolism involves ferroptosis of osteoblasts in osteoarthritis by Feng Li, Xin Wen, Pu Xue, Huiping Xu, Panyang Wu, Zhiming Xu, Xianwei Wang, Guofu Pi

“…Here, we observed that in caffeine consumers, fecal Prevotella copri abundance was positively correlated with subchondral bone mass, serum caffeine concentration was negatively correlated with bone mass, and fecal P. copri was negatively correlated with serum caffeine. …”
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Salivary clearance of caffeine in children by Basant K. Puri, Christopher R. Heard, Jean A. Monro

“…The salivary caffeine clearance was negatively correlated with age (r = −0.59, p = 0.01). …”
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Evaluation Of Life Quality In Colorectal Cancer Patients by Gülşah Kayserilioğlu, Dilek Aygin

“…The diagnostic period of cancer, the treatment process and the complications caused by the treatments negatively affect the quality of life of the patients and his relatives who support his care. …”
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Hepatopulmonary syndrome in patients with porto-sinusoidal vascular disorder: Characteristics and outcome by Sabrina Sidali, Ylang Spaes, Kinan El Husseini, Odile Goria, Vincent Mallet, Armelle Poujol-Robert, Anne Gervais, Adrien Lannes, Dominique Thabut, Jean-Baptiste Nousbaum, Isabelle Hourmand-Ollivier, Charlotte Costentin, Alexandra Heurgué, Pauline Houssel-Debry, Sophie Hillaire, Nathalie Ganne-Carrié, Nicolas Drilhon, Shanta Ram Valainathan, Lucile Moga, Marion Tanguy, Estelle Marcault, Aurélie Plessier, François Durand, Sarah Raevens, Valérie Paradis, Agnès Cachier, Laure Elkrief, Pierre-Emmanuel Rautou

“…Conclusions: HPS in patients with PSVD was associated with genetic disorders, less preserved liver function, and higher plasma concentrations of angiogenic mediators. …”
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Intermittent Fasting and Its Health Implications: A Systematic Review of Existing Research by Jagoda Kubicka, Martyna Grabowska, Karolina Grabowska, Aleksandra Wiśniewska, Jakub Dąbek, Wiktoria Kosucka, Dominik Balik, Joanna Lara, Anna Kwasniewska, Karolina Kaszyńska

“…Moreover, IF is believed to have neuroprotective effects, improve cognitive functions and slow the progression of neurodegenerative diseases. …”
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Overview of imaging methods used in the diagnosis of stable coronary artery disease by I. V. Tarasova, A. L. Vertkin, V. A. Kozhushkov, I. A. Kozhushkov, N. E. Chebotar, E. A. Geydarova

“…Computed tomographic angiography is preferred in patients with the lowest values of the pre-test probability of coronary heart disease, as it has a very high negative prognostic value. The growing availability of software analysis makes computed tomographic angiography of the heart a universal imaging method capable of determining the anatomical and functional significance of stenotic lesions of the coronary arteries, identifying signs of intra- and pericoronary inflammation, and evaluating non-coronary structures. …”
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Synthesis of ternary nanocomposites of GO–MnO2@Tau and GO-MnO2@CA for efficient removal of dyes by Iram Bibi, Khalid Raza, Prof.Wajid Rehman, Siddiqa Begum, Magda H. Abdellatif, Saz Muhammad, Waqar Hussain Shah, Luqman A. Shah, saira Bibi, Wajiha Khan

“…These functionalized-MnO2 ­were then exploited as reinforcement in graphene oxide (GO) to fabricate nanohybrids. …”
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Variable Dose-Constraints Method Based on Multiplicative Dynamical Systems for High-Precision Intensity-Modulated Radiation Therapy Planning by Omar M. Abou Al-Ola, Takeshi Kojima, Ryosei Nakada, Norihisa Obata, Kohei Hayashi, Tetsuya Yoshinaga

“…Specifically, because it is as an iterative process derived from discretization of a linear differential equation system using the additive Euler method, a lower-bound clipping procedure is required to prevent the state variables for both beam coefficients and dose constraints from taking negative values. This issue could prevent constrained optimization from functioning properly and undermine the feasibility of the treatment plan. …”
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Study on the Wind Pressure Distribution in Complicated Spatial Structure Based on k-ε Turbulence Models by Jing Wang, Shixiong Zhou, Hui Liu, Shixing Zhao, Fei He, Lei Zhao

“…Furthermore, scalable wall functions and non-structured grids with appropriate refinement on both turbulent regions and structural surfaces are also adopted in the RANS method. …”
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Diminished reward circuit response underlies pain avoidance learning deficits in problem drinkers by Thang M. Le, Takeyuki Oba, Chiang-Shan R. Li

“…Our behavioral findings indeed showed a negative relationship between drinking severity and learning from successful pain avoidance. …”
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Point Cloud Geometry Scalable Coding Using a Resolution and Quality-Conditioned Latents Probability Estimator by Daniele Mari, Andre F. R. Guarda, Nuno M. M. Rodrigues, Simone Milani, Fernando Pereira

“…A naive solution to this problem is to encode multiple independent streams, each covering a different possible requirement for the clients, with an obvious negative impact in both storage and computational requirements. …”
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Impact of Vitamin D Deficiency on Iron Deficiency Anemia by Sleman Y. Omar, Awat H. Awla, Musher I. Salih, Badinan J. Hamadamin

“… Two important health problems are iron deficiency anemia and vitamin D deficiency, as well as the ability to cope with acute and chronic diseases, because iron and vitamin D are the main elements of physiological functions in the human body. Recent studies have indicated that generalized IDA in both healthy and diseased populations may be associated with inadequate levels of VD. …”
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Dual roles of innate immune cells and cytokines in shaping the breast cancer microenvironment by Chen Zhang, Chen Zhang, Wei Liu, Ping Yang, Ping Yang, Rubing Lin, Lulan Pu, Hongying Zhang

“…Innate immune effectors, including tumor-associated macrophages (TAMs) and natural killer (NK) cells, exert dual functions by either initiating robust antitumor responses or facilitating immune evasion, metastatic dissemination, and therapeutic resistance. …”
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Comparative metabolomic profiling of Lupinus albus and L. angustifolius harvest residues: exploring chemical diversity and valorization potential by Salma Halime, Salma Halime, Jenny Renaut, Stéphanie Zimmer, Hanna Heidt, Cédric Jacquard, Kjell Sergeant

“…Correlation analysis confirmed that a positive relationship exists between flavonoids and antioxidant activity, while saponins showed a negative correlation with antioxidant potential. This study highlights the distinct valorization opportunities of Lupinus residues: L. albus, rich in antioxidants and defense-related metabolites, holds promise for nutraceutical, pharmaceutical, and functional food applications as well as plant protection strategies. …”
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A qualitative study exploring depressed participants’ experiences of receiving Augmented Depression Therapy (ADepT) by Rebecca Watson, Kim A Wright, Nigel Reed, Barney Dunn, Emily Widnall, Kalliopi Demetriou, Laura Warbrick, Katie Marchant, Nicole Geschwind, Isabella Magner-Parsons, Rachel Barter

“…Helpful aspects of therapy were a positive therapeutic bond, the structure and flow of therapy scaffolding the learning journey, the tools and techniques of therapy helping building wellbeing and booster sessions supporting long-term recovery. Negative aspects for some participants were therapy feeling too intense and triggering feelings of failure. …”
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Assessment of safety and tolerability of hybrid gel oral administration in an experiment on Wistar rats by N. V. Nepovinnykh, S. V. Kozlov, I. V. Ziruk, V. S. Kutsenkova, Z. B. Ghorghi, M. A. Hesarinejad, S. Yeganehzad

“…Due to the negative health effects such as cardiovascular diseases, diabetes and obesity, the consumers avoid foods high in saturated fatty acids. …”
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Hair Metabolomic Profiling of Diseased Forest Musk Deer (<i>Moschus berezovskii</i>) Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry (UHPLC-MS/MS) by Lina Yi, Han Jiang, Yajun Li, Zongtao Xu, Haolin Zhang, Defu Hu

“…A total of 2119 metabolites were identified in the FMD hair samples, comprising 1084 metabolites in positive ion mode and 1035 metabolites in negative ion mode. Differential compounds analysis was conducted utilizing the orthogonal partial least squares–discriminant analysis (OPLS-DA) model. …”
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Membrane Permeability Monitoring to Antipsychotic Olanzapine Using Platinum Black-Modified Electrodes by Murugaiya Sridar Ilango, Dayananda Desagani, Srikanth Jagadeesan, Alexander Snezhko, Gad Vatine, Hadar Ben-Yoav

“…The blood–brain barrier (BBB) is key to the regular functioning of the central nervous system. The dysfunction of the BBB has been described in various neurological disorders, including schizophrenia. …”
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The role of galectin-1 and galectin-3 in the mechanisms of T-cell immune response dysregulation in colon cancer by V. S. Poletika, Yu. V. Kolobovnikova, O. I. Urazova, O. A. Vasileva, A. I. Dmitrieva, K. I. Yankovich, V. V. Novitsky, L. M. Ryabova, M. Yu. Grishchenko

“…In colon cancer, increased levels of galectin-1 and galectin-3 in the blood are associated with quantitative deficiency and inhibited secretory activity of effector T lymphocytes and activation of the immunosuppressive functions of regulatory T cells. These results suggest a negative role of galectin 1 and galectin 3 in the mechanisms of regulation of the T cell immune response in colon cancer.…”
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Efficiency mark postoperative pain management and normalization of adaptation status in patients with reproductive system oncopathology by D. A. Rozenko, A. I. Shikhlyarova, N. N. Popova, E. V. Verenikina, A. P. Menshenina, A. Yu. Ardzha, A. V. Shulga

“…Stages of the study included functional assessment of the patient's condition before surgical treatment and on the 1st and 5th days of the postoperative period.Results. …”
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