LncRNA EP300-AS1 interacts with PTBP1 to destabilize PRMT5 mRNA and suppresses NSCLC growth and metastasis by Jingyi Chen, Chongyu Fan, Songze Song, Deyu Zhang

“…EP300-AS1 inhibits NSCLC cell growth and metastasis both in vitro and in vivo, and is associated with better clinical outcomes. The function of EP300-AS1 depends on EP300-AS1-PTBP1 interaction and PTBP1-mediated PRMT5 mRNA stability. …”
Get full text

Comprehensive insights into cytomegalovirus anterior segment infections: A narrative review by Yih-Shiou Hwang, Po-Yi Wu, Eugene Yu-Chuan Kang, Wei-Chi Wu, Linda Yi-Hsing Chen, Chi-Chun Lai, Kyung Seek Choi

“…Early diagnosis and targeted antiviral treatment are key to preserving visual function and preventing complications, such as glaucoma and keratopathy. …”
Get full text

The dysregulation and regulatory mechanism of long non-coding RNA LBX2-AS1 in children with epilepsy by Qian Li, Ning Li

“…Target association was validated using dual-luciferase reporter assays. Function analysis for miR-873-5p target genes was analyzed by GO, KEGG, and PPI. …”
Get full text

Low Dose Theophylline Showed an Inhibitory Effect on the Production of IL-6 and IL-8 in Primary Lung Fibroblast from Patients with COPD by Jing Zhang, Ming-xiang Feng, Jie-ming Qu

“…There was a significant increase in both the mRNA expressions and protein levels for IL-6 and IL-8 in fibroblasts in COPD group, and the values were negatively correlated with lung function (P<0.05). For COPD fibroblasts, the protein levels of IL-6 and IL-8 decreased from 993.0 ± 738.9 pg/mL to 650.1 ± 421.9 pg/mL (P=0.014) and from 703.1 ± 278.0 pg/mL to 492.0 ± 214.9 pg/mL (P=0.001), respectively, with 5 μg/mL theophylline treatment. …”
Get full text

Evaluation of Thyroid Dysfunction in Type 2 DM in Duhok Governorate by Sefar Mohamad Al Haj, Bayar Ahmed Qasim

“…The patients were interviewed and examined, and their blood samples were taken for lipid profiles, Thyroid function tests, and at least 2 fasting blood sugars were checked. …”
Get full text

Nutritional strategies for minimizing gastrointestinal symptoms during endurance exercise: systematic review of the literature by Janez Mlinaric, Nina Mohorko

“…These disturbances are particularly prevalent in endurance sports, where GI function is commonly compromised, leading to adverse effects on performance. …”
Get full text

Tetraspanin (TSP-17) protects dopaminergic neurons against 6-OHDA-induced neurodegeneration in C. elegans. by Neda Masoudi, Pablo Ibanez-Cruceyra, Sarah-Lena Offenburger, Alexander Holmes, Anton Gartner

“…We show that TSP-17 is expressed in dopaminergic neurons and provide genetic, pharmacological and biochemical evidence that it inhibits DAT-1, thus leading to increased 6-OHDA uptake in tsp-17 loss-of-function mutants. TSP-17 also protects against toxicity conferred by excessive intracellular dopamine. …”
Get full text

Analysis of Pulsed Laser Target Echo Characteristics in Non-Uniform Smoke Environments by Chenyoushi Xu, Ruihua Zhang, Zhen Zheng, Bingting Zha, Weiping Cao, He Zhang

“…A semi-analytical Monte Carlo method for laser reception is developed by integrating the T-matrix scattering phase function rejection method with the characteristics of the non-uniform smoke environment. …”
Get full text

Effects of pattern dynamics on carbon storage capacity in the Qinghai-Tibetan Plateau from 1980 to 2020 by Jiajia Li, Guohua Liu, Xukun Su, Junyan Zhao, Lingli Zuo, Shuyuan Zheng, Kui Luo

“…Carbon storage was positively correlated with Aggregation Index and Largest Patch Index, but negatively correlated with Patch Density and Edge Density. …”
Get full text

Increase of labour efficiency and career potential of civil servants in Ukraine by V.F. Zagurska-Antonyuk, S.A. Berezenska, T.P. Vovkotrub, О.V. Bondarenko

“…Therefore, one of the ways of achievement of high efficiency of functioning the public administration bodies is the use of motivation function, which will allow to promote the personal interest of civil servants to work actively and full of initiative, to expose and realize their labour potential for the sake of the state and service the people of Ukraine. …”
Get full text

Prevalence of mental health conditions in post-conflict Kasai Province, Democratic Republic of the Congo: A repeated, cross-sectional study. by Maaike L Seekles, Jacob K Kadima, Pierre O L Omumbu, Junior K Kukola, Joy J Kim, Christian B Bulambo, Raphael M Mulamba, Motto Nganda, Laura Dean

“…As a key public health issue, these conditions negatively affect individuals, communities, and societies to function after a conflict. …”
Get full text

Postural instability and gait disturbance are associated with abnormal stereopsis in Parkinson's disease. by Jungyeun Lee, Sung Hoon Kang, Seong-Beom Koh

“…We collected data from medical history taking, scales, cognitive function tests, gait analysis, and tilt table tests. …”
Get full text

Plant traits linked to field-scale flammability metrics in prescribed burns in Eucalyptus forest. by Bianca J Tumino, Thomas J Duff, Jason Q D Goodger, Jane G Cawson

“…Vegetation is a key determinant of wildfire behaviour at field scales as it functions as fuel. Past studies in the laboratory show that plant flammability, the ability of plants to ignite and maintain combustion, is a function of their traits. …”
Get full text

Assessment of quality of life in children with allergic rhinitis by N. E. Tarasova, A. A. Lebedenko, O. E. Semernik, A.-A. A. Kostornaya, E. V. Kabachenko, A. A. Rvacheva

“…Hypoxia, induced by impaired ventilation of the respiratory tract, can negatively affect brain function, leading to decreased attention span, memory impairment, and cognitive dysfunction. …”
Get full text

Validation of Indonesian Graves’ Ophthalmopathy Quality of Life Questionnaire and Its Association with Clinical Activity and Severity of Graves’ Ophthalmopathy by Cecilia Anggraini, Syntia Nusanti, Dicky Levenus Tahapary, Levina Chandra Khoe

“…Background: Graves’ ophthalmopathy (GO) ocular abnormalities can persist even after treatment, negatively impacting patients’ psychological and social health. …”
Get full text

Wear Prediction and Mechanism Study of Tunnel Boring Machine Disc Cutter Breaking in Hard–Soft Rock Considering Thermal Effect by Xiongfei Lyu, Youliang Chen, Shaoming Liao, Tomas Manuel Fernandez-Steeger

“…The amount of abrasive wear is negatively correlated with the hardness of the cutter ring. …”
Get full text

Atrazine-Induced Intestinal Histopathology in Juvenile African catfish, Clarias gariepinus (Burchell, 1822) by P. A. Opute, F. E. Mbajiorgu

“…Abstract Atrazine is a frequently detectable, persistent, and ubiquitous pesticide that could negatively impact the survival of aquatic life including fish. …”
Get full text

Utilizing coffee bean subgrade quality by designing product development using integrated kansei words and Fuzzy QFD by Irvansyah Tri Ummarta, Imam Santoso, Dodyk Pranowo, Annisa’u Choirun

“…Although these beans have a low market value and can negatively impact quality and flavor, they still contain various beneficial compounds. …”
Get full text

Metformin diminishes the unfavourable impact of Nrf2 in breast cancer patients with type 2 diabetes by Elina Urpilainen, Jenni Kangaskokko, Ulla Puistola, Peeter Karihtala

“…Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a major regulator of the oxidative stress response and it is negatively regulated by Kelch-like ECH-associated protein 1 (Keap1). …”
Get full text

IGFBP2 enhances adipogenic differentiation potentials of mesenchymal stem cells from Wharton's jelly of the umbilical cord via JNK and Akt signaling pathways. by Yuejun Wang, Yunsong Liu, Zhipeng Fan, Dayong Liu, Fu Wang, Yongsheng Zhou

“…Moreover, IGFBP2 was negatively regulated by BCOR, which inhibited adipogenic differentiation of WJCMSCs. …”
Get full text