Mechanistic Role of the Mdm2/MdmX Lid Domain in Regulating Their Interactions with p53 by Qiuyin Wei, Chenqi Li, Yibing Tang, Jinping Bai, Wang Li, Jidong Liu, Zhengding Su, Xiyao Cheng

“…p53 functions as a critical guardian of the genome, orchestrating tumor suppression pathways and ensuring the integrity of chromosomal stability. …”
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Intracranial directed connectivity links subregions of the prefrontal cortex to major depression by John Myers, Jiayang Xiao, Raissa K. Mathura, Ben Shofty, Victoria Gates, Joshua Adkinson, Anusha B. Allawala, Adrish Anand, Ron Gadot, Ricardo Najera, Hernan G. Rey, Sanjay J. Mathew, Kelly Bijanki, Garrett Banks, Andrew Watrous, Eleonora Bartoli, Sarah R. Heilbronner, Nicole Provenza, Wayne K. Goodman, Nader Pouratian, Benjamin Y. Hayden, Sameer A. Sheth

“…Our findings support the overarching hypothesis that depression worsens with prefrontal disinhibition and functional imbalance between hemispheres.…”
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Fronto-occipital dyscommunication associates with brain hierarchy in schizophrenia by Haonan Pei, Hechun Li, Changyue Hou, Yayun Liu, Jiashuo Liu, Mingjun Duan, Dezhong Yao, Sisi Jiang, Cheng Luo

“…We measured the brain’s functional separation and quantified bidirectional information transfer changes between the frontal and occipital regions. …”
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Influence of pulmonary sequestration on growth and body weight: Case report and literature review by Joanna Rypel-Bośka, Natalia Siuta, Kamil Ciechomski, Izabela Brynczka, Marcin Migiel, Jakub Miaśnikiewicz, Klaudia Goleniowska, Aleksandra Gieras, Elżbieta Siuda, Wiktoria Cecuła

“…Background: Pulmonary sequestration is a rare congenital anomaly involving non-functional lung tissue with systemic arterial blood supply. …”
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Study on GPR Image Restoration for Urban Complex Road Surfaces Using an Improved CycleGAN by Xinxin Huang, Jialin Liu, Feng Yang, Xu Qiao, Liang Gao, Tingyang Fu, Jianshe Zhao

“…These unstable factors decrease GPR detection signal strength and cause signal shape distortion, negatively affecting detection accuracy. This reduces the interpretive accuracy of GPR images, impacting precise diagnosis of underground structures and hidden defects in urban roads. …”
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Role of intrinsic and supplemented antioxidants in follicular fluid: a shield against oxidative stress in oocyte health and embryo development by Nidhi Gairola, Himanko Gogoi, Janhvi Dubey, Jasvinder Singh Khatiyaan, Harsh Chaudhary

“…The excessive presence of ROS (Reactive Oxygen Species) can cause oxidative stress, which negatively affects follicular fluid (FF) and oocyte maturation. …”
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Study on the pore structure of eco-regenerated mortar using corn cob based on nuclear magnetic resonance by Zhou Zhang, Chaolin Wang, Yu Zhao, Kun Zhang, Mingxuan Shen

“…The probability density function of grayscale values transitions from being “thin and tall” to “short and wide”, with an increasing proportion of high grayscale values. …”
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Regulation of α-Ketoglutarate levels by Myc affects metabolism and demethylation in porcine early embryos by Ran Ding, Yongfeng Zhou, Qi Zhang, Xiangjie Kong, Qi Li, Sheng Zhang, Yibing Chen, Xinglan An, Ziyi Li

“…The Myc family is essential for cell proliferation, differentiation, and metabolism, particularly in embryonic development and stem cell functions. However, the specific role of Myc in porcine early embryonic development is not fully understood. …”
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The role of fermented foods in maternal health during pregnancy and infant health during the first 1,000 days of life by Arun Pandiyan, Arun Pandiyan, Arun Pandiyan, Manoj Gurung, Manoj Gurung, Bharath Kumar Mulakala, Bharath Kumar Mulakala, Bharath Kumar Mulakala, Sathish Kumar Ponniah, Laxmi Yeruva, Laxmi Yeruva

“…With the increasingly negative health outcomes from using low-quality diets like processed diets, functional products like fermented foods are getting more attention than ever. …”
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Multifunctional nitrogen-sulfur codoped carbon quantum dots: Determining reduced glutathione, broad-spectrum antibacterial activity, and cell imaging by Zhipeng Ruan, Zhifeng Xu, Tianhui Liu, Liwen Chen, Xiaoling Liu, Kaiying Chen, Chengfei Zhao

“…In this study, nitrogen-sulfur codoped carbon quantum dots (N-S/CQDs) with various functions and properties were synthesized through a one-step method utilizing citric acid and cysteine as reaction substrates. …”
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Risk Factors for Mortality Among Older Adults with Hospital-Acquired Bloodstream Infections in the Intensive Care Unit: A Multicenter Cohort Study by Tomer Hoffman, Ili Margalit, Alexis Tabah, Stéphane Ruckly, François Barbier, Pierre Singer, Jean-François Timsit, Virginie Prendki, Nasreen Hassoun-Kheir, Niccolò Buetti, Dafna Yahav, the EUROBACT-2 Study Group, the European Society of Intensive Care Medicine (ESICM), the European Society of Clinical Microbiology, Infectious Diseases (ESCMID) Study Groups for Infections in Critically Ill Patients (ESGCIP), Infections in the Elderly (ESGIE), the OUTCOMEREA Network

“…Among functionally independent patients, age itself was not associated with mortality. …”
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LONG-TERM AND LATE EFFECTS OF CHEMOTHERAPY IN CHILDHOOD ACLEUKEMIA AND THEIR MANAGEMENT SINGLE INSTITUTION OBSERVATIONUTE LYMPHOBLASTIC by Konul Baghirova

“…However, the toxicity of chemotherapy regimens, particularly late effects, negatively impacts long-term quality of life and clinical outcomes. …”
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Sleep Quality Among Medical Students: A Cross-Sectional Study at SRM Medical College and Research Centre by Prasath Thirumalai Raju, Kanimozhi Sadasivam, Sreekumar Ragupathy, K. N. R Aanantha, Kalyanipraba Premsundar, Yuvasri Srinivasan, Saravanan Ayyavoo, Panneerselvam Periasamy

“…Background: Sleep quality is crucial for medical students’ academic performance, cognitive function, and mental health. Poor sleep quality is prevalent among medical students, negatively impacting their well-being and future professional competence. …”
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GLS-YOLO: A Lightweight Tea Bud Detection Model in Complex Scenarios by Shanshan Li, Zhe Zhang, Shijun Li

“…To tackle the challenges posed by varying poses and occlusions of tea buds, Shape-IoU was employed as the loss function to improve the scoring of similarly shaped objects, reducing false positives and false negatives while improving the detection of non-rectangular or irregularly shaped objects. …”
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Association of serum homocysteine levels with acute kidney injury in patients with idiopathic membranous nephropathy by XIE Yi-yi, LI Qiu-lin, PAN Ling, LIAO Yun-hua

“…Objective To investigate the association of serum homocysteine levels with acute kidney injury(AKI)in patients with idiopathic membranous nephropathy(IMN).Methods We retrospectively analyzed 120 participants diagnosed as IMN between March 2011 and October 2015 in the Department of Nephrology,the First Affiliated Hospital of Guangxi Medical University.The patients were divided into high Hcy group(Hcy≥10μmol/L)and normal control group(Hcy<10μmol/L)according to serum Hcy levels.The clinical baseline data of the two groups were collected,such as gender,age,blood pressure,height,weight,blood pressure,renal function,blood lipids,complements C3 and C4,CRP,serum ferritin,serum albumin and 24-h urinary protein.The differences in the clinical baseline data and the incidence of AKI between two groups were analyzed.The related factors of Hcy were analyzed.The clinico-pathological factors of AKI in patients with IMN were analyzed by Logistic regression.Results The proportion of high Hcy in IMN patients was 65.5%,and the proportion of AKI in IMN patients was 26.7%.Moreover,the incidence of AKI in the high Hcy group was significantly higher than in the normal control group(32.9% vs.14.6%,P = 0.046).The Hcy level was positively correlated with SCr level,but negatively with eGFR.Binary logistic regression analysis showed that high Hcy(OR:3.455,95% CI:1.052-11.342,P=0.041)and high blood pressure(OR:4.279,95% CI:1.586-11.544,P=0.004)were independent risk factors for AKI.Conclusions High Hcy may increase the risk of AKI in patients with IMN and controlling the level of Hcy may play an important role in the prevention and treatment of AKI in IMN patients.…”
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Heat stress on sperm quality in dogs: effect of natural antioxidant supplementation by Lucrezia Forte, Matteo Burgio, Annalisa Rizzo, Aristide Maggiolino, Alice Carbonari, Pasquale De Palo, Giovanni Michele Lacalandra, Vincenzo Cicirelli

“…IntroductionHeat stress negatively affects canine reproductive health by inducing oxidative stress and impairing sperm quality. …”
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Trust and AI weight: human-AI collaboration in organizational management decision-making by Yanjun Wen, Jiale Wang, Xiaoxi Chen

“…The findings of Study 2 revealed that the perceived free will of AI agents negatively moderates the relationship between trust in AI and willing to collaborate with AI, such that the relationship is weaker when individuals perceive a higher degree of free will in AI agents than a lower degree.DiscussionTheoretically, this paper advances the understanding of the function of trust in human-AI interaction by exploring the trust development from attitude to act in human-AI cooperative decision-making. …”
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Effects of aerobic training and following detraining on continuous attention and brain-derived neurotrophic factor in sedentary girl students by Asiyeh Dehghani, Ehsan Zareian, Khosro Ebrahim

“…The brain-derived neurotrophic factor (BDNF) is an important factor affecting cognitive function and has been recently discussed in a bulk trend of efforts in the health context. …”
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Multiple Domain Associations within the Arabidopsis Immune Receptor RPP1 Regulate the Activation of Programmed Cell Death. by Karl J Schreiber, Adam Bentham, Simon J Williams, Bostjan Kobe, Brian J Staskawicz

“…Finally, we observed numerous intramolecular interactions that likely function to negatively regulate RPP1, and present a model describing the transition to an active NLR protein.…”
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Systematic analysis identifies TRIM22 as an oncogenic and immunological biomarker in glioma by Yuanyuan Hu, Haimei Zhi, Amin Zhang, Siyu Lu, Chen Zhang

“…The genes positively and negatively co-expressed with TRIM22 were identified using TCGA data to explore the functions and pathways affected by TRIM22 in glioma. …”
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