Investigation of white matter functional networks in young smokers by Junxuan Wang, Ting Xue, Daining Song, Fang Dong, Yongxin Cheng, Juan Wang, Yuxin Ma, Mingze Zou, Shuailin Ding, Zhanlong Tao, Wuyuan Xin, Dahua Yu, Kai Yuan

“…Aims: This study investigated the changes in the organizational and intrinsical activities of the white matter functional networks (WMFNs) in young smokers using resting-state functional magnetic resonance imaging. …”
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Exploring the Adhesion Properties of Extracellular Vesicles for Functional Assays by Bianca C. Pachane, Bess Carlson, Suzanne E. Queen, Heloisa S. Selistre‐de‐Araujo, Kenneth W. Witwer

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Preliminary Functional Analysis of the Gut Microbiome in Colic Horses by Pamela Thomson, Daniel Garrido, Rodrigo Santibáñez, Felipe Lara

“…PICRUSt2 was used to predict metabolic functions. Statistical analyses were performed with the Mann–Whitney U test from the Python scipy v1 package. …”
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Predictors of functional communication in people with aphasia after stroke by Adriana Fernandes, Helena Fraga-Maia, Iara Maso, Isabela Guimarães Matos, Lene Gomes, Matheus Matos, Andressa Santana, Jamary Oliveira-Filho, Pedro Antônio de Jesus, Elen Beatriz Pinto

“…Background Aphasia, the most common language disorder secondary to stroke, has been associated with increased mortality, longer hospitalization and rehabilitation times, worse performance in daily activities, increased financial burden, and short- and long-term complications. Aphasia can negatively impact functional communication skills, including social networks, social activities, relationships with other people and social support. …”
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Reduction of Glucocorticoid Receptor Function in Chronic Fatigue Syndrome by Megan Lynn, Laura Maclachlan, Andreas Finkelmeyer, James Clark, James Locke, Stephen Todryk, Wan-Fai Ng, Julia L. Newton, Stuart Watson

“…In the combined group (CFS plus HC), cortisol concentrations positively and ex vivo GR function (determined by dex-mediated suppression of IL-10) negatively correlated with childhood adversity score. …”
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Mediation analysis of depressive symptoms in the relationship between pulmonary function (measured by peak expiratory flow) and cognitive function among older adults in Chinese. by Chui-Yu Li, Hui-Rong Hu, Xiao-Qi Zhang, Yu-Mei Lin, Zhi-Yuan Chen

“…<h4>Results</h4>Spearman correlation analysis showed that PEF was positively correlated with cognitive function (r = 0.20, P < 0.001) and negatively correlated with depressive symptoms (r = -0.15, P < 0.001). …”
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Application progress of mindfulness-based stress reduction therapy in patients with depressive disorders (正念减压疗法在抑郁障碍患者中的应用进展) by DING Shengnan (丁圣楠), TANG Shiming (唐世明), ZHANG Lin (张林), WANG Yan (王岩), CHEN Qi (陈奇)

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Household Consumption Expenditures in Türkiye: Socio-Economic Determinants, Spending Patterns, and Policy Perspectives by Dilek Başar, Emre Yüksel

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Differences in motor function and psychological factors across phenotypic patterns of freezing of gait in Parkinson’s disease by CHANG Song, CUI Xiao, HUANG Heqing

“…Results‍　‍① There were significant differences between the PD-FOG and PD-NFOG groups in terms of motor parameters (stride width, length, height and cadence) and cognitive function (MoCA) score (P<0.05). The largest effect sizes were found for cognitive function scores of RMET [η²=0.716 (95%CI: 0.611~0.761), P<0.05], DSST [η²=0.667 (95%CI: 0.553~0.744), P<0.05], and MoCA [η²=0.597 (95%CI: 0.425~0.750), P<0.05], all of which were classified as medium effect sizes. ② Associative characteristics of motor and psychological factors in the PD-FOG group: H&Y stage was positively correlated with HADS-A [r=0.470 (95%CI: 0.080~0.735), P=0.018] and HADS-D [r=0.560 (95%CI: 0.199~0.787), P=0.004], while the total score of UPDRS-Ⅲ was negatively correlated with DSST [r=-0.574 (95%CI: -0.794~-0.219), P=0.003]. ③Subgroup analysis revealed significant differences (P<0.05) between the TP and SS patterns in motor parameters (stride length and cadence). …”
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Impact of negative symptom reduction on employment and vocational activity outcomes following cognitive remediation therapy in schizophrenia: A 1‐year follow‐up study by Yasuhisa Nakamura, Keito Shimada, Reiko Miyamoto, Akihiro Koreki, Sachiko Anamizu, Masaru Mimura

“…Pre‐ and post‐CRT assessments included the Global Assessment of Functioning (GAF), Positive and Negative Syndrome Scale (PANSS), Brief Assessment of Cognition in Schizophrenia (BACS), modified Tinkertoy Test (m‐TTT), Idea Fluency Test (IFT), Design Fluency Test (DFT), and Life Skills Profile (LSP). …”
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Genetic mechanisms of dynamic functional connectivity density in diabetic retinopathy brains: a combined transcriptomic and resting-state functional magnetic resonance imaging stud... by Yu-Lin Zhong, Hao Liu, Xin Huang

“…The abnormal dFCD variability is linked to 1,318 positively and 1,318 negatively associated genes, primarily enriched for biological functions such as ion channels, synapses, and cellular junctions. …”
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Unveiling Hidden Genetic Architectures: Molecular Diagnostic Yield of Whole Exome Sequencing in 50 Children With Autism Spectrum Disorder Negative for Copy Number Variations by Zhiwei Wang, Yali Zhao, Shuting Yang, Yongan Wang, Leilei Wang

“…All SNVs and InDels were loss-of-function (LOF) and were slightly more frequent among females (male vs. female: 9.3% vs. 14.3%). …”
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Supplementation with porcine placenta extract reduces negative emotions and enhances positive emotions in healthy adults: a randomized, double-blind, placebo-controlled study by Naoya Morita, Eiichi Hirano

“…The primary endpoint was TMD score, while secondary endpoints included fatigue, quality of life, sleep quality, autonomic function, and stress hormone levels.ResultsThe pPE group showed significant reductions in TMD scores and improvements in Anger-Hostility, Confusion-Bewilderment, Vigor-Activity, and Friendliness subscales compared to the placebo group. …”
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A multifunctional biomimetic nanoplatform combined with immune checkpoint blockade for triple-negative breast cancer immunotherapy through inhibiting polarization of M2 macrophages by Qianqian Zhou, Zongfang Jia, Yang Mu, Ya Xu, Fang Gao, Ruirui Wang, Liangliang Gu, Feifei Liu, Sheng Zhang, Weidong Chen, Yunna Chen, Lei Wang

“…Abstract Immune checkpoint inhibitor (ICI) therapy has become a hopeful treatment for triple-negative breast cancer (TNBC). However, most patients exhibit a low immune response. …”
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The circDUSP1/miR-429/DLC1 regulatory network affects proliferation, migration, and invasion of triple-negative breast cancer cells by Canhui Jian, Xiaoxue Tian, Shuai Luo, Jiafei Zeng, Jin Li, Ting Xu, Jinjing Wang

“…Although circRNAs function as miRNA sponges in TNBC, the specific role of circDUSP1 in the miR-429/DLC1 pathway remains unknown. …”
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Evaluation of the efficacy of hydrated sodium calcium aluminosilicate at mitigating the negative impact of aflatoxicosis on nutrient digestibility and other production- and health-... by Ahmed Ali Saleh, Rashed A. Alhotan, Mohammed A.A. Al-Badwi, Elsayed Osman Hussein, Livio Galosi, Giuseppe Crescenzo, Mahmoud Alagawany, Walied Abdo, Sara Mahmoud Omar, Claudia Zizzadoro

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Annonacin induces apoptosis and modulates programmed death-ligand 1 and interferon-gamma expression in triple-negative breast cancer: Integrated in silico and in vitro analysis by Retina Yunani, Sri Agus Sudjarwo, Mustofa Helmi Effendi, Rochmah Kurnijasanti, Nurul Hidayah

“…Background and Aim: Triple-negative breast cancer (TNBC) presents therapeutic challenges due to its aggressive nature and lack of targeted treatments. …”
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Cytotoxic properties, glycolytic effects and high-resolution respirometry mitochondrial activities of Eriocephalus racemosus against MDA-MB 231 triple-negative breast cancer by Francis Adu-Amankwaah, Candice Februarie, Kudakwashe Nyambo, Gerald Maarman, Ndivhuwo Tshililo, Lawrence Mabasa, Vuyo Mavumengwana, Lucinda Baatjies

“…Abstract Introduction Triple-negative breast cancer (TNBC) represents a significant global health crisis due to its resistance to conventional therapies and lack of specific molecular targets. …”
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Ubiquitin‐specific protease 25 improves myocardial ischemia–reperfusion injury by deubiquitinating NLRP3 and negatively regulating NLRP3 inflammasome activity in cardiomyocytes by Bozhi Ye, Diyun Xu, Lingfeng Zhong, Yi Wang, Wei Wang, Haowen Xu, Xue Han, Julian Min, Gaojun Wu, Wenhai Huang, Guang Liang

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The role of ultra-high field MRI and image processing in the presurgical workup in MRI-negative focal epilepsy: A validated 7T MRI case study by Daniel Uher, Gerhard S. Drenthen, Christianne M. Hoeberigs, Rick H.G.J. van Lanen, Albert J. Colon, Roy A.M. Haast, Vivianne H.J.M. van Kranen-Mastenbroek, Guido Widman, Paul A.M. Hofman, Louis G. Wagner, Jan C. Beckervordersandforth, Jacobus F.A. Jansen, Olaf E.M.G. Schijns, Walter H. Backes

“…This case study demonstrates the value of combined 7 T structural and functional MRI in the presurgical workup of a 24-year-old male with drug-resistant focal epilepsy who was initially considered MRI-negative on clinical 3 T MRI. …”
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