A dominant-negative mutation of mouse Lmx1b causes glaucoma and is semi-lethal via LDB1-mediated dimerization [corrected]. by Sally H Cross, Danilo G Macalinao, Lisa McKie, Lorraine Rose, Alison L Kearney, Joe Rainger, Caroline Thaung, Margaret Keighren, Shalini Jadeja, Katrine West, Stephen C Kneeland, Richard S Smith, Gareth R Howell, Fiona Young, Morag Robertson, Rob van T' Hof, Simon W M John, Ian J Jackson

“…We conclude that Icst is a dominant-negative allele of Lmx1b. These findings indicate a reassessment of whether nail-patella syndrome is always haploinsufficient. …”
Get full text

Early posttranscriptional response to tetracycline exposure in a gram-negative soil bacterium reveals unexpected attenuation mechanism of a DUF1127 gene by Jennifer A. F. Kothe, Till Sauerwein, Theresa Dietz, Robina Scheuer, Muhammad Elhossary, Susanne Barth-Weber, Jan Wähling, Konrad U. Förstner, Elena Evguenieva-Hackenberg

“…The gram-negative, soil-dwelling plant symbiont Sinorhizobium meliloti shares its free-living habitat with antibiotic producers. …”
Get full text

USP51/GRP78/ABCB1 axis confers chemoresistance through decreasing doxorubicin accumulation in triple-negative breast cancer cells by Yang Ou, Kun Zhang, Qiuying Shuai, Chenyang Wang, Huayu Hu, Lixia Cao, Chunchun Qi, Min Guo, Zhaoxian Li, Jie Shi, Yuxin Liu, Siyu Zuo, Xiao Chen, Yanjing Wang, Mengdan Feng, Hang Wang, Peiqing Sun, Yi Shi, Guang Yang, Shuang Yang

“…The present study provides evidence of USP51's functions as the prominent DUB in chemoresistant triple-negative breast cancer (TNBC) cells. …”
Get full text

Towards liquid biopsy on chip for Triple Negative Breast Cancer: preliminary results on monitoring circulating miRNA-21 using portable diagnostics by Alessandra Glovi, Panagiota M. Kalligosfyri, Antonella Miglione, Sima Singh, Gabriella Iula, Antonio Giordano, Michelino De Laurentiis, Stefano Cinti

“…In this work, miRNA-21 was selectively detected using a complementary DNA probe modified with methylene blue, as a redox mediator, immobilized onto an AuNPs-functionalized, paper-based screen-printed electrode. …”
Get full text

ELK3-CYFIP2 axis-mediated actin remodeling modulates metastasis and natural killer cell responses in triple-negative breast cancer by Seung Hee Choi, Hye Jung Jang, Joo Dong Park, Ki Seo Ryu, Eunchong Maeng, Seohyun Cho, Hail Park, Hae-Yun Jung, Kyung-Soon Park

“…Abstract Triple-negative breast cancer (TNBC) is an aggressive, highly metastatic disease with a poor prognosis. …”
Get full text

Fatigue is distinct from sleepiness and negatively impacts individuals living with obstructive sleep apnea (OSA): results from qualitative research of individuals with OSA by Helene A. Emsellem, Hilary H. Colwell, John Cronin, Ronald H. Farkas, Susan D. Mathias

“…Participants reported that their OSA symptoms negatively impact daily activities, functioning, work, and relationships. …”
Get full text

Cancer-associated fibroblasts promote doxorubicin resistance in triple-negative breast cancer through enhancing ZFP64 histone lactylation to regulate ferroptosis by KeJing Zhang, Lei Guo, Xin Li, Yu Hu, Na Luo

“…Abstract Background Cancer-associated fibroblasts (CAFs) have been identified to drive chemotherapy resistance in triple-negative breast cancer (TNBC). This study evaluated the functions of CAFs-mediated suppressive ferroptosis in doxorubicin (DOX) resistance in TNBC and its detailed molecular mechanisms. …”
Get full text

Construction of a novel five programmed cell death-related gene signature as a promising prognostic model for triple negative breast cancer by Quanfeng Shao, Hai-yan Gao, Zi-ying Wang, Yu-ling Qian, Wei-xian Chen

“…Background Triple negative breast cancer (TNBC) is a more aggressive subtype of breast cancer that usually progresses rapidly, develops drug resistance, metastasis, and relapses, and remains a challenge for clinicians to treat. …”
Get full text

Genomic characterisation of nasal isolates of coagulase-negative Staphylococci from healthy medical students reveals novel Staphylococcal cassette chromosome mec elements by Soo Sum Lean, Linah Wetthasinghe, Kai Shian Sim, Hong Xu Chong, Shafeeq Irshaad Bin Sharfudeen, Yee Wei Chen, Yu Yin Lim, Hoon Koon Teoh, Chew Chieng Yeo, Hien Fuh Ng

“…Abstract Coagulase-negative staphylococci (CoNS) are a diverse group of Gram-positive bacteria that are part of the normal human microbiota. …”
Get full text

A20 negatively regulates necroptosis-induced microglia/macrophages polarization and mediates cerebral ischemic tolerance via inhibiting the ubiquitination of RIP3 by Meiqian Qiu, Wenhao Zhang, Jiahua Dai, Weiwen Sun, Meijing Lai, Shiyi Tang, En Xu, Yuping Ning, Lixuan Zhan

Get full text

Elevated prolactin levels before endometrial transformation negatively impact reproductive outcomes in frozen embryo transfer cycles under hormone replacement therapy by Yaxin Wang, Fei Sheng, Li Cao, Jiaying Ni, Meishan Wang, Yan Yang, Jiating Wang, Jingyi Lu, Jian Zhou, Hongfang Shao

Get full text

Assessing international alcohol consumption patterns during isolation from the COVID-19 pandemic using an online survey: highlighting negative emotionality mechanisms by Henrietta Bowden-Jones, Valerie Voon, Samantha N Sallie, Valentin Ritou

Get full text

Does Mirabegron the β3 Agonist Frequently Used in the Treatment of Overactive Bladder Really Affect the Respiratory System Negatively ? A Prospective Study by Şenol Adanur, Ahmet Gedik, Ömer Araz, Elif Yılmazel Ucar, Kadir Ozmen, Fatih Akkaş, Tugay Aksakalli, Adem Utlu, Ahmet Cinislioğlu

“…Spirometry and body plethysmography were performed to objectively evaluate the respiratory functions of patients with OAB.ResultsThe spirometry and body plethysmography showed that the FVC value was 102.51 ± 16.99 L before, 101.77 ± 14.17 L at the first month, and 100.52 ± 15.98 L at the third month after mirabegron treatment. …”
Get full text

Association of plasma homocysteine with cognitive impairment in patients with Parkinson’s disease by Yan Xiao, Lin-Hua Gan, Xiao-Niu Liang, Zhi-Heng Xu, Tian-Yu Hu, Xiu-Yuan Li, Yi-Lin Tang, Jian Wang, Yi-Qi Liu

“…After adjusting for confounding factors, a negative correlation was observed between plasma Hcy levels and the performance on specific cognitive tests evaluating executive functions in PD, such as the Stroop Color-Word Test-C (β = −1.123, 95% CI = −1.845 ∼−0.401, p = 0.0023).ConclusionThis study underscores a significant link between plasma Hcy levels and PD-MCI, particularly concerning executive dysfunction, even within the normal range of Hcy levels (< 15 μmol/L).…”
Get full text

Effects of intraoperative open-lung strategy on cardiopulmonary function in frail elderly patients undergoing laparoscopic surgery: a randomized controlled trial by Yinyin Ding, Tianfeng Huang, Ju Gao, Xiangpeng Zhu, Yali Ge, Yang Zhang

“…Conclusion The application of OLS can effectively improve intraoperative respiratory mechanics and oxygenation in frail elderly patients, reduce the occurrence of PPCs, and shorten hospital stays of patients, without continuous negative impact on cardiac function. Trial registration Retrospectively registered; Chinese Clinical Trial Registry, www.chictr.org.cn , number: ChiCTR2200058783; Registered on April 17, 2022.…”
Get full text

Characteristics of motor function in children with hereditary neuromuscular disease by LI Wen-zhu, HUANG Zhen, FAN Yan-bin, XIONG Hui

“…Objective To analyze the characteristics of motor function in children with different types of hereditary neuromuscular disease (HNMD). …”
Get full text

Effect of atmospheric particulate matter on the functional state of mitochondria by Elena V. Kondratyeva, Tatyana I. Vitkina

“…Atmospheric air pollution negatively affects a number of key aspects of human health, including the functioning of the respiratory, cardiovascular and central nervous systems, but many issues remain unresolved about the relationship between atmospheric air pollution and the development and course of pathologies. …”
Get full text

Functional regulation of cytotoxic T Cells by gut microbial metabolites by Chang H. Kim

“…Metabolites from gut microbes have a wide range of functions within the host body. One important function of these metabolites is to either positively or negatively control CD8+ cytotoxic T lymphocytes (CTLs), which can kill cancer and virus-infected cells. …”
Get full text

The Effect of the Hemodialysis Practice on the Dialysis Patients’ Sexual Functions by Sibel Şentürk, Alev Yıldırım Keskin

“…Objective: This study aims to analyze the effect of the hemodialysis practice on the patients’ sexual functions and sexual experiences. Materials and Methods: Designed as phenomenological research, the study was performed with 19 patients who had hemodialysis treatment from 20 January 2021 to 20 February 2021 and agreed to participate in the study. …”
Get full text

Differential lipid dependence of the function of bacterial sodium channels. by Nazzareno D'Avanzo, Emily C McCusker, Andrew M Powl, Andrew J Miles, Colin G Nichols, B A Wallace

“…NavMs and NavSp showed strong preference for different negatively-charged lipids (phosphatidylinositol and phosphatidylglycerol, respectively), whilst NaChBac exhibited a more modest variation with lipid type. …”
Get full text