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miR-375-3p negatively regulates osteogenesis by targeting and decreasing the expression levels of LRP5 and β-catenin.
Published 2017-01-01“…The mRNA levels of important negative modulators relating to osteogenesis increased after the functions of LRP5 were blocked in mice. …”
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Positive and Negative Affect Differentially Predict Individual Differences and Intra-Individual Changes in Daily Cognitive Failures in Younger and Older Adults
Published 2024-12-01“…(1) Background: Cognitive failures, including lapses in attention, memory, and executive functioning, can negatively affect daily performance and well-being. …”
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HMGA2 interacts with KAT6A to regulate MMPs chromatin architecture and promote triple-negative breast cancer metastasis
Published 2025-05-01“…BackgroundTriple-negative breast cancer (TNBC), the most lethal breast cancer subtype, demonstrates poor prognosis due to its high rates of metastasis, recurrence, and mortality. …”
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Controlled Synthesis of Gold Nanoparticles Using Aspergillus terreus IF0 and Its Antibacterial Potential against Gram Negative Pathogenic Bacteria
Published 2014-01-01“…In addition, the synthesized gold nanoparticles were found to be selectively bactericidal against the pathogenic gram negative bacteria, Escherichia coli.…”
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The inner nuclear membrane protein, Banf1, has an essential role in triple negative breast cancer cell proliferation and survival
Published 2025-07-01“…Abstract Triple negative breast cancers (TNBCs) are a heterogenous subcategory of breast cancers which have significantly worse survival outcomes compared to other breast cancer subtypes. …”
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O-GlcNAcylation on serine 40 of histone H2A promotes proliferation and invasion in triple-negative breast cancer
Published 2025-03-01“…Abstract Triple-negative breast cancer (TNBC) is characterized by resistance to conventional treatment and a poor prognosis. …”
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Hydroxyacid Oxidase 2 (HAO2) Inhibits the Tumorigenicity of Hepatocellular Carcinoma and Is Negatively Regulated by miR-615-5p
Published 2022-01-01“…Furthermore, we examined the biological activity of HAO2 utilizing cell-based functional assays. Additionally, we evaluated the relationship between miR-615-5p and HAO2 in Hep3B cells using a dual-luciferase reporter system and assessed the downstream regulatory mechanisms of miR-615-5p on HAO2. …”
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Enhancing Negative Film Colorization through Systematic CycleGAN Architectural Modifications: A Comprehensive Analysis of Generator and Discriminator Performance
Published 2025-06-01“…The dataset consists of 500 negative images (train A), 500 unpaired color images (train B), as well as 5 negative images and 5 color images for testing purposes. …”
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Exploration of the role of drug resistance-associated anoikis-related genes in HER2-Negative breast cancer through bioinformatics analysis
Published 2025-03-01“…Aims: To explore the potential functions and impacts of anoikis-related genes (ARGs) in breast cancer chemotherapy and to construct a prognosis model for HER2-negative breast cancer (HNBC) based on drug resistance-related ARGs. …”
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Understanding the selectivity in silico of colistin and daptomycin toward gram-negative and gram-positive bacteria, respectively, from the interaction with membrane phospholipids
Published 2025-07-01“…Colistin exhibits activity only against gram-negative bacteria, while daptomycin only against gram-positive bacteria. …”
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Serum Magnesium Levels Are Negatively Associated with Obesity and Abdominal Obesity in Type 2 Diabetes Mellitus: A Real-World Study
Published 2024-11-01“…Furthermore, the independently negative association of serum magnesium with obesity may be explained by its anti-inflammatory functions. …”
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Cytotoxic Activity and Senescence Modulatory Effect of Hesperetin on Triple-Negative Breast Cancer Cells and Kidney Cells Co-Treatment with Cisplatin
Published 2023-10-01“…Hesperetin (HST), a flavanone found in various citrus fruits, exhibits bioactive properties, functioning as an antioxidant, anti-inflammatory, and anticancer agent. …”
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Exploring the potential of Gonolobus condurango as a histone deacetylase inhibitor in triple-negative breast cancer cell lines: in vitro study
Published 2025-05-01“…Abstract Background Triple-negative breast cancer (TNBC) is a subtype associated with poor prognosis, low survival rates, and high expression of histone deacetylases (HDAC). …”
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Peripheral blood markers predict prognosis and irAEs of stage IV driver gene-negative lung adenocarcinoma treated with ICIs
Published 2025-03-01“…Subsequent logistic regression analysis revealed that both platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR) functioned as independent predictors of irAEs with statistical significance (P=0.032; P=0.02).ConclusionFor patients with stage IV driver gene-negative lung adenocarcinoma undergoing ICI therapy, PNI and metastatic status can serve as initial predictors of PFS. …”
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TRPC6-Mediated Zn<sup>2+</sup> Influx Negatively Regulates Contractile Differentiation of Vascular Smooth Muscle Cells
Published 2025-02-01“…There were no significant differences in TRPC6-dependent cation currents among all RAoSMCs pretreated with or without TGFβ and/or PPZ2, suggesting that TRPC6 channels are functionally expressed in RAoSMCs regardless of their phenotype. …”
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