Application of deep learning models on single-cell RNA sequencing analysis uncovers novel markers of double negative T cells by Tian Xu, Qin Xu, Ran Lu, David N. Oakland, Song Li, Liwu Li, Christopher M. Reilly, Xin M. Luo

“…Abstract Double negative T (DNT) cells are a unique subset of CD3 + TCRαβ + T lymphocytes that lack CD4, CD8, or NK1.1 expression and constitute 3–5% of the total T cell population in C57BL/6 mice. …”
Get full text

Negative effects of forest harvest on coastal tailed frog (Ascaphus truei) emerge after a decade‐long experiment by Aimee P. McIntyre, Reed Ojala‐Barbour, Jay E. Jones, Andrew J. Kroll, Eric M. Lund, Timothy Quinn, William J. Ehinger, Stephanie M. Estrella, Dave E. Schuett‐Hames, Marc P. Hayes

“…Abstract Perennial, low‐order headwater streams provide critical ecosystem functions, including habitat for specialized aquatic species. …”
Get full text

CD151 Promotes Cancer Progression in Triple-Negative Breast Cancer by Inducing EMT through the MAPK Signaling Pathway by Lv H, Zhang B, Weng X, Li Y, Deng C, Wang R, Shi L, Yin Y

“…However, the specific functions of CD151 in triple-negative breast cancer (TNBC) remain unclear. …”
Get full text

Impaired response inhibition to negative emotional stimuli in depressed adolescents with non-suicidal self-injury: a neurophysiological perspective by Lin Zhao, Su Hong, Xinyu Peng, Xiaoqing He, Jinhui Hu, Lingli Ma, Xinyi Liu, Wanqing Tao, Ran Chen, Zhenghao Jiang, Chenyu Zhang, Jing Liao, Jiaojiao Xiang, Qi Zeng, Linqi Dai, Qi Zhang, Wo Wang, Li Kuang

“…Moreover, depressed adolescents with NSSI showed significant event-related synchronization (ERS) in the Delta and Theta bands of FCz electrode from 0 to 0.6 seconds, and event-related desynchronization (ERD) in the Theta and Alpha bands of Pz electrode from 0.2 to 1.2 seconds, collectively reflecting functional processes associated with response inhibition.ConclusionsDepressed adolescents with NSSI showed increased P3d amplitudes, enhanced Delta/Theta ERS, and heightened Theta/Alpha ERD when receiving negative emotional stimuli, suggesting that depressed adolescents with NSSI have impaired response inhibition, which may contribute to the development of NSSI.…”
Get full text

Safavid Libraries: Continuity and Change in Functions by Mahshid Borjian Borujeni, Zahra Abazari, Gholamreza Amirkhani, Fereshteh Sepehr, Nadjla Hariri

“…Objective: The main objective of the research is to study and analyze the function and role of libraries during the Safavid dinasty. …”
Get full text

Digital Devices and Cognitive Functions in Children by George A. Karkashadze, Leyla S. Namazova-Baranova, Elena A. Vishneva, Natalia Е. Sergeeva, Tinatin Yu. Gogberashvili, Nadezhda A. Ulkina, Elena V. Kaytukova, Dmitriy S. Kratko, Svetlana E. Kondratova, Safarbegim Kh. Sadilloeva, Marina A. Kurakina, Anastasiya I. Rykunova, Leonid M. Yatsick, Inessa A. Povalyeva, Tatiana A. Konstantinidi, Daria A. Bushueva, Pavel A. Prudnikov, Natalia S. Sergienko, Yuliya V. Nesterova, Elizaveta V. Leonova, Aishat M. Gazalieva, Irina V. Zelenkova, Natella V. Sukhanova

Get full text

Effect of Supplementation of Quercetagetin on the Antioxidant Function, Liver Mitochondrial Function and Gut Microbiota of Broilers at High Stocking Density by Shuo Yang, Zixuan Su, Min Huo, Cuihong Zhong, Fangfang Wang, Yongying Zhang, Yaqi Song, Yuxiang Shi

“…However, dietary supplementation with 20 mg/kg QG significantly alleviated the negative effects induced by HSD, restoring growth performance, stress hormone levels, immune parameters, and liver antioxidant and mitochondrial function. …”
Get full text

Echinochrome A inhibits epithelial–mesenchymal transition and induces cell death mediated by DNA damage in human triple-negative breast cancer cells by Soon Yong Park, Mi-So Jeong, Cong So Tran, Jinyoung Lee, Da-Young Eum, Seyeon Jung, Elena A. Vasileva, Seoung Rak Lee, Hyoung Kyu Kim, Natalia P. Mishchenko, Jin Han, Yoo Jin Choi, Si Ho Choi, Hwayoung Yun, Kyu Heo

Get full text

Accelerated unconstrained latent factorization of tensor model for Web service QoS estimation by Mingwei LIN, Wenqiang LI, Xiuqin XU, Jian LIU

“…Aiming at the problem that the Web service quality of service (QoS) estimation methods based on the non-negative latent factorization of tensor model (NLFT) depend heavily on non-negative initial random data and specially designed non-negative training schemes, which lead to low compatibility and scalability, an accelerated unconstrained latent factorization of tensor (AULFT) model was proposed.The proposed model consisted of three main parts.The non-negative constraints from decision parameters were transferred to output latent factors and they were connected through the single-element-dependent mapping function.A momentum-incorporated stochastic gradient descent (MSGD) algorithm was used to effectively improve the convergence rate and estimation accuracy of the proposed AULFT model.The detailed algorithm and result analysis of the proposed AULFT model were presented.The empirical study on two dynamic QoS datasets in real industrial applications demonstrates that the proposed AULFT model has higher computational efficiency and estimation accuracy than the state-of-the-art QoS estimation models.…”
Get full text

Male reproductive function in diabetes mellitus by Roman Viktorovich Rozhivanov, Natalya Sergeevna Parfenova, Dmitriy Gennad'evich Kurbatov

Get full text

Sexual Shame and Women’s Sexual Functioning by Camilla Graziani, Meredith L. Chivers

“…Sexual shame negatively affects women’s sexual functioning, impacting arousal, desire, orgasm, and pain. …”
Get full text

Methionine metabolism, functions, and application in swine by Mengliao Wan, Yulong Yin, Yehui Duan, Jiashun Chen

“…Additionally, Met can be converted into several functional derivatives, such as S-adenosylmethionine (SAM) and homocysteine (Hcy) through which it exerts its biological functions. …”
Get full text

Functional traits mediate the elevational patterns of functional diversity and community structure of mosses in a tropical mountain area by Liqin Fu, Chengxiu Zhan, Haozhe Wang, Shikai Song, Peng Xu, Lina Zhang, Jiancheng Zhao, De Gao

“…We found the first DCCA axis accounted for the largest dissimilarities between the two groups of species and correlated mainly with the water-utilization traits. Although both functional diversity and community structure displayed negatively skewed pattern along the elevational gradient, habitat complexity and climatic variables contributed differently to their respective patterns. …”
Get full text

Efficacy of ABC-X model care intervention combined with omalizumab on moderate to severe allergic asthma and negative emotional of family members by ZHAO Nina, YUE Xueyan, RU Liang

“…Observe and compare clinical efficacy before and after intervention, incidence of adverse reactions to omalizumab, pulmonary function, immune function, inflammatory indicators, and negative emotions of family members.Results A total of 120 children with asthma and their families were recruited in the study, with 60 pairs in each group. …”
Get full text

Dominant-Negative Effect of a Missense Variant in the TASK-2 (KCNK5) K+ Channel Associated with Balkan Endemic Nephropathy. by Alan P Reed, Giovanna Bucci, Firdaus Abd-Wahab, Stephen J Tucker

“…Furthermore, these mutant subunits have a suppressive or 'dominant-negative' effect on channel function when coexpressed with wild-type subunits. …”
Get full text

Integrating multi-omics data reveals the antitumor role and clinical benefits of gamma-delta T cells in triple-negative breast cancer by Guixin Wang, Shuo Wang, Wenbin Song, Chenglu Lu, Zhaohui Chen, Long He, Xiaoning Wang, Yizeng Wang, Cangchang Shi, Zhaoyi Liu, Yue Yu, Xin Wang, Yao Tian, Yingxi Li

Get full text

Suppression of scant identifies Endos as a substrate of greatwall kinase and a negative regulator of protein phosphatase 2A in mitosis. by Hélène Rangone, Eva Wegel, Melanie K Gatt, Eirene Yeung, Alexander Flowers, Janusz Debski, Janusz Debski, Michal Dadlez, Veerle Janssens, Adelaide T C Carpenter, David M Glover

Get full text

Tumor cell-derived EMP1 is essential for cancer-associated fibroblast infiltration in tumor microenvironment of triple-negative breast cancer by Qi Wang, Dandan Li, Haixiu Ma, Zengyan Li, Juan Wu, Jinwan Qiao, Jun Liu, Jing Zhao, Ronghua Ma, Lin Tian, Lei Zhang, Jianye Yang, Jianing Wang, Shanshan Qin, Zhanhai Su

“…In addition, the biological function of EMP1 in triple-negative breast cancer (TNBC) is largely unclear. …”
Get full text

Beclin1-mediated vascular autophagy negatively regulates angiogenesis and secondary neural damage in the thalamus following cerebral cortical infarction by Mengzhi Liu, Yuqian Chen, Xinyan Fan, Jinmin Gu, Shihui Xing

Get full text

Exercise Leads to Brain Glucose Metabolism Activation, Increased Dopamine D1 Receptor Levels and is Negatively Correlated with Social Behavior by Michael Bobick, Colin Hanna, John Tyler, Patrick Mohr, Huy Lu, Aidan Powell, Kenneth Blum, David Baron, Kai-Uwe Lewandrowski, Igor Elman, Albert Pinhasov, Mark S. Gold, Panayotis K. Thanos

“…These regions are associated with enhanced functional connectivity related to movement, olfaction, cardiovascular function, and predator awareness. …”
Get full text