Pyroptosis‐Inducing Platinum(IV) Prodrugs via GSDME Pathway for Chemoimmunotherapy and Metastasis Inhibition in Triple‐Negative Breast Cancer by Xinda Yang, Chuansheng Xu, Youliang Zeng, Chunhui Wang, Yan Gao, Jie Ding, Sirui Chen, Yuheng Pan, Xin Zhang, Zongwan Mao, Shuo Shi

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Efficacy of Tamponade of Vitreal Cavity by Perfluororganic Compound Emulsion with Antibiotics Solutions in Treatment of Gram Negative Endopthalmitis (Experimental Study) by I. A. Frolychev, N. P. Pashtaev, N. A. Pozdeyeva, D. V. Sycheva

“…Besides functional loss anatomic loss of eye was observed in 33.33 % cases in the first group. …”
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Single-cell RNA sequencing of human double-negative T cells reveals a favorable cellular signature for cancer therapy by Li Zhang, Sergio Rutella, Jongbok Lee, Ismat Khatri, Yoosu Na, Enoch Tin, Karen Fang, Michele Nawata, Juan Arteaga, Mark D Minden

“…Collectively, this hinders our ability to bolster DNT functionalities in cancer therapy. Here, we performed single-cell RNA sequencing with in vitro and in vivo functional analysis on DNTs. …”
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Analysis of the Transcriptional Control of <i>Bcl11b</i> in Chicken: IRF1 and GATA1 as Negative Regulators by Lingling Qiu, Haojie Wang, Wenhao Li, Ting Yang, Hao Bai, Guobin Chang

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Identification of three T cell-related genes as diagnostic and prognostic biomarkers for triple-negative breast cancer and exploration of potential mechanisms by Zhi-Chuan He, Zheng-Zheng Song, Zhe Wu, Peng-Fei Lin, Xin-Xing Wang

“…BackgroundTriple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer (BRCA) with limited therapeutic targets. …”
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Single-cell ligand–receptor profiling reveals an immunotherapy-responsive subtype and prognostic signature in triple-negative breast cancer by Chuanzhi Chen, Jiahui Qi, Weichao Lin, Chunlan Fu, Xin Jin

“…BackgroundTriple-negative breast cancer (TNBC) is an aggressive form of cancer that lacks specific targeted therapies. …”
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APC orchestrates microtubule dynamics by acting as a positive regulator of KIF2A and a negative regulator of CLASPs by Yong Wang, Xinping Liu, Zheng Liu, Shasha Hua, Kai Jiang

“…Reconstitution experiments demonstrate that APC potentiates KIF2A-induced MT catastrophes and antagonizes the stabilizing effect of CLASP2 in vitro. In summary, APC functions as a positive regulator of MT-destabilizer and a negative regulator of MT-stabilizer to orchestrate MT dynamics.…”
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A novel role for the transcription factor Cwt1p as a negative regulator of nitrosative stress in Candida albicans. by Adnane Sellam, Faiza Tebbji, Malcolm Whiteway, André Nantel

“…In summary, we have characterized a novel negative regulator of NSR and bring new insights into the transcriptional regulatory network governing fungal NSR.…”
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Jab1 regulates HRR mRNA stability to modulate PARP inhibitor sensitivity in triple-negative breast cancer by Xin Peng, Yingying Wang, Zixiang Yu, Shengfan Huang, Shaolu Zhang, Zhenxing Zhong, Yongzhe Wang, Shanshan Liu, Kailin Wang, Christophe Nicot, Francois X. Claret, Dexin Kong

“…Mechanistically, Jab1 functioned as an RBP through its MPN domain, stabilizing HRR-related transcripts by competitively antagonizing the RNA exosome complex. …”
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MAFLD in Patients with Cushing’s Disease Is Negatively Associated with Low Free Thyroxine Levels Rather than with Cortisol or TSH Levels by Kuangyang Chen, Lijiao Chen, Jiarong Dai, Hongying Ye

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TROP2 is highly expressed in triple-negative breast cancer CTCs and is a potential marker for epithelial mesenchymal CTCs by Qingyu Liao, Ruiming Zhang, Zuli Ou, Yan Ye, Qian Zeng, Yange Wang, Anqi Wang, Tingmei Chen, Chengsen Chai, Bianqin Guo

“…Real-time dynamic molecular and functional typing of CTCs is necessary to precisely guide personalized treatment. …”
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Method for modelling the number of HIV and AIDS cases using least square spline Biresponse nonparametric negative binomial regression by Arip Ramadan, Nur Chamidah, I Nyoman Budiantara, Budi Lestari, Dursun Aydin

“…We propose a new statistical modeling method to analyze functional relationship between predictor variables and correlated response variables, and apply it for modeling the number of HIV and AIDS cases influenced by early-age marriages and contraceptive users. …”
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The abscisic acid signaling negative regulator OsPP2C68 confers drought and salinity tolerance to rice by Beilei Wang, Yuping Luo, Binxia Zhong, Han Xu, Fengping Wang, Wen Li, Meiqi Lin, Juan Chen, Liangbi Chen, Manzhong Liang, Xiaojun Dai

“…However, a comprehensive understanding of the functions of individual members of rice PP2CA gene families remains limited. …”
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Metformin Inhibits Cell Motility and Proliferation of Triple-Negative Breast Cancer Cells by Blocking HMGB1/RAGE Signaling by Shazie Yusein-Myashkova, Desislava Vladimirova, Anastas Gospodinov, Iva Ugrinova, Jordana Todorova

“…Metformin, a well-established antidiabetic drug, directly interacts with HMGB1, inhibiting its pro-inflammatory functions. This study investigates metformin’s effects on the HMGB1/RAGE signaling pathway in triple-negative breast cancer (TNBC) cells. …”
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IL-6 Negatively Regulates IL-22Rα Expression on Epidermal Keratinocytes: Implications for Irritant Contact Dermatitis by Benjamin Frempah, Lerin R. Luckett-Chastain, Randle M. Gallucci

“…Furthermore, it was shown that IL-6 negatively regulates the expression of IL-22Rα on epidermal keratinocytes. …”
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Combination of cerium oxide nanoparticles and antimalarial drug chloroquine: characterization and anti-cancer potential for triple negative breast cancer by Chantal-Kristin Wenzel, Elayaraja Kolanthai, Craig Neal, Claudia Wyrich, Andrea Borchardt, Claudia von Montfort, Nahal Brocke-Ahmadinejad, Sudipta Seal, Peter Brenneisen

“…Triple negative breast cancer (TNBC) is highly aggressiveness, has a poor prognosis, and standard therapy is often associated with adverse effects. …”
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Measuring cognitive and affective empathy across positive and negative emotions: psychometric properties and measurement invariance of the Perth Empathy Scale by Arezou Lashkari, Jack D. Brett, Jack D. Brett, Ghasem Abdolpour, Mahdi Mazidi

“…IntroductionEmpathy, a complex and multidimensional construct essential for social functioning and mental health, has been extensively studied in both research and clinical settings. …”
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Force-induced unfolding simulations of the human Notch1 negative regulatory region: possible roles of the heterodimerization domain in mechanosensing. by Jianhan Chen, Anna Zolkiewska

“…Importantly, the mechanical force can further drive local unfolding of the HD domain in a functionally relevant fashion that would provide full proteolytic access to the S2 site prior to heterodimer disassociation. …”
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Estimation of Positive‐, Negative‐, and Zero‐Sequence Current and Voltage Phasors of UIPC VSCs for Short‐Circuit Faults in Transmission Lines by Babak Bahadori, Ali Nahavandi, Mahyar Abasi

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Development of Immune-Regulatory Pseudo-Protein-Coated Iron Oxide Nanoparticles for Enhanced Treatment of Triple-Negative Breast Tumor by Ying Ji, Juan Li, Li Ma, Zhijie Wang, Bochu Du, Hiu Yee Kwan, Zhaoxiang Bian, Chih-Chang Chu

“…Triple-negative breast cancer (TNBC) frequently evades immune recognition and elimination, resulting in an immunosuppressive microenvironment. …”
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