Characterizing SSTR2 expression and modulation for targeted imaging and therapy in preclinical models of triple-negative breast cancer by Shannon E. Lynch, Corinne I. Crawford, Hailey A. Houson, James M. Omweri, Piyasuda Pukkanasut, Carlos A. Gallegos, Jason D. Whitt, Renata Jaskula-Sztul, Suzanne E. Lapi, Anna G. Sorace

“…These studies demonstrate that HDAC inhibition can upregulate SSTR2 at the transcriptional, translational, and functional levels in breast cancer. Importantly, SSTR2 expression can be characterized non-invasively via PET imaging and modulation with HDAC inhibitors can be monitored longitudinally. …”
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The integrated single-cell analysis interpret the lactate metabolism-driven immune suppression in triple-negative breast cancer by Xinhai Gao, Tianhua Wang, Cun Liu, Ye Li, Wenfeng Zhang, Minpu Zhang, Yan Yao, Chundi Gao, Ruijuan Liu, Changgang Sun

“…A single-cell transcriptomic approach was employed to examine functional differences across cells with varying lactate metabolism. …”
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The role of natural and synthetic zeolites as soil amendments for mitigating the negative impacts of abiotic stresses to improve agricultural resilience by Ayesha Javaid, Neelma Munir, Zainul Abideen, Zamin Shaheed Siddiqui, Jean Wan Hong Yong

“…Furthermore, based on extensive literature review, zeolites (specifically natural zeolites) possess extraordinary adsorption capacity, highly functional nutrient and water holding and releasing characteristics. …”
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Sulfatase 2 inhibition sensitizes triple-negative breast cancer cells to paclitaxel through augmentation of extracellular ATP by Jasmine M. Manouchehri, Jharna Datta, Lynn M. Marcho, Daniel Stover, Ramesh K. Ganju, Bhuvaneswari Ramaswamy, William E. Carson, Arjun Mittra, Xiaoli Zhang, Patrick M. Schnell, Yu Yue, Mark P. Rubinstein, Mathew A. Cherian

“…Sulfatase 2 (SULF2) removes sulfate from HS, the functional group essential for ATPase inhibition. Consequently, we propose that TNBC cell death and eATP release induced by chemotherapy would be intensified by SULF2 inhibitors. …”
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Clinical and biological significance of estrogen receptor-positive/progesterone receptor-negative in invasive breast cancer: bioinformatic analysis by Maryam Althobiti, Raef Albugami, Mohammed Alnamnakani, Samir Alharbi, Michael Toss, Rajennder Kumar, Fahad Alkhureeb

“…Multiple online tools were employed to conduct functional enrichment analysis. STRING was used to create protein-protein interaction networks for the identified DEGs. …”
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Predictive circulating biomarkers of the response to anti‐PD‐1 immunotherapy in advanced HER2 negative breast cancer by Yuhan Wei, Hewei Ge, Yalong Qi, Cheng Zeng, Xiaoying Sun, Hongnan Mo, Fei Ma

“…Patients were categorized as responders and non‐responders according to 6‐month progression‐free survival (PFS), followed by phenotypic and functional comparations to identify candidate predictive biomarkers. …”
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External negative pressure improves lung aeration in near-term rabbit kittens at risk of developing respiratory distress by C. Diedericks, C. Diedericks, K. J. Crossley, K. J. Crossley, D. Jurkschat, M. J. Wallace, M. J. Wallace, I. M. Davies, I. M. Davies, P. J. Riddington, P. J. Riddington, A. B. te Pas, M. J. Kitchen, M. J. Kitchen, S. B. Hooper, S. B. Hooper

“…Kittens were ventilated with an 8 ml/kg tidal volume and PEEP of 0 cmH2O and lungs imaged using phase contrast x-ray imaging.ResultsCompared to external atmospheric pressures, external negative pressures expanded the chest (by 2100 ± 43 vs. 1805 ± 59 mm2; Control kittens; P = 0.028), directed tidal ventilation into lower, larger lung regions and increased functional residual capacity (FRC) levels in both Control (26.7 ± 2.0 vs. 12.6 ± 2.2 ml/kg; P < 0.001) and EL (19.6 ± 1.6 vs. 10.0 ± 2.9 ml/kg; P < 0.01) kittens. …”
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SBFI-26 enhances apoptosis in docetaxel-treated triple-negative breast cancer cells by increasing ROS levels by Gang He, Mei Liu, Tang cong Chen, Li fen Huang, You qiang Ke

“…This study delves into the functional mechanism and impact of combining SBFI-26 with docetaxel in treating MDA-MB-231 cells of triple-negative breast cancer. …”
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Immune microenvironment of Epstein-Barr virus (EBV)-negative compared to EBV-associated gastric cancers: implications for immunotherapy by Ke Xu, Qingfeng Zhu, Suzanne L Topalian, Robert A Anders, Janis M Taube, Mark Yarchoan, Keziban Ünsal-Kaçmaz, Logan L Engle, Tracee L McMiller, Sepideh Besharati, Junghwa Lee, Feriyl Bhaijee, Alan E Berger

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Post-Concussion Syndrome and Functional Neurological Disorder: Diagnostic Interfaces, Risk Mechanisms, and the Functional Overlay Model by Ioannis Mavroudis, Foivos Petridis, Eleni Karantali, Alin Ciobica, Sotirios Papagiannopoulos, Dimitrios Kazis

“…Background: Post-concussion syndrome (PCS) and Functional Neurological Disorder (FND), including Functional Cognitive Disorder (FCD), are two frequently encountered but diagnostically complex conditions. …”
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Role of Oxygen Functional Groups in Electrochemical Sodium Ion Intercalation into Oxygen-Functionalized Graphitic Carbon Materials by Junichi INAMOTO, Akane INOO, Rika MATSUMOTO, Yoshiaki MATSUO

“…We focused on oxygen-containing functional groups in GLG and investigated their effect on the sodium ion intercalation potential using density functional theory calculations. …”
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The R-RAS2 GTPase is a signaling hub in triple-negative breast cancer cell metabolism and metastatic behavior by Claudia Cifuentes, Lydia Horndler, Pilar Grosso, Clara L Oeste, Alejandro M. Hortal, Jennifer Castillo, Isabel Fernández-Pisonero, Alberto Paradela, Xosé Bustelo, Balbino Alarcón

“…Abstract Background Recent research from our group has shown that the overexpression of the wild-type RAS-family GTPase RRAS2 drives the onset of triple-negative breast cancer (TNBC) in mice following one or more pregnancies. …”
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Suppression of Reverse Drain-Induced Barrier Lowering in Negative Capacitance FETs Using a Hetero-Metal-Gate Structure by Jae Yeon Park, Seungwon Go, Dong Keun Lee, Seonggeun Kim, Sihyun Kim, Sangwan Kim

“…To address this issue, a hetero-metal-gate negative capacitance field-effect transistor (HM NCFET), which features the metal-gate composed of two different work function materials at source and drain sides, is proposed and its electrical characteristics are analyzed with the help of technology computer-aided design (TCAD) simulation. …”
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Detection of carbapenem-resistant gram-negative bacilli in Japan using the fully automated bacterial testing device RAISUS S4 by Yumiko Funashima, Rin Hamabe, Kei Tominaga, Kentaro Wakamatsu, Takahiro Yaguchi, Zenzo Nagasawa, Tsukuru Umemura

“…Methods: We used the function that can monitor the growth curve with the resistant bacteria monitoring function (RAISUS S4). …”
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MiR‐182‐3p targets TRF2 and impairs tumor growth of triple‐negative breast cancer by Roberto Dinami, Luca Pompili, Eleonora Petti, Manuela Porru, Carmen D'Angelo, Serena Di Vito, Angela Rizzo, Virginia Campani, Giuseppe De Rosa, Alejandra Bruna, Violeta Serra, Miguel Mano, Mauro Giacca, Carlo Leonetti, Gennaro Ciliberto, Madalena Tarsounas, Antonella Stoppacciaro, Stefan Schoeftner, Annamaria Biroccio

“…We also observed that treatment with lipid nanoparticles (LNPs) containing miR‐182‐3p impaired tumor growth in triple‐negative breast cancer (TNBC) models, including patient‐derived tumor xenografts (PDTXs), without affecting mouse survival or tissue function. …”
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Beyond negative valence: 2-week administration of a serotonergic antidepressant enhances both reward and effort learning signals. by Jacqueline Scholl, Nils Kolling, Natalie Nelissen, Michael Browning, Matthew F S Rushworth, Catherine J Harmer

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Small interfering RNAs generated from the terminal panhandle structure of negative-strand RNA virus promote viral infection. by Wan Zhao, Qiong Li, Mengqi Sun, Lan Luo, Xiaoming Zhang, Feng Cui

“…This study elucidates a unique function of vsiRNAs derived from the conserved panhandle structure of negative-strand RNA viruses in enhancing viral infection.…”
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Bovine lactoferricin exerts antibacterial activity against four Gram-negative pathogenic bacteria by transforming its molecular structure by Jie Pei, Jie Pei, Lin Xiong, Lin Xiong, Xiaoyun Wu, Xiaoyun Wu, Min Chu, Min Chu, Pengjia Bao, Pengjia Bao, Qianyun Ge, Qianyun Ge, Xian Guo, Xian Guo

“…Our findings suggest that Lfcin can reversibly interconvert between two distinct molecular states under varying ionic strengths and hydrophobic effects, with the resulting structural transformations enhancing its antibacterial function.…”
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ATP-Binding Cassette (ABC) Transporters and Antibiotic Resistance: Specialized Systems for Capsular Polysaccharide Export in Gram-Negative Pathogens by Loreleï Masselot--Joubert, María Agostina Di Renzo

“…Knowledge of the ABC transporter-dependent system and its function is incomplete, requiring further research to better understand the processes of capsular polysaccharide export. …”
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Crk adaptors negatively regulate actin polymerization in pedestals formed by enteropathogenic Escherichia coli (EPEC) by binding to Tir effector. by Elvira Nieto-Pelegrin, Eugenia Meiler, José Manuel Martín-Villa, María Benito-León, Narcisa Martinez-Quiles

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