Working in negative space: Type I interferon mediated immuno-modulation through transcriptional suppression in disease and homeostasis by Ella L Brunsting, Darren J Perkins

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Acute Effects of a Single-Bout Session of High-Intensity Functional Training and Moderate-Intensity Functional Training on Cognitive Functions, Anxiety, and Stress in Healthy Adult... by Francisco José Trujillo-Gutiérrez, José López-Aguilar, Francisco Álvarez-Salvago, Honorato Morente-Oria, José Daniel Jiménez-García

“…Background: Currently, it has been observed that a fast-paced lifestyle, along with factors such as work pressure and economic and political uncertainty, among others, negatively impacts cognitive functions and increases levels of anxiety and stress in the population. …”
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Reduced expression of argininosuccinate synthetase 1 has a negative prognostic impact in patients with pancreatic ductal adenocarcinoma. by Qingqing Liu, John Stewart, Hua Wang, Asif Rashid, Jun Zhao, Matthew H Katz, Jeffrey E Lee, Jason B Fleming, Anirban Maitra, Robert A Wolff, Gauri R Varadhachary, Sunil Krishnan, Huamin Wang

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Activated Tim-3/Galectin-9 participated in the development of multiple myeloma by negatively regulating CD4 T cells by Rui Zhang, Shuang Chen, Tingting Luo, Sha Guo, Jianhua Qu

“…The interaction between Tim-3 on T cells and its ligand Galectin-9 negatively regulates the cellular immune response. However, the regulation of Tim-3/Galectin-9 on CD4 T cell subsets in multiple myeloma (MM) remains unclear. …”
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Ultrasound-Targeted Microbubble Destruction Enhances Inhibitory Effect of Apatinib on Angiogenesis in Triple Negative Breast Carcinoma Xenografts by Dengke Hong, Jiajia Yang, Jingjing Guo, Yu Zhang, Zhikui Chen

“…Routine blood test and detection of liver and kidney function were done after treatments. The tumor size and microcirculation were examined by two-dimensional ultrasonography (2DUS) and contrast-enhanced ultrasonography (CEUS), respectively. …”
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Acyl CoA-binding protein in brown adipose tissue acts as a negative regulator of adaptive thermogenesis by Albert Blasco-Roset, Tania Quesada-López, Alberto Mestres-Arenas, Joan Villarroya, Francisco J. Godoy-Nieto, Rubén Cereijo, Celia Rupérez, Ditte Neess, Nils J. Færgeman, Marta Giralt, Anna Planavila, Francesc Villarroya

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Affective state-dependent effects of prefrontal rTMS on the cognitive control of negative stimuli in healthy and depressed individuals by Jasmina Paneva, Teresa Schuhmann, Stefanie De Smet, Terence De Meza, Felix Duecker, Alexander T. Sack

“…HF-rTMS produced distinct performance changes dependent on baseline BDI-II scores. As a function of BDI-II scores, we observed either increased or decreased response times on the task. …”
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A Single-Cell Transcriptome Atlas of Epithelial Subpopulations in HPV-Positive and HPV-Negative Head and Neck Cancers by Mary C. Bedard, Cosette M. Rivera-Cruz, Tafadzwa Chihanga, Andrew VonHandorf, Alice L. Tang, Chad Zender, Matthew T. Weirauch, Robert Ferris, Trisha M. Wise-Draper, Mike Adam, Susanne I. Wells

“…Persistent infection with HPV causes nearly 5% of all cancers worldwide, including cervical and oropharyngeal cancers. Compared to HPV-negative (HPV−) head and neck squamous cell carcinomas (HNSCCs), HPV-positive (HPV+) HNSCCs exhibit a significantly improved treatment response; however, established treatment regimens were largely developed for HPV− disease. …”
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LRPPRC confers enhanced oxidative phosphorylation metabolism in triple-negative breast cancer and represents a therapeutic target by Qiqi Xue, Wenxi Wang, Jie Liu, Dachi Wang, Tianyu Zhang, Tingting Shen, Xiangsheng Liu, Xiaojia Wang, Xiying Shao, Wei Zhou, Xiaohong Fang

“…Abstract Background Triple-negative breast cancer (TNBC) is a highly malignant tumor that requires effective therapeutic targets and drugs. …”
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<i>AtPADRE13</i> Negatively Regulates Salt Stress Tolerance in <i>Arabidopsis thaliana</i> by Ziru Chang, Xiaona Tian, Xiaocui Niu, Meiting Bai, Wei Bai, Ruigang Wang, Guojing Li, Qi Yang

“…However, the specific functions of this family in the salt stress response remain unknown. …”
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Negative Regulation of <i>GmNAC35</i> by miR164 Enhances Drought Tolerance in Soybean by Wentao Hu, Man Zhang, Jie Lu, Miaomiao Zhang, Reqing He, Youlin Zhu, Dong Wang, Liyun Jiang

“…Our findings indicate that miR164 negatively regulates <i>GmNAC35</i>, a positive regulator of drought tolerance. …”
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USP25 attenuates anti-GBM nephritis in mice by negative feedback regulation of Th17 cell differentiation by Ranran Xu, Fei Huang, Qingquan Liu, Yongman Lv, Liu Hu, Qian Zhang

“…Furthermore, changes in USP25 expression were monitored during Th17 differentiation, both in vivo and in vitro.Results USP25−/− mice with anti-GBM GN exhibited accelerated renal function deterioration, increased infiltration of Th1 and Th17 cells, and elevated RORγt transcription. …”
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Research on frost resistance and life prediction of fly ash manufactured sand concrete under negative temperature curing by Li Gong, Tao Ran, Yanzhong Bu, Tianle Xu, Xuehao Zhao

“…Finally, utilizing the Weibull distribution function, a durability deterioration damage model for manufactured sand concrete was established. …”
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Prognostic and Predictive Markers for Early Stage Triple‐Negative Breast Cancer Treated With Platinum‐Based Neoadjuvant Chemotherapy by Zhenhui Zhao, Li Li, Mei He, Yan Li, Xiaoping Ma, Bing Zhao

“…Our study identified several genetic and clinical features that might function as prognostic and predictive markers.…”
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Spatial transcriptomic analysis of immune checkpoint blockade response in triple negative breast cancers with tertiary lymphoid structures by Richard H. Mebane, Teia Noel, Nathan Ing, Kenneth H. Gouin, III, Aagam Shah, David Zitser, Andrew Martinez, Gaorav Gupta, Sandra Demaria, Lorenzo Galluzzi, Alice Ho, Heather McArthur, Stephen L. Shiao, Simon.R.V. Knott

“…However, TLSs vary in their ability to elicit anticancer immune activity, so it is important to develop databases that allow study of variables that regulate their function. We applied single RNA molecule resolution imaging to longitudinal biopsies taken from women with TLS-enriched triple negative breast cancers prior to therapy, after pembrolizumab and after pembrolizumab plus radiation therapy. …”
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CDK4 inactivation inhibits apoptosis via mitochondria-ER contact remodeling in triple-negative breast cancer by Dorian V. Ziegler, Kanishka Parashar, Lucia Leal-Esteban, Jaime López-Alcalá, Wilson Castro, Nadège Zanou, Laia Martinez-Carreres, Katharina Huber, Xavier Pascal Berney, María M. Malagón, Catherine Roger, Marie-Agnès Berger, Yves Gouriou, Giulia Paone, Hector Gallart-Ayala, George Sflomos, Carlos Ronchi, Julijana Ivanisevic, Cathrin Brisken, Jennifer Rieusset, Melita Irving, Lluis Fajas

“…While CDK4 is known for its role in cell proliferation, its metabolic function in cancer, particularly in triple-negative breast cancer (TNBC), remains unclear. …”
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Supplementing sialic acid analogs overcomes radiotherapy resistance in triple-negative breast cancer by exacerbating ER stress by Muwen Yang, Dongni Shi, Jianbo Lyu, Yibing Pan, Yiyang Lyv, Xiangfu Chen, Ying Ouyang, Yajie Liu, Yue Li, Libing Song

“…Radiotherapy is a cornerstone treatment for triple-negative breast cancer (TNBC), and its incorporation has significantly delayed tumor recurrence. …”
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Hyaluronic acid-engineered milk extracellular vesicles to target triple negative breast cancer through CD44 by Filipa A. Soares, Beatriz Salinas, Salette Reis, Cláudia Nunes

“…Context Cancer therapy remains a challenge in healthcare, particularly in the context of triple-negative breast cancer (TNBC), where targeted therapies are still scarce.Objective Addressing this issue, our study explores a novel targeting approach using small extracellular vesicles (sEVs) isolated from cow milk, functionalized with hyaluronic acid (HA) to target the overexpressed cluster of differentiation 44 (CD44) cell surface receptor in TNBC cells.Materials & methods A method for isolating sEVs from cow milk was optimized, and the obtained sEVs were fully characterized in terms of size, morphology, and protein markers. …”
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CK2α-mediated phosphorylation of GRP94 facilitates the metastatic cascade in triple-negative breast cancer by Hye-Youn Kim, Young-Mi Kim, Suntaek Hong

“…While emerging studies have hinted a pivotal role of glucose-regulated protein 94 (GRP94) in tumorigenesis, the exact biological functions and molecular mechanisms of GRP94 in modulating cancer metastasis remain to be elucidated. …”
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Theoretical Studies of Some Fluoro Compounds with Silicon, Phosphorus and Sulphur and Establishment of Negative Hyperconjugation through Calculation of Charge by P. K. Mohamed Imran, K. Subramani

“…An attempt is made to study the negative hyperconjugation (Anomeric Effect) by the calculation of the charges at the Density Functional Theory (DFT) level for some compounds with hypervalent atoms like Si, P & S…”
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