Exploring ID4 as a driver of aggression and a therapeutic target in triple-negative breast cancer by C. Toro, S. Real, S. Laurito, M. T. Branham

“…Here, we used CRISPR–Cas9-mediated ID4 knockout, pharmacologic inhibition, in vivo xenografts, and transcriptomic analysis to investigate ID4 function. ID4 loss in MDA-MB-231 cells reduced proliferation, colony formation, Ki67 expression, and tumor growth in vivo. …”
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Conditional Expression of Human PPARδ and a Dominant Negative Variant of hPPARδ In Vivo by Larry G. Higgins, Wojciech G. Garbacz, Mattias C. U. Gustafsson, Sitheswaran Nainamalai, Peter R. Ashby, C. Roland Wolf, Colin N. A. Palmer

“…In this paper, treatment of mice conditionally expressing human PPARδ with GW501516 resulted in a marked loss in body weight that was not evident in nontransgenic animals or animals expressing a dominant negative derivative of PPARδ. Expression of either functional or dominant negative hPPARδ blocked bezafibrate-induced PPARα-dependent hepatomegaly and blocked the effect of bezafibrate on the transcription of PPARα target genes. …”
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Ubiquitin Ligase Gene <i>OsPUB57</i> Negatively Regulates Rice Blast Resistance by Jian Zhang, Qiang Du, Yugui Wu, Mengyu Shen, Furong Gao, Zhilong Wang, Xiuwen Xiao, Wenbang Tang, Qiuhong Chen

“…In this study, we identified the function of a U-box E3 ubiquitin ligase gene <i>OsPUB57</i> in rice. …”
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Differential fMRI neural synchrony associated with migraine during naturalistic stimuli with negative emotional valence by Keva Klamer, Joshua Craig, Christina Haines, KiAnna Sullivan, Peter Seres, Chelsea Ekstrand

“…These findings suggest that migraine involves hypersensitivity to audiovisual movies as a function of negative emotional valence, where negative/aversive emotional states may drive greater synchrony in multisensory integration. …”
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Design and modeling of a highly compact negative index floral shape metamaterial for flight navigation applications by M. Pallavi, Praveen Kumar, B. R. Shivakumar

“…Furthermore, to analyze the function of the structure on the antenna, the unit-element (UE) is expanded to a 5 × 4 array and deployed as an additional layer on the radiator at a predetermined distance. …”
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Associations between the mismatch-negativity component and symptom severity in children and adolescents with attention deficit/hyperactivity disorder by Yamamuro K, Ota T, Iida J, Nakanishi Y, Kishimoto N, Kishimoto T

“…Event-related potentials (ERPs) represent the noninvasive measurement of neural correlates of cognitive function. Mismatch negativity (MMN) is an ERP component that is presumed to index the preattentive monitoring of changes in the auditory environment. …”
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Immunohistochemical Analysis of Scarring Trachoma Indicates Infiltration by Natural Killer and Undefined CD45 Negative Cells. by Victor H Hu, Philip J Luthert, Tamsyn Derrick, James Pullin, Helen A Weiss, Patrick Massae, Tara Mtuy, William Makupa, David Essex, David C W Mabey, Robin L Bailey, Martin J Holland, Matthew J Burton

“…<h4>Introduction</h4>The phenotype and function of immune cells infiltrating the conjunctiva in scarring trachoma have yet to be fully characterized. …”
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The linc009 negatively regulates cell apoptosis in turbot (Scophthalmus maximus L.) during bacterial challenge by Beibei Wang, Xiaocheng Zhu, Xinghua Zhuang, Xiaoli Liu, Zhongyi Wang, Ning Yang, Chao Li

“…This study provided valuable insights into the function and regulatory mechanism of lncRNAs in teleost.…”
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Sztuczne raje prawdopodobieństwa. 
O funkcjach negowania w wierszu 
pt. Dworzec Wisławy Szymborskiej 
i jego angielskim przekładzie 
autorstwa Stanisława Barańczaka i Clare Cavanag... by Anna Stanisz

“…The aim of this article is to interpret Szymborska’s poem entitled The Railroad Station and its English translation, from the point of view of the key poetics of negation. From the point of view of linguistics, literary studies, and translation studies, the poem is demonstrative of the variety of forms of negation and their semantic functions used in Szymborska’s entire oeuvre. …”
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The role of UBR2 in triple-negative breast cancer and its implications for immune checkpoint blockade therapy by Yanlin Jiang, Yi Fu, Xinyan Song, Yongjie Xie, Xiaobin Shang, Xi Liang

“…It was initially identified as a crucial oncogene during embryonic development. Nevertheless, the function of UBR2 in triple-negative breast cancer (TNBC) and its non-ubiquitination role, particularly in suppressing antitumor immune responses, remain elusive. …”
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Pathogenic TP53 mutations influence chemotherapy response and survival rate of HPV-negative oral carcinomas by Jović Saša, Kozomara Ružica, Stošić Srboljub, Jovandić Stevo, Zeljić Katarina, Šupić Gordana

“…Thus, we investigated the association of TP53 gene mutations with survival and response to cisplatin chemotherapy in human papilloma virus (HPV)-negative OSCC patients. Methods. The potential clinical relevance of TP53 mutations was analyzed in 82 patients with HPV-negative OSCC. …”
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PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications by Man Zheng, Yeting Li, Lei Gu, Chunyan Xiang, Xiaoning Li, Shanshan Li, Nannan Li, Hongtao Lan, Fenglei Zhang

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Spatial distribution pattern and negative density dependence analysis of northern subtropical forest communities in Baohua Mountain by Naiwei Li, Baocheng Wu, Xiangui Yi, Weibing Zhuang, Zhong Wang, Tao Wang

“…Negative density dependence (NDD) serves as a crucial regulatory mechanism for maintaining biodiversity in forest ecosystems. …”
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Author Correction: Multifunctional nanoagents for ultrasensitive imaging and photoactive killing of Gram-negative and Gram-positive bacteria by Jiali Tang, Binbin Chu, Jinhua Wang, Bin Song, Yuanyuan Su, Houyu Wang, Yao He

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Negative Differential Resistance in Single‐Molecule Junctions Based on Heteroepitaxial Spherical Au/Pt Nanogap Electrodes by Dongbao Yin, Miku Furushima, Eiji Tsuchihata, Seiichiro Izawa, Tomoya Ono, Ryo Shintani, Yutaka Majima

“…Abstract Single‐molecule junctions exploit the internal structure of molecular orbitals to construct a new class of functional quantum devices. The demonstration of negative differential resistance (NDR) in single‐molecule junctions is direct evidence of quantum mechanical tunneling through a molecular orbital. …”
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A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities by Franco J Vizeacoumar, Roland Arnold, Frederick S Vizeacoumar, Megha Chandrashekhar, Alla Buzina, Jordan T F Young, Julian H M Kwan, Azin Sayad, Patricia Mero, Steffen Lawo, Hiromasa Tanaka, Kevin R Brown, Anastasia Baryshnikova, Anthony B Mak, Yaroslav Fedyshyn, Yadong Wang, Glauber C Brito, Dahlia Kasimer, Taras Makhnevych, Troy Ketela, Alessandro Datti, Mohan Babu, Andrew Emili, Laurence Pelletier, Jeff Wrana, Zev Wainberg, Philip M Kim, Robert Rottapel, Catherine A O'Brien, Brenda Andrews, Charles Boone, Jason Moffat

“…Abstract Improved efforts are necessary to define the functional product of cancer mutations currently being revealed through large‐scale sequencing efforts. …”
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Single-cell transcriptomic profiling of immune landscape in triple-negative breast cancer during neoadjuvant chemotherapy by M. R. Patysheva, P. S. Iamshchikov, A. A. Fedorenko, O. D. Bragina, M. A. Vostrikova, E. Y. Garbukov, N. V. Cherdyntseva, E. V. Denisov, T. S. Gerashchenko

“…Abstract Triple-negative breast cancer (TNBC) is the most aggressive subtype, typically requiring neoadjuvant chemotherapy (NAC) as an obligatory component of the treatment regimen. …”
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Effects of intravenous immunoglobulin on the negatively transformed subpopulations of neutrophilic granulocytes in newborns with congenital pneumonia and neonatal sepsis by I. V. Nesterova, S. V. Kovaleva, G. A. Chudilova, L. V. Lomtatidze, T. V. Smerchinskaya, V. N. Chapurina

“…The aim of our study was to assess the effects of intravenous immunoglobulin (IVIG) injections on the negatively transformed subpopulations of neutrophilic granulocytes (NG) СD64-CD16+СD32+СD11b+, СD64+CD16+СD32+СD11b+ and evaluation of their functional activity in newborns with CP and NS. …”
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Development of lesion and organ negative cast modelling technique for quality assurance and optimization of nuclear medicine images by Roberto Fedrigo, Robin J. N. Coope, Guillaume Chaussé, Ingrid Bloise, Claire Gowdy, François Bénard, Arman Rahmim, Carlos F. Uribe

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Clinical spectrum and long-term outcomes of antibody-negative severe autoimmune encephalitis: a retrospective study by Fangfang Li, Yu He, Yu He, Xiaoqian Chen, Ali Yang, Jiewen Zhang, Weizhou Zang

“…Additionally, 30.6% of patients had relapsed, with refractory status epilepticus being an independent risk factor for relapse.ConclusionAlthough patients with antibody-negative severe AE experience significant disability in the early stages of their disease, the majority eventually regain independent functioning. …”
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