APOE4 triggers dysregulated synaptic vesicle release by disrupting SNARE complex assembly by Feng Chen, Yanting Chen, Sifan Feng, Huiyi Chen, Liehua Deng, Fubin Ma, Qiongwei Ke, Qiuhao Liang, Ji Chen, Xiaoping Peng, Jiongtong Lu, Yingxuan Liu, Yuying Xie, Hao Cao, Yuanhong Sun, Wenxian Wu, Lili Cui, Yan Wang

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Immune age is correlated with decreased TCR clonal diversity and antibody response to SARS-CoV-2 by Merlin Davies, Hubert Denise, Michael Day, Sian M Henson, Chris J Scotton, Lorna W. Harries

“…This suggests that future treatments targeting cellular ageing of immune cells may be a useful avenue for investigation to improve immune function in older people.…”
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Entanglemnt in nonlinear three-qubits Jaynes — Cummings by Alexander R. Bagrov, Eugene K. Bashkirov

“…We have found solutions to the quantum time Schrodinger equation for the total wave function of the system for the initial separable, biseparable and true entangled states of qubits and the Fock initial state of the resonator field. …”
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Treadmill with Transcutaneous Electrical Nerve Stimulation Impact on Peak Velocity in Peripheral Arterial Disease: a Randomized Controlled Trial by Hadeer K. Abdelazim, Azza A. Abdelhady, Ahmed A. Shaker, Asmaa H. I. Habib, Marwa M. Elsayed

“…INTRODUCTION. Patients’ functional ability and quality of life are negatively impacted by peripheral arterial disease, which presents as incapacitating leg discomfort that affects walking. …”
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COMPARATIVE ASSESSMENT OF LARGE ARTERY ELASTICITY IN PATIENTS WITH STABLE ANGINA RECEIVING METABOLIC THERAPY by O. V. Ilukhin, D. L. Tarasov, A. K. Prom, E. L. Kalganova, T. Kh. Termisultanova, M. V. Ilukhina

“…The study included 74 patients with coronary heart disease (CHD), stable angina of II–III Functional Class (FC), and FC II–III chronic heart failure (CHF). …”
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Metagenomic Comparison of Gut Microbes of <i>Lemur catta</i> in Captive and Semi-Free-Range Environments by Chunzhong Xu, Xinzi Guo, Lian Li

“…Environmental variations between the two rearing systems led to distinct profiles in microbial functions and carbohydrate-active enzyme gene composition. …”
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Gastrointestinal changes in paediatric malnutrition that may impact on nutrition choice by Rosan Meyer, Lauren Arpe, Aydan Kansu, Veronica Kelly, Keith Lindley, Mairéad O'Meara, Maria del Carmen Rivero, Suzanne van Zundert, Saioa Vicente-Santamaría, Orjena Žaja, Elena Oliveros, Leanne Olivier, Koen Joosten

“…The presence of compromised gastrointestinal function in children with DRM is critical as it negatively impacts the efficacy of nutritional support and recovery. …”
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Effects of Occupational Noise Exposure on Disease Control and Psychological Status in Patients with Diabetic Nephropathy by Xue Zhou, Ting Guo, Liangfeng Lin

“…However, glycaemic indicators such as HbA1c, FPG, PBG, GSP; renal function indicators such as BUN, UAER, SCr, 24hUP and psychological status (SAS and SDS scores) in Group A were significantly higher than those in Group B (P < 0.05). …”
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DTI Histogram and Texture Features as Early Predictors of Post-Radiotherapy Cognitive Decline by Jincheng Wang, Philip Kyeremeh Jnr Oppong, Maho Kitagawa, Hidefumi Aoyama, Shunsuke Onodera, Satoshi Terae, Khin Khin Tha

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Effect of plasma lipoprotein-associated phospholipase A₂ levels on structure and function of heart in patients undergoing maintenance hemodialysis by WANG Yun-qian, CHEN Bao-ping, SHI Jun

“…Objective To investigate the clinical application of plasma lipoprotein-associated phospholipase phospholipaseA₂（Lp-PLA₂） levels in evaluation of structure and function of heart in patients undergoing maintenance hemodialysis（MHD）.Methods Seventy MHD patients were involved in the study,who were treated with MHD for at least 6 months before the study and in a stable clinical status.The plasma Lp-PLA₂ levels were examined by ELISA.The serum B-type natriuretic peptide（BNP） levels were measured by immunofluorescent assay.The parameters of left ventricular end-diastolic diameter（LVEDD）,left atrial diameter（LAD）,left ventricular posterior wall depth（LVPWD） and left ventricular ejection fraction（LVEF） were measured by cardiac color ultrasound,the left ventricular mass index(LVMD was calculated,and the relationship between plasma Lp-PLA₂ levels and parameters determined by cardiac color ultrasound was analyzed.Another 40 healthy volunteers served as normal control group.Results（1） The levels of Lp-PLA₂,BNP,LVMI,LVEF and systolic pressure in MHD group were significantly higher than those in normal control group（P<0.05）.（2） In MHD group,the patients with abnormal LVEF（LVEF<50%）,left ventricle hypertrophy and/or cardiac insufficiency（BNP>300 ng/L） had higher levels of Lp-PLA₂ than the other patients without abnormal LVEF（LVEF>50%）,left ventricle hypertrophy and/or cardiac sufficiency（BNP<300 ng/L）.（3） The plasma Lp-PLA₂ level was positively correlated with the levels of BNP（r =0.43,P<0.05） and LVMI（r = 0.58,P<0.01）,but negatively with the level of LVEF（r =- 0.67,P<0.01） in patients undergoing MHD.（4） Multiple stepwise regression analysis demonstrated that the plasmaLp-PLA₂ level was correlated with the levels of LVMI（β=0.342,P<0.01）and LVEF（β=- 0.396,P<0.01）.Conclusions Higher plasma Lp-PLA₂ levels extensively exists in patients undergoing MHD.Plasma Lp-PLA₂ level can reflect structure and function of left ventricle,which may play an important role in the evaluation of left ventricular hypertrophy and function of left ventricle.…”
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An Evaluation of the Predatory Function of <i>Orius strigicollis</i> (Poppius) (Hemiptera: Anthocoridae) on <i>Megalurothrips usitatus</i> (Bagnall) (Thysanoptera: Thripidae) by Zuying Fu, Yuanrun Cheng, Yifan Cui, Changyu Xiong, Ziyu Cao, Ying Wang, Rong Zhang, Chang Liu, Wei Sun, Liping Ban, Yao Tan, Shuhua Wei

“…To understand the predatory function and biological control potential of <i>O. strigicollis</i> on <i>M. usitatus</i>, the predatory ability of adults of <i>O. strigicollis</i> on second-instar larvae and adults of <i>M. usitatus</i> was measured under indoor conditions, and the Holling II and Hassell–Varley models were fitted to calculate the predatory function response, search efficiency, intraspecific interference, and predation preference of <i>O. strigicollis</i> on second-instar larvae and adults of <i>M. usitatus</i>. …”
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Association of Serum Thyroid Hormone Levels with Androgen and Metabolic Parameters in Chinese Women with Polycystic Ovary Syndrome: A Retrospective Cross-Sectional Study by Manman Pan, Jinghua Zhang, Qing Zhang, Fangfang Wang, Fan Qu, Mei Jin

“…PCOS patients with TSH ≥2.5 mIU/L had significantly higher TG, fasting insulin, HOMA-IR and homeostatic model assessment of β-cell function (HOMA-B), however, these patients also displayed significantly lower DHEAS, HDL, and quantitative insulin sensitivity check index (QUICKI) when compared to patients with TSH levels <2.5 mIU/L. …”
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The effects of compound probiotics on production performance, rumen fermentation and microbiota of Hu sheep by Lijun Wang, Zhanqi Lv, Xiaodong Ning, Zhiguang Yue, Ping Wang, Chaoqi Liu, Sanjun Jin, Xinxin Li, Qingqiang Yin, Qun Zhu, Juan Chang

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<i>RUNX3</i> Methylation: An Epigenetic Biomarker for Early Liver Damage Induced by Co-Exposure to Aflatoxin B1 and Hepatitis B Virus by Yunying Mo, Xiaodan Lu, Shixiong Zheng, Junfeng Deng, Shihan Huang, Ye Hong, Xiaoyu Xian, Aliya Yijiati, Xingyu Yu, Xunwu Luo, Miner Xiao, Xingfen Yang, Michael N. Routledge, Yunyun Gong, Zhini He

“…In this study, we investigated 168 unpackaged peanut oil (UPP) consumers to evaluate associations among AFB1 exposure, HBV infection, <i>RUNX3</i> methylation, and liver function. Our findings indicated an average daily AFB1 intake of 3.14 ng/kg·bw/day from UPP oil consumption. …”
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Association between thyroid function and thyroid homeostasis parameters and the prevalence and all-cause and cardiovascular mortality of chronic kidney disease: a population-based... by Xue Liu, Yuhao Zhang, Yuchen Li, Xiude Fan, Haiqing Zhang

“…Kaplan–Meier curves compared survival across the quartiles of the thyroid function and thyroid homeostasis parameters among CKD patients. …”
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Impaired Cardiac Sympathetic Activity Is Associated With Myocardial Remodeling and Established Biomarkers of Heart Failure by Luis M. da Silva, Andréa Coy‐Canguçu, Layde R. Paim, Adriana A. Bau, Camila Nicolela Geraldo Martins, Stephan Pinheiro, Vinicius Citeli Ribeiro, Walter E. Magalhães Rocha, Jose R. Mattos‐Souza, Roberto Schreiber, Lígia Antunes‐Correa, Andrei Sposito, Wilson Nadruz, Celso D. Ramos, Tomas Neilan, Michael Jerosch‐Herold, Otávio R. Coelho‐Filho

“…The relationship of cardiac sympathetic function with myocardial remodeling and diffuse fibrosis remains largely unknown. …”
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Temporal Muscle Thickness as a New Biomarker: Its Association With Alzheimer Pathology and Cognitive Impairment in Chinese Adults by Yunxia Zhu, Yingying Ke, Chenxi Ren, Jiehua Zhu, Zhen Zhang, Liang Cui, Yuehua Li, Fang Xie, Qihao Guo

“…Functional performance was evaluated using the Functional Activities Questionnaire. …”
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Aldo-keto Reductase 1B10 (AKR1B10) Suppresses Sensitivity of Ferroptosis in TNBC by Activating the AKT/GSK3β/Nrf2/GPX4 Axis by Shanli Wu, Gun Yang, Xiaosha Wen, Yi Lin, Shenglong Wang, Jing Wang, Quan Liu, Dixian Luo

“…Several studies have highlighted the essential function of AKR1B10 in lipid metabolism and in the detoxification of lipid peroxides. …”
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Changes in left ventricular structure and function in Type 2 diabetic patients, depending on the presence of cardiac autonomic neuropathy and metabolic syndrome components by E. Yu. Lunina, I. S. Petrukhin

“…Over 50% of the patients with 0–1 MS component and two-thirds of the patients with ≥2 MS components had disturbed LV diastolic function. In the former, CAN presence did not affect the prevalence of diastolic dysfunction, while in the latter, diastolic dysfunction was significantly more prevalent among CAN-positive individuals (90,7%, compared to 56,2% in CAN-negative patients with ≥2 MS components; p=0,001). …”
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The effect of early childhood stature on later cognitive functions in Indonesian adolescents: comparation using the National growth reference and the WHO growth standard by Annang Giri Moelyo, Aman B. Pulungan, Mei Neni Sitaresmi, Madarina Julia

“…Conclusions Childhood stature was associated with later negative cognitive function only when the children were classified as short using NIGC. …”
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