Eighteen‐Month Real‐World Experience Using Mavacamten for Treatment of Obstructive Hypertrophic Cardiomyopathy in a Racially Diverse Population by Diego Ramonfaur, Alessio Gasperetti, Victoria E. Blake, Bryana Rivers, Ali A. Kassamali, Edward K. Kasper, Lili A. Barouch, Katherine C. Wu, Jose A. Madrazo, Richard T. Carrick

“…Mavacamten was temporarily discontinued in 3 patients due to left ventricular ejection fraction decrease <50%. …”
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Development of a Widely Accessible, Advanced Large-Scale Microfluidic Airway-on-Chip by Brady Rae, Gwenda F. Vasse, Jalal Mosayebi, Maarten van den Berge, Simon D. Pouwels, Irene H. Heijink

“…On-chip microfluidics are advanced in vitro models that simulate lung tissue’s native 3D environment more closely than static 2D models to investigate the complex lung architecture and multifactorial processes that lead to pulmonary disease. …”
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Airway Organoid Models as Pivotal Tools for Unraveling Molecular Mechanisms and Therapeutic Targets in Respiratory Diseases: A Literature Review by Jiang SP, Lin BQ, Zhou XQ, Li MH, Feng ZC, Qin YY, Lin SQ, Zhou ZQ, Peng Y, Li L

“…Key findings include: (1) the convergence of traditional culture techniques with advanced methodologies — including 3D matrix embedding, bioprinting and organoids-on-chips technologies — has enabled unprecedented recapitulation of human airway architecture and multicellular interactions; (2) these novel models provide unique insights into disease pathogenesis, host-microbe dynamics, and drug response variability; (3) the inherent capacity to maintain native cellular diversity and disease-associated phenotypes positions airway organoids as crucial platforms for personalized medicine approaches. …”
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New Temporin A Analogues Modified in Positions 1 and 10—Synthesis and Biological Studies by Dilyana Dimitrova, Veronica Nemska, Ivan Iliev, Stoyko Petrin, Nelly Georgieva, Dancho Danalev

“…The antibacterial activity was evaluated with both disk diffusion and broth microdilution methods. The BALB 3T3 NRU test and MTT dye reduction assay were used to determine safety and antiproliferative activity. …”
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Views of democracy and society and support for political violence in the USA: findings from a nationally representative survey by Garen J. Wintemute, Sonia L. Robinson, Andrew Crawford, Daniel Tancredi, Julia P. Schleimer, Elizabeth A. Tomsich, Paul M. Reeping, Aaron B. Shev, Veronica A. Pear

“…Nearly 1 in 5 (18.9%, 95% CI 18.0%, 19.9%) agreed strongly or very strongly that “having a strong leader for America is more important than having a democracy”; 16.2% (95% CI 15.3%, 17.1%) agreed strongly or very strongly that “in America, native-born white people are being replaced by immigrants,” and 13.7% (95% CI 12.9%, 14.6%) agreed strongly or very strongly that “in the next few years, there will be civil war in the United States.” …”
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Olfactory responses of the variegated fruit fly, Phortica variegata, an emerging vector of the zoonotic eyeworm Thelazia callipaeda, to ecologically relevant volatiles by Anna Laura Erdei, Magdolna Olívia Szelényi, Ferenc Deutsch, Balázs Kiss, Béla Péter Molnár

“…Results Male P. variegata showed higher antennal responses to phenol, 3-octanone, and sulcatone than females, indicating olfactory sexual dimorphism. …”
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Exposure of medical students to sexism and sexual harassment and their association with mental health: a cross-sectional study at a Swiss medical school by Carole Clair, Joelle Schwarz, Alexandre Berney, Valerie Carrard, Sylvie Berney, Jeanne Marie Barbier

“…Regression models adjusted for gender, academic year, native language, parental education level, partnership and an extracurricular paid job.Results Being targeted by sexism or sexual harassment was reported by 16% of participants with a majority of women (96%). …”
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Preclinical evaluation of a gel composition based on a flavonoid complex for the treatment of periodontal diseases in orthodontic patients by O. V. Hodovanyi, N. L. Chukhrai, O. I. Mrochko, O. I. Martovlos

“…It was found that the coefficient of GCB irritant action was 5 (the mean score of Me (Q1; Q3) was 5 (4; 5)). The coefficient of cumulation (Kcum) exceeded 8.2. …”
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RELATIONSHIP OF LIPOPROTEINE-ASSOCIATED PHOSPHOLIPASE A2 WITH CORONARY AND CAROTID ATHEROSCLEROSIS IN KIRGIZ ETHNIC GROUP by A. G. Polupanov, Yu. N. Lomteva, T. A. Romanova, A. S. Dzhumagulova

“…Patients with CHD had higher level oftotal cholesterol (5,64±0,97 mmol/l vs. 5,23±1,33 mmol/l, р=0,057), LDL (3,63±0,89 mmol/l vs. 3,16±0,98 mmol/l, p&lt;0,01), and the mass of LP-PLA2 (296±70 ng/ml vs. 237±76 ng/ml, p&lt;0,005) comparing to the patients with EH and CHD. …”
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DFT and Molecular Docking Study of HA-Conjugated SWCNTs for CD44-Targeted Delivery of Platinum-Based Chemotherapeutics by Muhammad Uzair Khan, Ishrat Jabeen, Abdulhamid Althagafi, Muhammad Umar Farooq, Moussab Harb, Bassim Arkook

“…Molecular docking to CD44 (PDB ID: 4PZ3) used Molegro Virtual Docker, validated by re-docking the native HA fragment (RMSD 1.79 Å). …”
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Fatores relacionados à suscetibilidade da erosão em entressulcos sob condições de uso e manejo do solo Factors influencing susceptibility to interrill soil erosion under different... by Flávio P. de Oliveira, Diogo C. Buarque, Ana C. Viero, Gustavo H. Merten, Elemar A. Cassol, Jean P. G. Minella

“…Simulated rainfall intensity of 100 mm h-1 was applied to the following treatments: (I) conventionally tilled soil; (II) no-till soil; and (III) native forest soil. Total kinetic energy (rainfall and runoff) to soil loss, average rate of detachment, and aggregate stability indexes were used to assess susceptibility to interrill erosion. …”
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ACL repair vs. reconstruction: a meta-analysis of outcomes across different tear characteristics by Hongcheng Zheng, Yongtao Zeng, Nacke Daoerji, Husen Wang, Bin Tang, Li Shu

“…Modern ACL repair techniques theoretically preserve native proprioception and enable faster rehabilitation. …”
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Immunoregulatory potential of pregnancy-specific β1-glycoprotein by V. P. Timganova, M. S. Bochkova, M. B. Rayev, P. V. Khramtsov, S. A. Zamorina

“…Our team of authors possesses a patented method for obtaining native human PSG preparation from blood serum of pregnant women, a mixture of PSG1, PSG3, PSG7, PSG9, and their isoforms and precursors. …”
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Impact of levator ani muscle avulsions on Manchester procedure outcomes: A 5‐year follow‐up study by Sissel Hegdahl Oversand, Anne Cathrine Staff, Ingrid Volløyhaug, Rune Svenningsen

“…Abstract Introduction Levator ani muscle avulsion is a risk factor for inferior outcomes after native tissue pelvic organ prolapse repair. In a previously published study, we found no such association 1 year after the Manchester procedure (anterior repair combined with cardinal and uterosacral ligament suspension and perineal repair). …”
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Identifying a Complex Carbohydrate Mixture in Context of a High-Protein Diet That Is Able to Steer Microbial Fermentation to Improve Metabolic Health: The DISTAL Study by Thirza van Deuren, Colin van Kalkeren, Koen Venema, Ellen Blaak

“…Results: Of all the tested combinations, combining potato fiber and pectin resulted in the highest distal SCFA production (26.3 vs 6.4 mmol) and SCFA:BCFA ratio (13.3 vs 2.2) compared to the protein control. …”
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Erythrocyte binding peptides: a story in the search for a malaria vaccine by Mauricio Urquiza-Martinez, Daniela Benavides-Rubio, Fanny Guzmán-Quimbayo

“…SERA-5 HABP-6725 contains sequences targeted by native SERA-5 antibodies, while HABPs 6727 and 6733 are recognized by antibodies from natural infection and vaccination. …”
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Tuberculosis household contact tracing in children: axes of inequality, Barcelona 2003–2022 by Raquel Prieto-García, Raquel Prieto-García, Raquel Prieto-García, Raquel Prieto-García, Joan Pau Millet, Joan Pau Millet, Joan Pau Millet, Antonio Soriano-Arandes, María Espiau, Claudia Broto, Mar Ronda, Núria López, Antoni Noguera-Julian, Antoni Noguera-Julian, Antoni Noguera-Julian, Eva Masdeu Corcoll, Eva Masdeu Corcoll, Cristina Domingo Jimenez, Cristina Domingo Jimenez, Miriam Ros Samsó, Miriam Ros Samsó, Maria Isabel Marcos Arroita, Maria Isabel Marcos Arroita, Jesús Edison Ospina Valencia, Jesús Edison Ospina Valencia, Carmen García Rebollo, Pere Simon Viván, Pere Simon Viván, Pere Simon Viván, Pere Simon Viván, Cristina Rius Gibert, Cristina Rius Gibert, Cristina Rius Gibert, Cristina Rius Gibert

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Aseptic germination and bulblet formation of wild tulip (Tulipa sinkiangensi) by LI Yue, WU Yun, ELMONGY Mohamed, LÜ Xuesi, REN Ziming, SUN Minyi, XIA Yiping

“…It is of great importance for the preservation and utilization of wild tulips with excellent traits in China.The study aims to screen out the optimal conditions for the seed germination of Tulipa sinkiangensi native to Xinjiang, including sterilization method (ethanol, 2% NaClO or 0.1% HgCl₂), peeling or not, gibberellin (GA₃) pretreatment concentration (0, 300, 600 mg/L), basal medium (MS, 1/2MS) and culture temperature (4 ℃, 25 ℃).The results showed that 75% ethanol treatment for 30 seconds and 2% sodium hypochlorite for 10 minutes were the best sterilization method for tulip seeds, with the contamination rate of 0%. …”
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Influência de métodos de secagem na conservação de sementes de Ipê-branco The influence of drying methods on the conservation of Tabebuia roseo-alba (Ridl.) Sand. seeds by Patrícia Degan, Ivor B. de Aguiar, Rubens Sader, Dilermando Perecin, Luciana R. Pinto

“…Depois da secagem, o teor de água das sementes foi reduzido para 3,7, 4,0 e 11,7% e a germinação para 49,0, 44,7 e 45,5%, respectivamente. …”
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Sistemas de manejo e atributos físico-hídricos de um Latossolo Vermelho cultivado com milho Tillage systems and hydro-physical attributes of an Oxisol cultivated with maize by Karina de V. Rossetti, José F. Centurion

“…Furthermore, the K&#952; in the soil showed similar behavior between SPC and periods of SPD, although this was shown in a part of maize cycle, macroporosity values near 0.10 m³ m-3 and soil water tensions near 0.09 MPa.…”
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