Clinical characteristics and risk factors of Clostridioides difficile infection in children with diarrhoea by Ning Wang, Kun Jiang, Jinyue Huang, Mengzhu Hou, Lu Wang, Wei Wang, Yulian Fang

“…Multi-factor logistic regression analysis was used to show that a history of hospitalisation within the last three months, a history of antibiotic treatment for ≥7 days, non-breastfeeding, and a history of antibiotic combined with probiotic treatment were risk factors for CDI in children with diarrhoea (P < 0.05).ConclusionsA history of hospitalisation within the last three months, previous antibiotic treatment for ≥7 days or combined with probiotic treatment, and non-breastfeeding are risk factors for CDI in children with diarrhoea, so children with diarrhoea who present as described above need to be alerted to CDI and are advised to have active investigations to facilitate rapid and effective control of the disease and improve prognosis.…”
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Yiqi Juanshen decoction alleviates renal interstitial fibrosis by targeting the LOXL2/PI3K/AKT pathway to suppress EMT and inflammation by Kaiyue Tan, Jingwei Deng, Yi Liu, Yudi Zhang, Yu Xiong, Su Yuan, Jun Liu, Zhiwei Chen, Yuanyuan Liu, Wenfu Cao

“…Mechanistically, YQJSD exerts its effects by modulating multiple pathways: it inhibits the NF-κB signaling pathway, inhibiting the expression of pro-inflammatory cytokines like NF-κB1, IL-1β, TNF-α, and CCR1. …”
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Gonadal aspects, testosterone and estradiol profiles of the Lebranche mullet Mugil liza subjected to different temperatures during the larviculture phase by Marco Shizuo Owatari, Vanessa Martins da Rocha, Cleize Sales da Silva, Marina Cesconeto dos Santos, Mariana Rangel Pilotto, Fabiola Santiago Pedrotti, Caio Magnotti, Maurício Laterça Martins, Vinicius Ronzani Cerqueira

“…The results suggest that temperature exerts a masculinizing effect on M. liza. Furthermore, temperature directly affected larval growth. …”
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Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats by Hong Yang, Cheng Zhang, Woonghee Kim, Mengnan Shi, Metin Kiliclioglu, Cemil Bayram, Ismail Bolar, Özlem Özdemir Tozlu, Cem Baba, Nursena Yuksel, Serkan Yildirim, Shazia Iqbal, Jihad Sebhaoui, Ahmet Hacımuftuoglu, Matthias Uhlen, Jan Boren, Hasan Turkez, Adil Mardinoglu

“…Overall, our data provides novel insights into the molecular basis by which JNK inhibition exerts its metabolic effect in the metabolically active tissues. …”
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Benefits of Gardenia jasminoides Ellis’s floral volatile components on human emotions and moods by Yan Cai, Hannan Chen, Xin Zhang, Wanning Bu, Wei Ning

“…Investigating the impact of the aromatic scent of plants on the physical and mental well-being of college students is essential. …”
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Increased Intra-Abdominal Pressure as One of the Links in the Pathogenesis of Secondary Diffuse Purulent Peritonitis by D. V. Cherdantsev, O. V. Ovchinnikova, Yu. G. Trofimovich, I. G. Noskov, O. V. Pervova, A. A. Kovalenko

“…To measure this indicator, a Foley catheter inserted into the bladder is used in medical practice. …”
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Design, synthesis and biological evaluation of buthutin derivatives as cardioprotective agents by Yuan Liu, Fa-Qi Wang, Xin-Hao Hua, Shu-Han Yang, Li-Ning Wang, Yun-Sheng Xu, Chen-Yue Shao, Xiang-Bo Gou, Yu-Ming Liu

“…Among all target compounds at 1 μM, compounds 9d, 9f, 9k, 9m, and 9n, with a protection ratio exceeding 30%, exerted stronger protective effects on H9c2 cardiomyocyte than positive control dexrazoxane and buthutin A. …”
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Discovery of the bacterial HslV protease activators as lead molecules with novel mode of action by Aurangzeb Sana, Aurongzeb Muhammad, Shamim Shahbaz, Rashid Yasmeen, Khan Khalid Mohammed, Aziz Tariq, Alharbi Metab, Alasmari Abdullah F.

“…These proteins come together to form a functional enzyme complex, where the C-terminal helix of each HslU subunit is inserted into the binding pocket of each HslV dimer. …”
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Clinical Recommendations of the Northwest Society for Enteral and Parenteral Nutrition, Interregional Association for Emergency Surgery, Russian Gastroenterological Association, Un... by Yu. V. Averyanova, E. M. Batyrshin, A. E. Demko, G. E. Ivanova, V. T. Ivashkin, L. N. Kostyuchenko, A. V. Lapitsky, I. N. Leiderman, V. M. Luft, I. V. Maev, I. G. Nikitin, M. S. Novruzbekov, Е. A. Poluektova, A. L. Potapov, A. V. Sytov, A. S. Trukhmanov

“…To mitigate the dependence on intravenous fluid- and nutrient administration and attain enteral autonomy in SBS-IF patients, the use of recombinant glucagon-like peptide-2 (GLP-2) is justified as exerting a pronounced trophic effect on the epithelial regenerative potential as well as structural and functional adaptation of intestinal mucosa. …”
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Structural insights into dynamics of the BMV TLS aminoacylation by Wen Yang, Ran Yi, Jing Yao, Yongxiang Gao, Shanshan Li, Qingguo Gong, Kaiming Zhang

“…The dynamic changes also include a more compact arrangement in the catalytic center of TyrRS and the insertion of 3’ CCA end into the enzyme’s active site, facilitating two-steps aminoacylation. …”
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Habitat fragmentation increases the risk of local extinction of small reptiles: A case study on Phrynocephalus przewalskii by Cui Yang, Yue Qi, Jiayuan Guo, Liangfei Peng, Neng Xiong, Wenya Zhang, Wei Zhao

“…Habitat fragmentation represents a multifaceted global conservation threat, exerting both direct and indirect effects on individual animals and communities. …”
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Advancements in Nanotechnology for Enhanced Food Safety and Hygiene: Pathogen Detection, Smart Packaging, and Preservation Applications by Farhang Hameed Awlqadr, Ammar B. Altemimi, Qausar Hamed AlKaisy, Syamand Ahmed Qadir, Aryan Mahmood Faraj, Tablo Azad H.Slih, Rawaa H. Tlay, Tarek Gamal Mohamed Abd El-Maksoud, Franscesco Cacciola

“…Smart packaging systems equipped with nanomaterials provide real-time contamination alerts and extend shelf life by enhancing barrier and antimicrobial properties. …”
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Improving photovoltaic water pumping system performance with ANN-based direct torque control using real-time simulation by Ikram Saady, Btissam Majout, Ismail El Kafazi, Mohammed Karim, Badre Bossoufi, Najib El Ouanjli, Said Mahfoud, Ahmed Althobaiti, Thamer A. H. Alghamdi, Mohammed Alenezi

“…The second controller is responsible for regulating the operation of the induction motor through the switching pulses of the Voltage Source Inverter (VSI). These two controllers play an essential role in the system, which increases efficiency and performance. …”
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Health inequities among persons with disabilities: a global scoping review by Emre Umucu, Andrew A. Vernon, Deyu Pan, Sang Qin, Guillermina Solis, Rebecca Campa, Beatrice Lee

“…These studies collectively reveal disparities in healthcare access, utilization, and outcomes among persons with disabilities, highlighting the urgent need for targeted interventions to address systemic barriers and promote equitable healthcare provision.ConclusionThis review underscores the challenges faced by individuals with disabilities in accessing quality healthcare and imperative for concerted efforts to advance health equity.…”
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Purpurin suppresses Salmonella invasion of host cells by reducing the secretion of T3SS-1 effector proteins by Zhenxu Shi, Zhimin Guo, Siqi Li, Chenxiao Jiang, Jianfeng Wang, Xuming Deng, Hongtao Liu, Jiazhang Qiu

“…Antivirulence drugs offer a new approach to treating bacterial infections by targeting specific virulence factors without affecting bacterial growth, thus helping to combat infection without exerting selective pressure on bacteria or inducing resistance. …”
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Modified iris system: initial experience with a new technology for safety in hiatal surgery in pediatric patients by Joel Cazares, Eduardo De la Rosa-Bustamante, Jorge Colín-Garnica, Arturo Guillen-Cárdenas, Marbella Sepulveda-Valenzuela, Miguel Torres-Salas, Jorge Alberto Cantú-Reyes

“…This system utilized an illuminated ureteral stent with optical fibers inserted into a feeding tube (bougie). Results: Five pediatric patients with an average age of 6.2 years successfully underwent laparoscopic NF. …”
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Associations between phenol and paraben exposure and the risk of developing breast cancer in adult women: a cross-sectional study by Yao Xiong, Zhiyu Li, Xiong Xiong, Zixuan Luo, Kaixin Zhong, Jiawei Hu, Shengrong Sun, Chuang Chen

“…The nonlinear association between TRS concentrations and the risk of developing BC was statistically significant (P nonlinear = 0.007), with the restricted cubic splines (RCS) curve exhibiting an inverted U shape. The association between TRS concentrations and the risk of developing BC was more pronounced among overweight individuals (BMI ≥ 25 kg/m2), those aged < 60 years, and white individuals. …”
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La hipocalcemia severa, una emergencia endocrina de difícil manejo by Amanda Páez Talero

“… En la práctica de la Endocrinología son raras las complicaciones que ponen en riesgo la vida de los pacientes, pero una de ellas es la hipocalcemia severa, la cual puede presentarse con síntomas de tetania, espasmo cardiopedal, convulsiones, disminución de la contractilidad miocárdica e incluso muerte. Para reducir la morbimortalidad por esta complicación, es recomendable realizar un diagnóstico adecuado de la causa, instaurar el manejo convencional y en los casos en los que se pueda instaurar un manejo preventivo, realizarlo de manera precoz y adecuada para evitar consecuencias en la evolución de los pacientes. …”
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KNOWLEDGE, ATTITUDES AND PRACTICES TOWARDS OPEN EDUCATIONAL RESOURCES IN HIGHER EDUCATION INSTITUTIONS IN THE PHILIPPINES by Liezel G. Mohillo, Angie R. Jalandoon, Dave E. Marcial

“…It suggests providing OER seminars and training, promoting OER through collaboration, funding, institutional incentives, and support for OER activities. …”
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Optimizing Soft Tissue Emergence Profile Around One-Piece Dental Implants by Abduljaleel Azad Samad

“…After 3 months among 137 inserted implants; 97.8% of the implants were successfully osseointegrated. …”
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