The role of glucagon-like peptide-1 receptor (GLP-1R) agonists in enhancing endothelial function: a potential avenue for improving heart failure with preserved ejection fraction (H... by Darshan Hullon, Ghasaq K. Subeh, Yelizaveta Volkova, Karolina Janiec, Adam Trach, Ruslan Mnevets

“…Further research is needed to elucidate the precise mechanisms through which GLP-1R agonists exert their benefits and to establish their long-term safety and efficacy in diverse HFpEF populations.…”
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Microbubble dynamics in brain microvessels. by James H Bezer, Paul Prentice, William Lim Kee Chang, Sophie V Morse, Kirsten Christensen-Jeffries, Christopher J Rowlands, Andriy S Kozlov, James J Choi

“…We observed that microbubbles can exert mechanical stresses on a wide region of tissue beyond their initial location and immediate surroundings. …”
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CORPORATE GOVERNANCE MECHANISMS, INVESTMENT POLICY AND FINANCIAL SUSTAINABILITY OF PENSION FUND ADMINISTRATORS IN NIGERIA by Adeoye Amuda Afolabi, Mubaraq Sanni, Muritala Olatunji Oladele, Yusuf Alabi Olumoh, Muhammed Kamaldeen Usman

“…Consequently, it can be inferred that corporate governance mechanisms and investment policy do not exert a significant influence on the financial sustainability of authorized pension fund administrators in Nigeria. …”
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Multi-scale comparison of the formation mechanisms in landscape genes of traditional villages by Chao Yu, Zhiyuan Zhou, Junbo Gao, Xiangmin Zhang, Qian Zheng, Zhengbing Liu, Zhifei Ma, Weichun He, Suping Wen

“…Convergence analysis challenges the simplistic correspondence between subjective judgment and quantitative findings, indicating that macro-level geographic environmental features may not exert as substantial an influence on micro-level architectural clusters as previously assumed. …”
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Vasorelaxant effects and its mechanisms of the rhizome of Acorus gramineus on isolated rat thoracic aorta by Jueon Lee, Sujin Shin, Junkyu Park, Ho-Young Choi, Kyungjin Lee

“…Decoctions containing AGR exert vasorelaxant effects. Therefore, this research aimed to delve deeper into the vasorelaxant effects and underlying mechanisms of AGR and its constituents (α-asarone and β-asarone). …”
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Design of a Waste Water Treatment System for Kampala International University-Western Campus. by Tayebwa, Gift

“…By considering the topography of the area, a gravity collection system was considered for the design and using design equations and the data obtained from the field, to obtain the flow of each pipe section, velocity, slope pipe sizes, residual head and head losses the pipe hydraulics were obtained. The invert levels for the manholes were also calculated and used to obtain the profile of the system. …”
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In-situ composite formation of vanadium carbide in CrFeCoNiCu high-entropy alloy cladded on AISI304 stainless steel by Saeed Hosseini, Mahmoud Sarkari Khorrami, Mahmoud Heydarzadeh Sohi

“…In the present study, CrFeCoNiCu(VC)x (x = 0, 1, and 2) high-entropy alloy (HEA) composites were cladded on AISI304 stainless steel using tungsten-inert gas (TIG) cladding. For this purpose, elemental powders of Cr, Co, Fe, Ni, and Cu together with V and C were mechanically mixed, and then by adding the proper amount of polyvinyl alcohol as a binder, a uniform paste was prepared. …”
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Variability in storm season intensity modulates ocean acidification conditions in the northern Strait of Georgia by Wiley Evans, Katie Campbell, Carrie Weekes, Justin Del Bel Belluz, Jessy Barrette, Drew Jordison, Chris Mackenzie, Jonathan Bergshoeff, Carolyn Prentice, Rosie Savage, Isabelle Desmarais, Bryn Fedje, Emma Myers, Kimberly Bedard, Alex Hare, Ian J. W. Giesbrecht, Colleen T. E. Kellogg, Zoe Sandwith, Jennifer M. Jackson

“…Abstract Large changes in marine CO2 chemistry manifest in areas with weakly-buffered seawater where ocean acidification (OA) acts in concert with natural CO2 additions. These settings can exhibit periods of extreme OA in the form of multiple co-occurring stressors, including calcite undersaturation and low pH. …”
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Desenvolvimento e avaliação de aplicativo móvel para determinação da densidade mineral em ossos secos de cães by Thiago André Carreo Costa, Adriana Castro de Jesus, Thiago Borges de Oliveira, Alexandre Redson Soares da Silva, Cássio Aparecido Pereira Fontana, Valcinir Aloísio Scalla Vulcani

“… Sabe-se que, anualmente, são diagnosticadas cerca de 9 milhões de fraturas osteoporóticas no mundo e, por se tratar de uma doença considerada um problema de saúde pública, assintomática e, até certo ponto negligenciada, o diagnóstico precoce da diminuição da densidade mineral óssea ainda constitui um desafio. …”
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Cost Effectiveness Analysis of Eribulin Mesylate as a Treatment for Metastatic Breast Cancer in Spain: Management in the Later Line of Therapy by Gabriel Tremblay, Unnati Majethia, Ilias Kontoudis, Jesús De Rosendo

“…In both settings, deterministic sensitivity analyses demonstrated that the ICER is most sensitive to the eribulin price. **Conclusion:** Eribulin is cost-effective as second-line treatment for HER2-negative MBC patients in Spain; albeit, slightly less so than as third-line treatment for MBC patients who have received capecitabine (an ICER per QALY difference of €1,668). …”
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Lipotoxicity and metabolic disorders at obesity by V. T. Ivashkin, M. V. Mayevskaya

“…Recent studies demonstrated, that the visceral fat is in the higher degree associated to insulin resistance and the increased cardio-vascular risk while subcutaneous fat is metabolically more inert. In this aspect it is necessary to focus on glitazones (PPARs ligands), metformin among pharmacological substances, which has no influence on insulin secretion, however it has a lot of extrapancreatic effects by which it reduces increased concentrations of glucose in blood, improves tissue sensitivity to insulin and, thus, increases uptake of glucose by liver and muscles cells. …”
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Tumor-associated macrophage-derived exosome miR-194 confers cisplatin resistance in GC cells by Yi Zhou, Yang-cheng Sun, Qiong-yan Zhang, Jing Wang, Xian-ya Zhu, Xiang-yu Su

“…Cellular uptake experiments demonstrated that miR-194 can transfer from macrophages to GC cells and exert functional effects. Western blotting and PCR analysis further confirmed that macrophage-derived miR-194 inhibits apoptosis in GC cells and enhances cisplatin resistance by downregulating PTEN. …”
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Interpersonal, not existential, adversities predict postwar deterioration in youth social support by Kelly E. Dixon, Christopher M. Layne, Kimberly S. Ho Misiaszek, Chloe Golden

“…In contrast, adverse living conditions did not exert predictive effects on any sectors of adolescent perceived social support.…”
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Burden of HPV-induced diseases and cost effectiveness of catch-up vaccination in Czech Republic: a model-based study by Vojtech Kamenský, Lukáš Dostálek, Martin Rožánek, Aleš Tichopád, Roman Prymula, Ivana Šarkanová

“…In the female cohort, all analysed rates of catch-up vaccination were the dominant strategy, while in the male cohort, the incremental cost-effectiveness ratios (ICERs) remained consistently below 42,000 CZK/QALY. …”
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What are the perceived influences on asthma self-management at the workplace? A qualitative study by Adrian Loerbroks, Katherina Heinrichs, Patricia Vu-Eickmann, Stefan Hummel, Jalal Gholami

“…Support by colleagues, line managers, and the employer, for example, practical, emotional, or structural support, was perceived to exert effects on symptom prevention, acute symptom management, and communication (ie, self-disclosure of one’s condition).Conclusions Perceived JDL and social support were experienced as influencing successful implementation of asthma SMB at the workplace.Trial registration number German Clinical Trials Register no: DRKS00011309.…”
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Supramolecular interactions-driven aggregation to prepare lipoic acid-bioadhesives for seawater-immersed wounds by Rui Lei, Wenjun Wang, Guan Li, Qian Yu, Haowei Fang, Jinghong Xu, Kunxi Zhang, Yinghai Ye

“…The released H+ can instantly adjust the pH of weakly alkaline seawater-immersed wounds to normal pH, while deprotonated LA is released into wounds to exert anti-inflammatory functions. Together with antibacterial property, bioadhesives applied to seawater-immersed wounds provide stable barrier protection and correct adverse microenvironment, promoting wound healing.…”
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A Cost-effectiveness Analysis of Brentuximab Vedotin in Relapsed or Refractory Systemic Anaplastic Large Cell Lymphoma by Margaret Hux, Denise Zou, Esprit Ma, Peter Sajosi, Andreas Engstrom, Ross Selby, Eugene Benson, Andrew Briggs, Vijayveer Bonthapally

“…Comparing only first-line salvage patients reduced the ICER to £26 800 per QALY gained. Conversely, considering only patients with Eastern Corporative Oncology Group performance status of 0 or 1 increased the ICER to approximately £38 200. …”
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Genes of Inflammation and Placental Function GWAS Associated with Idiopathic Recurrent Miscarriage in the Kazakh Population by Alexandra Murtazaliyeva, Gulnara Svyatova, Galina Berezina, Gulfairuz Urazbayeva, Aigerim Sadyrbekova

“…Aims: The aim of the study is to study the relationship between gene polymorphisms of anti- and pro-inflammatory cytokines – interferon-gamma (T874A), interleukin (IL1B) (C3954T), IL6 (G572C) and IL10 (G1082A); placental function, apoptosis and angiogenesis – apolipoprotein C-III (APOC3) (G5163C), kinase insert domain receptor (A1719T, G1192A), P53 (Arg72Pro) and signal transducer and activator of transcription 3 (STAT3) (C1697G) with the development of idiopathic RM (iRM) in the Kazakh population. …”
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TepiSense: A Social Computing-Based Real-Time Epidemic Surveillance System Using Artificial Intelligence by Bilal Tahir, Muhammad Amir Mehmood

“…Our results show that mBERT LLM achieves the highest F-measure values of 0.96 and 0.83 for topic and indication tweets classification, respectively. …”
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Hepatoprotective effects of propolis ethanol extract on D-galactose-induced aging mice: A metabolomics and transcriptomics analysis focusing on insulin resistance pathways by Jinjia Liu, Songhao Tian, Jixiang Wang, Qing Sang, Wenting Su, Jinqiang Wu, Fenglei Zai

“…Mechanistically, PEE appeared to exert hepatoprotective effects by modulating the insulin resistance pathway, particularly through the PI3K-AKT/PP1 signaling axis, thereby enhancing glycogen synthesis in the damaged liver. …”
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