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    Clinical outcomes after immune checkpoint inhibitor-associated acute kidney injury: a cohort study by Vin-Cent Wu, Ting-Ya Yang, Min-Hsiang Chuang, Hong-Min Lin, Heng-Chih Pan, Yun Chou, Jui-Yi Chen

    Published 2025-02-01
    “…Kaplan-Meier analyses coupled with log-rank tests were conducted to estimate the survival probabilities.Setting Data were sourced from the TriNetX database spanning records from 25 March 2011 to 5 April 2024.Participants Patients with cancer aged ≥18 years treated with ICPi with or without AKI occurrence.Primary and secondary outcome measures The primary outcome was all-cause mortality, and secondary outcomes included major adverse kidney events (MAKE), major adverse cardiovascular events (MACE), the composite of MAKE or MACE with death, and end-stage renal disease.Results The study identified 926 patients with cancer who developed ICPi-AKI (mean age, 67.1±11.8 years; 57.4% men). …”
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