DWI Positivity in Mild, Nondisabling Acute Cerebral Ischemia: Data From the PRISMS Trial by Lily L. Wang, Pooja Khatri, Shyam Prabhakaran, Heidi Sucharew, Thomas A. Tomsick, Janice A. Carrozzella, Robert J. Stanton, Joseph Broderick, Dawn Kleindorfer, Steven R. Levine, Jose G. Romano, Jeffrey L. Saver, Sharon D. Yeatts, Achala Vagal

“…Background In patients with acute cerebral ischemia (ACI) and mild deficit, acute infarction on magnetic resonance imaging (diffusion‐weighted imaging [DWI]‐positivity) is inconsistently detected. …”
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Targeted Prostate Biopsies Overestimate International Society of Urological Pathology Grade Group, Particularly in Smaller Tumors by Lisa J. Kroon, Ivo I. de Vos, Charlotte F. Kweldam, Monique J. Roobol, Geert J.L.H. van Leenders, Roderick C.N. van den Bergh

“…The risk of downgrading was 18% for tumors of 0–10 mm, 14% for 10–20 mm, and 14% for >20 mm. In a multivariable analysis among patients with targeted biopsy GG ≥2, with covariates including clinical tumor stage, prostate-specific antigen (PSA), maximal MRI index lesion diameter, number of positive target biopsies, and GG at targeted biopsy, the statistically significant predictors for downgrading were PSA, maximum MRI index lesion diameter, and target biopsy GG. …”
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Apolipoprotein E genotype is associated with island sign in lobar intracerebral hemorrhage by Qiong Yang, Haixin Sun, Haixin Sun, Xinran Ma, Lu Tang, Xiaolu Liu, Xin Huang, Xiao Huang, Yong Chen, Danyang Tian, Xiangzhu Zeng, Nan Li, Wenzhi Wang, Wenzhi Wang, Dongsheng Fan, Dongsheng Fan, Dongsheng Fan

“…After stratifying by ICH location, multivariable analysis revealed that APOE ε4 (OR 3.510, 95% CI 1.393–8.846, p = 0.008), rather than ε2 (OR 0.621, 95% CI 0.203–1.901, p = 0.404), was associated with the island sign in lobar ICH patients. …”
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Cerebral Microhemorrhages in Children With Congenital Heart Disease: Prevalence, Risk Factors, and Association With Neurodevelopmental Outcomes by Kristen N. Andersen, Sicong Yao, Brian R. White, Marin Jacobwitz, Jake Breimann, Jharna Jahnavi, Alexander Schmidt, Wesley B. Baker, Tiffany S. Ko, J. William Gaynor, Arastoo Vossough, Rui Xiao, Daniel J. Licht, Evelyn K. Shih

“…We found no significant risk factors for preoperative CMH. In multivariable analysis, neurodevelopmental duration (P<0.0001), use of extracorporeal membrane oxygenation support (P<0.0005), postoperative seizure(s) (P=0.02), and lower birth weight (P=0.03) were associated with new or worsened CMH postoperatively. …”
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The elevated levels of soluble growth stimulation expressed gene 2 are associated with coronary atherosclerotic plaque destabilization in unstable angina patients: a case control s... by Ning Li, Xinjian Li, Lin Ni, Xuewen Li

“…Among UA patients, sST2 levels were significantly elevated in those with OCT-defined plaque destabilization features compared to those without (p < 0.001). In multivariable logistic regression analysis, elevated sST2 levels emerged as an independent factor associated with the presence of OCT-defined plaque destabilization (p = 0.013). …”
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A practical guide for nephrologist peer reviewers: evaluating artificial intelligence and machine learning research in nephrology by Yanni Wang, Wisit Cheungpasitporn, Hatem Ali, Jianbo Qing, Charat Thongprayoon, Wisit Kaewput, Karim M. Soliman, Zhengxing Huang, Min Yang, Zhongheng Zhang

“…Future directions in AI-driven nephrology include multimodal data fusion for improved predictive modeling, deep learning for automated imaging analysis, wearable-based monitoring, and clinical decision support systems (CDSS) that integrate comprehensive patient data. …”
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Early urea-to-creatinine ratio to predict rapid muscle loss in critically ill patients with sepsis: a single-center retrospective observational study by Jie Jiang, Hui Chen, Shan-shan Meng, Chun Pan, Jian-Feng Xie, Feng-Mei Guo

“…Results Of the 482 patients, 141 (29.2%) experienced rapid muscle loss during their ICU stay. Multivariable logistic regression analysis revealed that ΔUCR was significantly associated with an increased risk of rapid muscle loss, with an odds ratio (OR) of 1.02 [95% CI: 1.01, 1.02]. …”
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Soluble suppression of tumorigenicity 2 associated with left ventricular thrombosis in patients with ST-segment elevation myocardial infarction by Xinjia Du, Perkash Kumar, Chen Liu, Jiahua Liu, Lei Chen, Yuan Lu, Zhuoqi Zhang

“…Results A total of 38 patients developed LVT after STEMI, multivariable logistic regression analysis showed that sST2 [P = 0.002, OR = 1.01 (1.01 ~ 1.02)] an independent predictor of LVT formation. …”
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Evaluation of factors predicting adherent perinephric fat in laparoscopic retroperitoenal partial nephrectomy by Samet Senel, Antonios Koudonas, Fatih Sandikci, Jens Rassweiler

“…The most common complications were conversion to open surgery due to failure of dissection of the tumor and bleeding requiring intraoperative transfusion in the groups. On multivariable analysis using stepwise regression model, we identified male gender (OR = 3.328; 95% Cl = 1.552–7.133; p = 0.002), PFD>-100.4 Hounsfield Unit (HU) (OR = 3.24; 95% Cl = 1.549–6.777; p = 0.002) and presence of diabetes mellitus (DM) (OR = 2.513; 95% Cl = 1.192–5.299; p = 0.015), as predictor of APF. …”
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Thrombus iodine-based perviousness is associated with recanalisation and functional outcomes in endovascular thrombectomy by Yu Sun, Song Jin, Huiying Wang, Chao Tian, Song Liu, Ming Wei, Tao Ren, Leilei Luo, Sifei Wang, Lejun Fu, Jingjing Guo, Chen Cao, Luotong Wang, Shuang Xia, Tong Han, Nina Hao

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Role of late gadolinium enhancement in the risk stratification of pediatric hypertrophic cardiomyopathy: based on a Chinese cohortResearch in context by Xingrui Chen, Wei Xiangli, Xuan Ma, Yun Tang, Jiaxin Wang, Zhixiang Dong, Kankan Zhao, Zhuxin Wei, Xi Jia, Pengyu Zhou, Yujie Liu, Yanyan Song, Chen Cui, Minjie Lu, Kai Yang, Xiuyu Chen, Shujuan Yang, Shihua Zhao

“…In multivariable Cox analysis adjusted by clinical and imaging factors, LGE extent was independently associated with composite outcomes (adjusted HR: 1.15; P < 0.001) and SCD (adjusted HR: 1.11; P = 0.009). …”
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DEcreased Cognitive functiON, NEurovascular CorrelaTes and myocardial changes in women with a history of pre-eclampsia (DECONNECT): research protocol for a cross-sectional pilot st... by Marc E A Spaanderman, Chahinda Ghossein-Doha, Sander MJ van Kuijk, Gwyneth Jansen, Walter H Backes, Emma B N J Janssen, Yentl Brandt, Robert-Jan Alers, Lisanne P W Canjels, Laura M Jorissen, Tamara Michelle Went, Dennis Koehn, Suzanne C Gerretsen, Petra P M Hurks, Vincent van de Ven, M Eline Kooi, Jacobus FA Jansen

“…Cardiac images are recorded using a 3 Tesla MRI to assess cardiac perfusion, strain, dimensions, mass, and degree of fibrosis. …”
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Inflammatory markers mediate the association between alternative adiposity indices and mortality in patients with rheumatoid arthritis: data from NHANES 1999–2018 by Feng Luo, Jia-jie Guo, Xue-mei Yuan, Heng Zhou, Qiu-yi Wang, Chang-ming Chen, Xue-ming Yao, Wu-kai Ma

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Metabolic parameters on baseline and early [18F]FDG PET/CT as a predictive biomarker for resistance to BRAF/MEK inhibition in advanced cutaneous BRAFV600-mutated melanoma by Bernies van der Hiel, Berlinda J. de Wit - van der Veen, Alfons J. M. van den Eertwegh, Wouter V. Vogel, Marcel P. M. Stokkel, Marta Lopez-Yurda, Ronald Boellaard, Ellen W. Kapiteijn, Geke A. P. Hospers, Maureen J. B. Aarts, Filip Y. F. L. de Vos, Marye J. Boers-Sonderen, Astrid A. M. van der Veldt, Jan Willem B. de Groot, John B. A. G. Haanen

“…Results Seventy-five patients with metastatic melanoma were enrolled in a multi-center trial and treated with vemurafenib/cobimetinib. [18F]FDG-PET/CT scans were performed at baseline, week-2, and week-7. Imaging analysis included SUVpeak, MTV, and TLG of summed metastases, as well as percentage changes over time (∆). …”
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Abstract 253: Impact of Gender and Marital Status on Door‐To‐Needle and Door‐To‐Puncture time and Acute Stroke Outcome by Nurose Karim, Dmitry Tumin, Sehrish Karim, Shailesh Male

“…Median DTN time, DTP time, and discharge NIHSS were 36min, 79min, and 4, respectively. On multivariable analysis (Table), none of the outcomes were improved among married men relative to any other combination of sex and marital status. …”
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Establishment and validation of a convenient and efficient screening tool for active pulmonary tuberculosis in lung cancer patients based on common parameters by Fan Zhang, Fei Qi, Mengyan Sun, Peng Jiang, Minghang Zhang, Xiaomi Li, Yujie Dong, Juan Du, Liang Li, Tongmei Zhang

“…Five machine learning methods, including logistic regression (LR), random forest (RF), support vector machine (SVM), decision tree (DT), and neural network (NN), were employed to develop a screening model for PTB-LC. Results: Through multivariable analysis, gender, pleural effusion, cavitation, monocyte count (MONO), and plasma adenosine deaminase (ADA) levels were identified as independent predictors of PTB-LC and included in model construction. …”
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Anterior cruciate ligament tissue stiffness and anterior tibial translation are increased in patients with medial meniscus posterior root tear by Yavuz Selim Karatekin, Harun Altınayak, Ahmet Serhat Genç, Mirsad Yalçınkaya, Mehmet Seyfi Buruk, Orhan Balta

“…The comparison revealed a significantly greater anterior translation in the knees with MMPRT (p < 0.05). Multivariable regression analysis demonstrated a significant positive relationship between ACL SWE values and tibial slope (β = 1.11; CI, 0.24–1.99; P: 0.01). …”
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Factors Influencing Nerinetide Effect on Clinical Outcome in Patients Without Alteplase Treatment in the ESCAPE-NA1 Trial by Mayank Goyal, Bijoy K. Menon, Johanna Ospel, Mohammed Almekhlafi, Charlotte Zerna, Raul Nogueira, Ryan McTaggart, Andrew M. Demchuk, Alexandre Y. Poppe, Brian Buck, Kathy Heard, Manish Joshi, Diogo Haussen, Shawna Cutting, Shelagh B. Coutts, Daniel Roy, Jeremy L. Rempel, Thalia S. Field, Dar Dowlatshahi, Brian van Adel, Richard Swartz, Ruchir Shah, Eric Sauvageau, Volker Puetz, Frank L. Silver, Bruce Campbell, René Chapot, Michael Tymianski, Michael D. Hill, on Behalf of the ESCAPE-NA1 Investigators

“…We assessed baseline, clinical, and imaging variables as predictors of outcome and for evidence of treatment effect modification. …”
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Late pandemic COVID-19 positivity at the time of thrombectomy is associated with poor outcomes and tandem carotid pathology by Lewis John Rubin Thompson, Clifton Houk, Nathaniel R. Ellens, Gurkirat Singh Kohli, Derrek Schartz, Diana Proper, Tarun Bhalla, Matthew T. Bender, Thomas K. Mattingly

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Differences in risk factors associated with the initiation and progression of mitral annular calcification in asymptomatic individuals by Kyung An Kim, Hae-Ok Jung, So-Young Lee, Yuran Ahn, Mi-Hyang Jung, Woo-Baek Chung, Dong-Hyeon Lee, Ho-Joong Youn, Donghee Han, Hyuk-Jae Chang

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