Regional lymph node invasion in pediatric non-rhabdomyosarcoma soft tissue sarcoma: an international cohort study from the International Soft Tissue Sarcoma ConsortiumResearch in c... by Daniel Orbach, Matthieu Carton, Amadeus T. Heinz, Lise Borgwardt, J Herve Brisse, Carlo Morosi, Erin R. Rudzinski, Akmal Safwat, Monika Sparber-Sauer, Stephanie Terezakis, Andrea Ferrari, Aaron R. Weiss, William H. Meyer, David O. Walterhouse, Timothy B. Lautz

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Radiomics to predict outcomes and abscopal response of patients with cancer treated with immunotherapy combined with radiotherapy using a validated signature of CD8 cells by Jean-Charles Soria, Charles Ferte, Christophe Massard, Roger Sun, Guillaume Louvel, Eric Deutsch, Benjamin Frey, Markus Hecht, Rainer Fietkau, Nora Sundahl, Florian Putz, Andrea Lancia, Angela Rouyar, Marina Milic, Alexandre Carré, Enzo Battistella, Emilie Alvarez Andres, Stéphane Niyoteka, Edouard Romano, Jérôme Durand-Labrunie, Sophie Bockel, Rastilav Bahleda, Charlotte Robert, Celine Boutros, Maria Vakalopoulou, Nikos Paragios, Piet Ost, Udo Gaipl

“…Entropy of the radiomics scores distribution on all lesions was shown to be associated with progression-free survival (HR=1.67, p=0.040), out-of-field abscopal response (AUC=0.70, p=0.014) and overall survival (HR=2.08, p=0.023), which remained significant in a multivariate analysis including clinical and biological variables.Conclusions These results enhance the predictive value of the biologically inspired CD8 radiomics score and suggests that tumor heterogeneity should be systematically considered in patients treated with IORT. …”
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Assessment of myocardial deformation by CMR tissue tracking reveals left ventricular subclinical myocardial dysfunction in patients with gynecologic cancer undergoing chemotherapy by Kai Tao, Kai Tao, Lu Ye, Yan-Jia-Ni Xu, Yan-Jia-Ni Xu, Meng-Xi Yang, Ru-Tie Yin, Qing-Li Li, Xiao-Juan Lin, Ke-Min Li, Liang Song, Yu Ma, Lan Zhong, Ying Hu, Hua-Yan Xu, Dan-Qing Wang, Ying-Kun Guo

“…GRS (39.71 ± 8.09% vs. median 30.56% [IQR 26.52 to 38.15%]; p = 0.001), GCS (-23.45 ± 2.09% vs. median -19.71% [IQR -21.71 to -19.10%]; p < 0.001) and GLS (-16.17 ± 2.42% vs. median -12.12% [IQR -14.10 to -8.53%]; p< 0.001) further decreased as the number of chemotherapy cycles increased during follow-up (all p < 0.05). Multivariate analysis showed that GCS was independently associated with the number of chemotherapy regimens (Standard regression coefficient [β] = 0.397, p < 0.001).ConclusionsMyocardial deformation is more sensitive than LVEF in detecting subclinical left ventricular dysfunction in patients with gynecologic cancer undergoing chemotherapy. …”
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Tocilizumab-Based Treatment of Microvascular Inflammation in Kidney Transplant Recipients: A Retrospective Study by Johan Noble, Johan Noble, Johan Noble, Giorgia Comai, Giorgia Comai, Valeria Corredetti, Reda Laamech, Celine Dard, Thomas Jouve, Thomas Jouve, Diane Giovannini, Audrey Le Gouellec, Shivani Wadnerkar, Paolo Cravedi, Della Apuzzo, Della Apuzzo, Daniele Vetrano, Daniele Vetrano, Marco Busutti, Chiara Abenavoli, Chiara Abenavoli, Paolo Malvezzi, Lionel PE Rostaing, Lionel PE Rostaing, Gaetano Lamanna, Gaetano Lamanna

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Existing drug treatments cannot significantly shorten the clinical cure time of children with COVID-19 by Mengting Li, Yang Wang, Hua Xu, Changlin Liu, Liang Shi, Qi Ye, Jun Wang, Sichan Li, Yan Mei, Liuliu Gao

“…A variety of treatments were employed and the outcomes were evaluated by Cox regression analysis. Multivariable analysis was performed to evaluate cure rate at 14 days with different drug treatment. …”
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Development and validation of an interpretable nomogram for predicting the risk of the prolonged postoperative length of stay for tuberculous spondylitis: a novel approach for risk... by Parhat Yasin, Haopeng Luan, Cong Peng, Xinghua Song

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Sloping retina: a novel feature associated with primary open-angle glaucoma in an African ancestry cohort by Gui-Shuang Ying, Ebenezer Daniel, Roy Lee, Yan Zhu, Rebecca Salowe, Victoria Addis, Prithvi S Sankar, Yineng Chen, Isabel Di Rosa, Amy-Ann Edziah, Joan M O’Brien

“…Objective To define sloping of the retina, a novel stereoscopic feature in primary open-angle glaucoma (POAG), and to evaluate its prevalence and associated risk factors in an African ancestry population.Methods and analysis Digital stereo disc images were graded for sloping by trained non-physician graders. …”
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Development and validation of a risk score to predict adverse birth outcomes using maternal characteristics in northwest Ethiopia: a retrospective follow-up study by Rahel Mulatie Anteneh, Getayeneh Antehunegn Tesema, Ayenew Molla Lakew, Sefineh Fenta Feleke

“…Stepwise, backward multivariable analysis was conducted. The model's accuracy was assessed using density plots, discrimination, and calibration. …”
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Cerebral perfusion and gray matter volume alterations associated with cognitive impairment in metabolic syndrome with cerebral small vessel disease by Han Liu, Han Liu, Wenhui Zheng, Jie Geng, Jie Geng, Xia Zhou, Yu Xia, Yan Liu, Gang Zhang, Gang Zhang, Xiaoqun Zhu, Daping Lv, Daping Lv, Zhongwu Sun

“…The relationships among cognitive performance, CBF, and GMV were evaluated using partial correlation analysis and multivariable linear regression analysis (MLRA). …”
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Serum albumin-to-creatinine ratio as a novel and cost-effective biomarker for silent cerebral infarction: a retrospective cohort study by Mustafa Mazıcan, Ismail Karluka

“…In multivariable logistic regression analysis, each 1-point decrease in sACR was independently associated with a 1.790-fold increase in the odds of SCI (95% CI: 1.384–2.315, p < 0.001). …”
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Efficacy of Mammographic Artificial Intelligence-Based Computer-Aided Detection in Predicting Pathologic Complete Response to Neoadjuvant Chemotherapy by Ga Eun Park, Bong Joo Kang, Sung Hun Kim, Han Song Mun

“…In multivariable analysis, negative MRI, histologic grade 3, and HER2 positivity remained significant predictors. …”
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Care Utilization and Measures of the Subjective by Alexander Drost, Nadia Azib, Ali Azarpey, Philippe Dentino, Diego Tijerina, David Ring, Amin Razi

“…Furthermore, no difference observed between statistical groups of the subjective regarding planned care utilization. Multivariable analysis revealed an association between scheduling a return visit and lower extremity clinicians (RC = 0.3; 95% CI 0.05 to 0.5; P-value, 0.02) but not with statistical groupings of measures of personal factors. …”
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Multimodal MRI radiomics based on habitat subregions of the tumor microenvironment for predicting risk stratification in glioblastoma. by Han Wang

“…Kaplan‒Meier survival analysis and the log-rank test were used to compare survival between the high-risk and low-risk groups. …”
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A real-world pharmacovigilance study of adverse drug reactions associated with lecanemab and aducanumab based on WHO-VigiAccess and FAERS databases by Haoxiang Hu, Yunhan Zhao, Jiesheng Mao, Jianghai He, Yihan Zhang, Hongyu Ye, Xiaokai Yang

“…Results from both the VigiAccess and FAERS databases indicated that the most SOC associated with both drugs was nervous system disorders (34.7% in VigiAccess, 36.8% in FAERS). Further multivariable logistic regression analysis revealed that Aducanumab was associated with a higher risk of nervous system disorders (OR = 4.72, 95% CI: 3.53–6.39, P < 0.001). …”
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Usefulness of Noncontrast MRI-Based Radiomics Combined Clinic Biomarkers in Stratification of Liver Fibrosis by Ru Zhao, Hong Zhao, Ya-Qiong Ge, Fang-Fang Zhou, Long-Sheng Wang, Hong-Zhen Yu, Xi-Jun Gong

“…To develop and validate a radiomic nomogram based on texture features from out-of-phase T1W images and clinical biomarkers in prediction of liver fibrosis. …”
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Periodontal diseases, potential mediators and development of liver fat content: a community-based large cohort by Bofu Liu, Bofu Liu, Yu Jia, Zhihan Gu, Zhihan Gu, Yizhou Li, Yizhou Li, Yiheng Zhou, Yu Cao, Yu Cao

“…LFC was measured by Fatty Liver Index (>60 indicates SLD) in cross-sectional analysis and by magnetic resonance imaging (quantified by Proton Density Fat Fraction, PDFF) in longitudinal analysis. …”
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Prognostic value of global longitudinal strain in patients with preserved left ventricular systolic function: A cardiac magnetic resonance real-world study by Preeyaporn Janwetchasil, Ahthit Yindeengam, Rungroj Krittayaphong

“…Methods: This retrospective cohort analysis enrolled patients with known or suspected CAD who underwent cardiac magnetic resonance imaging from September 2017 to December 2019. …”
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Deep learning helps discriminate between autoimmune hepatitis and primary biliary cholangitis by Alessio Gerussi, Oliver Lester Saldanha, Giorgio Cazzaniga, Damiano Verda, Zunamys I. Carrero, Bastian Engel, Richard Taubert, Francesca Bolis, Laura Cristoferi, Federica Malinverno, Francesca Colapietro, Reha Akpinar, Luca Di Tommaso, Luigi Terracciano, Ana Lleo, Mauro Viganó, Cristina Rigamonti, Daniela Cabibi, Vincenza Calvaruso, Fabio Gibilisco, Nicoló Caldonazzi, Alessandro Valentino, Stefano Ceola, Valentina Canini, Eugenia Nofit, Marco Muselli, Julien Calderaro, Dina Tiniakos, Vincenzo L’Imperio, Fabio Pagni, Nicola Zucchini, Pietro Invernizzi, Marco Carbone, Jakob Nikolas Kather

“…A training set of 354 cases (266 AIH and 102 PBC) and an external validation set of 92 cases (62 AIH and 30 PBC) were available for analysis. A novel DL model, the autoimmune liver neural estimator (ALNE), was trained on whole-slide images (WSIs) with H&E staining, without human annotations. …”
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Exposure to placental microplastic and placental and umbilical cord blood telomere length by Shuo Zhang, Huiyue Chen, Long Li, Zhipeng Li, Dan Wang

“…Adjusted multivariable regression models, stratified analysis, and mixture analyses, including Bayesian Kernel Machine Regression (BKMR) and quantile g-computation, were employed to assess associations and interactions. …”
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Elevated monocyte-to-high-density lipoprotein ratio is associated with increased risk of cognitive impairment and severe cerebral small vessel disease burden by Yueshan Zhao, Yueshan Zhao, Yueshan Zhao, Meixi Li, Meixi Li, Meixi Li, Meixi Li, Juan Zhang, Chao Wang, Mengyao Zhao, Qishuo Yang, Tianjun Wang, Peiyuan Lv, Peiyuan Lv, Peiyuan Lv, Peiyuan Lv, Peiyuan Lv

“…Restricted cubic spline analysis confirmed a non-linear association between MHR and both CI and severe CSVD burden. …”
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