Features of “All LNA” Duplexes Showing a New Type of Nucleic Acid Geometry by Charlotte Förster, André Eichert, Dominik Oberthür, Christian Betzel, Reinhard Geßner, Andreas Nitsche, Jens P. Fürste

“…The 2′-O,4′-C-methylene-β-D-ribofuranose nucleotides are used for single or multiple substitutions in RNA molecules and thereby introduce enhanced bio- and thermostability. …”
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Multi-omics analysis in inclusion body myositis identifies mir-16 responsible for HLA overexpression by Daphne Wijnbergen, Mridul Johari, Ozan Ozisik, Peter A.C. ‘t Hoen, Friederike Ehrhart, Anaïs Baudot, Chris T. Evelo, Bjarne Udd, Marco Roos, Eleni Mina

“…Conclusions Our analysis highlights the importance of interrogating multiple omics to enhance knowledge discovery in rare diseases. …”
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Renal Manifestations of IgG4-Related Disease: A Concise Review by Shahrukh T. Towheed, Wayel Zanjir, Kevin Yi Mi Ren, Jocelyn Garland, Marie Clements-Baker

“…IgG4-related disease (IgG4-RD) is an immune-mediated disorder marked by fibro-inflammatory masses that can infiltrate multiple organ systems. Due to its relatively recent discovery and limited understanding of its pathophysiology, IgG4-related disease may be difficult to recognize and is consequently potentially underdiagnosed. …”
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E3 Ubiquitin Ligases: Potential Therapeutic Targets for Skeletal Pathology and Degeneration by Ruiyin Zeng, Yuan Xiong, Ze Lin, Adriana C. Panayi, Yun Sun, Faqi Cao, Guohui Liu

“…Finally, this paper reviews the discovery of the relevant UPS inhibitors, drug molecules, and noncoding RNAs so far and prospects the future research and treatment.…”
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Extensive Intracardiac and Deep Venous Thromboses in a Young Woman with Heparin-Induced Thrombocytopenia and May-Thurner Syndrome by Yekaterina Kim, Daniel C. Choi, Ali N. Zaidi

“…Subsequent imaging confirmed multiple right atrial thrombi along with LLE venous stent thrombosis and a new right LE acute DVT. …”
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The Role of Celebrity Endorsement Perception and Self-Image Congruity on Purchase Intention of Early adulthood by N. Kardinah, Tintin Supriyatin, Khairunnisak Khairunnisak

“…During this period, students are subjected a process of self-discovery, characterized by a desire to appear more attractive and gain recognition from social environment. …”
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Planetary Sciences, Geodynamics, Impacts, Mass Extinctions, and Evolution: Developments and Interconnections by Jaime Urrutia-Fucugauchi, Ligia Pérez-Cruz

“…Planetary missions and enhanced exoplanets detection capabilities, with discovery of a wide range of exoplanets and multiple systems, have renewed attention to models of planetary system formation and planet’s characteristics, Earth’s interior, and geodynamics, highlighting the need to better understand the Earth system, processes, and spatio-temporal scales. …”
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Self-isolation of adolescents after Covid-19 pandemic between social withdrawal and Hikikomori risk in Italy by Loredana Cerbara, Giulia Ciancimino, Gianni Corsetti, Antonio Tintori

“…Notably, the discovery of a subgroup within the Lone Wolves, composed of adolescents who never meet their friends and whose number has doubled post-pandemic, highlights the chronic nature of the phenomenon that demands urgent intervention. …”
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Identifying Network Public Opinion Leaders Based on Markov Logic Networks by Weizhe Zhang, Xiaoqiang Li, Hui He, Xing Wang

“…In this paper, a network opinion leader recognition method based on relational data was put forward, and an opinion leader recognition system integrating public opinion data acquisition module, data characteristic selection, and fusion module as well as opinion leader discovery module based on Markov Logic Networks was designed. …”
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Mitochondrial abnormalities as a target of intervention in acute myeloid leukemia by Elissa Tjahjono, Megan R. Daneman, Bernadetta Meika, Alexey V. Revtovich, Natalia V. Kirienko

“…This review discusses the dual role mitophagy plays in AML survival, the importance of targeting mitophagy to treat AML, and current progress in the area. The discovery and mechanism of action of multiple compounds that were used to inhibit or stimulate mitophagy and their effects on AML survival are also described. …”
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TOPPER: Topology Prediction of Transmembrane Protein Based on Evidential Reasoning by Xinyang Deng, Qi Liu, Yong Hu, Yong Deng

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Towards Curative Therapy in Burkitt Lymphoma: The Role of Early African Studies in Demonstrating the Value of Combination Therapy and CNS Prophylaxis by Ian Magrath

“…This paper describes the treatment of Burkitt lymphoma (BL) from the time of its discovery in Africa up to the present. Pioneer investigators explored the value of chemotherapy since surgery and radiation were not effective modalities. …”
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Prediction of oxidation resistance of Ti-V-Cr burn resistant titanium alloy based on machine learning by Yuanzhi Sun, Guangbao Mi, Peijie Li, Liangju He

“…The results show that the two algorithms based on multiple learners, gradient boosting decision tree (GBDT) and eXtreme Gradient Boosting (XGBoost), show better performance. …”
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Multi-omic spatial effects on high-resolution AI-derived retinal thickness by V. E. Jackson, Y. Wu, R. Bonelli, J. P. Owen, L. W. Scott, S. Farashi, Y. Kihara, M. L. Gantner, C. Egan, K. M. Williams, B. R. E. Ansell, A. Tufail, A. Y. Lee, M. Bahlo

“…Analysis of common genomic variants, metabolomic, blood and immune biomarkers, disease PheCodes and genetic scores across a fine-scale macular thickness grid, reveals multiple novel genetic loci including four on the X chromosome; retinal thinning associated with many systemic disorders including multiple sclerosis; and multiple associations to correlated metabolites that cluster spatially in the retina. …”
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Why morphology matters: the negative consequences of hasty descriptions of putative novelties in asexual ascomycetes by Ondřej Koukol, Gregorio Delgado

“…ABSTRACT Recent progress in the discovery of fungal diversity has been enabled by intensive mycological surveys in centres of global biodiversity. …”
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Natural Products for Cancer Therapy: A Review of Their Mechanism of Actions and Toxicity in the Past Decade by Yasir Osman Ali Abdalla, Bavani Subramaniam, Shaik Nyamathulla, Noorasyikin Shamsuddin, Norhafiza M. Arshad, Kein Seong Mun, Khalijah Awang, Noor Hasima Nagoor

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First Record of Pyramica epinotalis (Hymenoptera: Formicidae) for the United States by Xuan Chen, Joe A. MacGown, Benjamin J. Adams, Katherine A. Parys, Rachel M. Strecker, Linda Hooper-Bui

“…We discuss the design and implementation of modified arboreal pitfall traps that were instrumental in this discovery.…”
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Emerging trends in the optimization of organic synthesis through high-throughput tools and machine learning by Pablo Quijano Velasco, Kedar Hippalgaonkar, Balamurugan Ramalingam

“…The discovery of the optimal conditions for chemical reactions is a labor-intensive, time-consuming task that requires exploring a high-dimensional parametric space. …”
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Online Pedagogical Tutorial Tactics Optimization Using Genetic-Based Reinforcement Learning by Hsuan-Ta Lin, Po-Ming Lee, Tzu-Chien Hsiao

“…It includes a genetic-based optimizer for rule discovery task by generating new rules from the old ones. …”
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Inhaled Therapy in Respiratory Disease: The Complex Interplay of Pulmonary Kinetic Processes by Jens Markus Borghardt, Charlotte Kloft, Ashish Sharma

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