A randomized, placebo-controlled trial of the BTK inhibitor zanubrutinib in hospitalized patients with COVID-19 respiratory distress: immune biomarker and clinical findings by Steven P. Treon, Camille N. Kotton, David J. Park, Giorgia Moranzoni, Camilla K. Lemvigh, Joseph C. Gathe, Tilly A. Varughese, Christopher F. Barnett, Johnny M. Belenchia, Nina M. Clark, Charles M. Farber, Muhammad Bilal Abid, Gulrayz Ahmed, Christopher J. Patterson, Maria L. Guerrera, Jacob D. Soumerai, Vipheaviny A. Chea, Isabel P. Carulli, Jackson Southard, Shuqiang Li, Catherine J. Wu, Kenneth J. Livak, Eric Holmgren, Pil Kim, Carrie Shi, Holly Lin, Vanitha Ramakrishnan, Ying Ou, Scott Olszewski, Lars Rønn Olsen, Derin B. Keskin, Derin B. Keskin, Zachary R. Hunter, Christopher Tankersley, Todd Zimmerman, Binod Dhakal

“…Lower levels of granulocyte colony-stimulating factor, interleukin (IL)-10, monocyte chemoattractant protein-1, IL-4, and IL-13 were observed in zanubrutinib-treated patients. …”
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Single-cell RNA sequencing highlights the role of distinct natural killer subsets in sporadic amyotrophic lateral sclerosis by Esther Álvarez-Sánchez, Álvaro Carbayo, Natalia Valle-Tamayo, Laia Muñoz, Joaquim Aumatell, Soraya Torres, Sara Rubio-Guerra, Jesús García-Castro, Judit Selma-González, Daniel Alcolea, Janina Turon-Sans, Alberto Lleó, Ignacio Illán-Gala, Juan Fortea, Ricard Rojas-García, Oriol Dols-Icardo

“…We also identified gene expression changes in other immune cells, such as classical monocytes, and distinct CD8 + effector memory T cells which suggested enhanced antigen presentation via major histocompatibility class-II (adj. p-value = 1.23 × 10− 8) in ALS. …”
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Characterization of the Complete Chloroplast Genomes and Phylogenetic Analysis of Sapotaceae by Wenyan He, Yumei Liu, Rui Gao, Zhiyu Song, Wentao Zhu, Jinliao Chen, Cuiyi Liang, Shasha Wu, Junwen Zhai

“…Each genome contains 84–85 protein-coding genes, 37 tRNA genes, and 8 rRNA genes, while the <i>ndhF</i> gene is absent in <i>Pouteria campechiana</i> and <i>Pouteria sapota</i>. The relative synonymous codon usage (RSCU) analysis showed that isoleucine (Ile) is the most commonly used, while the codon for methionine (Met) is the least utilized. …”
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Safety and efficacy of AMG 820, an anti-colony-stimulating factor 1 receptor antibody, in combination with pembrolizumab in adults with advanced solid tumors by Jeanne Tie, Dirk Jäger, Victor Moreno, Dirk Nagorsen, Gloria Juan, Kyriakos P Papadopoulos, Anthony J Olszanski, Erik Rasmussen, Nehal Lakhani, Albiruni RA Razak, James M Cleary, Michael Boyer, Emiliano Calvo Aller, William Edenfield, R Donald Harvey, Annemie Rutten, Manish A Shah, David P Ryan, Hansen Wong, Neelesh Soman, Marie-Anne Damiette Smit

“…Post-treatment there was accumulation of serum colony-stimulating factor 1 (CSF1) and interleukin-34, reduction in CSF1-dependent CD16-expressing monocytes, and increased PD-L1 expression and CD4 and CD8 cell numbers in tumor biopsies.Conclusions The recommended combination dose of 1100 mg AMG 820 plus 200 mg pembrolizumab had an acceptable safety profile. …”
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Comprehensive analysis of Pan-Immune Inflammation and all-cause mortality in rheumatoid arthritis: a database-driven approach, 1999-2018 by Muradil· Mardan, Huoliang Zheng, Qingyin Xu, Shaokuan Song, Zeyu Lu, Hui Deng, Hao Cai, Qizhu Chen, Bingyi Yang, Kudelaiti· Abuduwufuer, Pengbo Chen, Bo Li, Shengdan Jiang, Leisheng Jiang, Xin-feng Zheng

“…PIV was calculated as (neutrophil count×platelet count×monocyte count)/lymphocyte count and categorized into quartiles (Q1–Q4). …”
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Association of different inflammatory indices with risk of early natural menopause: a cross-sectional analysis of the NHANES 2013–2018 by Mengyu Zheng, Mengyu Zheng, Junying Li, Junying Li, Yushan Cao, Yushan Cao, Zhuo Bao, Zhuo Bao, Xing Dong, Xing Dong, Pei Zhang, Pei Zhang, Jinxiang Yan, Jinxiang Yan, Yixuan Liu, Yixuan Liu, Yongzhen Guo, Yongzhen Guo, Xianxu Zeng, Xianxu Zeng

“…Complete blood counts were derived from laboratory test data, and seven indices of inflammation were calculated, including lymphocyte count (LC), neutrophil count (NC), systemic immune inflammation index (SII), product of platelet and neutrophil count (PPN), platelet-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), and lymphocyte-monocyte ratio (LMR). A multivariate weighted logistic regression analysis was employed to estimate the association between these inflammatory indices and early natural menopause.ResultsA total of 2,034 participants were included in the analysis, of whom 460 reported experiencing menopause before the age of 45. …”
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First-in-human phase I trial of the bispecific CD47 inhibitor and CD40 agonist Fc-fusion protein, SL-172154 in patients with platinum-resistant ovarian cancer by Lini Pandite, Simon Metenou, Debra L Richardson, Erika Hamilton, Linda Van Le, Bo Ma, Fatima Rangwala, Nehal J Lakhani, Justin Call, Daphne Stewart, Lauren E Dockery, Guanfang Wang, Jade Huguet, Elliot Offman

“…The best response was stable disease in 6/27 (22%) patients.Conclusions SL-172154 was tolerable as monotherapy and induced, dose-dependent, and cyclical immune cell activation, increases in multiple serum cytokines, and trafficking of CD40-positive B cells and monocytes following each infusion. The safety, PK, and PD activity support 3.0 mg/kg as a safe and pharmacologically active dose.Trial registration number NCT04406623.…”
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Effects of autolytical fish protein hydrolysate on growth performance, survival rate, and hematological indices in farmed juvenile beluga, Huso huso by Ali Hosseinpour Zelaty

“…No significant differences were found between the experimental groups in other blood parameters, such as hemoglobin, hematocrit, red blood cell indices, monocyte and eosinophil percentages (p>0.05). Discussion: The present study showed that dietary supplementation of hydrolyzed protein in juvenile beluga diet significantly improved survival and growth performance (final weight, specific growth rate and daily growth rate) and did not induce any adverse alterations in the measured blood indices compared to the control group. …”
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Inflammatory markers predict efficacy of immunotherapy in advanced non-small cell lung cancer: a preliminary exploratory study by Yingqing Zhang, Na Yan, Yan Feng, Yonglei Wu, Yuejiao Sun, Xixi Gao, Chao Gu, Xiaolong Ma, Feng Gao, Hui Zhang, Jiaqi Zhou

“…Abstract Objective The purpose of this study is to analyze the predictive value of neutrophil to lymphocyte ratio (NLR), lymphocyte count to monocyte count ratio (LMR), platelet to lymphocyte ratio (PLR), platelet count multiplied by neutrophil count to lymphocyte count ratio (SII), red blood cell distribution width (RDW), packed cell volume (PCV), and plateletcrit (PCT) levels in advanced non-small cell lung cancer (NSCLC) patients treated with PD-1/PD-L1 inhibitors. …”
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Bispecific immune cell engager enhances the anticancer activity of CD16+ NK cells and macrophages in vitro, and eliminates cancer metastasis in NK humanized NOG mice by Ge Yang, Mohammad Massumi, Shahryar Khoshtinat Nikkhoi, Hajar Owji, Mayara Grizotte-Lake, Rick I Cohen, Lazaro Gil Gonzalez, Arash Hatefi

“…To advance this BiKE technology toward clinical application, the objective of this research was to demonstrate the ability of BiKE:E5C1 to activate CD16+ immune cells such as NK cells and macrophages to kill cancer cells, and eradicate metastatic HER2+ tumors in NK humanized NOG mice.Methods We assessed BiKE:E5C1’s potential to activate CD16-expressing peripheral blood (PB)-NK cells, laNK92 cells, and THP-1-CD16A monocyte-macrophages through flowcytometry and antibody-dependent cell-mediated cytotoxicity/phagocytosis (ADCC) assays. …”
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Significance of Biogenetic Markers in Giant Cell Tumor Differentiation and Prognosis: A Narrative Review by Muhammad Taqi, Haseeb ul Rasool, Mobeen Zaka Haider, Munjed Al Muderis

“…A neutrophil to lymphocyte ratio (NLR) > 2.70, platelet to lymphocyte ratio (PLR) > 215.80, lymphocyte to monocyte ratio (LMR) ≤ 2.80, and albumin to globulin ratio (AGR) < 1.50 were significantly associated with decreased disease-free survival (DFS) (<i>p</i> < 0.05). …”
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The Metempiricism of Margins: Professor Anthony Aṣiwaju and the Circumference of Knowledge by Toyin Falola

“…Strikingly, the inseparability of the man’s life from his career path appears to be synonymous with the bond between a snail and its shell: his origin and horizon live within the same shell. …”
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Association of ambient air pollutants with blood physiological and biochemical indicators and systemic immune inflammation index in people living around Beijing: an analysis of air... by Bingqian DU, Zhiqiang REN, Peian CHEN, Zhenjun LI

“…ResultsSpearman correlation analysis showed that the concentrations of particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5) and carbon monoxide (CO) were positively correlated with monocyte count (MO#), eosinophil count (EOS#), and red blood cell distribution width standard deviation (RDW-SD), and negatively correlated with mean corpuscular hemoglobin concentration (MCHC) and platelet crit (PCT) (all P < 0.05). …”
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Effects of high-intense resistance training on salivary cortisol in trained individuals: a systematic review (Efectos del entrenamiento de resistencia de alta intensidad sobre el... by Rogério Santos Aguiar, Gustavo Casimiro Lopes, Juliana Brandão Pinto de Castro, Vitor Ayres Prince, Mauro Lúcio Mazini Filho, Dirceu Ribeiro Nogueira da Gama, Rodolfo Alkmim Moreira, Jamilto Praxerdes Praxerdes, Rodrigo Gomes Vale

“…The search for scientific articles was carried out on the Scopus and MEDLINE (via PubMed) databases with the terms resistance training, saliva, cortisol, and their synonyms. We included interventions with high-intense resistance training that analyzed the salivary cortisol levels in physically trained men and women. …”
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Relationships of Thickness of Perirenal Fat with Urinary Levels of MCP-1 and NGAL in Patients with Hypertension by Anna Bragina, Yulia Rodionova, Konstantin Osadchiy, Daria Bayutina, Maria K. Vasilchenko, Alexander Fomin, Valeriy Podzolkov

“…Background : We conducted a study to determine the relationships between perirenal fat (PRF) thickness and urinary levels of monocyte chemoattractant protein-1 (MCP-1) and neutrophil gelatinase-associated lipocalin (NGAL) in patients with hypertension (HTN). …”
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Mechanism of Electroacupuncture Mediated Macrophages Infiltration on Dorsal Root Ganglion to Alleviate Paclitaxel-Induced Neuropathic Pain by XIANG Hongchun, ZHANG Hong, LI Jing, LONG Man, LI Man, CAI Guowei

“…ObjectiveTo observe the effects of electroacupuncture (EA) at bilateral Zusanli acupoint (ST 36) on the expressions of macrophage marker CD68, monocyte chemotactic protein-1 (MCP-1), interleukin-1β (IL-1β) and inducible nitric oxide synthase (iNOS) in dorsal root ganglion (DRG) of mouse model with paclitaxel-induced neuropathic pain, and to explore the mechanism of EA in regulating paclitaxel-induced neuropathic pain.MethodsA total of 30 adult C57 mice were randomly divided into control group, model group and EA group, with 10 mice in each group. …”
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Specifically blocking αvβ8-mediated TGF-β signaling to reverse immunosuppression by modulating macrophage polarization by Cuicui Guo, Hui Sun, Yulei Du, Xiaodong Dai, Yu Pang, Zhen Han, Xinhui Xiong, Shaowei Li, Junhua Zhang, Qingbing Zheng, Xun Gui

“…Furthermore, combining the antibody with PD-1 inhibition produced a synergistic anti-tumor effect. In human PBMCs, monocytes exhibited high αvβ8 expression, and the antibody directly modulated macrophage polarization. …”
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ALTRE PAROLE DEL «DISSESTO FINANZIARIO»: BANCAROTTA, DECOZIONE, INSOLVENZA by Francesca Fusco

“…This contribution traces the history of the term bancarotta, a compound that has come down to us from French and that, from being synonymous with fallimento, over the centuries has specialised in indicating «lo stato di un negoziante che cessa i suoi pagamenti, non costrettovi da immeritate sventure, ma per sua colpa o delitto» (Gerolamo Boccardo, Dizionario universale di Economia politica e del Commercio, 2a ed., 1875). …”
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Cooling and Sterile Inflammation in an Oxygen-Glucose-Deprivation/Reperfusion Injury Model in BV-2 Microglia by Jana Lücht, Nele Rolfs, Sylvia J. Wowro, Felix Berger, Katharina R. L. Schmitt, Giang Tong

“…Furthermore, inducible nitric oxide synthase (iNOS), ionized calcium-binding adaptor molecule 1 (Iba1), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β), interleukin-1α (IL-1α), monocyte chemotactic protein 1 (MCP-1), transforming growth factor β (TGFβ), CIRBP, and RBM3 gene expressions were assessed via reverse transcription polymerase chain reaction, and TNF-α, IL-6, and IL-1β releases into the cultured supernatants were assessed via enzyme-linked immunosorbent assays (ELISA). …”
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The Metempiricism of Margins: Professor Anthony Aṣiwaju and the Circumference of Knowledge by Toyin Falola

“…Strikingly, the inseparability of the man’s life from his career path appears to be synonymous with the bond between a snail and its shell: his origin and horizon live within the same shell. …”
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