Baricitinib Mitigates Methotrexate-Induced Liver Fibrosis Model via YAP Pathway by Mehmet Ulusan, Mumin Alper Erdogan, Ozkan Simsek, Zafer Dogan, Bertug Bekir Ciftci, Gultekin Atalan, Oytun Erbas

“…Thus, the present research sought to evaluate the antifibrotic effects of baricitinib in a rat model of MTX-induced liver fibrosis through the yes-associated protein (YAP) pathway. …”
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Comparative analysis of the protective effects of fluoride compounds on dental erosion in mouse model by Julie Marie Haabeth Brox, Amela Tulek, Amer Sehic, Aida Mulic, Tor Paaske Utheim, Qalbi Khan

“…Molars applied NaF showed a 6% reduction in tooth tissue loss compared to the untreated positive control molars. …”
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Tibiofemoral Joint Contact Force Estimation Based on OpenSim Musculoskeletal Modeling by WANG Xiaoling, JIAN Jiawei, XIE Qiurong, LIAN Zhanghui, GUO Chunming, GUO Jiemei, LI Yurong

“…Through the model scale, inverse kinematics, inverse dynamics analysis, residual reduction processing and muscle control and analysis, medial/lateral tibiofemoral contact force is estimated during walking gait, considering the contribution of external force and internal muscle strength. …”
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Application of Support Vector Machines in High Power Device Technology by RAO Wei, LI Yong, YAN Ji

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Impact of the Type of Continuous Insulin Administration on Metabolism in a Diabetic Rat Model by A. Schaschkow, C. Mura, S. Dal, A. Langlois, E. Seyfritz, C. Sookhareea, W. Bietiger, C. Peronet, N. Jeandidier, M. Pinget, S. Sigrist, E. Maillard

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Mathematical modelling of the most effective goal of cholesterol-lowering treatment in primary prevention by Handrean Soran, Safwaan Adam, Paul Durrington, Zohaib Iqbal

“…Objective To compare quantitatively different recommended goals for cholesterol-lowering treatment in the primary prevention of atherosclerotic cardiovascular disease (ASCVD).Design Outcomes at pretreatment low-density lipoprotein (LDL) cholesterol concentrations from 2 to 5 mmol/L and 10-year ASCVD risk from 5% to 30% were modelled, using the decrease in risk ratio per mmol/L reduction in LDL cholesterol derived from randomised controlled trials (RCTs) of cholesterol-lowering medication.Data source Summary statistics from 26 RCTs comparing treatment versus placebo or less versus more effective treatment and 12 RCTs in which statin was compared with a higher dose of the same statin or with a similar statin dose to which an adjunctive cholesterol-lowering drug was added.Setting The different recommended goals are: (1) LDL cholesterol≤2.6 mmol/L (100 mg/dL); (2) LDL cholesterol≤1.8 mmol/L (70 mg/dL); (3) non-high density lipoprotein (HDL) cholesterol decrease of ≥40%; or (4) LDL cholesterol≤1.8 mmol/L (70 mg/dL) or decreased by ≥50% whichever is lower.Participants RCT participants.Interventions Statins alone or in combination with ezetimibe or proprotein convertase subtilisin/kexin type 9 inhibitors.Main outcome measures For each of the recommended therapeutic goals, our primary outcome was the number of events prevented per 100 people treated for 10 years (N100) and the number of needed to treat (NNT) to prevent one event over 10 years.Results At pretreatment LDL cholesterol 4–5 mmol/L, all four goals provided similar benefit with N100 1.47–16.45 (NNT 6–68), depending on ASCVD risk and pretreatment LDL cholesterol. …”
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Three-dimensional nonlinear modeling of ELM dynamics with biasing in HL-3 tokamak by J. Huang, G.Z. Hao, Y. Suzuki, Y.Q. Liu, J.X. Li, Z.J. Li, T.F. Sun, B.T. Cui, H.K. Yin, L. Wang, H.Z. Zhao, X.Q. Ji, W.L. Zhong, Y. Liang, HL-3 Team

“…These results demonstrate the potential of divertor biasing as a viable technique for ELM control in HL-3, offering a promising strategy for controlling edge instabilities and managing heat flux distribution in mega-ampere plasma current H-mode scenarios.…”
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Preventive effect of probiotics on periodontal ligament in a rat model of anorexia nervosa by Marta Rizk, S. Häck, S. Brenji, I. Knaup, C. Niederau, F. Kiessling, N. Marx, J. Moellmann, F. Kahles, T. Pufe, C. Apel, J. Kern, J. Seitz, L. Käver, C. Voelz, M. Wolf, S. Trinh, R. B. Craveiro

“…This study thus investigates changes in morphology and remodelling of alveolar bone and periodontal ligament (PDL) due to an AN-like condition, along with potential protective effects of probiotics, using a rat model. Three-week-old female Wistar rats were divided into three groups: a control group with ad libitum food and two groups undergoing an activity-based anorexia (ABA) model. …”
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Modeling and forecast of gas hydrate distribution in the Black Sea: main principles and approaches by Volodymyr Iemelianov, Olena Ivanik, Olena Ivanik, Tamara Kukovska, Natalia Fedoronchuk, Natalia Fedoronchuk, Ihor Shuraiev, Eduard Petrushenko, Kateryna Hadiatska

“…This model highlights potential hydrate-bearing zones and serves as a predictive tool for future exploration and hazard mitigation. …”
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Tibiofemoral Joint Contact Force Estimation Based on OpenSim Musculoskeletal Modeling by WANG Xiaoling, JIAN Jiawei, XIE Qiurong, LIAN Zhanghui, GUO Chunming, GUO Jiemei, LI Yurong

“…Based on the generic model gait2392 in the OpenSim model library, a new model was built, which contained 28 joints and 43 degrees of freedom, adjusted the knee joint structure to have 3 directional degrees of freedom in flexion-extension, adduction-abduction, and internal-external rotation, added an upper limb structure with 4 joints and 7 degrees of freedom in a single arm capable of torque actuation, and adjusted the contact point of the tibiofemoral joint from a single to a double contact point.Through the model scaling, inverse kinematics, inverse dynamics analysis, residual reduction processing and muscle control and analysis, the medial and lateral tibiofemoral contact forces were estimated during walking gait, comprehensively considering the contributions of external forces and internal muscle strength. …”
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Metabolic syndrome extenuation in rat model by feeding Stevia rebaudiana Bertoni cookies by Muhammad Farhan Jahangeer Chughtai, Imran Pasha, Samreen Ahsan, Tariq Mehmood, Muhammad Zubair Khalid, Muhammad Adil Farooq, Atif Liaqat, Adnan Khaliq, Saira Tanweer, Mădălina Ungureanu-Iuga, Ionica Cotovanu, Abdullah Ali Alkahtane, Saleh Alfarraj, Felix Kwashie Madilo

“…Stevia cookies were prepared by replacing sucrose with Stevia powder (10%), water extract (1%), and supercritical extract (3%). Bio-efficacy rats modeling trials were done to check their impact against hyperglycemia and hypercholesterolemia. …”
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Unveiling the Cardioprotective Potential of Hydroxytyrosol: Insights from an Acute Myocardial Infarction Model by Alejandra Bermúdez-Oria, Eugenia Godoy, Virginia Pérez, Camila Musci Ferrari, Martin Donato, Juan Fernández-Bolaños, Tamara Zaobornyj, Verónica D’Annunzio

“…The results revealed a remarkable 57% reduction in infarct size in HT-treated mice compared to untreated controls. …”
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U-Net-based VGG19 model for improved facial expression recognition by Xiaohu ZHAO, Jingyi ZHANG, Mingzhi JIAO, Lixun XIE, Lanfei WANG, Weiqing SUN, Di ZHANG

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Neuroprotective Effect of Methylene Blue in a Rat Model of Traumatic Optic Neuropathy by Nicolás S. Ciranna, Ronan Nakamura, Rafael Peláez, Álvaro Pérez-Sala, Patricia Sarrión, Juan C. Fernández, Alejandra Paganelli, Agustín P. Aranalde, Ulises P. Ruiz, Juan J. López-Costa, César F. Loidl, Alfredo Martínez, Manuel Rey-Funes

“…The group of rats treated with MB (n = 16) received five intraperitoneal injections with 2.0 mg/kg MB in the 24 h following IONC while the control group (n = 16) received just vehicle (PBS) as a control. …”
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Evaluation of Simulated Weightlessness Model of Hindlimb Unloading Miniature Pigs and Their Tissue Damage by TU Yingxin, JI Yilan, WANG Fei, YANG Dongming, WANG Dongdong, SUN Zhixin, DAI Yuexin, WANG Yanji, KAN Guanghan, WU Bin, ZHAO Deming, YANG Lifeng

“…Objective To establish a weightlessness simulation animal model using miniature pigs, leveraging the characteristic of multiple systems’ tissue structures and functions similar to those of humans, and to observe pathophysiological changes, providing a new method for aerospace research. …”
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Optimizing urban energy flows: Integrative vehicle-to-building strategies and renewable energy management by Jian Hern Yeoh, Kai-Yun Lo, I-Yun Lisa Hsieh

“…The results reveal significant benefits: a 46.79% annual reduction in grid energy consumption, along with notable decreases in daily peak load (63.49%), electricity costs (51.15%), and carbon emissions (45.99%) compared to a control setup. …”
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Diesel Engine Urea Injection Optimization Based on the Crested Porcupine Optimizer and Genetic Algorithm by Xu Chen, Changhai Ma, Quanli Dou, Shuzhan Bai, Ke Sun, Zhenguo Li

“…In this study, test data were obtained from an engine test stand and a Support Vector Machine (SVM) was developed using the test data to predict NOx conversion efficiency and NH₃ slip. The SVM model was optimized using the Crested Porcupine Optimizer (CPO) to improve its prediction accuracy and was made to replace the mathematical model to save computational time. …”
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Estimation of Fiscal Reaction Functions and Determinants of Fiscal Sustainability in Iran Employing Linear and Nonlinear Functions by Hossein Aghilifar, Khosrow Piraei, hashem zare, Mehrzad Ebrahimi

“…Hence, the model with control variables results in the unsustainability of Iran's fiscal policy. …”
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Efficacy of a school-based mental health intervention among Zambian youth: a cluster-randomized controlled trial by Sherinah Saasa, Kaitlin P. Ward, Cleopas G. Sambo, Paula Barrett, Cheuk Yan Lau

“…Data were analyzed using longitudinal multilevel modeling and controlled for child and parent sociodemographic characteristics. …”
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Optimized step size control within the Rosenbrock solvers for stiff chemical ordinary differential equation systems in KPP version 2.2.3_rs4 by R. Dreger, T. Kirfel, T. Kirfel, A. Pozzer, S. Rosanka, R. Sander, D. Taraborrelli, D. Taraborrelli

“…Furthermore, we compared its efficiency to a second-order step size controller. We assessed the performance of the controllers in both a box and a global model for very stiff ODEs. …”
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