Film mulching can alleviate soil quality decrease and produce high maize yield under different irrigation strategies by Hao Quan, Lihong Wu, Jiaming Sun, Tibin Zhang, Lianhai Wu, Kadambot H.M. Siddique, Hao Feng, Bin Wang

“…However, CK, BI_PM, MDI_PM, and LDI_PM showed reductions in SQI in both soil layers, primarily due to decreased soil organic carbon (SOC) and structural stability, along with increased sand content and soil salinity; (3) according to the linear mixed-effects model, a low SQI (< 0.43), elevated temperatures, and drought indices negatively impact yield. …”
Get full text

Adolescent binge alcohol exposure accelerates Alzheimer’s disease-associated basal forebrain neuropathology through proinflammatory HMGB1 signaling by Rachael P. Fisher, Lindsay Matheny, Sarrah Ankeny, Liya Qin, Leon G. Coleman, Leon G. Coleman, Ryan P. Vetreno, Ryan P. Vetreno, Ryan P. Vetreno

“…In the post-mortem human AUD basal forebrain (Experiment 1), we report upregulation of Hmgb1 and the HMGB1 receptors Rage and Tlr4 as well as microglial activation and increased intraneuronal Aβ1–42 accumulation in association with reduced cholinergic neuron marker expression (ChAT). In the 5xFAD mouse model (Experiment 2), AIE accelerated AD-associated induction of Hmgb1 proinflammatory neuroimmune genes, microglial activation, and reductions of ChAT+ basal forebrain cholinergic neurons in the adult female, but not male, basal forebrain. …”
Get full text

Age, frequency, and strategy optimization for organized colorectal cancer screening: a decision analysis conducted in China for the years 2023–2038 by Zixing Wang, Wei Han, Ran Fei, Yaoda Hu, Fang Xue, Wentao Gu, Cuihong Yang, Yubing Shen, Luwen Zhang, Jingmei Jiang

“…These findings should be valuable for policy-making regarding cancer control and resource allocation.…”
Get full text

Impact of microgravity on retinal neuroimmune responses and visual dysfunction in rats by Jin-Shuo Liu, Nai-Qin Yan, Ying-Yan Mao, Chen Xin, Da-Peng Mou, Xin-Xiao Gao, Jia Guo, Ning-Li Wang, Si-Quan Zhu

“…Concurrently, the TLCPD shifted from a negative value in controls to a positive value. These pressure alterations were associated with retinal dysfunction, as evidenced by significant reductions in ERG b-wave and photopic negative response (PhNR) amplitudes. …”
Get full text

Gemcitabine-Loaded Microbeads for Transarterial Chemoembolization of Rabbit Renal Tumor Monitored by ¹⁸F-FDG Positron Emission Tomography/X-Ray Computed Tomography Imagi... by Xiaoli Zhang, Tingting Li, Jindong Tong, Meihong Zhou, Zi Wang, Xingdang Liu, Wei Lu, Jingjing Lou, Qingtong Yi

“…Compared with the untreated control group with increased tumor volume and intense ¹⁸F -FDG uptake, the G-DEBs group showed significant reductions in tumor volume and maximum standard uptake value (SUV_max) 10 or 14 days after the treatment. …”
Get full text

Chamomile Tincture and Lidocaine Hydrochloride Gel Ameliorates Periodontitis: A Preclinical Study by Jiahui Sun, Huiyi Wang, Junhong Xiao, Qiudong Yang, Heyu Liu, Zhengkun Yang, Yuqi Liu, Xin Huang, Liu Yang, Li Ma, Zhengguo Cao

“…<b>Methods</b>: A periodontitis model was induced in Sprague Dawley rats by ligating the mandibular first molars. …”
Get full text

Evaluating academic detailing as an antibiotic stewardship intervention in primary healthcare settings in Croatia by Darija Kuruc Poje, Domagoj Kifer, Maja Kuharić, Katarina Gvozdanović, Željka Draušnik, Ana Posavec Andrić, Vesna Mađarić, Vlatka Janeš Poje, Marina Payerl-Pal, Arjana Tambić Andrašević, Juraj Mark Poje, Vesna Bačić Vrca, Srećko Marušić

“…This feasibility quasi-experimental study had two control groups in two counties. Impact of AD intervention was assessed by analyzing antibiotic prescription patterns using log-linear model, adjusting for seasonality. …”
Get full text

Baicalin alleviates intestinal inflammation and microbial disturbances by regulating Th17/Treg balance and enhancing Lactobacillus colonization in piglets by Shunfen Zhang, Chengzeng Luo, Kai Li, Junhong Wang, Huixin Wang, Ruqing Zhong, Liang Chen, Qiugang Ma, Hongfu Zhang

“…Results In this study, we isolated an E. coli strain, SKLAN202302, from the colon of diarrheal piglets to create an intestinal inflammation model for evaluating the protective effects of baicalin. …”
Get full text

Butyrate-producing bacteria in pregnancy maintenance: mitigating dysbiosis-induced preterm birth by Azusa Uchida, Kenji Imai, Rika Miki, Tomonari Hamaguchi, Hiroshi Nishiwaki, Mikako Ito, Jun Ueyama, Satomi Hattori, Sho Tano, Kazuya Fuma, Seiko Matsuo, Takafumi Ushida, Kinji Ohno, Hiroaki Kajiyama, Tomomi Kotani

“…Methods We established a dysbiosis-induced PTB mouse model using vancomycin treatment combined with subclinical immune activation via anti-CD3ε antibody. …”
Get full text

Burden of laryngeal cancer in China caused by smoking from 1990 to 2021 and predictions for 2035: An age-period-cohort analysis of global burden of disease study 2021 by Xue Gu, Xiaopeng Sun, Xiao Ren, Yu Li, Yingying Fang, Hui Song, Pingli Luo, Mengfan Yuan

“…According to the APC model, the age effect on disease burden increased with age, while period and cohort risk ratios generally declined. …”
Get full text

Non-invasive monitoring of microcirculation dynamics in hypovolemic shock: a novel application of diffuse correlation spectroscopy by Hiroki Matsushita, Koki Kurono, Mikie Nakabayashi, Kei Sato, Hidetaka Morita, Yuki Yoshida, Masafumi Fukumitsu, Kazunori Uemura, Toru Kawada, Masashi Ichinose, Yumie Ono, Keita Saku

“…This study examined the utility of DCS in assessing the microcirculation during hypovolemic shock in a canine model. Methods Six male beagle dogs underwent controlled blood withdrawal to induce hypovolemic shock, defined as a ≥ 30% decrease in cardiac output (CO) and mean arterial pressure (MAP) < 60 mmHg or systolic arterial pressure (SAP) < 90 mmHg. …”
Get full text

PM_2.5 Exposure as a Risk Factor for Optic Nerve Health in Type 2 Diabetes Mellitus by Tianyi Yuan, Minna Cheng, Yingyan Ma, Haidong Zou, Haidong Kan, Xia Meng, Yi Guo, Ziwei Peng, Yi Xu, Lina Lu, Saiguang Ling, Zhou Dong, Yuheng Wang, Qinping Yang, Wenli Xu, Yan Shi, Cong Liu, Senlin Lin

Get full text

Characterization of the salivary microbiome in healthy individuals under fatigue status by Xianhui Peng, Na Han, Yanan Gong, Lihua He, Yanli Xu, Di Xiao, Tingting Zhang, Yujun Qiang, Xiuwen Li, Wen Zhang, Jianzhong Zhang

“…This study aimed to delineate the structural and functional alterations in the salivary microbiome of healthy individuals undergoing physiological fatigue compared to energetic controls, and to explore its potential as a biomarker for fatigue status.MethodsA cohort of 7 healthy individuals experiencing acute physiological fatigue (induced by prolonged study and confirmed via electroencephalography; Fatigue group, FTG) and 63 energetic healthy controls (Energetic group, ENG) were enrolled. …”
Get full text

Effects of lifestyle interventions on mental health in children and adolescents with overweight or obesity: a systematic review and meta-analysisResearch in context by Jiali Zhou, Yuan Song, Jiayao Ying, Chenhao Zhang, Jing Wu, Shiyi Shan, Jindian Zha, Liying Zhou, Wenhan Xiao, Peige Song

“…A random-effects meta-analysis model was performed to calculate pooled standardized mean differences (SMDs) and 95% confidence intervals (CIs). …”
Get full text

Organizational Culture and Stock Price Crash Risk by Gholamreza Kordestani, Ramin Eskandari, Mahdi Shams

“…Data from 124 companies listed on the Tehran Stock Exchange over ten years from 2012 to 2021 were selected, and the hypotheses were tested using multiple linear regression and panel data models. Organizational culture was assessed through four quadrants (control-oriented, Creation-oriented, collaboration-oriented, and competition-oriented) utilizing a text analysis approach and software tools including Adobe Acrobat, Microsoft Edge, and OCR (using Python programming language). …”
Get full text

Legal Challenges of Marine Insurance Laws in the Use of Unmanned Ships by Mahsa Bahadoran- Baghbaderani, Masoud Shirani, Reza Soltani

“…Key risks, such as cyber threats, software malfunctions, and design flaws, require innovative insurance models to ensure comprehensive coverage. The findings emphasize the importance of revising liability frameworks to clearly define the roles and responsibilities of stakeholders, including shipowners, remote-control operators, and software developers. …”
Get full text

Wildlife law and policy by S. Bertouille

“…CMS parties strive towards strictly protecting these animals, conserving or restoring the places where they live, mitigating obstacles to migration and controlling other factors that might endanger them. …”
Get full text

Early detection to improve outcome in people with undiagnosed psoriatic arthritis: the PROMPT research programme including RCT by Neil McHugh, Laura Bojke, Mel Brooke Turfrey, Rachel Charlton, Myka Ransom, Laura C Coates, Howard Collier, Claire Davies, Emma Dures, Philip Helliwell, Jana James, Anya Lissina, Vishnu B Madhok, Alison L Nightingale, Jonathan Packham, Catherine Smith, Eldon Spackman, Cerys Tassinari, William Tillett, Sarah T Brown

“…ES dominated SC on the basis of the imputed data set. Modelling analysis To estimate the long-term consequences and cost-effectiveness of screening for PsA, a hypothetical cohort of 45-year-old patients with mild psoriasis and without PsA was modelled. …”
Get full text

Effects of ginger supplementation in individuals with mild to moderate joint pain I: ratings of pain, functional capacity, and markers of inflammation by Jacob Broeckel, Landry Estes, Megan Leonard, Broderick Dickerson, Drew E. Gonzalez, Martin Purpura, Ralf Jäger, Ryan Sowinski, Christopher J. Rasmussen, Richard B. Kreider

“…Data were analyzed using the general linear model (GLM) analysis of variance with repeated measures, mean changes from baseline with 95% confidence intervals, and chi-squared analysis.Results There was evidence that ginger supplementation: 1.) attenuated perceptions of muscle pain in the vastus medialis (Day 2: χ2 p = 0.087); 2.) reported less pain from sitting (Day 2: χ2 p = 0.02), while nocturnal pain (Day 32: χ2 p = 0.075, Day 58: (χ2 p = 0.097), weight bearing pain (Day 32: χ2 p = 0.058), physical functioning of performing heavy duties (Day 32: χ2 p = 0.100), and physical functioning of performing light duties (Day 2: χ2 p = 0.064) on WOMAC questions; 3.) experienced significant reductions in WOMAC overall ratings of pain, stiffness, physical function, and total score values, particularly in 48-hour follow-up measures; 4.) reported less pain during nighttime bed rest (Day 2: χ2 p = 0.065; Day 32: χ2 p = 0.032) and when going up and down stairs (Day 32: χ2 p = 0.097) from the LEQ; and, 5.) promoted significant differences over time and/or between groups in IL-β, IL-5, IL-6, IL-8, INF-γ, TNF-α, and high sensitivity C-reactive Protein at various points during the study.Conclusion Ginger supplementation promotes some favorable effects on exercise-induced perceptions of pain, functional capacity, and inflammatory markers in men and women who have mild to moderate muscle and joint pain.Registered clinical trial #ISRCTN74292348.…”
Get full text

Changes in air pollutant emissions in China during two clean-air action periods derived from the newly developed Inversed Emission Inventory for Chinese Air Quality (CAQIEI) by L. Kong, L. Kong, X. Tang, X. Tang, Z. Wang, Z. Wang, Z. Wang, J. Zhu, J. Zhu, J. Li, H. Wu, H. Wu, Q. Wu, H. Chen, H. Chen, L. Zhu, W. Wang, B. Liu, Q. Wang, D. Chen, Y. Pan, Y. Pan, J. Li, J. Li, L. Wu, L. Wu, G. R. Carmichael

“…This suggests that the emission control policies may be improved in the 2018–2020 action plan. …”
Get full text