Therapeutic Effects of Lavender Oil on Streptozotocin-Induced Diabetes Mellitus and Experimental Thrombosis by Valeriu Mihai But, Vasile Rus, Tamás Ilyés, Mădălina Luciana Gherman, Ioana Cristina Stănescu, Sorana D. Bolboacă, Adriana Elena Bulboacă

“…Lavender oil exhibited dose-dependent benefits, with the 200 mg/kg bw dose leading to significant reductions in proinflammatory cytokines (e.g., tumor necrosis factor α (TNF-α); regulated upon activation, normal T cell expressed and secreted (RANTES); and monocyte chemoattractant protein-1 (MCP-1)) and oxidative stress, along with improved glycemic control, the partial restoration of C-peptide levels, and the attenuation of matrix metalloproteinase 2 and 9 (MMP-2 and MMP-9) activity (<i>p</i> < 0.0001). …”
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Cost-effectiveness of dog rabies vaccination programs in East Africa. by Rebekah H Borse, Charisma Y Atkins, Manoj Gambhir, Eduardo A Undurraga, Jesse D Blanton, Emily B Kahn, Jessie L Dyer, Charles E Rupprecht, Martin I Meltzer

“…<h4>Methods</h4>RabiesEcon uses a mathematical model of dog-dog and dog-human rabies transmission to estimate dog rabies cases averted, the cost per human rabies death averted and cost per year of life gained (YLG) due to dog vaccination programs (US 2015 dollars). …”
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6-mercaptopurine Metabolites as Predictors of Neutropenia and Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia by Ebrahim Salehifar, Omid Abed Khojasteh, Seyed Jalal Hosseinimehr, Hossein Karami, Mohammad Naderi Sorki, Hadi Darvish-Khezri, Kimia Karami

“…The concentrations of 6-MP metabolites were measured using high-performance liquid chromatography (HPLC) and analyzed by mixed model analysis. Results: No significant differences were found between the case and control groups regarding gender, age, body mass index, drug dose, and the number of dose reductions. …”
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Texture analysis of T1- and T2-weighted images identifies myofiber atrophy and grip strength decline in streptozotocin-induced type 1 diabetic sarcopenia rats by Dong Xing, Fang Liu, Yufan Gao, Ziyan Fei, Yunfei Zha

“…This study evaluated the potential of MRI texture analysis as a noninvasive imaging tool to assess myofiber size and grip strength alterations in a rat model of diabetic sarcopenia. Materials and methods Twenty SD rats were randomly and evenly allocated to the control (CON) and diabetic sarcopenia (DS) groups. …”
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Response of ozone to current and future emission scenarios and the resultant human health impact in Southeast Asia by Tingting Fang, Jie Hu, Yefu Gu, Joseph J.Y. Sung, Steve Hung Lam Yim

“…Our results show O3 in urban areas (i.e., Singapore, Jakarta, Kuala Lumpur, Bangkok, and Ho Chi Minh City) was sensitive to both nitrogen oxides (NOx) and volatile organic compounds (VOCs) emissions, and synergistic NOx and VOCs control is thus essential. Suburban, rural, and sea areas were under a NOx-limited regime, suggesting the high effectiveness of controlling NOx over these areas. …”
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FLOT chemotherapy treatment affects adipocyte’s lipid metabolism: an in vitro study by Lisa Guerrier, Ruddy Richard, Jean Brac de la Perrière, Ophélie Bacoeur-Ouzillou, Julianne Touron, Johan Gagnière, Alexandre Pinel, Corinne Malpuech-Brugère

“…The murine cell line 3T3-L1, a model of mature adipocytes, was used in this study. …”
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The Effect of Heat Stress on the Performance and Genetic Parameters of Milk Production, Reproduction, and Somatic Cell Scores in Iranian Holstein Cows by Reza Seyedsharifi, Fatemeh Ala Noshahr, Jamal Seif Davati, Nemat Hedayat Evrigh

“…The genetic potential of an animal can play an important role in controlling reductions in milk production, reproductive performance, and herd udder health in stressful weather conditions. …”
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Tracking Long-Term Ozone Pollution Dynamics in Chinese Cities with Meteorological and Emission Attribution by Hongrui Li, Xiaoyong Liu, Zijian Liu, Mengyang Li, Tong Wu, Peicheng Li, Peng Zhou

“…Although China has achieved substantial reductions in particulate matter pollution, continually rising ground-level ozone now constitutes the primary challenge to further air-quality improvements. …”
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Bortezomib and quercetin as effective modulators of lipopolysaccharide-induced systemic inflammatory response and metabolic disorders by Ye. O. Morhun, V. O. Kostenko, A. V. Mishchenko, N. V. Solovyova

“…This study aimed to evaluate the effects of combined administration of bortezomib and quercetin on serum ceruloplasmin levels, carbohydrate and lipid metabolism parameters, and secondary products of lipid peroxidation in a lipopolysaccharide (LPS)-induced rat model. Materials and methods. Systemic inflammatory response (SIR) was modeled in male Wistar rats by intraperitoneal administration of Salmonella typhi LPS. …”
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Dose-dependent therapeutic effects of gum acacia on kidney and metabolic dysfunction in adenine-induced chronic kidney disease in rats: involvement of antioxidant pathways by Hadeer Badry, Nadia M. El-Beih, Aya M. Hussein, Hanaa F. Abd El-Kareem, Wael M. El-Sayed

“…This study aimed to evaluate the therapeutic potential of gum acacia (GA) in an adenine (AD)-induced CKD rat model. Methods Rats were randomly assigned to five groups (n = 7 per group): Group I (control), Group II (GA at 600 mg/kg for 14 days), Group III (AD at 600 mg/kg for 10 days), and Groups IV and V (AD for 10 days followed by GA at 300 mg/kg or 600 mg/kg for 14 days). …”
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Efficacy and safety of anticoagulants in elderly atrial fibrillation patients: a systematic review and network meta-analysis by Xingran Zhao, Jun Luo, Xuanda Pan, Linlin Fang, Chengjiang Liu

“…Statistical analysis was performed using a Bayesian random-effects network meta-analysis model to calculate odds ratios (ORs) and 95% confidence intervals (CIs). …”
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Global, regional and national burden of HIV/AIDS among individuals aged 15-79 from 1990 to 2021 by Yuanfang Chen, An-Dong Li, Yizhou Yang, Jing Lu, Yu Xu, Xinyu Ji, Liting Wu, Lei Han, Baoli Zhu, Ming Xu

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Area-level socioeconomic inequalities in hypertension care cascade in China: a nationwide population-based study based on the ChinaHEART projectResearch in context by Wenyao Peng, Siqi Lin, Xuan Liu, Bowang Chen, Xueke Bai, Chaoqun Wu, Xiaoyan Zhang, Yang Yang, Jianlan Cui, Wei Xu, Lijuan Song, Hao Yang, Wenyan He, Yan Zhang, Xi Li, Jiapeng Lu

“…The composite value of area-level SES was generated from national census data and categorized into tertiles. Multivariable mixed models with random effects to account for county-level administrative area were fitted to compute odds ratios (OR) and 95% confidence intervals (CIs) for the independent and interactive associations of both area- and individual-level SES with hypertension management (awareness, treatment, combination therapy and control) and their disparities across different population subgroups. …”
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Impact of mRNA and Inactivated COVID-19 Vaccines on Ovarian Reserve by Enes Karaman, Adem Yavuz, Erol Karakas, Esra Balcioglu, Busra Karaca, Hande Nur Doganay, Koray Gorkem Sacinti, Orhan Yildiz

“…Conversely, AMH expression in the granulosa cells of primary, secondary, and antral follicles showed marked reductions (<i>p</i> < 0.001). The counts of primordial, primary, and secondary follicles decreased significantly in the inactivated vaccine group relative to controls and further in the mRNA vaccine group compared to the inactivated group (<i>p</i> < 0.001). …”
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Multimodal DTI-ALPS and hippocampal microstructural signatures unveil stage-specific pathways in Alzheimer’s disease progression by Peng Yu, Lu Shen, Lijun Tang, Lijun Tang

“…Receiver operating characteristic (ROC) analysis identified right hippocampal MD and t-tau as optimal classifiers for AD.ConclusionThe framework reveals distinct biomarker trajectories: DTI-ALPS distinguishes symptomatic AD from preclinical stages, while right hippocampal MD progression reflects tau-mediated neurodegeneration. Early FA reductions in MCI combined with CSF profiles suggest a hierarchical staging model: amyloid-associated perivascular dysfunction is associated with asymmetric tau-driven hippocampal degeneration. …”
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Optimizing the lead time of operational flexibility trading from distributed industrial energy systems in future energy and flexibility markets by Daniel Bull, Adrian Bürger, Markus Bohlayer, Marco Braun, Anke Weidlich

“…In this study, we analyze this cost effect of varying lead times on flexibility provision by simulating a 48-hour moving horizon model predictive control for multiple distributed energy systems on a market platform, delivering flexibility under different lead time scenarios. …”
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Temporal RAGE Over-Expression Disrupts Lung Development by Modulating Apoptotic Signaling by Derek M. Clarke, Madison N. Kirkham, Logan B. Beck, Carrleigh Campbell, Hayden Alcorn, Benjamin T. Bikman, Juan A. Arroyo, Paul R. Reynolds

“…This study sought to evaluate the role of RAGE in lung development by using a transgenic (TG) mouse model that spatially and temporally controlled RAGE overexpression. …”
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Network pharmacology and experimental validation of Compound Kushen Powder for the treatment of diarrhea in vivo by Bo Yu, Yuanfeng Zhao, Lingling Jiang, Jingrui Zhou, Haoxiang Xu, Lu Lei, Longxin Xu, Xin Wang, Shijin Bu

“…Except for IL-10 and STAT3, the expression of all targets exhibited noteworthy reductions when compared to the positive control group (P < 0.05). …”
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Peripheral skin cooling during gravitational challenges in parabolic flight – experimental protocol, implementation, and case study of the CoolFly experiment by Tomas L. Bothe, Viktor Heinz, Viktor Heinz, Niklas Pilz, Leon Fesseler, Andreas Patzak, Renana Bruckstein, Michael Nordine, Hanns-Christian Gunga, Oliver Opatz

“…Parabolic flight is a model for gravity induced cardiovascular instability. …”
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Biodegradation of CAHs and BTEX in groundwater at a multi-polluted pesticide site undergoing natural attenuation: Insights from identifying key bioindicators using machine learning... by Feiyang Xia, Tingting Fan, Mengjie Wang, Lu Yang, Da Ding, Jing Wei, Yan Zhou, Dengdeng Jiang, Shaopo Deng

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