Methanolic stem-bark extracts of Adansonia digitata modulates haematological and antioxidant parameters in streptozotocin-induced diabetic rats by Ojochenemi Ejeh Yakubu, Chukwuma Stephen Ezeonu, David Ata Agyo, Tsuvini Jonah, Ebenezer Morayo Ale

“…Furthermore, there was a marked (P < 0.05) reduction in the activity of hepatic CAT and SOD and a considerable (P < 0.05) elevation in Malondialdehyde (MDA) level in the hepatic tissue of the diabetic control. …”
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Tuberculosis prevention in South Africa. by Gwenan M Knight, Peter J Dodd, Alison D Grant, Katherine L Fielding, Gavin J Churchyard, Richard G White

“…<h4>Methods</h4>We used a transmission model to investigate whether the NSP targets could be reached if immediate scale up of control methods had happened in 2014. …”
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LEGAL STATUS AND COST-EFFECTIVENESS OF SUPERVISORY BODIES IN PREVENTING OFFENSES IN THE CONSTRUCTION SECTOR by Volodymyr Buha, Valentyn Tulinov, Valerii Kosse

“…The present study employed a range of general scientific methods of formal logic (analysis, synthesis, deduction, induction, analogy, abstraction and modelling) as well as a number of special methods (a logico-legal method and an axiomatic method). …”
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Radiomic analysis of patient and interorgan heterogeneity in response to immunotherapies and BRAF-targeted therapy in metastatic melanoma by Riyue Bao, Yana G Najjar, Diwakar Davar, John M Kirkwood, Jason John Luke, Sarah Newman, Hassane M Zarour, Afsaneh Amouzegar, Rivka R Colen, Murat Ak, Priyadarshini Mamindla, Serafettin Zenkin, Vishal Peddagangireddy, Sarah Behr, Alexandra G Tompkins, Zane N Gray, Rebekah E Dadey, Nasim Batavani, Nursima Ak, Taha Yasin Pak, Mohammadreza Amjadzadeh, Amy Goodman, Darcy L Ploucha, Curtis Tatsuoka

“…Overall and organ-specific machine-learning models were constructed to predict disease control (DC) versus progressive disease (PD) using XGBoost. 291 patients with MEL were identified, including 242 ICI (91 I+N, 151 PD-1) and 49 BRAF. 667 metastases were analyzed, including 541 ICI (236 I+N, 305 PD-1) and 126 BRAF. …”
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Effects of women's groups practising participatory learning and action on preventive and care-seeking behaviours to reduce neonatal mortality: A meta-analysis of cluster-randomised... by Nadine Seward, Melissa Neuman, Tim Colbourn, David Osrin, Sonia Lewycka, Sonia Lewycka, Kishwar Azad, Anthony Costello, Sushmita Das, Edward Fottrell, Abdul Kuddus, Abdul Kuddus, Dharma Manandhar, Nirmala Nair, Bejoy Nambiar, Neena Shah More, Tambosi Phiri, Prasanta Tripathy, Audrey Prost

“…To determine whether behaviour change was related to group attendance, we used random effects models to assess associations between outcomes and the following categories of group attendance and allocation: women attending a group and allocated to the intervention arm; women not attending a group but allocated to the intervention arm; and women allocated to the control arm. …”
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Parenting interventions to promote early child development in the first three years of life: A global systematic review and meta-analysis. by Joshua Jeong, Emily E Franchett, Clariana V Ramos de Oliveira, Karima Rehmani, Aisha K Yousafzai

“…We included randomized controlled trials (RCTs) of parenting interventions delivered during the first 3 years of life that evaluated at least 1 ECD outcome. …”
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Association of Dietary Choline Intake With Incidence of Frailty: A Nationwide Prospective Cohort Study From China by Lian‐hong Chen, Jian‐feng Zhong, Ying‐ying Niu, Cheng‐ping Li, Jing Li, Zhi‐quan Diao, Hao‐yu Yan, Miao Xu, Wen‐qi Huang, Zhi‐tong Xu, Chang Su, Dan Liu

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Pope Leo and Chalcedon: how to prepare, appreciate and defend a problematic council by Philippe Blaudeau

“…In the middle of the 5th century, in a context where the Alexandrian and Constantinopolitan models were experiencing an exacerbation of their rivalry, the See of Rome also put its claims to the test of the ecclesial realities of the Eastern Roman Empire. …”
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Under frequency load shedding aware unit commitment in island power systems by Miad Sarvarizadeh, Mohammad Rajabdorri, Enrique Lobato, Lukas Sigrist, Behzad Kazemtabrizi, Matthias Troffaes

“…The efficacy of the proposed method is demonstrated through simulations on the model of a Spanish island power system, highlighting potential reductions in operation costs and system security improvements.…”
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The Impacts of Water Policies and Hydrological Uncertainty on the Future Energy Transition of the Power Sector in Shanxi Province, China by Xingtong Chen, Jijian Lian, Qizhong Guo

“…The current study develops an optimization model to investigate the impacts of water conservation policies and hydrological uncertainties on the regional energy transition process in Shanxi Province, China. …”
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C. elegans sperm and oocytes differentially transmit diet-induced adaptations to their progeny by Alexandria B. Pete, Craig P. Hunter

“…We measured reproductive fitness via hermaphrodite self-brood size and found that novel diets often caused 20–45% brood-size reductions compared to controls. However, animals adapt to the new diet producing normal-sized broods within 5 to 10 generations. …”
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Loss of synaptic connectivity, particularly in second order neurons is a key feature of diabetic retinal neuropathy in the Ins2Akita mouse. by Jose R Hombrebueno, Mei Chen, Rosana G Penalva, Heping Xu

“…Specifically, photoreceptor presynaptic ribbons were reduced by 25% and postsynaptic boutons by 70%, although the density of horizontal, rod- and cone-bipolar cells remained similar to non-diabetic controls. Significant reductions in GABAergic and glycinergic amacrine cells and Brn3a+ retinal ganglion cells were also observed in 9-month old Ins2Akita mice. …”
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Pharmacological modulation of Sigma-1 receptor ameliorates pathological neuroinflammation in rats with diabetic neuropathic pain via the AKT/GSK-3β/NF-κB pathway by Yuyu An, Shanshan Cao, Leilei Shi, Yuhan Zhang, Xin Wang, Shiyu Yuan, Yongheng Shi, Bin Wang, Jiping Liu, Chao-jun Han

“…The rats were divided into Control, Model, Sig-1R agonist PRE-084 (0.3, 0.6, 1 mg/kg), and metformin (Met, 20 mg/kg) groups, with seven rats per group, and their body weight, fasting blood glucose, mechanical withdrawal threshold and thermal withdrawal latency were tested weekly for two weeks. …”
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Loss of HIV candidate vaccine efficacy in male macaques by mucosal nanoparticle immunization rescued by V2-specific response by Mohammad Arif Rahman, Massimiliano Bissa, Hanna Scinto, Savannah E. Howe, Sarkis Sarkis, Zhong-Min Ma, Anna Gutowska, Xunqing Jiang, Christina C. Luo, Luca Schifanella, Ramona Moles, Isabela Silva de Castro, Shraddha Basu, Kombo F. N’guessan, LaTonya D. Williams, Manuel Becerra-Flores, Melvin N. Doster, Tanya Hoang, Hyoyoung Choo-Wosoba, Emmanuel Woode, Yongjun Sui, Georgia D. Tomaras, Dominic Paquin-Proulx, Mangala Rao, James D. Talton, Xiang-Peng Kong, Susan Zolla-Pazner, Timothy Cardozo, Genoveffa Franchini, Jay A. Berzofsky

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Exploiting a natural instance of vertebrate-posed chemical aposematism for tick bite prevention: Repellency of Ixodes scapularis with (E)-Oct-2-enal. by Eric L Siegel, Sophia Goodnow, Lucy Thompson, Sarah Nicolson, Elizabeth MacLeod, Andrew Y Li, Guang Xu, Stephen M Rich

“…Changes in velocity and peregrination were assessed relative to negative (ethanol) control groups using multivariable robust regression models. …”
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Reducing weight and BMI following gestational diabetes: a systematic review and meta-analysis of digital and telemedicine interventions by Nia Roberts, Andrew J Farmer, Julia Halligan, Maxine E Whelan

“…Digital and telemedicine interventions targeting weight loss and reductions in body mass index (BMI) may help reduce risk for women with GDM. …”
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Targeting oxidative stress and metal imbalance in cerebral ischemia: the neuroprotective role of sodium valproate by Mustafa Ulaş, Ömer Gökay Argadal, Ebru Bardaş Özkan

“…Forty rats were randomly assigned into five groups (n = 8 per group): Control, Sham, Brain Ischaemia (BI), BI + Valproic Acid (VPA), and VPA only. …”
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Exogenous interferon-alpha and interferon-gamma increase lethality of murine inhalational anthrax. by Jeffrey A Gold, Yoshihiko Hoshino, Marcus B Jones, Satomi Hoshino, Anna Nolan, Michael D Weiden

“…<h4>Methodology and principal findings</h4>We sought to extend these findings in an in vivo model of inhalational anthrax, utilizing the Sterne strain (34F2) of B.anthracis. …”
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Wolbachia stimulates immune gene expression and inhibits plasmodium development in Anopheles gambiae. by Zakaria Kambris, Andrew M Blagborough, Sofia B Pinto, Marcus S C Blagrove, H Charles J Godfray, Robert E Sinden, Steven P Sinkins

“…Upregulation of six selected immune genes was observed compared to controls, at least two of which (LRIM1 and TEP1) influence the development of malaria parasites. …”
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Denosumab as an immune modulator in HER2-negative early breast cancer: results of the window-of-opportunity D-BIOMARK clinical trial by Andrea Vethencourt, Eva M. Trinidad, Eduard Dorca, Anna Petit, M. Teresa Soler-Monsó, Marina Ciscar, Alexandra Barranco, Gema Pérez-Chacón, María Jimenez, Mario Rodríguez, Clara Gomez-Aleza, Elvira Purqueras, Enrique Hernández-Jiménez, Ander Urruticoechea, Idoia Morilla, Isaac Subirana, Amparo García-Tejedor, Miguel Gil-Gil, Sonia Pernas, Catalina Falo, Eva Gonzalez-Suarez

“…Results Denosumab demonstrated its ability to reduce serum free RANKL levels (experimental p < 0.001, control p = 0.270). However, a reduction in tumor cell proliferation or cell survival was not observed. …”
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