Global, regional, and national burden of chronic respiratory diseases,1990–2021 and predictions to 2035: analysis of data from the global burden of disease study 2021 by Ying Zhai, Chuanmiao Zhu, Tengxiao Zhu, Wenjing Song, Yu Tang, Luqing Jiang, Fengxia Ruan, Zichen Xu, Lei Li, Xia Fu, Daoqin Liu, Aidong Chen, Qiwen Wu

“…Risk factor studies have shown that solid fuels burden remained higher among females in low-middle sociodemographic index (SDI) areas, while smoking-attributable burden predominated among males.Conclusion This study characterizes the CRD burden across regions, ages, and sexes, identifying key risk factors to inform burden–reduction policies.…”
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Prevalence of tick-borne pathogens in feeding and questing Ixodes ricinus ticks from Southern Sweden by Chiara Cialini, Alessandra Cafiso, Mattias Waldeck, Åsa Lundgren, Johan Fält, Bo Settergren, Phimphanit Choklikitumnuey, Giulia Chiappa, Eleonora Rosso, Laura Roveri, Elisa Fesce, Nicola Ferrari, Per-Eric Lindgren, Chiara Bazzocchi, Giulio Grandi

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COMPARATIVE ESTIMATION OF THE STATE OF THE CAPILLARY NETWORK OF THE MUCOUS MEMBRANE OF UNDERDENTURE SPACE AND SPEED OF THE ATROPHY OF ALVEOLAR PROCESS WITH PROSTHETICS MADE FROM DI... by V.G. Shuturminskiy

“…Studies of the speed of the atrophy of alveolar processes were studied employing the procedure of Ivannikov (Ukraine) in the our modification. The study of models was produced before the apparatus for measuring the models, which operating unit - inductive measuring device with the numerical indication. …”
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Enhanced Anti-Melanoma Activity of Nutlin-3a Delivered via Ethosomes: Targeting p53-Mediated Apoptosis in HT144 Cells by Arianna Romani, Giada Lodi, Fabio Casciano, Arianna Gonelli, Paola Secchiero, Giorgio Zauli, Olga Bortolini, Giuseppe Valacchi, Daniele Ragno, Agnese Bondi, Mascia Benedusi, Elisabetta Esposito, Rebecca Voltan

“…The potential of nutlin-3a-loaded ethosomes was investigated on two in vitro models of melanoma: the HT144 cell line p53^wild-type and the SK-MEL-28 cell line p53^mutated. …”
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Metabolic profiling and antimicrobial activity of Bistorta amplexicaulis D. don by in-vitro implicated through computational studies by Hanan Javid, Umar Yousuf, Roof Ul Qadir, Junaid A. Magray, Bilal A. Wani, Tajamul Islam, Irshad A. Nawchoo, Shabana Gulzar

“…At a concentration of 600 μg/mL, ethyl acetate extracts from the underground parts exhibited the most significant inhibition against Penicillium notatum, leading to an 84.56% ± 2.56% reduction in mycelial growth compared to the control. …”
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On-Demand Maintenance Method Using Fault Prediction to Reduce Elevator Entrapment by Tianshun Cui, Linlin Wu, Libin Wang, Zhiqun Luo, Yugang Dong, Qiang Wang

“…Next, we establish an entrapment prediction model based on our historical data. Then, we design an elevator entrapment risk index report according to the prediction results. …”
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Dihydroartemisinin-piperaquine versus sulfadoxine-pyrimethamine for intermittent preventive treatment of malaria in pregnancy: a systematic review and individual participant data m... by Michelle E. Roh, Julie R. Gutman, Maxwell Murphy, Jenny Hill, Mywayiwawo Madanitsa, Abel Kakuru, Hellen C. Barsosio, Simon Kariuki, John P.A. Lusingu, Frank Mosha, Richard Kajubi, Moses R. Kamya, Don Mathanga, Jobiba Chinkhumba, Miriam K. Laufer, Eulambius Mlugu, Appolinary A.R. Kamuhabwa, Eleni Aklillu, Omary Minzi, Roland Nnaemeka Okoro, Ado Danazumi Geidam, John David Ohieku, Meghna Desai, Prasanna Jagannathan, Grant Dorsey, Feiko O. ter Kuile

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Costs and Outcomes of a Therapist-Guided Internet-Delivered Cognitive Behavioral Therapy: Multicenter Observational Study by Zareen Abbas Khan, Jørn Heggelund, Stian Lydersen, Kristian Kidholm, Henrik Pedersen, Imre Janszky, Tine Nordgreen, Vidar Halsteinli

“…Patients reported a mean reduction of 3.2 sick leave days (95% CI –5.4 to –0.9) at T2 and 7.7 sick leave days (95% CI –11.5 to –3.9) at T3. …”
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Association Between Estimated Pulse Wave Velocity and Endovascular Thrombectomy Outcome: A Secondary Analysis of the OPTIMAL‐BP Trial by Minho Han, Haram Joo, Hyungwoo Lee, JoonNyung Heo, Jae Wook Jung, Young Dae Kim, Eunjeong Park, Kwang Hyun Kim, Jaeseob Yun, Jin Kyo Choi, Il Hyung Lee, Byung Moon Kim, Dong Joon Kim, Na Young Shin, Bang‐Hoon Cho, Seong Hwan Ahn, Hyungjong Park, Sung‐Il Sohn, Jeong‐Ho Hong, Tae‐Jin Song, Yoonkyung Chang, Gyu Sik Kim, Kwon‐Duk Seo, Kijeong Lee, Jun Young Chang, Jung Hwa Seo, Sukyoon Lee, Jang‐Hyun Baek, Han‐Jin Cho, Dong Hoon Shin, Jinkwon Kim, Joonsang Yoo, Minyoul Baik, Kyung‐Yul Lee, Yo Han Jung, Yang‐Ha Hwang, Chi Kyung Kim, Jae Guk Kim, Chan Joo Lee, Sungha Park, Soyoung Jeon, Hye Sun Lee, Sun U Kwon, Oh Young Bang, Ji Hoe Heo, Hyo Suk Nam

“…Incorporating ePWV significantly improved prognostic model performance, with net reclassification improvement of 0.28 (95% CI, 0.06–0.50) and integrated discrimination improvement of 0.02 (95% CI, 0.003–0.04). …”
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GuBenPeiYuan Formula Inhibits Lung Cancer Metastasis by Suppressing Myeloid-Derived Suppressor Cells and Related Immune Cells by Yizhao Du MD, Yongming Zhou PhD, Lijing Jiao PhD, Wenxiao Yang PhD, Ling Xu PhD, Hailun Zhou MD, Jingwen Zhao MD, Quanyao Li MD, Yang Han MD, Yabin Gong PhD, Qin Wang PhD

“…Methods: Lung metastasis models were established by injecting Lewis lung cancer cells (LLCs) into the tail vein of 20 specific pathogen free (SPF)—grade male C57BL/6 mice. …”
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Inactivation of Tnf‐α/Tnfr signaling attenuates progression of intervertebral disc degeneration in mice by Chu Tao, Sixiong Lin, Yujia Shi, Weiyuan Gong, Mingjue Chen, Jianglong Li, Peijun Zhang, Qing Yao, Dongyang Qian, Zemin Ling, Guozhi Xiao

“…However, at 21 months of age, the loss of Tnfr expression significantly alleviated IVDD‐like phenotypes, including a significant increase in height of the nucleus pulposus (NPs) and reductions of endplates (EPs) porosity and histopathological scores, when compared to controls. …”
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Anti-inflammatory effects of cyclodextrin nanoparticles enable macrophage repolarization and reduce inflammation by Felix E. B. Brettner, Stefanie Gier, Annika Haessler, Jonas Schreiner, Sarah Vogel-Kindgen, Maike Windbergs

“…In a human macrophage model, CD nanoparticles demonstrated superior anti-inflammatory activity, with derivative-specific effects tied to their physicochemical properties, surpassing the soluble β-CD control. …”
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Associations between inactivated COVID-19 vaccination status and timing and fertility and pregnancy outcomes following frozen-thawed embryo transfer: a prospective cohort study by Danmeng Liu, Lijuan Chen, He Cai, Hanying Zhou, Min Wang, Na Li, Xia Xue, Li Tian, Ben W. Mol, Ben W. Mol, Wenhao Shi, Juanzi Shi

“…Information on maternal sociodemographic and health-related factors, COVID-19 vaccination status, the IVF-ET process, and outcomes was collected. Generalized linear models or generalized estimating equation models were used to evaluate the associations between vaccination and fertility and pregnancy outcomes. …”
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SHP2 inhibition and adjuvant therapy synergistically target KIT‐mutant GISTs via ERK1/2‐regulated GSK3β/cyclin D1 pathway by Chunxiao He, Jiaying Yu, Shuang Mao, Shaohua Yang, Xianming Jiang, Lei Huang, Mingzhe Li, Yulong He, Xinhua Zhang, Xi Xiang

“…The combination of SHP2 inhibition and imatinib was further evaluated in GIST mouse models. Results In KIT‐mutant GIST, SHP2 was hyperactive and coprecipitated with KIT. …”
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Innovative treatment of toxic oily petroleum wastewater with magnetic sludge under UVA light by Saeedeh Rastgar, Habibollah Younesi, Hassan Rezeai, Hajar Abyar

“…Kinetic and isotherm studies further elucidated the behavior of the photocatalytic process, revealing that the removal of toxic oily wastewater with Char/Fe3O4/TiO2 adhered closely to pseudo-first-order kinetic models, as well as the Freundlich and Henderson isotherm models. …”
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Multifunctional hydrogel with mild photothermal properties enhances diabetic wound repair by targeting MRSA energy metabolism by Qian Gao, Fangfang Hu, Zihan Chai, Caiyun Zheng, Wenhui Zhang, Ke Pu, Ziyi Yang, Yanni Zhang, Seeram Ramrkrishna, Xianglong Wu, Tingli Lu

“…Concurrent silencing of quorum sensing and virulence genes (agr, sec, lac, opp, sdrD) further destabilized MRSA, while upregulation of stress-response genes (yidD, nfsA, kdpA) indicated bacterial metabolic paralysis. In diabetic murine models, the hydrogel attenuated oxidative stress (DHE-confirmed ROS reduction), polarized macrophages to pro-healing M2 phenotypes (Arg-1⁺/TNF-α↓), and enhanced angiogenesis (VEGF/CD31↑) alongside aligned collagen deposition. …”
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Dual drug-loaded tumor-targeted polymeric nanoparticles for enhancing therapeutic response in pancreatic ductal adenocarcinoma by Naga Malleswara Rao Nakka, Hari Krishnareddy Rachamala, Ramcharan Singh Angom, Nagamalleswara Rao Indla, Shamit Kumar Dutta, Enfeng Wang, Santanu Bhattacharya, Annadanam V. Sesha Sainath, Hani Babiker, Krishnendu Pal, Debabrata Mukhopadhyay

“…Furthermore, P(Gem + PTX) showed a significantly better tumor reduction and median overall survival in mouse models than single drug-loaded TTP-PNPs or a combination of free drugs (Gem + PTX). …”
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Spatiotemporal analysis of Anopheles gambiae larval sites and malaria transmission in Djilakh, Central Senegal by Assane Ndiaye, Camille Morlighem, Aminata Niang Diène, Moussa Kane, Abdoulaye Diallo, Fassiatou Tairou, Mohamed Abderemane Nourdine, Pape Cheikh Sarr, Lassana Konaté, Ousmane Faye, Oumar Gaye, El Hadji Amadou Niang, Catherine Linard, Ousmane Sy

“…The generated results indicate a need for targeted control actions in the studied site.…”
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Mechanism of Action and Efficacy of Wu-Hua-Yan-Xiao in the Treatment of Pediatric Acute Pharyngitis Based on Network Pharmacology and Experimental Validation by Zhang X, Zhang Z, Xu Y, Luo J, Shen Z, Liang H, Zeng Y, Liu W, Zheng C, Li J

“…TP53 signaling emerged as a central regulatory pathway. Compared with the model group, the high-dose WHYX volatile oil group showed marked improvements in pharyngeal pathology, significant reductions in inflammatory cytokines, downregulation of TNF-α, TP53, IL17A, IL6, and Bcl-2 expression, and suppressed apoptosis (P < 0.05). …”
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Air Pollution and the microvasculature: a cross-sectional assessment of in vivo retinal images in the population-based multi-ethnic study of atherosclerosis (MESA). by Sara D Adar, Ronald Klein, Barbara E K Klein, Adam A Szpiro, Mary Frances Cotch, Tien Y Wong, Marie S O'Neill, Sandi Shrager, R Graham Barr, David S Siscovick, Martha L Daviglus, Paul D Sampson, Joel D Kaufman

“…These reductions in CRAE are equivalent to 7- and 3-year increases in age in the same cohort. …”
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