Mechanisms of miR-18a-5p Target NEDD9-Mediated Suppression of H5N1 Influenza Virus in Mammalian and Avian Hosts by Jipu Wang, Yanan Xing, Lin Chen, Shuyi Han, Ye Wang, Zhilei Zhao, Gaojian Li, Wenchao Li, Hongxuan He

“…Our investigation revealed significant dysregulation of miR-18a-5p following influenza virus infection, observed consistently across both in vitro and in vivo models. Experimental evidence demonstrated that miR-18a-5p overexpression effectively inhibits H5N1 virus propagation through multiple mechanisms: (1) in vitro studies using A549 cells transfected with miR-18a-5p mimics showed a substantial reduction in viral replication; (2) animal models (mice and chickens) with elevated miR-18a-5p expression exhibited markedly suppressed AIV replication, reduced pathogenicity, and improved survival rates. …”
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Therapeutic effects of platelet-derived extracellular vesicles on viral myocarditis correlate with biomolecular content by Danielle J. Beetler, Danielle J. Beetler, Danielle J. Beetler, Presley Giresi, Damian N. Di Florio, Damian N. Di Florio, Damian N. Di Florio, Jessica J. Fliess, Elizabeth J. McCabe, Molly M. Watkins, Molly M. Watkins, Molly M. Watkins, Vivian Xu, Matthew E. Auda, Katelyn A. Bruno, Katelyn A. Bruno, Emily R. Whelan, Emily R. Whelan, Emily R. Whelan, Stephen P. C. Kocsis, Brandy H. Edenfield, Sierra A. Walker, Sierra A. Walker, Sierra A. Walker, Logan P. Macomb, Kevin C. Keegan, Angita Jain, Angita Jain, Angita Jain, Andrea C. Morales-Lara, Isha Chekuri, Anneliese R. Hill, Houssam Farres, Joy Wolfram, Joy Wolfram, Atta Behfar, Atta Behfar, Paul G. Stalboerger, Andre Terzic, Andre Terzic, Leslie T. Cooper, DeLisa Fairweather, DeLisa Fairweather, DeLisa Fairweather

“…We injected PEV, pmPEV, or vehicle control in a mouse model of viral myocarditis and examined histology, gene expression, protein profiles, and performed proteome and microRNA (miR) sequencing of EVs.ResultsWe found that both PEV and pmPEV significantly inhibited myocarditis; however, PEV was more effective, which was confirmed by a greater reduction of inflammatory cells and proinflammatory and profibrotic markers determined using gene expression and immunohistochemistry. …”
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EVA1B facilitates esophageal squamous carcinoma progression and recruitment of immunosuppressive myeloid-derived suppressor cells in the tumor microenvironment by Tian Xia, Yongkang Zhang, Haodong Peng, Xiangbo Jia, Dong Yang, Li Wei, Tian Li, Wenjian Yao

“…Silencing EVA1B notably attenuated proliferation of ESCC cells and tumor growth in syngeneic mouse models. Moreover, EVA1B suppression resulted in apoptosis and cell cycle arrest, and impaired ESCC cell aggressiveness. …”
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Efficacy of carbon dioxide laser combined with photodynamic therapy in the treatment of chronically infected wounds by Yinfeng Xia, Yongsong Chen, Han Luo, Yu Zhu, Qiang Tan, Ping Wu, Zhiyong Chen

“…Wounds were assessed for healing rate, bacterial quantification, blood vessels, collagen content, interleukin-6, and C-reactive protein at baseline and after treatment. Mixed-effects models and repeated-measures ANOVA were used for analysis. …”
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Genomic regions associated with bovine respiratory disease in pacific northwest Holstein cattle by Allison L. Herrick, Jennifer N. Kiser, Jennifer N. Kiser, Stephen N. White, Stephen N. White, Holly L. Neibergs

“…All 3,655 pre-weaned healthy control calves remained in the herd for a minimum of 60 days, and 3,210 healthy post-weaned control calves remained in the herd for a minimum of 421 days. …”
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Association of early acetaminophen administration with mortality in surgical intensive care patients: a retrospective cohort study by Jiajing Li, Yihao Li, Min Zhong, Hanli Chen, Ziyang Wang, Jianwei Wu, Yongyong Shi

“…The acetaminophen group demonstrated significantly lower in-hospital mortality (11.4% vs 14.4%; adjusted HR 0.75, 95% CI 0.62–0.89, P = 0.001) compared to controls. This mortality reduction persisted consistently through sensitivity analyses and subgroup evaluations. …”
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<i>Bacillus tropicus</i> YJ33 and <i>Medicago sativa</i> L. Synergistically Enhance Soil Aggregate Stability in Saline–Alkali Environments by Jingjing Li, Yajuan Che, Shiyang Chen, Mengge Liu, Mengmeng Diao, Chao Yang, Wenke Jia

“…Partial least squares (PLS) modeling further corroborated the role of <i>B. tropicus</i> YJ33 in enhancing soil nutrient content, improving aggregate stability, and increasing alfalfa yield. …”
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Effects of different phosphate lowering strategies in patients with CKD on laboratory outcomes: A systematic review and NMA. by Nigar Sekercioglu, Argie Angeliki Veroniki, Lehana Thabane, Jason W Busse, Noori Akhtar-Danesh, Alfonso Iorio, Luciane Cruz Lopes, Gordon H Guyatt

“…<h4>Methods</h4>Data sources included MEDLINE and EMBASE from January 1996 to April 2016, and the Cochrane Register of Controlled Trials up to April 2016. Teams of two reviewers, independently and in duplicate, screened titles and abstracts and potentially eligible full text reports to determine eligibility, and subsequently abstracted data and assessed risk of bias in eligible randomized controlled trials (RCTs). …”
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Extracellular mitochondria contribute to acute lung injury via disrupting macrophages after traumatic brain injury by Yafan Liu, Fanjian Li, Lujia Tang, Kaifeng Pang, Yichi Zhang, Chaonan Zhang, Hui Guo, Tianrui Ma, Xiaoyang Zhang, Guili Yang, Ying Li, Zijian Zhou, Hejun Zhang, Yang Li, Ying Fu, Jianning Zhang, Jingfei Dong, Zilong Zhao

“…The bronchoalveolar lavage fluid (BALF) of mice subjected to controlled cerebral cortical impact contained 4.2 ± 1.4 × 104/µl of exMt. …”
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Workplace-based dietary intervention study: Effects on body mass index and fat mass in metalworking industry workers by Luca DI GIAMPAOLO, Rossella MARTELLI, Daria ZICCARDI, Claudia GIURGOLA, Federica MARINO, Vittorio BARASSI, Paola BORRELLI, Laura FORCELLA, Maria Elisa MAIOLO, Rocco MANGIFESTA, Luca COPPETA, Francesca DI MECO

“…Statistical analyses included paired t-tests and mixed linear models to assess changes over time. Results: Significant reductions in BMI and fat mass were observed among participants. …”
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Mitofilin–mtDNA Axis Mediates Chronic Lead Exposure-Induced Synaptic Plasticity Impairment of Hippocampal and Cognitive Deficits by Lihong Su, Jinchao Hou, Boxuan Wang, Yuqi Li, Xiaodong Huo, Tao Wang, Yuankang Zou, Gang Zheng

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Value of voluntary carbon markets in energy systems decarbonization by John Bistline, Anahi Molar-Cruz, Geoffrey Blanford, Adam Diamant

“…Abstract Although companies are pledging emissions reductions, technical and economic challenges persist, particularly for factors beyond direct corporate control. …”
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Dual defense: Combining preemptive exclusion of members and knowledge distillation to mitigate membership inference attacks by Jun Niu, Peng Liu, Chunhui Huang, Yangming Zhang, Moxuan Zeng, Kuo Shen, Yangzhong Wang, Suyu An, Yulong Shen, Xiaohong Jiang, Jianfeng Ma, He Wang, Gaofei Wu, Anmin Fu, Chunjie Cao, Xiaoyan Zhu, Yuqing Zhang

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Application of type I and II error analysis to support economic decision-making of using an immunomodulator feed additive by L.T. Casarotto, A. De Vries, J.D. Chapman, L.O. Ely, G.E. Dahl

“…Uncertainty in the milk response was modeled following a normal distribution with mean 0.15 kg/cow per day and SD 0.81 kg/cow per day. …”
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A systematic review of impact of person-centred interventions for serious physical illness in terms of outcomes and costs by Richard Harding, Sridhar Venkatapuram, Alessandra Giusti, Ruwayda Petrus, Liz Gwyther, Lindsay Farrant, I Petersen, Amelia Cook, Kennedy Bashan Nkhoma

“…We synthesised findings across these two models:Self-management component: the interventions consisted of training of patients and/or caregivers or staff. …”
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Long COVID and Biomarker Dysregulation—A Shift Toward Immune Exhaustion? by Anne Kallaste, Kalle Kisand, Agnes Aart, Ahto Salumets, Kai Kisand, Pärt Peterson, Margus Lember

“…<i>Results:</i> We observed a general decline in inflammatory biomarkers in post-COVID-19 patients over time, with only a few cytokines elevated (CCL4 at month 3 and CST5 at month 6) compared to non-COV controls. In LC patients, an early phase of low-grade inflammation transitioned into significant reduction in proinflammatory biomarkers compared to recovered individuals. …”
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State of the antioxidant system in mitochondria of skin cells during experimental B16/F10 melanoma growth with chronic neurogenic pain by E. M. Frantsiyants, I. V. Neskubina, E. I. Surikova, L. K. Trepitaki, L. A. Nemashkalova, I. V. Kaplieva, N. S. Lesovaya

“…Experimental groups included an intact group, a control group – chronic neurogenic pain model, a comparison group – standard subcutaneous transplantation of В16/F10 melanoma, and a main group – transplantation of  В16/F10 melanoma 3 weeks after creation of a model of chronic neurogenic pain. …”
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Evaluating programmatic reactive focal drug administration impact on malaria incidence in northern Senegal: an interrupted time series analysis by Ellen Leah Ferriss, Yakou Dieye, Moustapha Cissé, Gnagna Dieng Sow, Jean Louis Lankia, Damien Diedhiou, Abiboulaye Sall, Tamba Souane, Tidiane Thiam, Doudou Sene, Elhadji Doucouré, Ibrahima Diallo, Adam Bennett, Caterina Guinovart

“…The model was used to estimate the number of cases averted via a counterfactual simulation. …”
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The Protective Effect of IL-17A in Pneumonic Plague Can Be Compensated by Effective Vaccines and Immunization Strategies in Mice by Emily K. Hendrix, Jian Sha, Paul B. Kilgore, Blake H. Neil, Atul K. Verma, Ashok K. Chopra

“…A remarkable reduction in Th1 (IFNγ or IL-2) and Th17 cell populations was observed in IL-17A-depleted mice compared to IgG controls in response to vaccination. …”
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Comparative Efficacy of NAFLD Therapies and Biomarker Associations: A Meta-Analysis Based on Liver Fat Content by Haoxiang Zhu, Ling Xu, Yinhua Lv, Juan Yang, Jihan Huang, Qingshan Zheng, Guang Ji, Lujin Li

“…For biomarkers showing significant correlations with LFC, further modeling analysis was conducted to examine their relationship characteristics. …”
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