Effectiveness of a training intervention in increasing the use of misoprostol in postabortion care in Malawi: a quasi-experimental study by Maria Lisa Odland, Alfred Maluwa, Address Malata, Ursula Kafulafula, Jon Øyvind Odland, Elisabeth Darj, Bertha Magreta Chakhame, Mphatso Mwapasa, Grace Chiudzu

“…The use of misoprostol was significantly higher at the intervention sites with OR of 5.02 (95% CI 1.7 to 14.7) p<0.05 compared with control sites at the endline in multivariable models, and there was a difference in the difference of 14.4% ((95% CI 10.4% to 18.2%) p<0.001) between the intervention and control sites after the intervention.Conclusions A training intervention effectively increased the use of misoprostol in the treatment of incomplete abortions. …”
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Efficacy of intracytoplasmic sperm injection in women with non‐male factor infertility: A systematic review and meta‐analysis by Liu Yang, Fuxiang Liang, Rongyan Zhu, Qi Wang, Liang Yao, Xuehong Zhang

“…The pooled estimates were calculated using the random‐effects models as relative risk (RR) with 95% confidence intervals (CIs). …”
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Deep learning and hyperspectral features for seedling stage identification of barnyard grass in paddy field by Siqiao Tan, Qiang Xie, Wenshuai Zhu, Yangjun Deng, Lei Zhu, Xiaoqiao Yu, Zheming Yuan, Zheming Yuan, Yuan Chen, Yuan Chen

“…Notably, this surpasses the capabilities of other models that rely on amalgamations of machine learning algorithms and feature dimensionality reduction methods. …”
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Sufficient reproduction numbers to prevent recurrent epidemics by Lorenzo Mari, Cristiano Trevisin, Andrea Rinaldo, Marino Gatto

“…The definition of sufficient RN thresholds to prevent transient outbreaks may have significant practical consequences for the design of control measures, as the weaker RN reductions and HITs associated with customary control targets may prove ineffective in preventing potentially recurrent flare‐ups that might degenerate into subthreshold epidemics. …”
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Dietary patterns and hypertension in Chinese adults: a systematic review and meta-analysis by Xi Wu, Jianwei Liu, Zhuofeng Wang, Shangya Chen, Jiazi Ma, Mao Cao, Yong Yang, Guangjian Wu, Wentao Li, Zhongjun Du, Zhongjun Du

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Helicobacter pylori eradication and gastric cancer prevention in a pooled analysis of large-scale cohort studies in Japan by Ayami Ono, Shiori Tanaka, Norie Sawada, Atsushi Goto, Shoichiro Tsugane, Isao Muraki, Kazumasa Yamagishi, Yu Sasaki, Yasuhiko Abe, Takamasa Kayama, Yoshiyuki Ueno, Eiko Saito, Taiki Yamaji, Motoki Iwasaki, Manami Inoue

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Impact of effective connectivity within the Papez circuit on episodic memory: moderation by perivascular space function by Ling-Ling Li, Jie Ma, Jia-Jia Wu, Xin Xue, Mou-Xiong Zheng, Xu-Yun Hua, Qi-Hao Guo, Jian-Guang Xu

“…Methods Sixty participants, all of whom underwent multimodal MRI (fMRI, dMRI, and sMRI) and neuropsychological testing, were recruited for this case‒control study. General linear models were used to compare the effective connectivity within the Papez circuit and PVS function between aMCI patients and healthy controls (HCs) and further explore the role of PVS function between the effective connectivity within the Papez circuit and episodic memory. …”
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Sex Differences in Cardiovascular Outcomes of Intravascular Imaging-Guided PCI by Chidubem Ezenna, MD, BS, Sammudeen Ibrahim, MD, Prasana Ramesh, MD, Mahmoud Ismayl, MBBS, Mrinal Murali Krishna, MBBS, Meghna Joseph, MBBS, Kuan-Yu Chi, MD, S. Elissa Altin, MD, Michael G. Nanna, MD, MHS, Andrew M. Goldsweig, MD, MS

“…Risk ratios (RRs) with 95% CIs were calculated using random-effects models. Results: Eight randomized controlled trials, comprising 14,812 patients (76.1% men and 23.9% women) were included. …”
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Gut microbiota modulation by Traditional Chinese Medicine: a translational strategy for metabolic dysfunction-associated steatotic liver disease by Ting Zhou, Ting Zhou, Ziwen Jin, Ziwen Jin, Rilei Jiang, Weiwei Li

“…Among the 10 botanical drugs and 11 formulations reviewed, significant reduction in liver steatosis were shown in rodent models. …”
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Bioremediation Potential of <i>Rhodococcus qingshengii</i> PM1 in Sodium Selenite-Contaminated Soil and Its Impact on Microbial Community Assembly by Mu Peng, Guangai Deng, Chongyang Hu, Xue Hou, Zhiyong Wang

“…Sodium selenite significantly reduced microbial diversity and simplified co-occurrence networks, whereas inoculation with strain PM1 partially reversed these effects by enhancing community complexity. Ecological modeling, including the normalized stochasticity ratio (NST) and Sloan’s neutral community model (NCM), suggested that stochastic processes predominated in the assembly of bacterial communities under selenium stress. …”
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Effects of exercise on body fat percentage and cardiorespiratory fitness in sedentary adults: a systematic review and network meta-analysis by Tian Huang, Huan Feng, Zhengwei Xie, Yubo Wang, Qingchuan Wang, Zhihua Wang

“…Network meta-analysis used random-effects models with SUCRA ranking and low to moderate heterogeneity (I2 = 28–41%). …”
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In vitro, in vivo, and cellular mechanisms of Astragalus onobrychis L. extract against protoscoleces and hydatid cysts of Echinococcus granulosus by Javad Ghasemian Yadegari, Amal Khudair Khalaf, Aram Oladi, Ali Shahbazi, Hossein Mahmoudvand

“…By in vivo, we found that treatment with AOCE mainly at 200 mg/kg significantly (p &lt; 0.001) reduced the number, size, and weight of hydatid cyst relative to the control group treated with normal saline group. Biochemical analysis also demonstrated that administration of AOCE to infected mice, led to a marked improvement and a reduction in serum levels of liver function factors.ConclusionThe results indicated that AOCE exhibits considerable in vitro and ex vivo scolicidal properties against hydatid cyst protoscoleces. …”
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Preclinical and first-in-human evaluation of AL002, a novel TREM2 agonistic antibody for Alzheimer’s disease by Hua Long, Adam Simmons, Arthur Mayorga, Brady Burgess, Tuan Nguyen, Balasubrahmanyam Budda, Anna Rychkova, Herve Rhinn, Ilaria Tassi, Michael Ward, Felix Yeh, Tina Schwabe, Robert Paul, Sara Kenkare-Mitra, Arnon Rosenthal

“…AL002 is currently being tested in a phase 2, randomized, double-blind, placebo-controlled study in early AD. Trial registration Clinicaltrials.gov, NCT03635047. …”
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The potential biomarker value of soluble CD36 in the treatment of diabetic kidney disease: evidence from GLP-1 and insulin interventions by Wenxuan Li, Yangang Wang

“…Generalized linear regression models were applied to assess the relationship between sCD36 and renal function.ResultsBaseline sCD36 and UACR levels were comparable across the three groups (P &gt; 0.05). …”
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Pharmacological activity of OST-01, a natural product from baccharis coridifolia, on breast cancer cells by HyunJun Kang, Dinh Hoa Hoang, Melissa Valerio, Khyatiben Pathak, William Graff, Alexis LeVee, Jun Wu, Mark A. LaBarge, David Frankhouser, Russell C. Rockne, Patrick Pirrotte, Bin Zhang, Joanne Mortimer, Le Xuan Truong Nguyen, Guido Marcucci

“…OST-01 also markedly inhibited TNBC tumor growth in vivo, with > 50% reduction in tumor size compared to vehicle control treatment in different in vivo models, i.e., cell line-derived (CDX), patient-derived (PDX), and mammary fat pad xenografts. …”
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The effect of motivational interviewing on patients with early post-stroke depression: a quasi-experimental study by Yingjie Fu, Yi Zhang, Qianying Deng, Yuenv Wang, Siyi Su, Zheng Wang, Luyi Xu, Beibei Lin, Yun Li, Jufang Li

“…The intervention group showed a significantly higher rate of decrease in the depression score from T0 to T1 (95% CI: -11.227 to -7.748, p < 0.001) and T0 to T2 (95% CI: -11.683, -6.170, p < 0.001), compared with the control group; the intervention group had a greater reduction in the sleep score from T0 to T1 (95% CI: -2.502 to -0.962, p < 0.001), compared with the control group. …”
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A community-based intervention to challenge attitudes towards intimate partner violence: results from a randomised community trial in rural South-West Nigeria by Olusegun Awolaran, Funmilola OlaOlorun

“…Difference-in-differences (DID) regression models were estimated to compare changes in IPV levels in the intervention and control arms, while qualitative data were analysed using a thematic approach. …”
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Cellular Cholesterol Loss Impairs Synaptic Vesicle Mobility via the CAMK2/Synapsin-1 Signaling Pathway by Atikam Qurban, Mengqi Zhang, Hengbing Zu, Kai Yao

“…Methods: Lentiviruses carrying 3β-hydroxysteroid-Δ24 reductase-complementary DNA (DHCR24-cDNA), DHCR24-short hairpin RNA (DHCR24- shRNA) or empty lentiviral vectors were transfected into SHSY-5Y cells in order to construct DHCR24 knock-down and knock-in models, along with corresponding controls. Filipin III cholesterol staining was employed to visualize membrane and intracellular cholesterol in the different cell models, and fluorescence intensity was assessed using confocal microscopy. …”
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Micronutrient Intakes and Status in the Protein Transition: A Systematic Review by Ursula M. Leonard, Clarissa L. Leydon, Elena Arranz, Mairead E. Kiely

“…Most studies were based on the modelling of dietary data (<i>n</i> = 45). Ten studies stratified observational data using an environmental outcome, and there was one randomised controlled trial (RCT). …”
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Association between dietary fatty acid intake and preserved ratio impaired spirometry in U.S. adults: a population-based cross-sectional study by Xiang Liu, Wei Zeng, Wangyan Zhou, Dayang Zheng, Xu Yang, Weijun Liao

“…A two-sided p-value &lt;0.05 was considered statistically significant.ResultsAmong the study population (mean age 45.6 ± 15.8 years; 47.7% male), 1,362 participants (15.0%) exhibited the PRISm phenotype. In models controlling for demographic, lifestyle, and clinical variables, each standard deviation increase in SFA [0.86 (0.75–0.99)] and PUFA [0.88 (0.79–0.99)] intake was associated with a statistically significant reduction in the odds of PRISm. …”
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