Therapeutic management of PI3Kα inhibitor-induced hyperglycemia with a novel glucokinase activator: Advancing the Frontier of PI3Kα inhibitor therapy by Guanqin Jin, Shihuang Liu, Kewei Zheng, Xiaobo Cheng, Ranran Chai, Wei Ye, Wei Wei, Yongguo Li, Ai Huang, Guiling Li, Huan Yi, Yu Kang

“…In the hyperglycemic mouse model, dorzagliatin significantly reduced blood glucose levels compared to controls. …”
Get full text

Effect of Dapagliflozin on Glycemic Variability in Patients with Type 2 Diabetes under Insulin Glargine Combined with Other Oral Hypoglycemic Drugs by Menghui Luo, Xiaocen Kong, Huiying Wang, Xiaofang Zhai, Tingting Cai, Bo Ding, Yun Hu, Ting Jing, Xiaofei Su, Huiqin Li, Jianhua Ma

“…This prospective, self-controlled, single-center clinical trial recruited 36 patients with T2D under combined insulin glargine and oral hypoglycemic drugs. …”
Get full text

Comparative efficacy and safety of Faricimab with other intravitreal anti-vascular endothelial growth factor in the treatment of Neovascular age related macular degeneration- A Sys... by Renuga Devi Kaliaperumal, Nandhini P, Reena Mohan, Nallamuthu P, Jenifer Florence Mary J

“…The secondary outcome was to compare the Faricimab (intervention) group with other intravitreal anti-VEGF (control) groups. The initial search yielded 57 records of which 48 articles underwent full-text evaluation, which identified six articles and a total of 4454 patients (intervention group-2226 and control group 2228) were included in the study. …”
Get full text

Efficacy and safety of traditional Chinese medicine for post-COVID-19 syndrome: a systematic review and meta-analysis by Yiting Wang, Xiao Li, Huaizheng Hui, Dianxing Yang

“…CHM showed a greater reduction in VAS scores compared to controls (MD = −1.03; 95% CI −2.10 to 0.03; P = 0.0577), with higher heterogeneity (I2 = 92%). …”
Get full text

Perinatal mortality and other severe adverse outcomes following planned birth at 39 weeks versus expectant management in low-risk women: a population based cohort studyResearch in... by Kylie Crawford, Waldemar A. Carlo, Anthony Odibo, Aris Papageorghiou, William Tarnow-Mordi, Sailesh Kumar

“…The reduction in odds for perinatal mortality, severe neurological, and non-neurological morbidity was greatest for birth by scheduled caesarean section. …”
Get full text

A Nonrandomized Pilot Study to Investigate the Acceptability and Feasibility of LivR Well: A Multifaceted 28-Day Home-Based Liver Optimization Program for Acute-on-Chronic Liver Fa... by Natalie L.Y. Ngu, Edward Saxby, Thomas Worland, Patricia Anderson, Lisa Stothers, Jo Hunter, Alexander T. Elford, Phil Ha, Imogen Hartley, Andrew Roberts, Dean Seah, George Tambakis, Declan Connoley, Anita Figredo, Dilip Ratnam, Danny Liew, Benjamin Rogers, William Sievert, Sally Bell, Suong Le

“…Health-care costs were reduced by 26% driven by a 40% reduction in 30-day readmission. Further evaluation includes a randomized controlled trial of LivR Well compared to standard care.…”
Get full text

Engineering biology and automation–Replicability as a design principle by Matthieu Bultelle, Alexis Casas, Richard Kitney

“…This is a direct consequence of the application of good engineering practices, the limited predictive power of current computational models and the desire to investigate very large design spaces in order to solve the hard, important problems the discipline promises to solve. …”
Get full text

Influence of programmed death ligand 1 (PD-L1) knockout on gut microbiota in experimental autoimmune uveitis by Junxiang Gu, Junxiang Gu, Junxiang Gu, Yixian Ma, Yixian Ma, Yixian Ma, Qing Chang, Qing Chang, Qing Chang, Ling Chen, Ling Chen, Ling Chen

“…EAU induced a reduction in the abundance of Akkermansia muciniphila A and an increased in CAG-485 sp002362485. …”
Get full text

Multi-Strategy Enhancement of YOLOv8n Monitoring Method for Personnel and Vehicles in Mine Air Door Scenarios by Lei Zhang, Hongjing Tao, Zhipeng Sun, Weixun Yi

“…These values indicate reductions of 21.6%, 23.5%, and 20.6% compared to the original model. …”
Get full text

Research Concept and Prospects of Key Technologies for Intelligent Perception, Early Warning, and Prevention of Bank Collapse Risks in the Middle and Lower Reaches of the Yangtze R... by Jinyou LU, Yinjun ZHOU, Caiyun DENG, Chao GUO, Lingyun LI

“…This will provide robust scientific support for decision-making by basin authorities, significantly enhance the predictability and management of bank collapse risks in the middle and lower Yangtze River, promote overall improvement in bank collapse hazard prevention and control, and advance flood control and disaster reduction technologies. …”
Get full text

Characteristics of the Emotional and Behavioral Reactions of Rats under Chronic Stress Immobilization During Treatment with 5-R-thio-tetrazol [1,5-c] quinazoline Derivatives by О. Y. Tozyuk

“…Daily administration of compound КВ-28, as well as bemityl to rats with chronic hypokinesia contributed to the increased locomotor and searching activity and normalization of autonomic balance indices in animals compared with the control group. Received data can show indications of psycho-emotional stress reduction in animals that was most clearly evident on the 4th and 12th day of the experiment when administering КВ-28 and on the 4th day - when applying bemityl. …”
Get full text

The Impact of Exercise Training Plus Dietary Interventions on Ectopic Fat in Population with Overweight/Obesity with and without Chronic Disease: A Systematic Review, Meta-analysis... by Fatemeh Kazeminasab, Mohammad Hossein Mahboobi, Motahareh Mohebinejad, Maedeh Nojoumi, Saba Belyani, Donny M Camera, Sajjad Moradi, Reza Bagheri

“…Background: The growing prevalence of obesity and related chronic diseases has led to increased interest in interventions targeting ectopic fat reduction to which its accumulation is linked to metabolic dysfunction. …”
Get full text

HISTORICAL DEVELOPMENT OF THE CONSTRUCTION INDUSTRY AND ITS IMPACT ON THE ECONOMIC SECURITY OF THE STATE by Volodymyr Buha, Natalia Blazhivska, Olha Kovalova

“…The article uses general scientific methods of formal logic (analysis, synthesis, deduction, induction, analogy, abstraction and modelling) and a special method (historical and legal) to reveal the historical development of the construction industry and its impact on the economic security of the state. …”
Get full text

Therapeutic efficacy and safety of a human fusion construct targeting the TWEAK receptor Fn14 and containing a modified granzyme B by Ana Alvarez de Cienfuegos, Lawrence H Cheung, Khalid A Mohamedali, Timothy G Whitsett, Jeffrey A Winkles, Walter N Hittelman, Michael G Rosenblum

“…Treatment of mice bearing established, subcutaneous A549 lung tumors showed impressive, long-term tumor suppression compared with a control group treated with vehicle alone. Administration of GrB(C210A)-Fc-IT4 (100 mg/kg total dose) was well-tolerated by mice and resulted in significant reduction of tumor burden in a lung cancer patient-derived xenograft model. …”
Get full text

Plant selection for semi-arid urban landscapes with an emphasis on climate change (case study: Tehran) by Malek Rabiei Sadeghabadi, Omid Nouri, Reza Deihimfard

“…Introduction: Urban landscape, especially urban forest and city trees, usually has vital and various effects on the mental and physical health of humans, environmental embellishment, and mitigating the destructive effect of climatic changes like wind storms and flood control, as well as reduction and control of hazardous contaminants. …”
Get full text

The FRIENDS preventive programme for reducing anxiety symptoms in children and adolescents: A systematic review and meta‐analysis by Trine Filges, Geir Smedslund, Tine Eriksen, Kirsten Birkefoss, Malene Wallach Kildemoes

“…One such programme is FRIENDS which is based on a firm theoretical model which addresses cognitive, physiological and behavioural processes. …”
Get full text

STUDY OF PINOSTROBIN INFLUENCE ON THE BEHAVOUR ACTIVITY AND PSYCHO-EMOTIONAL STATE OFANIMALS AGAINST THE BACKGROUND OF PHYSICAL AND PSYCHO-EMOTIONAL LOADS by A. V. Voronkov, N. A. Mouraviova, I. N. Diakova

“…The application of pinostrobin prevented for certain the reduction of motive and reference researching activity reduced the level of anxiety and fear of the animals that had intensive physical load, in comparison with the control group animals that had not a pharmacological support…”
Get full text

Structural Characterization and Hypolipidemic Activity of Highland Barley Polysaccharide-Polyphenol Complexes by Zibin GUO, Yang YANG, Bei FAN, Litao TONG, Yatao HUANG, Lili WANG, Ting ZHANG, Liya LIU, Peipei SUN, Jing SUN, Fengzhong WANG

Get full text

Impact of early antiviral therapy on SARS-CoV-2 clearance time in high-risk COVID-19 subjects: A propensity score matching study by Marta Colaneri, Federico Fama, Federico Fassio, Darcy Holmes, Giovanni Scaglione, Chiara Mariani, Lucia Galli, Alessia Lai, Spinello Antinori, Andrea Gori, Agostino Riva, Monica Schiavini

“…Unadjusted and adjusted negative binomial regression models and a Random Forest regression model were performed before and after matching subjects based on their propensity of being treated or not. …”
Get full text

PHRF-RTDETR: a lightweight weed detection method for upland rice based on RT-DETR by Xianjin Jin, Jinheng Zhang, Fei Wang, Mengyan Zhao, Yunshuang Wang, Jianping Yang, Jinfeng Wu, Bing Zhou

“…In terms of lightweight indicators, PHRF-RTDETR achieved reductions in floating-point operations, parameter count, and model size by 59.3%, 53.7%, and 53.9%, respectively, compared to the baseline model. …”
Get full text