Impact of intensive blood pressure lowering on atrial fibrillation risk in hypertensive patients: A systematic review and meta-analysis by Wenxi Zuo, Yuhe Huang, Ziyi Sun, Yuhan Yang, Jin Zhang, Xiaoxiao Zhang, Kuiwu Yao

“…A total of 6 randomized controlled trials involving 34,824 participants were included in the analysis. …”
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Effects of vitamin E administration on serum lipid profile in diabetic patients: a grade-assessed systematic review and dose–response meta-analysis of RCTs by Mehdi Karimi, Mohammad Amin Karimi, Farzad Fayedeh, Fatemeh Ziyafati Kafi, Kimia Kazemi, Sharareh Jahangiri, Omid Asbaghi

“…Methods A search was conducted on databases from inception to June 2025 to identify relevant randomized controlled trials (RCTs). Pooled effect sizes were estimated using weighted mean differences (WMDs) with 95% confidence intervals (CIs), applying a random-effects model. …”
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Exploring Microelement Fertilization and Visible–Near-Infrared Spectroscopy for Enhanced Productivity in <i>Capsicum annuum</i> and <i>Cyprinus carpio</i> Aquaponic Systems by Ivaylo Sirakov, Stefka Stoyanova, Katya Velichkova, Desislava Slavcheva-Sirakova, Elitsa Valkova, Dimitar Yorgov, Petya Veleva, Stefka Atanassova

“…The spectral characteristics of the visible–near-infrared region of pepper plants treated with microelements revealed subtle differences, particularly in the green (534–555 nm) and red edge (680–750 nm) regions. SIMCA models successfully classified control and treated plants with a misclassification rate of only 1.6%, highlighting the effectiveness of the spectral data for plant differentiation. …”
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Adolescent binge alcohol exposure accelerates Alzheimer’s disease-associated basal forebrain neuropathology through proinflammatory HMGB1 signaling by Rachael P. Fisher, Lindsay Matheny, Sarrah Ankeny, Liya Qin, Leon G. Coleman, Leon G. Coleman, Ryan P. Vetreno, Ryan P. Vetreno, Ryan P. Vetreno

“…In the post-mortem human AUD basal forebrain (Experiment 1), we report upregulation of Hmgb1 and the HMGB1 receptors Rage and Tlr4 as well as microglial activation and increased intraneuronal Aβ1–42 accumulation in association with reduced cholinergic neuron marker expression (ChAT). In the 5xFAD mouse model (Experiment 2), AIE accelerated AD-associated induction of Hmgb1 proinflammatory neuroimmune genes, microglial activation, and reductions of ChAT+ basal forebrain cholinergic neurons in the adult female, but not male, basal forebrain. …”
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Butyrate-producing bacteria in pregnancy maintenance: mitigating dysbiosis-induced preterm birth by Azusa Uchida, Kenji Imai, Rika Miki, Tomonari Hamaguchi, Hiroshi Nishiwaki, Mikako Ito, Jun Ueyama, Satomi Hattori, Sho Tano, Kazuya Fuma, Seiko Matsuo, Takafumi Ushida, Kinji Ohno, Hiroaki Kajiyama, Tomomi Kotani

“…Methods We established a dysbiosis-induced PTB mouse model using vancomycin treatment combined with subclinical immune activation via anti-CD3ε antibody. …”
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Non-invasive monitoring of microcirculation dynamics in hypovolemic shock: a novel application of diffuse correlation spectroscopy by Hiroki Matsushita, Koki Kurono, Mikie Nakabayashi, Kei Sato, Hidetaka Morita, Yuki Yoshida, Masafumi Fukumitsu, Kazunori Uemura, Toru Kawada, Masashi Ichinose, Yumie Ono, Keita Saku

“…This study examined the utility of DCS in assessing the microcirculation during hypovolemic shock in a canine model. Methods Six male beagle dogs underwent controlled blood withdrawal to induce hypovolemic shock, defined as a ≥ 30% decrease in cardiac output (CO) and mean arterial pressure (MAP) < 60 mmHg or systolic arterial pressure (SAP) < 90 mmHg. …”
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Blue light-emitting diode phototherapy presents in vitro efficacy against distinct Leishmania species and is therapeutic against tegumentary leishmaniasis in BALB/c mice by Breno Luiz Pimenta, Breno Luiz Pimenta, Daniela Pagliara Lage, Camila Simões de Freitas, Danniele Luciana Vale, Karolina Oliveira de Melo Falcão, Saulo Samuel Gonçalves Dias, Raquel Soares Bandeira Câmara, Isabela Amorim Gonçalves Pereira, Ana Luiza Silva, Lauro de Assis Duarte Júnior, Lauro de Assis Duarte Júnior, Miguel Angel Chavez-Fumagalli, Rodrigo Fernando Bianchi, Eduardo Antonio Ferraz Coelho, Eduardo Antonio Ferraz Coelho, André Talvani, André Talvani

“…In in vivo experiments, L. amazonensis-infected BALB/c mice were treated with AmpB, blue LED alone, combination of blue LED plus AmpB, or saline as a control. Animals treated with blue LED, particularly in combination with AmpB, exhibited significant reductions in parasite loads in infected tissues such as lesions, spleens, livers, and draining lymph nodes, as confirmed by limiting dilution assays and qPCR. …”
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Effects of lifestyle interventions on mental health in children and adolescents with overweight or obesity: a systematic review and meta-analysisResearch in context by Jiali Zhou, Yuan Song, Jiayao Ying, Chenhao Zhang, Jing Wu, Shiyi Shan, Jindian Zha, Liying Zhou, Wenhan Xiao, Peige Song

“…A random-effects meta-analysis model was performed to calculate pooled standardized mean differences (SMDs) and 95% confidence intervals (CIs). …”
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The effectiveness of Hope Groups, a mental health, parenting support, and violence prevention program for families affected by the war in Ukraine: Findings from a pre-post study by Susan Hillis, Sydney Tucker, Nicole Baldonado, Evgenia Taradaika, Lyudmyla Bryn, Svitlana Kharchenko, Tetiana Machabelii, Roisin Taylor, Phil Green, Philip Goldman, Isang Awah, Joshua Baldonado, Praveen Gomez, Seth Flaxman, Oliver Ratmann, Jamie M. Lachman, Andres Villaveces, Lorraine Sherr, Lucie Cluver

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Early detection to improve outcome in people with undiagnosed psoriatic arthritis: the PROMPT research programme including RCT by Neil McHugh, Laura Bojke, Mel Brooke Turfrey, Rachel Charlton, Myka Ransom, Laura C Coates, Howard Collier, Claire Davies, Emma Dures, Philip Helliwell, Jana James, Anya Lissina, Vishnu B Madhok, Alison L Nightingale, Jonathan Packham, Catherine Smith, Eldon Spackman, Cerys Tassinari, William Tillett, Sarah T Brown

“…ES dominated SC on the basis of the imputed data set. Modelling analysis To estimate the long-term consequences and cost-effectiveness of screening for PsA, a hypothetical cohort of 45-year-old patients with mild psoriasis and without PsA was modelled. …”
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Effects of ginger supplementation in individuals with mild to moderate joint pain I: ratings of pain, functional capacity, and markers of inflammation by Jacob Broeckel, Landry Estes, Megan Leonard, Broderick Dickerson, Drew E. Gonzalez, Martin Purpura, Ralf Jäger, Ryan Sowinski, Christopher J. Rasmussen, Richard B. Kreider

“…Data were analyzed using the general linear model (GLM) analysis of variance with repeated measures, mean changes from baseline with 95% confidence intervals, and chi-squared analysis.Results There was evidence that ginger supplementation: 1.) attenuated perceptions of muscle pain in the vastus medialis (Day 2: χ2 p = 0.087); 2.) reported less pain from sitting (Day 2: χ2 p = 0.02), while nocturnal pain (Day 32: χ2 p = 0.075, Day 58: (χ2 p = 0.097), weight bearing pain (Day 32: χ2 p = 0.058), physical functioning of performing heavy duties (Day 32: χ2 p = 0.100), and physical functioning of performing light duties (Day 2: χ2 p = 0.064) on WOMAC questions; 3.) experienced significant reductions in WOMAC overall ratings of pain, stiffness, physical function, and total score values, particularly in 48-hour follow-up measures; 4.) reported less pain during nighttime bed rest (Day 2: χ2 p = 0.065; Day 32: χ2 p = 0.032) and when going up and down stairs (Day 32: χ2 p = 0.097) from the LEQ; and, 5.) promoted significant differences over time and/or between groups in IL-β, IL-5, IL-6, IL-8, INF-γ, TNF-α, and high sensitivity C-reactive Protein at various points during the study.Conclusion Ginger supplementation promotes some favorable effects on exercise-induced perceptions of pain, functional capacity, and inflammatory markers in men and women who have mild to moderate muscle and joint pain.Registered clinical trial #ISRCTN74292348.…”
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Innovation Ecosystem of Iran's Tourism Industry with Emphasis on Supply Chain by Azizolah Jafari, mahdi alaei kerahrudi

“…On the other hand, innovation ecosystems have gained increasing importance in the last decade, and so far, numerous studies and models of innovation ecosystems have been presented in different industries and sectors. …”
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Development and Evaluation of a Powered Artificial Gastrocnemius for Transtibial Amputee Gait by Michael F. Eilenberg, Jiun-Yih Kuan, Hugh Herr

“…This paper presents the first powered biarticular transtibial prosthesis, which is a combination of a commercial powered ankle-foot prosthesis and a motorized robotic knee orthosis. The orthosis is controlled to emulate the human gastrocnemius based on neuromuscular models of matched nonamputees. …”
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Comparative Analysis of Air Pollution in Beijing and Seoul: Long-Term Trends and Seasonal Variations by Hana Na, Woo-Sik Jung

“…Using statistical analyses including Mann–Kendall tests and generalized additive models, we found that Beijing achieved notable reductions in particulate matter, largely due to stricter industrial controls and reduced coal use, though winter pollution peaks remain. …”
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Cortical microstructural abnormalities in dementia with Lewy bodies and their associations with Alzheimer’s disease copathologies by Elijah Mak, Robert I. Reid, Scott A. Przybelski, Angela J. Fought, Timothy G. Lesnick, Christopher G. Schwarz, Matthew L. Senjem, Sheelakumari Raghavan, Prashanthi Vemuri, Clifford R. Jack, Hoon Ki Min, Manoj K. Jain, Toji Miyagawa, Leah K. Forsberg, Julie A. Fields, Rodolfo Savica, Jonathan Graff-Radford, David T. Jones, Hugo Botha, Erik K. St. Louis, David S. Knopman, Vijay K. Ramanan, Dennis W. Dickson, Neill R. Graff-Radford, Gregory S. Day, Tanis J. Ferman, Ronald C. Petersen, Val J. Lowe, Bradley F. Boeve, John T. O’Brien, Kejal Kantarci

“…Amyloid and tau levels were measured using PiB and Flortaucipir PET imaging. Compared to controls, DLB exhibited increased MD and FWF, reduced tNDI across multiple regions, and focal ODI reductions in the occipital cortex. …”
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Chagas disease induces gut microbial metabolic stress: Disruption of energy and nucleotide pathways and partial reversal by antiparasitic therapy (TRIPOBIOME-2 study) by José A. Pérez-Molina, Elena Moreno, Clara Crespillo-Andújar, Sandra Chamorro-Tojeiro, Marta Arsuaga, Leticia Olavarrieta, Oihane Martín, Begoña Monge-Maillo, Francesca Norman, Val F. Lanza, Sergio Serrano-Villar

“…Compared with untreated patients and controls, benznidazole-treated individuals exhibited partial metabolic restoration, namely, up-regulated nucleotide and carbohydrate-degradation pathways, enhanced (5Z)-dodecenoate synthesis, and reduced reliance on the reductive tricarboxylic acid cycle, suggesting renewed microbial growth and improved short-chain-fatty-acid potential. …”
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The Impact of COVID-19 on DTP3 Vaccination Coverage in Europe (2012–2023) by Ines Aguinaga-Ontoso, Sara Guillen-Aguinaga, Laura Guillen-Aguinaga, Rosa Alas-Brun, Miriam Guillen-Aguinaga, Luc Onambele, Enrique Aguinaga-Ontoso, Esperanza Rayón-Valpuesta, Francisco Guillen-Grima

“…Results: The findings revealed significant regional disparities across Europe. Statistical models indicated reductions in DTP3 coverage in countries such as Ireland, Sweden, and Switzerland, whereas Ukraine and San Marino showed improvements. …”
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Unintended consequences of trade in environmental innovation: Agricultural emissions, sectoral leakage, and the Kuznets curve hypothesis by Xinyi Gu, Jianmin Li, Farzan Yahya, Muhammad Waqas, Amad Rashid

“…The AKC hypothesis holds across almost all models. These findings underscore the importance of developing tailored policies to design EST specifically for the agricultural sector, ensuring more effective emission reductions.…”
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Photobiomodulation therapy in keloid management: a comprehensive review by Arya Tjipta Prananda, Rony Abdi Syahputra

“…Clinical studies, including randomized controlled trials (RCTs) and case reports, show significant improvements in keloid height, elasticity, and texture, with reductions in pain and pruritus, as well as lower recurrence rates compared to conventional therapies. …”
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Omicron SARS-CoV-2 outcomes in vaccinated individuals with heart failure and ischaemic heart disease by Liang En Wee, Enoch Xueheng Loy, Jue Tao Lim, Yew Woon Chia, Shir Lynn Lim, Jonathan Yap, Khung Keong Yeo, Derek J Hausenloy, Mark Yan Yee Chan, David Chien Boon Lye, Kelvin Bryan Tan

“…Method: In a highly vaccinated cohort of adult Singapore citizens and permanent residents, we used Cox proportional hazards models (adjusted for sociodemographic variables and comorbidities) to compare the risks of Omicron infection, COVID 19–related hospitalisation, and severe COVID 19 between individuals with HF or IHD and matched controls without these conditions. …”
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