Associations between inactivated COVID-19 vaccination status and timing and fertility and pregnancy outcomes following frozen-thawed embryo transfer: a prospective cohort study by Danmeng Liu, Lijuan Chen, He Cai, Hanying Zhou, Min Wang, Na Li, Xia Xue, Li Tian, Ben W. Mol, Ben W. Mol, Wenhao Shi, Juanzi Shi

“…Information on maternal sociodemographic and health-related factors, COVID-19 vaccination status, the IVF-ET process, and outcomes was collected. Generalized linear models or generalized estimating equation models were used to evaluate the associations between vaccination and fertility and pregnancy outcomes. …”
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SHP2 inhibition and adjuvant therapy synergistically target KIT‐mutant GISTs via ERK1/2‐regulated GSK3β/cyclin D1 pathway by Chunxiao He, Jiaying Yu, Shuang Mao, Shaohua Yang, Xianming Jiang, Lei Huang, Mingzhe Li, Yulong He, Xinhua Zhang, Xi Xiang

“…The combination of SHP2 inhibition and imatinib was further evaluated in GIST mouse models. Results In KIT‐mutant GIST, SHP2 was hyperactive and coprecipitated with KIT. …”
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Innovative treatment of toxic oily petroleum wastewater with magnetic sludge under UVA light by Saeedeh Rastgar, Habibollah Younesi, Hassan Rezeai, Hajar Abyar

“…Kinetic and isotherm studies further elucidated the behavior of the photocatalytic process, revealing that the removal of toxic oily wastewater with Char/Fe3O4/TiO2 adhered closely to pseudo-first-order kinetic models, as well as the Freundlich and Henderson isotherm models. …”
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Multifunctional hydrogel with mild photothermal properties enhances diabetic wound repair by targeting MRSA energy metabolism by Qian Gao, Fangfang Hu, Zihan Chai, Caiyun Zheng, Wenhui Zhang, Ke Pu, Ziyi Yang, Yanni Zhang, Seeram Ramrkrishna, Xianglong Wu, Tingli Lu

“…Concurrent silencing of quorum sensing and virulence genes (agr, sec, lac, opp, sdrD) further destabilized MRSA, while upregulation of stress-response genes (yidD, nfsA, kdpA) indicated bacterial metabolic paralysis. In diabetic murine models, the hydrogel attenuated oxidative stress (DHE-confirmed ROS reduction), polarized macrophages to pro-healing M2 phenotypes (Arg-1⁺/TNF-α↓), and enhanced angiogenesis (VEGF/CD31↑) alongside aligned collagen deposition. …”
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Dual drug-loaded tumor-targeted polymeric nanoparticles for enhancing therapeutic response in pancreatic ductal adenocarcinoma by Naga Malleswara Rao Nakka, Hari Krishnareddy Rachamala, Ramcharan Singh Angom, Nagamalleswara Rao Indla, Shamit Kumar Dutta, Enfeng Wang, Santanu Bhattacharya, Annadanam V. Sesha Sainath, Hani Babiker, Krishnendu Pal, Debabrata Mukhopadhyay

“…Furthermore, P(Gem + PTX) showed a significantly better tumor reduction and median overall survival in mouse models than single drug-loaded TTP-PNPs or a combination of free drugs (Gem + PTX). …”
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The sustained effect of 5-week EmotionCore mindfulness training on emotion regulation and emotional intelligence: heterogeneous benefits for depression and anxiety across subgroups by Hui Kou, Wei Luo, Yiwei Wang, Jia Wu, Xiaodong Li, Yi Wu, Qianguo Xiao, Taiyong Bi

“…Both cross-section and longitudinal mediation models revealed that improvements in ACERSs and EI fully and sequentially mediated the relationship between mindfulness training and trait mindfulness enhancement. …”
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Parenting interventions to promote early child development in the first three years of life: A global systematic review and meta-analysis. by Joshua Jeong, Emily E Franchett, Clariana V Ramos de Oliveira, Karima Rehmani, Aisha K Yousafzai

“…We included randomized controlled trials (RCTs) of parenting interventions delivered during the first 3 years of life that evaluated at least 1 ECD outcome. …”
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Long-term trends and future projections of the burden of tuberculosis among children and adolescents in China. by Nan Li, Wei Wei, Yinglin Lao, Xi Zhu, Qi Ye, Junhong Chen, Yating Ji, Ruoqing Chen, Chongguang Yang

“…<h4>Methods</h4>The Joinpoint regression analysis was used to identify periods of significant change and autoregressive Integrated Moving Average (ARIMA) modeling was employed to predict the TB burden for 2022-2031.…”
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C. elegans sperm and oocytes differentially transmit diet-induced adaptations to their progeny by Alexandria B. Pete, Craig P. Hunter

“…We measured reproductive fitness via hermaphrodite self-brood size and found that novel diets often caused 20–45% brood-size reductions compared to controls. However, animals adapt to the new diet producing normal-sized broods within 5 to 10 generations. …”
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Loss of synaptic connectivity, particularly in second order neurons is a key feature of diabetic retinal neuropathy in the Ins2Akita mouse. by Jose R Hombrebueno, Mei Chen, Rosana G Penalva, Heping Xu

“…Specifically, photoreceptor presynaptic ribbons were reduced by 25% and postsynaptic boutons by 70%, although the density of horizontal, rod- and cone-bipolar cells remained similar to non-diabetic controls. Significant reductions in GABAergic and glycinergic amacrine cells and Brn3a+ retinal ganglion cells were also observed in 9-month old Ins2Akita mice. …”
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Associations of four important dietary pattern scores, micronutrients with sarcopenia and osteopenia in adults: results from the National Health and Nutrition Examination Survey by Yuan Li, Wen Gu, Wen Hao, Wen Hao, Yadan Xu, Kexin Li, Yueliang Zhao, Qingyun Huang

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Novel antibody reagents for characterization of drug- and tumor microenvironment-induced changes in epithelial-mesenchymal transition and cancer stem cells. by Tony Navas, Thomas D Pfister, Simona Colantonio, Amina Aziz, Lynda Dieckman, Richard G Saul, Jan Kaczmarczyk, Suzanne Borgel, Sergio Y Alcoser, Melinda G Hollingshead, Young H Lee, Donald P Bottaro, Tara Hiltke, Gordon Whiteley, Naoko Takebe, Robert J Kinders, Ralph E Parchment, Joseph E Tomaszewski, James H Doroshow

“…Similarly, our new anti-CD133 antibody enabled detection and quantitation of drug-induced reductions in CD133-positive tumor cells following treatment of SUM149PT triple-negative breast cancer xenograft models with the CSC/focal adhesion kinase (FAK) inhibitor VS-6063. …”
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Wolbachia stimulates immune gene expression and inhibits plasmodium development in Anopheles gambiae. by Zakaria Kambris, Andrew M Blagborough, Sofia B Pinto, Marcus S C Blagrove, H Charles J Godfray, Robert E Sinden, Steven P Sinkins

“…Upregulation of six selected immune genes was observed compared to controls, at least two of which (LRIM1 and TEP1) influence the development of malaria parasites. …”
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Clinical Evidence of Acupoint Stimulation for Primary Dysmenorrhea: A Systematic Review and Updated Meta-Analysis by Wang Y, Liu L, Wu X, Wu Y, Qin R, Wang M, Zhou B, Sun J, Song Y, Zhang M, Li M, Yu L

“…This systematic review aims to evaluate efficacy and safety of both invasive and noninvasive acupoint stimulation for PD through analysis of randomized controlled trials (RCTs).Methods: The PROSPERO registration number is CRD42024586857. …”
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Age, Spatial, and Temporal Variations in Hospital Admissions with Malaria in Kilifi County, Kenya: A 25-Year Longitudinal Observational Study. by Polycarp Mogeni, Thomas N Williams, Gregory Fegan, Christopher Nyundo, Evasius Bauni, Kennedy Mwai, Irene Omedo, Patricia Njuguna, Charles R Newton, Faith Osier, James A Berkley, Laura L Hammitt, Brett Lowe, Gabriel Mwambingu, Ken Awuondo, Neema Mturi, Norbert Peshu, Robert W Snow, Abdisalan Noor, Kevin Marsh, Philip Bejon

“…<h4>Background</h4>Encouraging progress has been seen with reductions in Plasmodium falciparum malaria transmission in some parts of Africa. …”
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Gender-affirming care, mental health, and economic stability in the time of COVID-19: A multi-national, cross-sectional study of transgender and nonbinary people. by Brooke A Jarrett, Sarah M Peitzmeier, Arjee Restar, Tyler Adamson, Sean Howell, Stefan Baral, S Wilson Beckham

“…This study examined the impact of the novel coronavirus disease (COVID-19) crisis and subsequent control measures on gender-affirming care, mental health, and economic stability among transgender and nonbinary people in multiple countries.…”
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Prevalent osteoporosis and fracture risk in patients with hepatic cirrhosis: a systematic review and meta-analysis by Amirhossein Shirinezhad, Fatemeh Mousavi Eshlaghi, Dorsa Salabat, Alireza Azarboo, Zahra Fotoohi Ardakani, Sina Esmaeili, Amir Human Hoveidaei, Amirhossein Ghaseminejad-Raeini

“…Integrating cirrhosis into current fracture-risk models could enhance the assessment and management of bone health in these patients.…”
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Geographical inequalities in use of improved drinking water supply and sanitation across Sub-Saharan Africa: mapping and spatial analysis of cross-sectional survey data. by Rachel L Pullan, Matthew C Freeman, Peter W Gething, Simon J Brooker

“…Spatially explicit logistic regression models were developed and fitted within a Bayesian framework, and used to predict coverage at the second administrative level (admin2, e.g., district) across SSA for 2012. …”
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Identification, Geographical Traceability, and Thermal Oxidation and Photodegradation Studies of Camellia Oil Based on Raman Spectroscopy by Boxue Chang, Jingyue Huang, Qingli Xie, Yinlan Ruan, Rukuan Liu

“…A unique peak at 1525 cm⁻¹, observed in samples from Gongcheng, Guangxi, was associated with carotenoids and served as a potential marker for geographical traceability. MCR-ALS modeling revealed significant reductions in the 1650 cm⁻¹ and 1525 cm⁻¹ peaks when temperatures exceeded 150 °C, indicating degradation of unsaturated fatty acids and carotenoids. …”
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Increased Insulin Secretion and Glucose Effectiveness in Obese Patients with Type 2 Diabetes following Bariatric Surgery by Roberto Visentin, Katrine Brodersen, Bjørn Richelsen, Niels Møller, Chiara Dalla Man, Andreas Kristian Pedersen, Jan Abrahamsen, Jens Juul Holst, Michael Festersen Nielsen

“…Insulin sensitivity and secretion, glucose effectiveness, and glucose rate of appearance were determined via oral minimal models. Results. RYGB and SG resulted in similar weight reductions (13%, RYGB (p<0.01); 14%, SG (p<0.05)). …”
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