miR-29c-3p downregulation accelerates spinal cord injury progression by targeting BRD4 by Dawei Wang, Xiaona Wang, Yingshuang Wu, Sina Qi, Haifeng Hu, Jifei Guo, Yi Luo

“…Methods In this research 105 healthy controls and 159 patients with SCI were recruited. …”
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Effects of multidisciplinary teamwork in non-hospital settings on healthcare and patients with chronic conditions: a systematic review and meta-analysis by Yanli Shi, Hongmin Li, Beibei Yuan, Xin Wang

“…Nurses, general practitioners, and specialists were the most common members of the multidisciplinary teams. Staffing models, shared care and role expansion or task shifting are the most common multidisciplinary teamwork interventions. …”
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Joint Pain and Leisure‐Time Physical Activity: Cross‐Sectional Findings From the Cardiovascular Health Study by Kailyn Witonsky, Xiaonan Zhu, Andrea L. Rosso, Anne Newman, Caterina Rosano

“…Separate multivariable ordinal regression models estimated the association between these indicators and LTPA, while controlling for demographics and other contributors of LTPA: number of medications, number of pain sites, body mass index, gait speed, digit substitution symbol test, brain white matter hyperintensities, and mood. …”
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The significant impact of meconium ileus on clinical outcomes among Brazilian individuals with cystic fibrosis—a retrospective analysis of a patient registryResearch in context by Luiz Vicente Ribeiro F. da Silva-Filho, Gianluca Belchior, Angela Tavares Paes, Nicole Costa Soriano Freire, Cintia Steinhaus, Matias Epifanio, Adriana S.C. Knabben, Adriana Goya, Alberto A. Vergara, Albin E. Augustin, Ana Cristina C.F. Fonseca, Antonio F. Ribeiro, Bruna Ziegler, Bruno P. Pessoa, Carlos A. Riedi, Claudia Castro-e-Silva, Claudia M. Gonçalves, Cleyde M.A. Nakaie, Constantino G.B. Cartaxo, Daniela S.P. Borgli, Daniela G. Meneses, Daniele M.T. Ferrao, Dayse V. Oliveira, Debora C. Chong-e-Silva, Denise M.C. Haidar, Edna L.S. Souza, Eduardo Piacentini-Filho, Elenara F.A. Procianoy, Elizabet V. Guimarães, Elizabeth P.S. Silva, Evalto M. Araujo-Filho, Fabiola V. Adde, Fernanda B.S. Malini, Flavia F. Fernandes, Francyelly W. Yamamoto, Gilberto B. Fischer, Glaunir M. Foletto, Izabela Sad, Jocemara Gurmini, Katharina V.N. Moura, Katia I. Oliveira, Lais R. Mota, Leonardo A. Pinto, Liana S. Coelho, Lilian C.F. Andries, Lorenna J.A. Prado, Luciana F. Velloso-Monte, Lusmaia D.C. Costa, Mara R.F. Figueiredo, Marcela D. De-Sillos, Marcelo B. Fuccio, Marcelo T. Rodrigues, Maria A.C.A. Sousa, Maria Angelica Santana, Maria E.S.A. Moreira, Maria F.B.H. Perez, Maria I.M. Fernandes, Mariane G.M. Canan, Marina M. Gonçalves, Marina P. Nishi, Marta C. Duarte, Murilo C.A. Britto, Neiva Damaceno, Patricia G.M. Bezerra, Paulo C. Kussek, Paulo T.R. Dalcin, Paulo J.C. Marostica, Raphael F.J. Oliveira, Roberta C.N.C. Melotti, Rosangela V. Garcia, Samia Rached, Silvia O.T. Tanaka, Sonia E.L. Valente, Sonia M. Chiba, Suzana F.O. Melo, Tania W. Folescu, Tiago N. Veras, Valeria C. Martins, Vera M. Dantas, Virginia A.F. Castro

“…Survival was significantly worse in the MI group, and the results of the Cox regression model revealed that the impact of MI on mortality was significant after controlling for other risk factors (HR = 1·84, 95% CI 1·50–2·25, p < 0·0001). …”
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Monitoring and Prediction of Monthly Drought using Standardized Precipitation Index and Markov Chain (Case study: southeast of Iran) by Abdol Rassoul Zarei, Moohamad Mehdi Moghimi, Mehdi Bahrami

“…Prediction of drought is recognized really useful in management of crisis and reduction of damages due to its the effect on different parts of environment, agricultural sections, natural resources, and wild life. …”
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In-Field Forage Biomass and Quality Prediction Using Image and VIS-NIR Proximal Sensing with Machine Learning and Covariance-Based Strategies for Livestock Management in Silvopasto... by Claudia M. Serpa-Imbett, Erika L. Gómez-Palencia, Diego A. Medina-Herrera, Jorge A. Mejía-Luquez, Remberto R. Martínez, William O. Burgos-Paz, Lorena A. Aguayo-Ulloa

“…This study investigates the in-field dynamics of Mombasa grass (<i>Megathyrsus maximus</i>) forage biomass production and quality using optical techniques such as visible imaging and near-infrared (VIS-NIR) hyperspectral proximal sensing combined with machine learning models enhanced by covariance-based error reduction strategies. …”
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Effect of periodontal therapy on lung function: a twelve-month follow-up intervention study by Anders Røsland, Randi J. Bertelsen, Joachim Heinrich, Stein Atle Lie, Andrei Malinovschi, Dagmar F. Bunæs

“…These findings suggest that oral infection control is valuable for respiratory health in young adults before chronic conditions establish. …”
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Early bevacizumab dose and time modifications may affect efficacy of atezolizumab plus bevacizumab for advanced hepatocellular carcinoma treatment by F. Rossari, D. Lavacchi, E. Alimenti, C. Soldà, F. Salani, L. Esposito, S. Foti, S. Camera, M. Persano, F. Lo Prinzi, F. Vitiello, E. Pellegrini, M. Bruccoleri, M.D. Rizzato, M. Caccese, I.G. Rapposelli, A. Guidolin, A. De Rosa, L. Antonuzzo, G. Masi, M.A. Iavarone, S. Lonardi, M. Rimini, A. Casadei-Gardini

“…Baseline clinical and laboratory characteristics were analyzed with uni-/multivariate models to explore potential differences on overall survival (OS), objective response rate (ORR) and disease control rate (DCR) based on eBEVmod. …”
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Is there a link between choroidal and retinal parameters in patients with systemic sclerosis? A prospective study by Aleksandra Leoniuk, Barbara Pieklarz, Ewa Gińdzieńska-Sieśkiewicz, Anna Szwedowicz, Iwona Obuchowska, Otylia Kowal-Bielecka, Joanna Konopińska, Diana A. Dmuchowska

“…The univariate regression analyses revealed only few significant associations with low fit of models to the data of the central macular ORL, ONL, RPE with the tested ocular and clinical parameters in the SSc and the controls. …”
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Health-related quality of life in children and adolescents born very preterm and its correlates: a cross-sectional study by Dirk Bassler, Giancarlo Natalucci, Sarah R Haile, Mark Adams, Susi Kriemler, Gabriela P Peralta, Thomas Radtke, Ajay N Bharadwaj, Alexander Moeller

“…A classification tree analysis explored potential correlates of HRQOL.Results On average, preterm children, both &lt;28 and 28–31 weeks gestational age, had similar KINDL total score to fullterm sibling controls (−2.3, 95% CI −3.6 to −0.6), and to population controls (+1.4, 95% CI 0.2 to 2.5). …”
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Exploring the Link Between Vitamin K and Depression: A Systematic Review by Mohamad Hisham Hashim, Nik Nasihah Nik Ramli, Siti Nur Atiqah Zulaikah Nasarudin, Maisarah Abdul Mutalib, Muhammad Najib Mohamad Alwi, Aswir Abd Rashed, Rajesh Ramasamy

“…<i>Conclusions:</i> While preliminary findings suggest a potential role for vitamin K in pathways relevant to depression, the current evidence is limited by cross-sectional designs, lack of isoform-specific analyses, and the absence of depression-focused preclinical models. Mechanisms including inflammation reduction, oxidative stress modulation, sphingolipid regulation, and vitamin K-dependent protein signaling (e.g., GAS6 and osteocalcin) were discussed based on indirect evidence and require further investigation in depression-specific contexts.…”
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Antioxidant action and potential neuroprotection of polyphenolics extracted from Astragalus membranaceus residue by Lu Li, Lu Li, Qiaona Wang, Ying Cao, Ying Cao, Jianmei Li, Yulong Wu, Chun Hua, Feng Zhou, Shengjie Li, Su Liu

“…An in vitro neuroprotective assessment using H2O2-stimulated PC12 neuronal cells demonstrated that the bound phenolic fractions significantly relieved oxidative stress, as evidenced by an increase in superoxide dismutase and catalase and a reduction in intracellular reactive oxygen species and malondialdehyde compared to untreated controls. …”
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Exploring a Novel Anti-Inflammatory Therapy for Diabetic Retinopathy Based on Glyco-Zeolitic-Imidazolate Frameworks by Elena Díaz-Paredes, Francisco Martín-Loro, Rocío Rodríguez-Marín, Laura Gómez-Jaramillo, Elena M. Sánchez-Fernández, Carolina Carrillo-Carrión, Ana I. Arroba

“…<b>Methods:</b> Extensive in vitro and ex vivo assays with diabetic retinopathy models unveil the mechanistic pathways of the designed GlycoZIF. …”
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Progress in 3D Printing Applications for the Management of Orbital Disorders: A Systematic Review by Luca Michelutti, Alessandro Tel, Massimo Robiony, Salvatore Sembronio, Riccardo Nocini, Edoardo Agosti, Tamara Ius, Caterina Gagliano, Marco Zeppieri

“…This systematic review of recent studies has examined the application of patient-specific 3D-printed models for preoperative planning, personalized implants, and prosthetics. …”
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Death or Taxes? An Examination of Recent Changes in Tobacco Taxation Policy in Canada by Michael DE Goodyear

“…Provision of an effective comprehensive national strategy to combat tobacco has yet to be realized. Econometric models predict significant changes in consumption from drastic tax reductions that effectively halved the retail price in a large part of Canada. …”
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Advancement in predictive biomarkers for gestational diabetes mellitus diagnosis and related outcomes: a scoping review by Fabricio Da Silva Costa, Hasini Rathnayake, Luhao Han, Cristiane Paganoti, Brett Dyer, Avinash Kundur, Indu Singh, Olivia J Holland

“…While GDM is diagnosed by oral glucose tolerance testing between 24–28 weeks, earlier prediction of risk of developing GDM via circulating biomarkers has the potential to risk-stratify women and implement targeted risk reduction before adverse obstetric outcomes. This scoping review aims to collate biomarkers associated with GDM development, associated perinatal outcome and medication requirement in GDM.Design The Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension for scoping reviews was used to guide the study.Data sources This review searched for articles on PubMed, Embase, Scopus, Cochrane Central Register of Controlled Trials, the Cumulative Index to Nursing and Allied Health Literature and the Web of Science from January 2013 to February 2023.Eligibility criteria The eligibility criteria included analytical observational studies published in English, focusing on pregnant women with maternal plasma or serum biomarkers collected between 6 and 24 weeks of gestation. …”
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Ethical Foundations of AI-Driven Avatars in the Metaverse for Innovation and User Privacy by Ammar Almomani, Ahmad Al-Qerem, Mohammad Alauthman, Amjad Aldweesh, Samer Aoudi, Said A. Salloum

“…Finally, we explore future directions, including integrating brain computer interfaces (BCIs), emotion detection, quantum-resistant cryptography, and international governance models. Validation through case study analysis demonstrates significant improvements in privacy protection metrics, substantial reduction in identity theft vulnerabilities, and marked enhancement in user autonomy controls compared to existing frameworks. …”
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Constrained Precipitation Extremes Reveal Unequal Future Socioeconomic Exposure by Ziyi Liu, Yao Yue, Louise Slater, Alistair G. L. Borthwick, Yuanfang Chai, Xiaofan Luan, Chiyuan Miao, Zhonghua Yang

“…Here, we quantify future precipitation characteristics from robust emergent constraint relationships between historical and future monthly precipitation extremes (99th percentile) across 19 CMIP6 models (r2 > 0.7 in 74–84% of 0.5° global land grids), and narrow uncertainty by 37.0–39.5% (absolute reduction being 0.753–0.774 mm/day). …”
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Effectiveness of mHealth interventions targeting physical activity, sedentary behaviour, sleep or nutrition on emotional, behavioural and eating disorders in adolescents: a systema... by H. Baumann, B. Singh, A. E. Staiano, C. Gough, M. Ahmed, J. Fiedler, I. Timm, K. Wunsch, K. Wunsch, A. Button, Z. Yin, M. F. Vasiloglou, B. Sivakumar, J. M. Petersen, J. Dallinga, C. Huong, S. Schoeppe, C. L. Kracht, K. Spring, C. Maher, C. Maher, C. Vandelanotte

“…Eight databases were searched for randomized controlled trials (RCTs) published up to September 2024. …”
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Do vigorous-intensity and moderate-intensity physical activities reduce mortality to the same extent? A systematic review and meta-analysis by Juan Pablo Rey Lopez, Maria Pastor-Valero, Angelo Sabag, Maria Martinez Juan, Leandro F M Rezende

“…For all-cause mortality and controlling by total physical activity, vigorous-intensity physical activity (vs moderate) was not associated with a larger reduction in mortality (HR 0.95, 95% CI 0.83 to 1.09). …”
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