The correlation between insulin resistance and blood lipids in children by Jiang Li, Xu Lulian, Lu Yang, Xu Xu

“…Results: After exercise, children in both groups possessed obvious reductions in body mass index (BMI), body fat percentage (BFP), triglyceride (TG), and homeostasis model assessment of IR (HOMA-IR), demonstrating remarkable differences in contrast to those after intervention (P<0.05). …”
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Screening for breast cancer: a systematic review update to inform the Canadian Task Force on Preventive Health Care guideline by Alexandria Bennett, Nicole Shaver, Niyati Vyas, Faris Almoli, Robert Pap, Andrea Douglas, Taddele Kibret, Becky Skidmore, Martin Yaffe, Anna Wilkinson, Jean M. Seely, Julian Little, David Moher

“…Methods We searched Ovid MEDLINE® ALL, Embase Classic + Embase and Cochrane Central Register of Controlled Trials to update our searches to July 8, 2023. …”
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Sex-specific and metabolic subgroup heterogeneity in high-density lipoprotein cholesterol associations with diabetic kidney disease risk: a retrospective cohort study by Huabin Wang, Xuanlin Jin, Fenfang Lin, Guangming Chen, Meili Lin, Yongjun Ma

“…Cox proportional hazards regression models were performed to investigate the potential relationship between HDL-C level and DKD risk. …”
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Incidence of Coronary Obstruction During Aortic Valve Implantation: Meta-Analysis and Mixt-Treatment Comparison of Self-Expandable Versus Balloon-Expandable Valve Prostheses by Yu Fei Wang, Zai Qiang Liu, Xiao Teng Ma, Li Xia Yang, Zhi Jian Wang, Yu Jie Zhou

“…The convergence of the model was evaluated using the trajectory map, density map, and the potential scale reduction factor (PSRF). …”
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Non-invasive colorectal cancer biomarkers: HAND2 and GPM6A methylation in circulating tumour DNA by Amir Mahdi Nili, Kamal Mohammadian, Fatemeh Namazi Nanehkaran, Faranak Jamshidian, Arash Moradi, Shahla Mohammad Ganji

“…Results Methylation levels of HAND2 and GPM6A were significantly elevated in pre-treatment colorectal cancer (CRC) patients compared to post-treatment patients and healthy controls. Specifically, HAND2 methylation exhibited a statistically significant reduction following therapeutic intervention (pre-treatment: 55.75% ± 26.75 vs. post-treatment: 37.98% ± 22.93, p < 0.001), with no significant correlation observed between pre- and post-treatment levels (Pearson r = 0.1030, p = 0.53). …”
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Optimizing seasonal performance of advanced heat mitigation solutions for city-scale thermal management in Greater Kuala Lumpur by Norishahaini Mohamed Ishak, Ansar Khan, Jamalunlaili Abdullah, Siti Aekbal Salleh, Mattheos Santamouris

“…We assess city-scale thermal management through high-resolution numerical simulations using the weather research and forecasting (WRF) model coupled with the single-layer urban canopy model (SLUCM), analysing one baseline and five mitigation scenarios: (a) control (no intervention), (b) cool materials (roof albedo 0.80, ground albedo 0.40), (c) super cool materials (roof albedo 0.95), (d) 30 % non-irrigated vegetation, (e) 60 percent non-irrigated vegetation, and (f) a combination of super cool materials with 60 % vegetation. …”
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Targeting the mTOR pathway in breast cancer by Jia Liu, Hui-Qing Li, Fu-Xia Zhou, Jie-Wen Yu, Ling Sun, Zhong-Hou Han

“…Blocking mechanistic target of rapamycin with rapamycin, first-generation and second-generation mechanistic target of rapamycin inhibitors, called rapalogs, have shown potent reduction of breast cancer tumor growth in preclinical models and clinical trials. …”
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Therapeutic effects of Jing Si herbal tea for chronic obstructive pulmonary disease: a comprehensive investigation from clinical to basic research by Chou-Chin Lan, Chou-Chin Lan, Po-Chun Hsieh, Kuo-Liang Huang, Kuo-Liang Huang, Mei-Chen Yang, Mei-Chen Yang, Guan-Ting Liu, Chan-Yen Kuo, I.-Shiang Tzeng, Yao-Kuang Wu, Yao-Kuang Wu

“…Cellular studies on lipopolysaccharide (LPS)-stimulated A549 cells demonstrated that JSHT effectively reduced the release of DAMPs such as HMGB1, FPR1, and extracellular ATP, and decreased the expression of inflammatory markers including pMAPK, pJNK, NF-kB, and cCaspase 3, and pro-inflammatory cytokines like IL-1, IL-6, IL-8, and TNF-α post-LPS induction.ConclusionJSHT improved the HRQL in patients with COPD, both in stable and exacerbated states. Cellular models demonstrated a reduction in DAMPs and inflammation, suggesting the potential of JSHT as a therapeutic agent for COPD through modulation of inflammatory responses.…”
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Analysis of the relationship between environmental particulate matter exposure and congenital diseases, as well as the epidemiological trends and burden of impact on newborns by Mulati Julaiti, Dilixiati Wubuli, Tingting Cui, Nadire Nijiati, Pengfei Huang, Bowen Hu

“…This may be attributed to improvements in air quality and the implementation of pollution control measures. However, forecasting models indicated potential future risks, suggesting that the burden of disease in newborns due to particulate matter exposure remains a concern.Conclusion: The study provides evidence of a causal link between environmental particulate and congenital diseases in newborns, highlighting the importance of air pollution reduction for the health of newborns. …”
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Evaluating machine learning pipelines for multimodal neuroimaging in small cohorts: an ALS case study by Shailesh Appukuttan, Shailesh Appukuttan, Aude-Marie Grapperon, Aude-Marie Grapperon, Mounir Mohamed El Mendili, Hugo Dary, Maxime Guye, Annie Verschueren, Jean-Philippe Ranjeva, Shahram Attarian, Wafaa Zaaraoui, Matthieu Gilson

“…In this study, we systematically evaluated the impact of various machine learning pipeline configurations, including scaling methods, feature selection, dimensionality reduction, and hyperparameter optimization. The efficacy of such components in the pipeline was evaluated on classification performance using multimodal MRI data from a cohort of 16 ALS patients and 14 healthy controls. …”
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A simplified hydroxyurea dosing approach for paediatric sickle cell anaemia in nigeria: addressing emergency care burden and adherence barriers in low-resource settings by Chisom Nri-Ezedi, Nwanneka Ugwu, Arinze Ulasi, Thomas Obiajulu Ulasi

“…Validation through larger or comparative studies is encouraged, and we recommend that healthcare policy-makers consider piloting and supporting similar models as part of national sickle cell control efforts.…”
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Coevolution of the Ile1,016 and Cys1,534 Mutations in the Voltage Gated Sodium Channel Gene of Aedes aegypti in Mexico. by Farah Z Vera-Maloof, Karla Saavedra-Rodriguez, Armando E Elizondo-Quiroga, Saul Lozano-Fuentes, William C Black Iv

“…Currently 2.5 billion people are at risk for infection and reduction of Ae. aegypti populations is the most effective means to reduce the risk of transmission. …”
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Optimized Water Management Strategies: Evaluating Limited-Irrigation Effects on Spring Wheat Productivity and Grain Nutritional Composition in Arid Agroecosystems by Zhiwei Zhao, Qi Li, Fan Xia, Peng Zhang, Shuiyuan Hao, Shijun Sun, Chao Cui, Yongping Zhang

“…Through a two-year field experiment (2020~2021), four irrigation regimes were implemented: rain-fed control (W0), single irrigation at the tillering–jointing stage (W1), dual irrigation at the tillering–jointing and heading–flowering stages (W2), and triple irrigation incorporating the grain-filling stage (W3). …”
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PCSK9 targeting therapies for familial hypercholesterolaemia: a meta-analysis of efficacy on lipid biomarkers and safety in adults and children across 23 RCTs by Vinh Q T Ho, Nghi Bao Tran, Nhan Nguyen, Giang Son Arrighini, David Downes, Mrunalini Dandamudi, Victoria Zecchin Ferrara, Tri Huynh Quang Ho, Hemank Walia, Alejandro Barbagelata, Thorsten M Leucker, Juliana Giorgi

“…The safety profile of these therapies was favourable, with adverse event rates comparable to those of the controls.Conclusions PCSK9i and Inclisiran demonstrate significant and sustained reductions in LDL-C, ApoB, Lp(a) and TGL in FH patients, especially in heterozygous FH patients. …”
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Locoregional Immune Checkpoint Blockade and Remodeling of Lymph Nodes by Engineered Dendritic Cell‐Derived Exosomes for Suppressing Tumor Progression and Metastasis by Yizhen Wang, Xiaomin Guo, Jingya Qin, Yifan Xue, Peng Zhang, Yadong Liu, Moyang Chen, Guanghao Zhu, Xinqiu Song, Lili Cheng, Bo Liu, Jie Liu, Jie Ren

“…In orthotopic breast cancer mouse model, local administration of EmDEX@GA remodels the immunosuppressive microenvironment of TDLNs and elicits potent anti‐tumor immunity, resulting in the suppression of tumor as well as the reduction of lymph node metastasis and distant metastasis. …”
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Implementing Telemedicine Intervention in Neonatal Intensive Care Units: Augmented Teleconsultation and Real-Time Monitoring Experience by Dalia M. Mominkhan, Faisal Aldahmashi, Ali H. Almudeer, Abdulaziz S. Alhmod, Muaddi F. Alharbi, Lamya M. Alzubaidi, Nada K. Alwehaibi, Khalid N. Alobeiwi, Manea M. Balharith, Ahmed A. Alahmari, Fahad A. Alamri, Ghadah Alsaleh, Yaser Almuzaini, Mohammed K. Alabdulaali

“…We employed the scheduled care model of TCC, in which an intensivist provides daily rounds, overnight calls, and critical care consultations upon request. …”
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CO2 sequestration potential in Depleted Hydrocarbon fields – A geochemical approach [version 2; peer review: 2 approved] by Pavlos Tyrologou, Nikolaos Koukouzas, Dounya Behnous, Eleni Gianni, Paula Fernández-Canteli Álvarez, Márton Pál Farkas, Ricardo Chacartegui Ramirez, Jesús García Crespo, Júlio Carneiro

“…Background The CO2 emissions reduction is crucial for the energy transition. New technologies for CO2 capture and storage are under development, such as CEEGS 1,2 . …”
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Refining lake volume estimation and critical depth identification for enhanced glacial lake outburst flood (GLOF) event anticipation by N. A. Bazai, N. A. Bazai, P. A. Carling, P. Cui, P. Cui, W. Hao, W. Hao, Z. Guotao, L. Dingzhu, L. Dingzhu, L. Dingzhu, J. Hassan

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Rapid tests to inform triage and antibiotic prescribing decisions for adults presenting with suspected acute respiratory infection: a rapid evidence synthesis of clinical effective... by Katie Scandrett, Jill Colquitt, Rachel Court, Fiona Whiter, Bethany Shinkins, Yemisi Takwoingi, Emma Loveman, Daniel Todkill, Paramjit Gill, Daniel Lasserson, Lena Al-Khudairy, Amy Grove, Yen-Fu Chen

“…The effects of procalcitonin point-of-care tests compared with usual care on hospital admission, escalation of care, and duration of symptoms were very uncertain as only one randomised controlled trial was included. The study found a large reduction in antibiotic prescriptions within 7 days. …”
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Non-Hospitalized Long COVID Patients Exhibit Reduced Retinal Capillary Perfusion: A Prospective Cohort Study by Clayton E. Lyons, Jonathan Alhalel, Anna Busza, Emily Suen, Nathan Gill, Nicole Decker, Stephen Suchy, Zachary Orban, Millenia Jimenez, Gina Perez Giraldo, Igor J. Koralnik, Manjot K. Gill

“…Neuro-PASC patients (<i>N</i> = 30; 60 eyes) exhibited a statistically significant (<i>p</i> = 0.005) reduction in DCP VLD compared to healthy controls (<i>N</i> = 44; 80 eyes). …”
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