Influence on mitogen-activated protein kinases as a new direction of connective tissue growth regulation by I. A. Shurygina, M. G. Shurygin, N. V. Zelenin, N. I. Ayushinova

Subjects: “…mitogen-activated protein kinase…”
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Early boosting of p38 MAPK signaling pathway by lycorine hydrochloride potently inhibits PRRSV proliferation in primary and established cells by Lizhan Su, Zhening Zhang, Siqi Zhang, Jiajing He, Yaoqi Chen, Guohong Wu, Zhiying Zhang, Weisan Chen, Mingxin Zhang, Jianxin Chen

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PDE4D drives rewiring of the MAPK pathway in BRAF-mutated melanoma resistant to MAPK inhibitors by Julie Delyon, Selma Becherirat, Anissa Roger, Mélanie Bernard-Cacciarella, Coralie Reger De Moura, Baptiste Louveau, Samia Mourah, Céleste Lebbé, Nicolas Dumaz

“…In the current work, we investigated the role of PDE4D in the resistance of BRAF-mutated melanoma to mitogen-activated protein kinase (MAPK) pathway-targeted therapy. …”
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The protein kinases family in fungi: adaptability, virulence and conservation between species by Emanoelle La Santrer, Cláudia Barbosa Assunção, Thiago Miguelito Navarro de Camargo, Izabella Rodrigues, Sabrina Sidney Campolina, Edgar Lacerda de Aguiar, Thiago de Souza Rodrigues, Rachel Basques Caligiorne

“…While many of these adaptive responses are regulated by diverse signaling pathways involving different kinase families, as mitogen-activated protein kinase (MAPK) for example, this review places a special focus on the General Control Nonderepressible 2 kinase (GCN2), a highly conserved sensor of amino acid scarcity in many fungi, as well as the species Cryptococcus neoformans, Candida albicans, and Aspergillus fumigatus. …”
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Alpha-enolase promotes progression of acute myeloid leukemia via MAPK/ERK signaling pathway by Shanshan Zhang, Haina Wang, Xuehong Zhang, Xiangjie Kui, Dan Huang, Menglu Qin, Shuqing Liu, Ming-Zhong Sun, Jinsong Yan

“…Mechanistically, ENO1 operates by activating the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling pathway, as evidenced by the reversal of shENO1 function through ERK activation. …”
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The effect of NF-kB and MAPK mediated Proinflammatory microenvironment on renal aging and amyloid deposition in elder rats by Mete Keçeci, Cenk Murat Özer, Esra Babaoğlu, Furkan Bodur, Ali Can Önal, Ayşe Zeynep Yılmazer Kayatekin, Osman Cengil, Ali Serdar Karataş

“…H&E, PAS, and Congo red staining and immunohistochemical staining for TNF-α, IL-6, occludin, GRP78, and mitogen-activated protein kinase (MAPK) were performed on the kidney tissues of the subjects. …”
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MAPK-targeted therapies in non-gastrointestinal stromal tumor soft tissue sarcomas: current landscape and future directions by Ouissam Al Jarroudi, Ouissam Al Jarroudi, Khalid El Bairi, Khalid El Bairi, Sami Aziz Brahmi, Sami Aziz Brahmi, Said Afqir, Said Afqir

“…Molecular profiling is urgently required to gain a deeper understanding of STS pathogenesis and to identify a comprehensive landscape of genomic alterations in order to develop effective targeted therapies. The mitogen-activated protein kinase (MAPK) signaling pathway is a key molecular mechanism involved in sarcoma development. …”
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Inhibition of ANXA1 Ameliorates Myocardial Ischemia/Reperfusion Injury by Targeting RAS/Raf/MAPK Axis-Mediated Ferroptosis by Yin Guo MD, Tian-xiao Lou BD, Yang Liu BD, Xin-yu Li MD, Xiao-yu Liu BD, Yi Huang MD

“…ANXA1 depletion alleviated ferroptosis and mitochondrial damage by activating RAS/Raf/mitogen-activated protein kinase (MAPK) pathway in H/R-induced cardiomyocytes. …”
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Targeting LINC02320 prevents colorectal cancer growth via GRB7-dependent inhibition of MAPK signaling pathway by Lingwei Zhang, Hong Chen, Yangmei Yang, Liangbo Zhao, Huimin Xie, Peixian Li, Xinrui Lv, Luyun He, Nian Liu, Benyu Liu

“…GRB7 then activates the mitogen-activated protein kinase (MAPK) signaling pathway, which contributes to CRC progression and leads to increased phosphorylation of the transcription factor FOS. …”
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P74 | EXPRESSION OF PISCIDIN, TLR-4, ERK2 AND P-P38 MAPK IN THE ZEBRAFISH GUT EXPOSED TO PCB-126 AND POSSIBLE PROTECTIVE EFFECTS OF GINESTEIN

“…ERK2 and p-p38 are mitogen-activated protein kinases (MAPKs) involved in the innate immune response that can be activated by pro-inflammatory cytokines and stress4. …”
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The anionic surfactant Sodium Dodecyl Benzene Sulfonate alleviates inflammatory responses in atopic dermatitis via NFκB/MAPK pathways in a STAT3-dependent manner by Han Zhang, Zizhuo Li, Zhanglei Mu, You Wu, Suli Zhang, Yaguang Zhou, Dongdong Zhang, Xiaojing Zhao, Weiwei Xing, Yanan Wang, Biwen Lin, Xiaoqiang Liang, Chunfu Zheng, Chengxin Li, Jianzhong Zhang

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Identification of components in scorpion and centipede traditional Chinese medicine formulations with potentially beneficial actions in asthma: network pharmacology and molecular d... by Yi-Ren Chen, Ya-Da Zhang, Wei Zhang, Bin-Qing Tang

“…Targets with degree values ≥ 16 included TP53, HSP90AA1, HSP90AB1, steroid receptor coactivator (SRC), epidermal growth factor receptor (EGFR), estrogen receptor 1 (ESR1), mitogen-activated protein kinase 1 (MAPK1), mitogen-activated protein kinase 3 (MAPK3), and histone deacetylase 1 (HDAC1). …”
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Immunomodulatory effects of 4-hydroxynonenal by Melina Ioannidis, Johanna Tjepkema, Michael R.P. Uitbeijerse, Geert van den Bogaart

“…This review explores how 4-HNE influences molecular mechanisms involved in inflammation and immune cell functions. 4-HNE modulates inflammation through the interaction with several signaling pathways, including nuclear factor kappa-light-chain enhancement of activated B cells (NF-κB), nuclear factor erythroid 2-related factor (Nrf2), mitogen-activated protein kinases (MAPK), toll-like receptor (TLR) 4, and stimulator of interferon genes (STING), thereby affecting immune responses and modulating cytokine production and inflammasome activation. …”
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Dynamic and structural insights into allosteric regulation on MKP5 a dual-specificity phosphatase by Erin Skeens, Federica Maschietto, Ramu Manjula, Shanelle Shillingford, James Murphy, Elias J. Lolis, Victor S. Batista, Anton M. Bennett, George P. Lisi

“…Abstract Dual-specificity mitogen-activated protein kinase (MAPK) phosphatases (MKPs) directly dephosphorylate and inactivate the MAPKs. …”
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Research progress on the regulation of signal pathways related to lung injury in sepsis by the active components of traditional Chinese medicine by RONG Jilintai*，SU He，ZHANG Ruifen，ZHANG Hairong，JIA Tingting，GUO Sihan，ZHAO Jian，LI Xiao，ZHONG Xin

“…Recent studies have shown that active components of traditional Chinese medicine（TCM）can exert anti⁃inflammatory，anti⁃oxidative stress，anti⁃pyroptosis，and anti⁃ferroptosis effects by regulating signaling pathways such as Toll⁃like receptor 4（TLR4）/nuclear factor κB（NF⁃κB），mitogen⁃activated protein kinase（MAPK），NOD⁃like receptor family pyrin domain containing 3（NLRP3）/caspase⁃1，phosphatidylinositol 3⁃kinase/protein kinase B，and nuclear factor E2⁃related factor 2/heme oxygenase⁃1，thereby alleviating sepsis⁃induced lung injury. …”
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Developmental effects of sulfated thyroid hormones in sea urchin skeletogenesis suggest activation of non-canonical thyroid hormone signaling pathway by Katherine Tieman, Andreas Heyland

“…One such pathway includes TH binding to the RGD-binding integrin dimer αVβ3, which activates the Mitogen-Activated Protein Kinase (MAPK) cascade, influencing cancer cell proliferation, metastasis, and angiogenesis. …”
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Unveiling the cancer-fighting potential of Rheum species (Rhubarb): Phytochemistry, ethnopharmacology, and mechanistic insights into the anticancer effects of key anthraquinones by Umer Majeed Khaja, Chirag Chopra, Amit Sehgal, Reena Singh, Showkat Ahmad Ganie

“…The chemopreventive and anti-carcinogenic potential of Rheum species stems from their modulation of critical molecular mechanisms and signaling pathways including NF-kappa B (NF-κB), Tumor Suppressor Gene (p53), tyrosine kinases, phosphoinositol 3-kinase (PI3K), mitogen-activated protein kinase (MAPK), protein kinase C (PKC) involved in various anti-cancer activities. …”
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Bark Extracts of <i>Chamaecyparis obtusa</i> (Siebold & Zucc.) Endl. Attenuate LPS-Induced Inflammatory Responses in RAW264.7 Macrophages by Bo-Ae Kim, Ji-A Byeon, Young-Ah Jang, Yong-Jin Kwon

“…Notably, COEB did not inhibit the LPS-induced activation of major inflammatory signaling pathways, including mitogen-activated protein kinase (MAPK), nuclear factor-kappa B (NF-κB), and Janus kinase/signal transducer and activator of transcription (JAK/STAT). …”
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Natural products as therapeutics for malignant melanoma: preclinical evidence and mechanism by Hongjin Gao, Jianli Huang, Dengfeng Zhang, Sixuan Li, Shengzhi Long, Yuesi Qin

“…Shikonin and plumbagin exert their antitumor effects through the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling pathway. …”
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Critical signaling pathways in osteoclast differentiation and bone resorption: mechanisms and therapeutic implications for periprosthetic osteolysis by Liangzi Yin, Liangzi Yin, Chenglin Sun, Junjie Zhang, Yan Li, Yansheng Wang, Yansheng Wang, Lunhao Bai, Zeming Lei, Zeming Lei

“…Emerging evidence highlights the pivotal roles of the RANKL/RANK/OPG axis, nuclear factor-κB (NF-κB) signaling, and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) cascades in osteoclast differentiation and pathological bone resorption. …”
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