Delphinidin attenuates cognitive deficits and pathology of Alzheimer’s disease by preventing microglial senescence via AMPK/SIRT1 pathway by Ying Liu, Ting Hong, Mingxuan Lv, Xiaoyu Guo, Panpan Zhang, Aijuan Yan, Wenshi Wei

“…It’s noteworthy that AMPK inhibitor Compound C inversed the protective effect of delphinidin against microglial senescence. Conclusion Our study reveals for the first time that delphinidin effectively improved cognitive deficits, alleviated synapse loss and Aβ pathology in APP/PS1 mice by mitigating microglial senescence. …”
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Qifuyin against CCL11-Induced cognitive impairment by inhibiting microglial senescence via CCR3 signaling by Sheng Tian, Tianyuan Ye, Chao Tian, Yipeng Zhang, He Li, Hui Shen, Youhua Xu, Xiaorui Cheng

“…Behavioral tests were conducted to evaluate the changes in cognitive function after Qifuyin treatment. …”
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Interleukin-4 prevents increased endothelial permeability by inducing pericyte survival and modulating microglial responses in diabetic retinopathy by Jang-Hyuk Yun

“…IL-4 promoted pericyte survival via PI3K/AKT activation and modulated microglial functional profiles through STAT6 signaling, favoring an anti-inflammatory phenotype. …”
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Therapeutic Potential of TPT-260 in Ischemic Stroke: An Investigation Into Its Anti-Inflammatory Effects and Impact on Microglial Activation by Qian J, Guo X, Xu Q, Huang Z

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Bulleyaconitine A Inhibits Visceral Nociception and Spinal Synaptic Plasticity through Stimulation of Microglial Release of Dynorphin A by Sheng-Nan Huang, Jinbao Wei, Lan-Ting Huang, Pei-Jun Ju, Jinghong Chen, Yong-Xiang Wang

“…The present study is aimed at evaluating the mechanisms underlying BAA visceral antinociception. …”
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Microglial exosome TREM2 ameliorates ferroptosis and neuroinflammation in alzheimer’s disease by activating the Wnt/β-catenin signaling by Ling Zhu, Tao Zhou, Lei Wu, Xuanang Zhu, Lvan Chen, Mi Zhang, Jing Zhou, Fan Wang

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Growth differentiation factor 15 aggravates sepsis-induced cognitive and memory impairments by promoting microglial inflammatory responses and phagocytosis by Lijiao Chen, Shiyuan Luo, Ting Liu, Zhewei Shuai, Yifan Song, Qianzi Yang, Ying Wang, Hongjun Huang, Yan Luo

“…Additionally, an in vitro investigation of LPS-stimulated microglia was conducted to evaluate the impacts of GDF15 on inflammatory cytokine productions and microglial phagocytic activity. …”
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Postoperative analgesia with morphine promoting microglial activation and neuroinflammation induced by surgery aggravates perioperative neurocognitive dysfunction in aged mice by Xiuzhi Shao, Liping Xie, Jingwen Zhai, Mingyue Ge

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Molecular mechanism of METTL14-mediated m6A modification regulating microglial function post ischemic stroke by Xiaomin Zhang, Pengyang Du, Bo Bai, Xia Lian, Guofang Xue

“…This study explores the molecular mechanism of METTL14 regulating microglial function post ischemic stroke. A murine model was established by tMCAO. …”
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Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis by Xu Zhiyan, Zhong Kaihua, Chen Weiyuan, Lan Huixia, Zhong Weifeng, Wang XiaoHong, Chen Mu, Pan Bin

“…In this study, we examined the role of the mmu‑miR‑125a/TRAF6 signaling axis in microglial activation under inflammatory conditions induced by lipopolysaccharide (LPS) and surgical trauma and evaluated whether dexmedetomidine (DEX) modulates this pathway to alleviate POCD.…”
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Stat3-mediated Th17 pathogenicity induced by periodontitis contributes to cognitive impairment by promoting microglial M1 polarization by Yining Zhou, Yining Zhou, Yining Zhou, Yining Zhou, Yining Zhou, Xinyi Xie, Xinyi Xie, Xinyi Xie, Xinyi Xie, Xinyi Xie, Xinyi Xie, Huiwen Chen, Huiwen Chen, Huiwen Chen, Huiwen Chen, Huiwen Chen, Lina Xu, Lina Xu, Lina Xu, Lina Xu, Lina Xu, Che Qiu, Che Qiu, Che Qiu, Che Qiu, Che Qiu, Hui Shen, Hui Shen, Hui Shen, Hui Shen, Hui Shen, Wei Zhou, Wei Zhou, Wei Zhou, Wei Zhou, Wei Zhou, Zhongchen Song, Zhongchen Song, Zhongchen Song, Zhongchen Song, Zhongchen Song

“…Expression of Th17-related cytokines and microglial pro-inflammatory markers was evaluated by reverse transcription-quantitative PCR (RT-qPCR), ELISA, flow cytometry, and immunohistochemistry. …”
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The role of n-3-derived specialised pro-resolving mediators (SPMs) in microglial mitochondrial respiration and inflammation resolution in Alzheimer’s disease by Mary Slayo, Christoph Rummel, Pasindu Hansana Singhaarachchi, Martin Feldotto, Sarah J. Spencer

“…However, a dysregulation in the resolution of this microglial response results in the chronic release of inflammatory mediators. …”
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Role of lncRNA Xist-miR-124-CCL2 axis in HIV Tat-mediated microglial activation and neuroinflammation by Palsamy Periyasamy, Seema Singh, Abiola Oladapo, Muthukumar Kannan, Shilpa Buch

“…Long noncoding RNAs (lncRNAs) regulate gene expression by sponging microRNAs (miRs), but their role in HIV Tat-mediated microglial activation remains poorly understood. This study aimed to investigate the involvement of the lncRNA Xist–miR-124–CCL2 axis in HIV Tat-exposed microglial cells.MethodsMouse primary microglial cells were exposed to HIV Tat, and the expression of lncRNA Xist, miR-124, and CCL2 was evaluated using qPCR, Western blotting, and ELISA. …”
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Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis by Ze-Xi Jia, Meng-Tian Guo, Mei-Mei Li, Pan Liao, Bo Yan, Wei Zhang, Fang-Yuan Cheng, Ya-Ru Liu, Zi-Han Zhang, Cheng Wei, Jie Zhou, Fang-Lian Chen, Ping Lei, Xin-Tong Ge

“…Finally, the cognitive effects of intranasal administration of IL-33 were evaluated in mice. Results IL-33KO mice exhibited pronounced cognitive impairment after rmTBI. …”
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ZC3H15 suppression ameliorates bone cancer pain through inhibiting neuronal oxidative stress and microglial inflammation by Li-Quan Huang, Ting-Xuan Yan, Bao-Sheng Wang, Hao Li, Nai-Bao Zhou

“…Conclusions: Our results provide evidence that suppressing ZC3H15 can alleviate BCP by restricting neuronal oxidative stress and microglial activation, contributing to the improvement of nociceptive behaviors. …”
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Effect of long-term constant irradiation on retinal glia by A. V. Potapov, E. Yu. Varakuta, A. V. Solonsky, S. V. Logvinov, A. V. Gerasimov, M. V. Svetlik, A. A. Zhdankina, E. A. Gereng, I. A. Petrov

“…To study the response of retinal glial cells to constant irradiation of various intensity and to develop a mathematical model allowing to evaluate the dynamics of damage to radial glial cells and predict their photodamage depending on the duration and intensity of irradiation.Materials and methods. …”
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Docosahexaenoic acid-acylated astaxanthin monoester enhances microglial autophagy for ameliorating amyloid-β load and cognitive deficits in models of Alzheimer’s disease by Xiaoxu Wang, Bo Dong, Yu Song, Zhigao Wang, Yuming Wang, Jie Xu, Changhu Xue

“…In microglial BV2 cells, AST-DHA and free astaxanthin (F-AST) recovered p62 and LC3Ⅱ/Ⅰ levels, and restored autophagy flux by rescuing the late phase of microglial autophagy. …”
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Extracellular vesicles from microglial cells activated by abnormal heparan sulfate oligosaccharides from Sanfilippo patients impair neuronal dendritic arborization by Chloé Dias, Nissrine Ballout, Guillaume Morla, Katia Alileche, Christophe Santiago, Ida Chiara Guerrera, Adeline Chaubet, Jerome Ausseil, Stephanie Trudel

“…This work provides a framework for further studies of biomarkers to evaluate efficiency of emerging therapies. Graphical Abstract…”
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Circular RNA APP contributes to Alzheimer’s disease pathogenesis by modulating microglial polarization via miR-1906/CLIC1 axis by Deng-Pan Wu, Yan-Su Wei, Li-Xiang Hou, Yu-Xuan Du, Qiu-Qing Yan, Ling-Ling Liu, Yuan-Dan Zhao, Ru-Yu Yan, Chao Yu, Zhen-Guo Zhong, Jin-Lan Huang

“…Abstract Background Abnormal microglial polarization phenotypes contribute to the pathogenesis of Alzheimer’s disease (AD). …”
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Microglial adenosine A2A receptor in the paraventricular thalamic nucleus regulates pain sensation and analgesic effects independent of opioid and cannabinoid receptors by Yiping Cao, Yiping Cao, Yiping Cao, Zhou Wu, Zhou Wu, Zhou Wu, Moruo Zhang, Moruo Zhang, Moruo Zhang, Ran Ji, Ran Ji, Ran Ji, Hongxing Zhang, Hongxing Zhang, Hongxing Zhang, Lingzhen Song, Lingzhen Song, Lingzhen Song

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