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3521
Preterm nutrition and brain development
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3522
Network pharmacology and experimental verification to investigate the mechanism of isoliquiritigenin for the treatment of Alzheimer’s disease
Published 2025-02-01“…The experimental results revealed that ISL decreased extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation and increased the expression of PPAR-γ, and suppressed the production of proinflammatory mediators. Our work revealed that ISL might be an effective treatment strategy in the treatment of AD by its anti-inflammatory effect towards microglia through the ERK/PPAR-γ pathway.…”
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3523
The effect of silymarin on ischemia-reperfusion injury in skeletal muscles of rats
Published 2024-03-01“…Aim: Although the precise process is not entirely elucidated, it is well-known that oxidative stress mediators contribute to ischemia-reperfusion (I/R) injury. …”
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3524
Unraveling the association and regulatory role of miR-146b-5p in coronary artery disease
Published 2025-02-01“…In addition, the inflammatory role of miR-146b-5p is mediated by targeting IKKβ.…”
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3525
TWIST1 regulates HK2 ubiquitination degradation to promote pancreatic cancer invasion and metastasis
Published 2025-02-01“…Western blotting was employed to detect proteins related to cuproptosis and apoptosis, while ubiquitination assays assessed TWIST1's regulation of HK2 ubiquitination. …”
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3526
Immune gene features and prognosis in colorectal cancer: insights from ssGSEA typing
Published 2025-02-01“…Between the two groups, a total of 1550 DEGs were identified and 395 differentially expressed immune-related genes (DE-IRGs) were identified by intersection with 2483 IRGs. …”
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3527
Building with Jelly, or, Concrete as the Concretion of the Abstract
Published 2025-02-01“…Expanding Jappe’s value-critical analysis of reinforced concrete with Moishe Postone’s account of how the peculiar social ‘self-mediating’ character of abstract labour in capitalism explains the transformation of labour into pure means and of its tools and products in mere objects, I intend to complement the question of cosmotechnics with an explanation of the decline of technodiversity grounded on the abstract logic of capital. …”
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3528
«Så sitter du der og plutselig leser for alle» – en nærstudie av barnehageansatte som litteraturformidlere
Published 2025-02-01“…ENGLISH ABSTRACT “All of the Sudden You Are Sitting There Reading for Everyone” – A Close Study of Pedagogical Staff as Literature Mediators Recent studies of pedagogical staff investigate practices that inform read-alouds in kindergartens (Alatalo & Westlund, 2021; Damber, 2015; Dybvik et al., 2022; Tjäru, 2023). …”
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3529
The relationship between vision status and its influencing factors among primary and secondary school students: The masking effect of physical activity level and the moderating eff...
Published 2025-02-01“…Results There was a significant negative correlation between vision status and lifestyle behaviors (r=-0.360, p < 0.01), physical activity level (r=-0.058, p < 0.05). …”
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3530
Breaking the biofilm barrier: Juglone derivatives as dual-action inhibitors and anti-quorum sensing agents
Published 2025-02-01“…Background: Most nosocomial infections are caused by bacteria that proliferate within quorum sensing mediated biofilms. The disruption of quorum sensing signals in biofilm-forming bacteria is the potential substitution strategy. …”
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3531
The agronomic mechanism of root lodging resistance and yield stability for sweet corn in response to planting density and nitrogen rates at different planting dates
Published 2025-02-01“…The results indicated that the plants in N150D25 presented better root system architecture, greater root biomass, and more roots per plant. These effects are mediated by the underlying metabolism of endogenous phytohormones, which balance the absorbing and anchoring function of the root system. …”
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3532
Synergistic enhancement of hydrophobic dental adhesives: autonomous strengthening, polymerization kinetics, and hydrolytic resistance
Published 2024-04-01“…This paper reports a self-strengthening adhesive formulation that resists hydrolysis-mediated degradation by providing intrinsic reinforcement of the polymer network through synergistic stimulation of free-radical polymerization, sol-gel reaction, and hydrophobicity. …”
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3533
Association between Growth Hormone and Insulin-like Growth Factor-1 (IGF-1) Levels, Liver Function and Short-Term Survival of Paediatric Liver Recipients
Published 2020-09-01“…The growth hormone/insulin-like growth factor-1 (IGF-1) system is an important humoral mediator of liver function with an inherent potential for assessing liver condition and survival prognosis following liver transplantation (LT).Aim. …”
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3534
Navigating the medical journey: Insights into medical students' psychological wellbeing, coping, and personality.
Published 2025-01-01“…Notably, problem-focused coping partially mediated the relationship between stress and depression. …”
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3535
Identification of HOXA9 methylation as an epigenetic biomarker predicting prognosis and guiding treatment choice in acute myeloid leukemia
Published 2025-02-01“…HOXA overexpression caused by genetic alterations, such as KMT2A rearrangements, NUP98- fusions and FLT3-ITD mutations, is frequently identified in AML. However, very few studies determined the DNA methylation-mediated epigenetic regulation of the HOXA cluster genes in AML. …”
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3536
Wnt/β-catenin signalling underpins juvenile Fasciola hepatica growth and development.
Published 2025-02-01“…Here, we identify five putative Wnt ligands and five Frizzled receptors in liver fluke transcriptomic datasets and find that Wnt/β-catenin signalling is most active in juveniles, the most pathogenic life stage. FISH-mediated transcript localisation revealed partitioning of the five Wnt ligands, with each displaying a distinct expression pattern, consistent with each Wnt regulating the development of different cell/tissue types. …”
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3537
Sacral neuromodulation outcomes in the management of lower urinary tract symptoms in multiple sclerosis patients
Published 2025-03-01“…INTRODUCTION/OBJECTIVE:: Multiple sclerosis (MS) is a common immune mediated disease of the central nervous system. The majority of patients will experience bothersome lower urinary tract symptoms (LUTS) over the course of their lifetime. …”
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3538
A comprehensive analysis of molecular characteristics of hot and cold tumor of gastric cancer
Published 2025-02-01“…Methods Consensus clustering was utilized to classify GC patients into distinct immune states, followed by an in-depth analysis of differences in mutation profiles, copy number variations, and DNA methylation patterns. …”
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3539
Efficacy and cost-effectiveness of an ACT and compassion-based intervention for women with breast cancer: study protocol of two randomised controlled trials {1}
Published 2025-01-01“…Analyses of moderators and mediators of change will also be performed. Discussion These trials examine the efficacy and cost-effectiveness of an integrative ACT and compassion-based intervention tailored for women with breast cancer. …”
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3540
Prognostic utility of neutrophil gelatinase-associated lipocalin (NGAL) levels for cardiovascular events in patients with stable coronary artery disease treated with percutaneous c...
Published 2025-02-01“…Abstract Introduction Neutrophil gelatinase-associated lipocalin (NGAL) modulates the enzymatic activity of matrix metalloproteinase-9, which is an important mediator of plaque instability in atherosclerosis. …”
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