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  1. 3521

    Preterm nutrition and brain development by Chiara Nava, Gianluca Lista, Enrica Lupo

    “…In particular, HM components such as long-chain polyunsaturated fatty acids (LCPUFA) and Human Milk Oligosaccharides (HMOs) appear to play a key role in mediating this influence. As HM nutritional content is insufficient to meet the nutritional needs of most preterm infants, the use of multicomponent fortifiers derived from cow's milk has entered common practice in Neonatal Intensive Care Unit. …”
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  2. 3522

    Network pharmacology and experimental verification to investigate the mechanism of isoliquiritigenin for the treatment of Alzheimer’s disease by Waimao Gao, Guang Yang, Xinjuan Liu, Kaifan Hu, Jie Pan, Xingyu Wang, Yan Zhao, Ying Xu

    Published 2025-02-01
    “…The experimental results revealed that ISL decreased extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation and increased the expression of PPAR-γ, and suppressed the production of proinflammatory mediators. Our work revealed that ISL might be an effective treatment strategy in the treatment of AD by its anti-inflammatory effect towards microglia through the ERK/PPAR-γ pathway.…”
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  3. 3523

    The effect of silymarin on ischemia-reperfusion injury in skeletal muscles of rats by Abdullah Ozer, Basak Kocak, Mustafa Arslan, Baris Mardin, Aysegul Kucuk, Saban Cem Sezen, Mustafa Hakan Zor, Mustafa Kavutcu

    Published 2024-03-01
    “…Aim: Although the precise process is not entirely elucidated, it is well-known that oxidative stress mediators contribute to ischemia-reperfusion (I/R) injury. …”
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  4. 3524

    Unraveling the association and regulatory role of miR-146b-5p in coronary artery disease by Xiaozhu Ma, Shuai Mei, Yi He, Qidamugai Wuyun, Li Zhou, Ziyang Cai, Qiushi Luo, Yi Wen, Jiangtao Yan

    Published 2025-02-01
    “…In addition, the inflammatory role of miR-146b-5p is mediated by targeting IKKβ.…”
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  5. 3525

    TWIST1 regulates HK2 ubiquitination degradation to promote pancreatic cancer invasion and metastasis by Xinxing Wang, Mingze Ma, Shuai Shao, Xianwen Xu, Chuan Qin, Ruxin Gao, Zhenhai Zhang

    Published 2025-02-01
    “…Western blotting was employed to detect proteins related to cuproptosis and apoptosis, while ubiquitination assays assessed TWIST1's regulation of HK2 ubiquitination. …”
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  6. 3526

    Immune gene features and prognosis in colorectal cancer: insights from ssGSEA typing by Anwen Huang, Jinxiu Wu, Jiakuan Wang, Chengwen Jiao, Yunfei Yang, Huaiwen Xiao, Li Yao

    Published 2025-02-01
    “…Between the two groups, a total of 1550 DEGs were identified and 395 differentially expressed immune-related genes (DE-IRGs) were identified by intersection with 2483 IRGs. …”
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  7. 3527

    Building with Jelly, or, Concrete as the Concretion of the Abstract by Alan Díaz Alva

    Published 2025-02-01
    “…Expanding Jappe’s value-critical analysis of reinforced concrete with Moishe Postone’s account of how the peculiar social ‘self-mediating’ character of abstract labour in capitalism explains the transformation of labour into pure means and of its tools and products in mere objects, I intend to complement the question of cosmotechnics with an explanation of the decline of technodiversity grounded on the abstract logic of capital. …”
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  8. 3528

    «Så sitter du der og plutselig leser for alle» – en nærstudie av barnehageansatte som litteraturformidlere by Malgorzata Wild, Christina Berg Tveitan

    Published 2025-02-01
    “…ENGLISH ABSTRACT “All of the Sudden You Are Sitting There Reading for Everyone” – A Close Study of Pedagogical Staff as Literature Mediators Recent studies of pedagogical staff investigate practices that inform read-alouds in kindergartens (Alatalo & Westlund, 2021; Damber, 2015; Dybvik et al., 2022; Tjäru, 2023). …”
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  9. 3529

    The relationship between vision status and its influencing factors among primary and secondary school students: The masking effect of physical activity level and the moderating eff... by Jiyan Xu, Yanjun Li, Siyuan Ma, Shimeng Dai, Weiwei Xu, Mengjiao Sang, Kaijie Feng

    Published 2025-02-01
    “…Results There was a significant negative correlation between vision status and lifestyle behaviors (r=-0.360, p < 0.01), physical activity level (r=-0.058, p < 0.05). …”
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  10. 3530

    Breaking the biofilm barrier: Juglone derivatives as dual-action inhibitors and anti-quorum sensing agents by Muhammad Abdullah Bhatti, Atif Ali Khan Khalil, Sayed Muhammad Ata Ullah Shah Bukhari, Faisal Hanif, Mi-Jeong Ahn, Sumra Wajid Abbasi, Nazir Ahmed Lone, Wen-Jun Li, Wasim Sajjad

    Published 2025-02-01
    “…Background: Most nosocomial infections are caused by bacteria that proliferate within quorum sensing mediated biofilms. The disruption of quorum sensing signals in biofilm-forming bacteria is the potential substitution strategy. …”
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  11. 3531

    The agronomic mechanism of root lodging resistance and yield stability for sweet corn in response to planting density and nitrogen rates at different planting dates by Qinggan Liang, Qinggan Liang, Qinggan Liang, Qinggan Liang, Hailong Chang, Hailong Chang, Hongrong Chen, Hongrong Chen, Qingdan Wu, Qingdan Wu, Yuanxia Qin, Zhuqing Wang, Gang Wang, Xuhui Li, Weiwei Chen, Jiantao Wu, Jiantao Wu, Qinnan Wang, Jianqiang Wang, Jianqiang Wang

    Published 2025-02-01
    “…The results indicated that the plants in N150D25 presented better root system architecture, greater root biomass, and more roots per plant. These effects are mediated by the underlying metabolism of endogenous phytohormones, which balance the absorbing and anchoring function of the root system. …”
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  12. 3532

    Synergistic enhancement of hydrophobic dental adhesives: autonomous strengthening, polymerization kinetics, and hydrolytic resistance by Burak Korkmaz, Erhan Demirel, Qiang Ye, Qiang Ye, Anil Misra, Anil Misra, Candan Tamerler, Candan Tamerler, Candan Tamerler, Paulette Spencer, Paulette Spencer, Paulette Spencer

    Published 2024-04-01
    “…This paper reports a self-strengthening adhesive formulation that resists hydrolysis-mediated degradation by providing intrinsic reinforcement of the polymer network through synergistic stimulation of free-radical polymerization, sol-gel reaction, and hydrophobicity. …”
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  13. 3533

    Association between Growth Hormone and Insulin-like Growth Factor-1 (IGF-1) Levels, Liver Function and Short-Term Survival of Paediatric Liver Recipients by R. M. Kurabekova, O. M. Tsiroulnikova, I. E. Pashkova, L. V. Makarova, N. P. Mozheiko, A. R. Monakhov, O. P. Shevchenko

    Published 2020-09-01
    “…The growth hormone/insulin-like growth factor-1 (IGF-1) system is an important humoral mediator of liver function with an inherent potential for assessing liver condition and survival prognosis following liver transplantation (LT).Aim. …”
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  14. 3534

    Navigating the medical journey: Insights into medical students' psychological wellbeing, coping, and personality. by Aisha Ali Hawsawi, Neil Nixon, Elena Nixon

    Published 2025-01-01
    “…Notably, problem-focused coping partially mediated the relationship between stress and depression. …”
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  15. 3535

    Identification of HOXA9 methylation as an epigenetic biomarker predicting prognosis and guiding treatment choice in acute myeloid leukemia by Fei Xie, Ting-juan Zhang, Xin-long Zhang, Zi-jun Xu, Liang Qiao, Yun Wang, Yang-jing Zhao, Jun Qian, Jing-dong Zhou

    Published 2025-02-01
    “…HOXA overexpression caused by genetic alterations, such as KMT2A rearrangements, NUP98- fusions and FLT3-ITD mutations, is frequently identified in AML. However, very few studies determined the DNA methylation-mediated epigenetic regulation of the HOXA cluster genes in AML. …”
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  16. 3536

    Wnt/β-catenin signalling underpins juvenile Fasciola hepatica growth and development. by Rebecca Armstrong, Nikki J Marks, Timothy G Geary, John Harrington, Paul M Selzer, Aaron G Maule

    Published 2025-02-01
    “…Here, we identify five putative Wnt ligands and five Frizzled receptors in liver fluke transcriptomic datasets and find that Wnt/β-catenin signalling is most active in juveniles, the most pathogenic life stage. FISH-mediated transcript localisation revealed partitioning of the five Wnt ligands, with each displaying a distinct expression pattern, consistent with each Wnt regulating the development of different cell/tissue types. …”
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  17. 3537

    Sacral neuromodulation outcomes in the management of lower urinary tract symptoms in multiple sclerosis patients by Tyler Trump, Po-Ming Chow, Vivian Hua, Omer Anis, Mazen Mansour, Howard B. Goldman

    Published 2025-03-01
    “…INTRODUCTION/OBJECTIVE:: Multiple sclerosis (MS) is a common immune mediated disease of the central nervous system. The majority of patients will experience bothersome lower urinary tract symptoms (LUTS) over the course of their lifetime. …”
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  18. 3538

    A comprehensive analysis of molecular characteristics of hot and cold tumor of gastric cancer by Chenxi Lv, Tianwei Chen, Jiangtao Li, Yuqiang Shan, Hong Zhou

    Published 2025-02-01
    “…Methods Consensus clustering was utilized to classify GC patients into distinct immune states, followed by an in-depth analysis of differences in mutation profiles, copy number variations, and DNA methylation patterns. …”
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  19. 3539

    Efficacy and cost-effectiveness of an ACT and compassion-based intervention for women with breast cancer: study protocol of two randomised controlled trials {1} by Inês A. Trindade, Andreia Soares, David Skvarc, Diogo Carreiras, Joana Pereira, Óscar Lourenço, Filipa Sampaio, Bruno de Sousa, Teresa C. Martins, Paula Boaventura, Joana Marta-Simões, Mind Project Team, Helena Moreira

    Published 2025-01-01
    “…Analyses of moderators and mediators of change will also be performed. Discussion These trials examine the efficacy and cost-effectiveness of an integrative ACT and compassion-based intervention tailored for women with breast cancer. …”
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  20. 3540

    Prognostic utility of neutrophil gelatinase-associated lipocalin (NGAL) levels for cardiovascular events in patients with stable coronary artery disease treated with percutaneous c... by Ting-Yu Lin, Hsin-Bang Leu, Yen-Wen Wu, Wei-Kung Tseng, Tsung-Hsien Lin, Hung-I Yeh, Kuan-Cheng Chang, Ji-Hung Wang, Wei-Hsian Yin, Chau-Chung Wu, Chun-Yao Huang, Shing-Jong Lin, Chien-Yi Hsu, Jaw-Wen Chen

    Published 2025-02-01
    “…Abstract Introduction Neutrophil gelatinase-associated lipocalin (NGAL) modulates the enzymatic activity of matrix metalloproteinase-9, which is an important mediator of plaque instability in atherosclerosis. …”
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