Systemic immune response at gastroesophageal reflux disease by Yu. V. Yevsyutina, A. S. Trukhmanov, V. T. Ivashkin, S. V. Lyamina, I. Yu. Malyshev

“…High level of IL-8 was associated with increased frequency of relapses of erosive esophagitis within 2 years, despite of carried out therapy.Conclusions. Relation of cytokine levels to the form of GERD was revealed. …”
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Deciphering the generation of heterogeneity in esophageal squamous cell carcinoma metastasis via single-cell multiomics analysis by Kaiwen Sheng, Jun Chen, Ruitang Xu, Haoqiang Sun, Ran Liu, Yongjie Wang, Wenwen Xu, Jiao Guo, Miao Zhang, Shuai Liu, Juan Lei, Yawen Sun, Yang Jia, Dianhao Guo

“…Abstract Background Chromatin accessibility plays a crucial role in mediating transcriptional dysregulation and heterogeneity in Esophageal Squamous Cell Carcinoma (ESCC). …”
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The Characteristics of PM2.5 Pollution Episodes during 2016–2019 in Sichuan Basin, China by Xiaodong Wu, Guangming Shi, Xing Xiang, Fumo Yang

“…However, they focused on either specific regional pollution events from different aspects or the megacities, such as Chengdu and Chongqing. To provide a panorama gram of PM2.5 pollution episodes in the whole basin area, we identified all the PM2.5 pollution events in 17 cities during 2016–2019 and analyzed the characteristics of these events. …”
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Peyami Safa Romanları Örneğinde Türk Modernleşmesi Bağlamında Oryantalist Zihniyetin Eleştirisi by Hanife Ayaz

“…Araştırma sonucunda ise yazarın romanlarının yakın okuması neticesinde belirlenen kadın ve erkek karakter tahlilleri üzerinden Batı hayranlığı, mekân, müzik, dil, din ve milliyetçilik, Avrupalılık, aile ve evlilik temaları çerçevesinde Safa’nın Türk modernleşmesinde öncü bir etkiye sahip olan, Batı’yı Doğu’dan üstün gören oryantalist zihniyete, yanlış Batılılaşma anlayışına dair ürettiği eleştirel söylem açığa çıkartılmıştır.…”
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tDCS cranial nerve Co-stimulation: Unveiling brainstem pathways involved in trigeminal nerve direct current stimulation in rats by Alireza Majdi, Liyi Chen, Lars E. Larsen, Robrecht Raedt, Myles Mc Laughlin

“…However, recent evidence suggests that some tDCS effects may be mediated through co-stimulation of peripheral or cranial nerves, particularly the trigeminal nerve (TN). …”
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A peripheral subepithelial network for chemotactile processing in the predatory sea slug Pleurobranchaea californica. by Tigran Norekian, Yichen Liu, Ekaterina D Gribkova, Jilai Cui, Rhanor Gillette

“…Ciliary clusters likely drive the sensory nerve spikes via SeN, mediating appetitive and stimulus place codes to CNS. …”
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Competitive displacement of lipoprotein lipase from heparan sulfate is orchestrated by a disordered acidic cluster in GPIHBP1 by Anamika Biswas, Samina Arshid, Kristian Kølby Kristensen, Thomas J.D. Jørgensen, Michael Ploug

“…In functional assays, we showed that the acidic cluster at 19–30 also had the greatest impact on preserving LPL activity, mitigating ANGPTL4-catalyzed LPL inactivation, preventing PSCK3-mediated LPL cleavage, and, importantly, displacing LPL from HSPGs. …”
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REDD1 expression in podocytes facilitates renal inflammation and pyroptosis in streptozotocin-induced diabetic nephropathy by Siddharth Sunilkumar, Sandeep M. Subrahmanian, Esma I. Yerlikaya, Allyson L. Toro, Edward W. Harhaj, Scot R. Kimball, Michael D. Dennis

“…Furthermore, exposure of podocytes to hyperglycemic conditions promoted REDD1-dependent pyroptotic cell death, evidenced by an NLRP3-mediated increase in caspase-1 activity and LDH release. …”
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Role of exercise on ncRNAs and exosomal ncRNAs in preventing neurodegenerative diseases: a narrative review by Shangwu Liu, Runhong Zhang, Jamal Hallajzadeh

“…Abstract Engaging in activity has proven to have beneficial effects on different facets of well-being, such as conditions related to the deterioration of the nervous system. …”
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The impact of apolipoprotein E, type ∊4 allele on Alzheimer's disease pathological biomarkers: a comprehensive post-mortem pilot-analysis. by Ziyu Wan, Tao Ma

“…This correlation is mediated by both tau and amyloid pathology, suggesting a higher hierarchical role in determining AD pathological effects than other biomarkers. …”
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Biology of selective caries removal: a systematic scoping review protocol by Helge Knüttel, Matthias Widbiller, Rita Weiler, Kerstin M Galler, Wolfgang Buchalla, Konstantin J Scholz

“…In the course of phase I, a total of 100 systematic reviews related to selective caries removal were searched in MEDLINE and information or theories on the biological processes were extracted. …”
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Vagal nerve stimulation dynamically alters anxiety-like behavior in rats by A.G. Butler, J.K. Bassi, A.A. Connelly, M.R. Melo, A.M. Allen, S.J. McDougall

“…The VNS current required to elicit the A-fiber-mediated Hering-Breuer Reflex (HBR) was determined for each animal. …”
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Duodenal Organoids From Metabolic Dysfunction-Associated Steatohepatitis Patients Exhibit Absorptive and Barrier Alterations by Alia Hadefi, Morgane Leprovots, Gilles Dinsart, Maryam Marefati, Marjorie Vermeersch, Daniel Monteyne, David Pérez-Morga, Anne Lefort, Frédérick Libert, Laurine Verset, Claire Liefferinckx, Christophe Moreno, Jacques Devière, Eric Trépo, Marie-Isabelle Garcia

“…MDEOs displayed altered digestive potential associated with reduced mature absorptive cell fate, but they retained their lipid metabolic capacity, possibly mediated by lipid oxidation in stem/progenitor cells. …”
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MicroRNA-541-3p/Rac2 signaling bridges radiation-induced lung injury and repair by Jiandong Zhang, Lei Ma, Limin He, Quanxiao Xu, Yan Ding, Lidong Wang

“…MicroRNA-541-3P/Rac2 act as mediators of radiation damage and repair signaling.…”
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Early health technology assessment of tongue swab for non-sputum based pulmonary tuberculosis diagnosis in ThailandResearch in context by Langming Mou, Teerawat Wiwatpanit, Apiwat Piriyapol, Puwadol Chawengkul, Janjira Thaipadungpanit, Puttarin Kulchaitanaroaj, Yot Teerawattananon, Yi Wang

“…An early health economic model evaluated the cost-effectiveness of two innovative strategies: tongue swab with Loop-Mediated Isothermal Amplification (LAMP) and tongue swab with real-time polymerase chain reaction (RTPCR). …”
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CSF3 promotes colorectal cancer progression by activating p65/NF-κB signaling pathway and inducing an immunosuppressive microenvironment by Junfeng Xu, Na Li, Hui Xie, Changwei Duan, Xingchen Liao, Ruoran Li, Heng Zhang, Yuanming Pan, Xianzong Ma, Shuwen Du, Jianqiu Sheng, Xin Wang, Lang Yang, Peng Jin

“…Mechanistically, CSF3 was found to mediate CRC development by activating the NF-κB signaling pathway, as evidenced by the decreased phosphorylation of p65 and reduced IκBα ubiquitination in CSF3-silenced cells. …”
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Influence of Conflict Management on Organizational Performance: A Case Study of Bubaare Sub-County Rubanda District Uganda. by Niwamanya, Lillian

“…The connection between employees and top management is because of the impact it has on the effectiveness of conflict management strategies and the organizations should focus on increasing the utilization of conflict management strategies like negotiation and mediation to increase organizational performance.…”
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Bee Venom—A Potential Complementary Medicine Candidate for SARS-CoV-2 Infections by Keneth Iceland, Kasozi, Simon Peter, Musinguzi

“…BV anti-inflammatory properties are associated with melittin and phospholipase A2 (PLA2), both of which show activity against enveloped and non-enveloped viruses, including H1N1 and HIV, with activity mediated through antagonist activity against interleukin-6 (IL-6), IL-8, interferon-g (IFN-g), and tumor necrosis factor-a (TNF-a). …”
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Effects of B-Blockers on the Sympathetic and Cytokines Storms in Covid-19. by Al-kuraishy, Hayder M., Al-Gareeb, Ali Ismail, Mostafa-Hedeab, Gomaa, Keneth Iceland, Kasozi, Zirintunda, Gerald, Aslam, Akhmed, Allahyani, Mamdouh, Welburn, Susan Christina, Batiha, Gaber El-Saber

“…In conclusion, b-blockers interrupt this interaction through inhibition of several mediators of CS and SS with prevention development of neural-cytokine loop in SARS-CoV-2 infection. …”
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Impaired RelA signaling and lipid metabolism dysregulation in hepatocytes: driving forces in the progression of metabolic dysfunction-associated steatotic liver disease by Yihuai He, Jinlian Jiang, Lili Ou, Yunfen Chen, Aikedaimu Abudukeremu, Guimei Chen, Weiwei Zhong, Zhigang Jiang, Nuerbiye Nuermaimaiti, Yaqun Guan

“…Mechanistically, during hepatic steatosis, altered lipid profiles exhibited lipotoxicity, inducing hepatocyte apoptosis and necroptosis, whereas endoplasmic reticulum (ER) stress triggered lipid remodeling processes similar to those observed in MASLD. …”
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