Resveratrol, a food-derived polyphenol, promotes Melanosomal degradation in skin fibroblasts through coordinated activation of autophagy, lysosomal, and antioxidant pathways by Saki Okamoto, Saya Kakimaru, Mayuko Koreishi, Mika Sakamoto, Yoshimasa Nakamura, Hideya Ando, Yoshio Tsujino, Ayano Satoh

“…RNA sequencing revealed upregulation of lysosomal and autophagy-related genes, including cathepsins. Furthermore, reporter assays showed resveratrol's activation of antioxidant response via nuclear factor erythroid 2-related factor 2 (NRF2)-mediated, leading to upregulation of transcription factor EB/transcription factor E3 (TFEB/TFE3), master regulators of lysosomal function. …”
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Antiemetic activity of Sesamol possibly through serotonergic and dopaminergic receptor interaction pathways: In vivo and in silico studies by Touhidul Islam Tanim, Ayman M. Al-Qaaneh, Raihan Chowdhury, Md. Shimul Bhuia, Tabassum Islam, Md Showkoth Akbor, Md. Tahajul Islam, Md. Mohasin Miah, Ali Raza Ishaq, Mostafa A. Abdel-Maksoud, Mohamed A. El-Tayeb, Mohamed El-Shazly, Muhammad Torequl Islam, Heba A.S. El-Nashar

“…Further, molecular docking was carried out to understand the molecular interaction between selected ligands and different receptors liable for mediating emesis. SEL (25 and 50 mg/kg) showed dose-dependent elevation in latency (133.20 ± 2.19 and 293.00 ± 5.27 s) and diminishment in the retching number (16.40 ± 1.15 and 9.40 ± 1.04 times), compared to control. …”
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Manganese-pyrochloric acid photosensitizer nanocomplexes against osteosarcoma: achieving both high activatability and high effectiveness by Xuran Zhang, Xuran Zhang, Jian Wang, Qun Feng, Li Lei, Zhiyong Zhu

“…Additionally, Mn2+ ions activated the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, promoting maturation of dendritic cells (DCs) and augmenting CD8+-mediated antitumor immune responses.DiscussionThis study advances the on-demand activation of photosensitive drugs and photodynamic immunotherapy toward clinical applicability by exploiting Mn2+–PPa nanocomplexes with high activatability and effectiveness for targeted PDT and immunotherapy.…”
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The Role of Traditional Leadership in Addressing Gender-Based Violence in Seke Community, Zimbabwe by Blessing Hodzi

“…Findings from interviews with two officers and 10 village heads and chiefs and five observations that involved 14 participants indicate that traditional leaders use mediation, the traditional court system, referrals to the police, and awareness campaigns to address GBV. …”
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Temporal legacies of coal mining in the West Coast, New Zealand: path-dependency or path-creation? by Sean Connelly, Etienne Nel, Alison Floyd

“…We draw on concepts from evolutionary economic geography to highlight how iterative processes of path creation and path dependency have played out and identify the important role of community agency and external support in mediating those processes. The temporal component of Blackball’s coal transition presents useful lessons for other mining communities which currently face closure.…”
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Konfrontacja ascetyki Hieronima ze Strydonu i Pelagiusza z Brytanii na podstawie wybranych dzieł by Anita Mularczyk-Budzan

“…Jerome’s meeting with Pelagius could be chance for them, but unfortunately – missed this chance. …”
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WNT11 Promotes immune evasion and resistance to Anti-PD-1 therapy in liver metastasis by Weiliang Jiang, Bingjie Guan, Hongcheng Sun, Yushuai Mi, Sanjun Cai, Rong Wan, Xinxiang Li, Peng Lian, Dawei Li, Senlin Zhao

“…Mechanistically, WNT11-overexpressing tumor cells directly reduce CD8+ T-cell recruitment and activity by decreasing CXCL10 and CCL4 expression through CAMKII-mediated β-catenin/AFF3 downregulation. WNT11-overexpressing tumor cells promote immunosuppressive macrophage polarization by inducing IL17D expression via the CAMKII/NF-κB pathway, which result in CD8+ T-cell suppression. …”
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Peripheral membrane protein endophilin B1 probes, perturbs and permeabilizes lipid bilayers by Arni Thorlacius, Maksim Rulev, Oscar Sundberg, Anna Sundborger-Lunna

“…We also show that endophilin B1 efficiently permeabilizes negatively charged liposomes that contain mitochondria-specific lipid cardiolipin and propose a new model for Bax-mediated cell death.…”
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Disruption of the β-catenin destruction complex via Ephexin1-Axin1 interaction promotes colorectal cancer proliferation by Jeeho Kim, Young Jin Jeon, In-Youb Chang, Jung-Hee Lee, Ho Jin You

“…Through comprehensive analysis, including RNA sequencing data from TCGA and functional assays, we observed that Ephexin1 promotes tumor proliferation and migration by activating the Wnt/β-catenin pathway. This effect was mediated by the interaction of Ephexin1 with Axin1, a critical component of the β-catenin destruction complex, which in turn enhanced the stability and activity of β-catenin in signaling pathways critical for tumor development. …”
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Heterogeneous occurrence of evergreen broad-leaved forests in East Asia: Evidence from plant fossils by Jiagang Zhao, Shufeng Li, Jian Huang, Wenna Ding, Mengxiao Wu, Tao Su, Alexander Farnsworth, Paul J. Valdes, Linlin Chen, Yaowu Xing, Zhekun Zhou

“…The occurrence of these forests in East Asia has been a subject of debate across various disciplines. In this study, we explored the occurrence of East Asian EBLFs from a paleobotanical perspective. …”
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ROS-induced cytosolic release of mitochondrial PGAM5 promotes colorectal cancer progression by interacting with MST3 by Shiyang Wang, Xi Wu, Wenxin Bi, Jiuzhi Xu, Liyuan Hou, Guilin Li, Yuwei Pan, Hanfu Zhang, Mengzhen Li, Sujuan Du, Mingxin Zhang, Di Liu, Shuiling Jin, Xiaojing Shi, Yuhua Tian, Jianwei Shuai, Maksim V. Plikus, Moshi Song, Zhaocai Zhou, Lu Yu, Cong Lv, Zhengquan Yu

“…This, in turn, prevents STK25-mediated LATS1/2 phosphorylation, leading to YAP activation and CRC progression. …”
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The zinc receptor, ZnR/GPR39, modulates taste sensitivity by regulating ion secretion in mouse salivary gland by Moran Melamed, Hila Asraf, Noa Livne, Milos Bogdanovic, Anil Shendge, Gilad Shamir, Maayan Mero, Omer Adir, Avi Schroeder, Israel Sekler, Michal Hershfinkel

“…Here, we identified the Zn2+ sensing receptor ZnR/GPR39 as a mediator of ion transport in salivary gland epithelium. …”
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¿Cómo piensan los empresarios y trabajadores del mar argentino sobre la captura incidental y el descarte pesquero? by María Soledad Schulze, María Eva Góngora

“…Entendemos que las soluciones no son simples e implican un sincero debate entre actores. …”
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Use of spent yeasts from bioethanol production plant as low-cost nitrogen sources for ethanol fermentation from sweet sorghum stem juice in low-cost bioreactors by Thanawat Thanapornsin, Rattanaporn Phongsri, Lakkana Laopaiboon, Pattana Laopaiboon

“…When three bioreactors, a stirred-tank bioreactor (STR, a typical bioreactor), a column bioreactor with stirrer (CS-R, a tower bioreactor) and an external loop bioreactor (ELR, a low-cost bioreactor with no agitation), were used for ethanol production from the SSJ supplemented with SYH, the fermentation efficiencies of all bioreactors were not different. Appropriate aeration during fermentation (0.31 vvm for 12 h) in the three bioreactors could enhance the QE value, reaching 3.36 g/L·h. …”
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Ameliorated Impact of Fenugreek Seed Extract on Some Blood Cellular and Biochemical Parameters in Female Albino Rats Exposed to Lead Acetate by Rozhya Abduljalil Naser, Rabar Yousif Mameik, Nazar M. Shareef Mahmood, Kurdo Bapir Chato

“…It has a several diverse-organ toxicant effect in various healthy issues included diseases of the hepatic, renal, and other body systems. Fenugreek seeds (Trigonella foenum graecum L.) were used in curing medicine and as food supplement since ancient times. …”
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Integrating phylogeographic and phenotypic evidence to delimit deep evolutionary lineages in the Dryophytes japonicus species complex, with an assessment of their conservation need... by Amaël Borzée, Yikweon Jang, Siti N. Othman, Jordy Groffen, Irina V. Maslova, Zoljargal Purevdorj, Kiyomi Yasumiba, Tomohiko Shimada, Yoonjung Yi, Natalya Alekseevna Schepina, Desiree Andersen, Yoonhyuk Bae, Ikuo Miura, Christophe Dufresnes

“…Finally, despite the relatively narrow ranges of many lineages, none crosses the threshold to be currently listed as threatened. …”
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Anti-Obesity Effects of Arum maculatum, Nasturtium officinale Plant Extracts and Exercise in High Fat Diet-Induced Obese Rats by Zana Hassan Ibrahim

“…Conclusions: Consumption of HFD for 8 weeks caused HFD-C rats obese, hyperglycemic and hyperlipidemic with hepatic cellular injury when compared to the NC rats. …”
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A Woman with a Long History of Smoking and a Debilitating Dry Cough by N. D. Potskhverashvili, N. I. Kokina, E. L. Bueverova, O. Yu. Zolnikova, A. S. Cherenda, V. A. Morozova, M. V. Feldsherov, A. P. Kiryukhin, P. V. Pavlov

“…A 56-year-old patient with a long history of smoking was hospitalized in the pulmonology department of the clinic with a leading complaint of a constant debilitating dry cough during the day, not amenable to the action of drugs, as well as general weakness, sweating and weight loss by 2 kg in 3 months. The examination revealed a moderately differentiated adenocarcinoma of the hepatic bend of the colon with generalized lymphadenopathy and metastatic lung damage, iron deficiency anemia. …”
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Ultrasound radiomics-based logistic regression model for fibrotic NASH by Fei Xia, Wei Wei, Junli Wang, Yuhe Wang, Kun Wang, Chaoxue Zhang, Qiwei Zhu

“…Methods The study used SD rats to create a model of hepatic steatosis and fibrosis by feeding them a high-fat diet and injecting Ccl4 subcutaneously. …”
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