Bufalin targets the SRC-3/c-Myc pathway in chemoresistant cells to regulate metastasis induced by chemoresistance in colorectal cancer by Jinbao Chen, Chenqi Wu, Kun Yu, Jinpei Liu, Jiahua Yang, Wei Li, Xiaoxia Tang, Yihai Shi, Ke Xu, Yi Chen, Xiaoyu Qin

“…Bufalin has a therapeutic effect on both metastasis and drug resistance, but how bufalin affects chemoresistance-mediated metastasis remains unclear. Methods The role of BU in the inhibition of EMT and angiogenesis induced by chemoresistant cells using wound healing assays, invasion assays, HUVEC tube formation and adhesion assays. …”
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The Modern University’s Mission and Transformation: Addressing Challenges in a Multipolar World by Ainash Davletova, Nazerke Orazova, Víctor Renobell, Rafael Khairullin, Vadim Ponkratov, Irina Burmykina, Natalya Savenko, Olesya Dudnik

“…The findings suggest that leadership (β = 0.32, p < 0.001), technological innovation (β = 0.28, p < 0.001), sociopolitical engagement (β = 0.19, p < 0.001), and curriculum and skills development (β = 0.25, p < 0.001) have a substantial positive impact on the adaptability of universities. Furthermore, the mediation analysis demonstrated that institutional collaboration partially mediated the relationship between university adaptability and both leadership (indirect effect = 0.14, p < 0.01) and technological innovation (indirect effect = 0.12, p < 0.01). …”
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Research on guest comfort and satisfaction with indoor environmental quality in former GBI-certified green hotels: a study case from Malaysia by Hayder Saadoon Abdulaali, Hayder Saadoon Abdulaali, Ismar M. S. Usman, Mohsen Alawi, Shagea Alqawzai

“…The research evaluates IEQ performance, suggests additional parameters, and explores how comfort mediates the relationship between IEQ and satisfaction. …”
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Antisecretory factor in severe traumatic brain injury (AFISTBI): protocol for an exploratory randomized placebo-controlled trial by Linus Réen, David Cederberg, Niklas Marklund, Edward Visse, Peter Siesjö

“…Secondary outcomes will be inflammatory mediators in plasma and intracerebral microdialysis perfusate days 1, 3, and 5 during trial treatment. …”
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NMR probing of copper–amyloid β1–16 interactions and self-assembly by Punnepalli Sunanda, Srinivasarao Raghothama, Uma Maheswari Devi Palempalli, Bankala Krishnarjuna

“… Trace metal ions, such as copper, play an important role in the development of amyloid β (Aβ)-mediated Alzheimer’s disease (AD). …”
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Alpha-defensins increase NTHi binding but not engulfment by the macrophages enhancing airway inflammation in Alpha-1 antitrypsin deficiency by Jungnam Lee, Naweed Mohammad, Kyudong Han, Kyudong Han, Tammy Flagg-Dowie, Maria Magallon, Mark L. Brantly, Karina A. Serban, Karina A. Serban

“…A high concentration of free α-defensins induced NTHi adherence to MDMs but decreased IgG-mediated phagocytosis by MDMs. The decreased phagocytosis was associated with TLR4 activation, downstream signaling via NF-κB p65 and marked increased secretion of inflammatory cytokines, CXCL8, IL-1b, and TNFα by the α-defensin-treated and NTHi-infected MDMs. …”
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De la neuroplasticidad a las propuestas aplicadas: estimulación temprana y su implementación en Costa Rica / From Neuroplasticity to Applied Proposals: Early Stimulation and Its Im... by Johanna Sibaja-Molina, Tracy Sánchez-Pacheco, Mijail Rojas-Carvajal, Jaime Fornaguera-Trías

“…Finally, bringing up the scope and limitations of ES, we conclude that the professional experiences need to be systematized, in order to open an academic debate on the subject. …”
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The spiritual mentality profile of female pietists on the South African frontier, 1750-1860 by A. W. G. Raath

“…Such a  reconstruction of the religious mentality profile of pietistic women on the frontier reveals a number of important aspects for understanding their spiritual life: self-awakenings and conversions; self-purification; self-illumination and mystically tainted experiences; recollection and the experience of quiet; meditation, contemplation, ecstasy and rapture; spiritual desertion, and abandonment of the soul and the unitive life with God in Christ. …”
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Social Acceptance of Smart Glasses in Health Care: Model Evaluation Study of Anticipated Adoption and Social Interaction by Niek Zuidhof, Oscar Peters, Peter-Paul Verbeek, Somaya Ben Allouch

“…ObjectiveAssuming that smart glasses mediate contact between the health care provider and patient, the objectives of this research are two-fold: (1) to develop an instrument that combines the adoption and mediation perspectives, and (2) to gain insights into how the intention to use is influenced through aspects of adoption and social interaction. …”
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Immunologic and inflammatory consequences of SARS-CoV-2 infection and its implications in renal disease by Hiam Naiditch, Michael R. Betts, H. Benjamin Larman, Moshe Levi, Avi Z. Rosenberg

“…In the kidney, acute tubular injury, early myofibroblast activation, and collapsing glomerulopathy in select populations likely account for COVID-19-related AKI and CKD development. The development of COVID-19-associated nephropathy (COVAN), in particular, may be mediated through IL-6 and signal transducer and activator of transcription 3 (STAT3) signaling, suggesting a direct connection between the COVID-19-related immune response and the development of chronic disease. …”
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Saussurea gossypiphora extracts reduce inflammation by reversing inflammatory cytokine levels in in-vitro and in-vivo by Kalyani Jatoth, Pawan Kumar Anoor, Ramesh Kande, Sandeepta Burgula

“…This activity seems to be mediated by the suppression of NO by MESGD and also via suppression of NLRP3 mediated inflammasome pathway leading to suppression of inflammatory cytokines IL-1β and TNF-α. …”
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Unveiling Hidden Aspects of Intermediary Organizations in Innovation: A Systematic Review through the Lens of Industry Taxonomy by Mostafa Mohseni kiasari, ‌Javad Soltanzadeh, Amirhossein Azizi Hasanabadi, Hamed Talebi

“…Methods In this study, using the Systematic Literature Review (SLR) method, all related qualitative and quantitative studies, including articles published in journals and conferences until 2022, were examined, and finally 77 articles were found and analyzed in the field of innovative intermediary institutions. …”
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A controversial legacy from the Romantic period. Al-Andalus echoes in films featuring tourists (1905-1975) by Alfonso Fernández-Tabales, María C. Puche-Ruiz

“…Furthermore, the secondary objectives are to analyse the intense debate, running since the beginning of the 19th century, about the image of Al-Andalus among Spanish intellectuals; and analyse the (re)production of “phantom image” linked to Al-Andalus in films with tourists, using a qualitative method of film image analysis that can be considered novel (Grounded Theory built through visual analysis with NVivo software). …”
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Eclecticism in child welfare by Terje Halvorsen

“…The presentation is largely based on the author’s observations from debates between Norwegian scholars over the last four decades. …”
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Entre Baltimore1915 y Barcelona 1968. Las continuidades históricas en el primer congreso de la profesión del Estado español. by Xoán Lombardero Posada

“…Este trabajo aborda de forma demorada las claves de estos debates, así como las formas organizativas en que tuvieron lugar. …”
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spatial-temporal transformation of the volga reservoirs’ soil complex. communication 7. sediment formation in the highly running reservoirs of the volga cascade by Viktor V. Zakonnov, Аrina V. Zakonnova, Aleksandr I. Tsvetkov

“…The reservoirs under consideration are transit reservoirs for suspended substances and aerators for the oxidation of chemical pollutants and their neutralization, so they play a crucial role in the natural self-purification and management of natural water quality.…”

O papel político do sociólogo na América Latina: Diálogos entre Fals Borda e Florestan Fernandes by Diogo Valença de Azevedo Costa, Edcarlos Ribeiro Bomfim

“…O período específico abordado neste trabalho se refere à década de 1960, girando em torno dos debates sobre a “sociologia comprometida”. A pesquisa aqui desenvolvida envolve investigações documentais realizadas em janeiro de 2018 no arquivo e biblioteca pessoais de Florestan Fernandes, disponíveis na Universidade Federal de São Carlos (UFSCar). …”
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