Evaluating the effects of dietary glutamine on performance, carcass traits, blood biochemistry, and intestine morphology in laying quail by Ewa Tomaszewska, Kamil Drabik, Kornel Kasperek, Piotr Dobrowolski, Monika Hułas-Stasiak, Renata Pyz-Łukasik, Waldemar Paszkiewicz, Monika Ziomek, Janine Donaldson, Katarzyna Dobrowolska, Artur Burmaczuk, Justyna Batkowska, Marcin B. Arciszewski, Siemowit Muszyński

“…Seven-week-old dual-purpose female quails at the onset of laying were assigned to diets containing 0% (control), 0.5%, 1%, or 1.5% Gln. Performance metrics included laying rate, daily feed intake, and feed efficiency. …”
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Safety and efficacy of oral edible bird’s nest supplementation: Anti-inflammatory and immunomodulatory benefits for Arabian race stallions during exercise by Khalid Obaid AL-Khaldi, Khalid Hamed Al-Ruzaiqi, Abdul Salam Babji, Seng Joe Lim, Mohammed Babatunde Sadiq, Nurhusien Yimer

“…Key objectives included assessing EBN’s impact on hepatic and renal function, hematological profiles, and sialic acid (SA) levels. Materials and Methods: Two experiments were conducted on 18 Arabian stallions. …”
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Identification and functional analysis of a novel SMARCC2 splicing variant in a family with syndromic neurodevelopmental disorder by Ming Li, Jingqi Lin, Hongjun Fei, Jinyu Liu, Yiyao Chen, Xu Han, Yanlin Wang, Jian Wang, Renyi Hua, Shuyuan Li, Niu Li

“…Abstract Background To determine the pathogenicity of a novel splicing variant in the SMARCC2 gene identified from a pair of adult male monozygotic twins with neurodevelopmental disorder, and to investigate the genotype-phenotype characteristics associated with SMARCC2 variants. Methods Whole-exome sequencing (WES) was conducted on the proband, and candidate variants were validated using Sanger sequencing within the family. …”
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Association between echocardiographic parameters of cardiac structure and function and mild cognitive impairment by Kai Zhang, Xiaoxia Liu, Siyu Huang, Xinrui Liu, Meiqi Zhao, Chao Xue, Shijun Xia, Jianzeng Dong, Yu Kong, Changsheng Ma

“…We aimed to explore the association between echocardiographic parameters of cardiac structure and function and MCI in CVD patients. Methods We conducted an age-, gender-, and education level-matched case–control study in general CVD participants with a 1:3 ratio of MCI (Montreal Cognitive Assessment [MoCA] score < 26 and Mini-Mental State Examination [MMSE] score ≥ 24) and cognitively normal participants at a tertiary hospital in Beijing, China. …”
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Association between exposure to ambient air pollutants and metabolic syndrome in the vicinity of the Taklamakan Desert by Zhe Wang, Weidong Ji, Yushan Wang, Lin Li, Kai Wang, Hongze Liu, Yining Yang, Yi Zhou

“…Background: Air pollution is a recognized contributor to metabolic syndrome (MetS); but studies in developing regions, including China, remain limited, especially in severely polluted areas near the Taklamakan Desert. Methods: Health data from 2,689,455 individuals aged ≥ 18 years in five regions near the Taklamakan Desert were analyzed. …”
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Real-world treatment patterns and clinical characteristics in patients with moderate-to-severe systemic lupus erythematosus: an analysis of the SLE Prospective Observational Cohort... by Raj Tummala, Richard A Furie, Laurent Arnaud, Eric F Morand, Martin Aringer, Stephanie Chen, Barnabas Desta, Alberta Hoi, Bo Ding, Christine Peschken, Jonatan Hedberg, Tina Grünfeld Eén, Alessandro Sorrentino, Danuta Kielar

“…We report real-world patterns of medication use in patients enrolled in SPOCS.Methods Data were collected at study entry; patients were followed twice annually according to local practice. …”
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Electrochemotherapy with bleomycin, oxaliplatin, or cisplatin in mouse tumor models, from tumor ablation to in situ vaccination by Katja Uršič Valentinuzzi, Katja Uršič Valentinuzzi, Urška Kamenšek, Urška Kamenšek, Simona Kranjc Brezar, Chloe Heranney, Chloe Heranney, Tilen Komel, Tilen Komel, Simon Buček, Simon Buček, Maja Čemažar, Maja Čemažar, Gregor Serša, Gregor Serša

“…By evaluating ECT’s potential for in situ vaccination, our goal was to pave the way for future advancements for its combination with emerging (immuno)therapies, leading to enhanced responses and outcomes.MethodsWe employed two mouse tumor models, the immunologically cold B16F10 melanoma and 4T1 mammary carcinoma, to explore both local and systemic (i.e., abscopal) antitumor effects following equieffective intratumoral ECT with BLM, OXA, and CDDP. …”
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Helicobacter pylori SlyD stabilizes TPT1 via hnRNPK and enhances OCT1-mediated CDX2 transcriptional activation to drive gastric intestinal metaplasia by Shuwen Zheng, Yingying Wang, Chuxuan Ni, Rui Guo, Xunan Qiu, Jijun Chen, Lu Wang, Xiaohu Sun, Moye Chen, Yunen Liu, Yuan Yuan, Yuehua Gong

“…However, the underlying mechanism remains undetermined. Methods Gastric epithelial cells were stimulated with H. pylori 26695, a SlyD inactivated mutant (ΔSlyD), and purified HpSlyD protein, respectively. …”
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Peri‐ictal yawning: A potential lateralizing sign in temporal lobe epilepsy by Xiaoping Du, Yi Yao, Jiani Chen, Xiaoping Yang, Lei Zhang, Yingying Tang, Xiaoting Hao, Dong Zhou, Shizhong Lian, Fengpeng Wang, Xiaobin Zhang, Meizhen Sun, Junhong Guo

“…We aimed to determine whether PY could serve as an indicator to help lateralize seizure onset during epileptic seizures. Methods Among 236 consecutive TLE patients admitted for video‐EEG monitoring, we analyzed the clinical characteristics, along with scalp video‐EEG, magnetic resonance imaging (MRI), fluorodeoxyglucose‐positron emission tomography (FDG‐PET), Wada test, and stereo EEG (SEEG) in patients with PY. …”
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Investigating mental health disparities in rural sexual and gender minority adults: protocol for the rural exploration and approaches to LGBTQ + Mental Health (REALM) prospective c... by Shoshanna L. Fine, Kalai Willis, Iaah L. Lucas, Kirsten F. Siebach, Jennifer L. Glick, Mariah Valentine-Graves, Savannah Winter, Michael Smith, Thomas Waltz, Gina Bailey Herring, Marissa Hannah, Holly C. Wilcox, Travis Sanchez, Stefan D. Baral, Sarah M. Murray

“…This paper describes the protocol for a prospective cohort study, “Rural Exploration and Approaches for LGBTQ + Mental Health (REALM),” that will explore minority stress in relation to mental health conditions and suicidal behaviors among rural SGM adults. Methods Online processes will be used to recruit and enroll a diverse sample of up to 2,500 SGM adults aged 18 + living in rural counties and small metropolitan areas in the United States to complete an online baseline survey. …”
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Development of a TCR-like antibody and chimeric antigen receptor against NY-ESO-1/HLA-A2 for cancer immunotherapy by Xin Liu, Yang Du, Ningyan Zhang, Zhiqiang An, Wei Xiong, Yixiang Xu, Bingnan Yin, Yuqian Huang, Junjun Chu, Changsheng Xing, Chen Qian, Tianhao Duan, Helen Y Wang, John S. Yu, Rongfu Wang

“…To mimic the feature of T-cell receptor (TCR) that recognizes the complex of major histocompatibility class I and peptide on the cell surface derived from the processed intracellular antigen, we used NY-ESO-1, a cancer-testis antigen, to develop a TCR-like fully human IgG1 antibody and its derivative, CAR-T cells, for cancer immunotherapy.Methods Human single-chain variable antibody fragment (scFv) phage library (~10∧11) was screened against HLA-A2/NY-ESO-1 (peptide 157–165) complex to obtain target-specific antibodies. …”
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Characteristics, clinical manifestations and management of leprosy in KwaZulu-Natal, South Africa: A 20-year retrospective study by J S Sons, Z N Mkhize, N C Dlova, C Aldous, P R Bhat, A V Chateau

“…To describe the biographical profile, clinical manifestations and treatment outcomes in patients with leprosy in KwaZulu-Natal Province. Methods. This retrospective study aimed to analyse the clinical data of leprosy patients in SA from 2002 to 2022. …”
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New clinical insights into the treatment of benign uretero‐ileal anastomotic stricture following radical cystectomy and urinary diversion by Yixuan Mou, Cenchao Yao, Zhenghong Liu, Pu Zhang, Xiaolong Qi, Dahong Zhang, Yiyang Chen, Weiwen Yu, Shuai Wang

“…To preserve residual renal function and improve prognosis, it is crucial to derive insights from experience and tailor individualized treatment strategies for different patients. Patients and Methods From October 2014 to June 2021, a total of 47 patients with benign UIAS underwent endoscopic management (n = 19) or reimplantation surgery (n = 28). …”
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Analytical Accuracy of a Continuous Glucose Monitor in Adult Diabetic KetoacidosisTake-Home Points by Nathan L. Haas, MD, Lynn Ang, MD, Nazanene H. Esfandiari, MD, Ahsan M. Khan, MBBS, James A. Cranford, PhD, Ashley Cohen, MD, Jordan Sell, MD, Mostafa Abdel-Hamid, MD, Kevin E. Romanchik, BSN, RN, Frederick K. Korley, MD, PhD

“…Research Question: What is the clinical and analytical accuracy of CGM in adults with DKA? Study Design and Methods: This was a prospective observational study at a single academic medical center emergency department. …”
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A randomized, double-blind, Phase 1, single- and multiple-dose placebo-controlled study of the safety and pharmacokinetics of IN-006, an inhaled antibody treatment for COVID-19 in... by Thomas R. Moench, Lakshmi Botta, Brian Farrer, Jason D. Lickliter, Hyunah Kang, Yoona Park, Cheolmin Kim, Marshall Hoke, Miles Brennan, Morgan D. McSweeney, Zachary Richardson, John B. Whelan, Jong Moon Cho, Soo Young Lee, Frances Faurot, Jeff Hutchins, Samuel K. Lai

“…We investigated the safety, tolerability, and pharmacokinetics of IN-006, a reformulation of regdanvimab for nebulized delivery by a handheld nebulizer. Methods: A Phase 1 study was conducted in healthy volunteers aged 18–55 a Phase 1 unit in Melbourne, Australia (ACTRN12621001235897). …”
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Tear glucose is associated with the presence and severity of diabetic retinopathy by Ningyao Cao, Lili Feng, Wei Xu, Fanglin He, Caiwen Xiao, Yan Liu, Weirong Xu, Jingjing Cui, Yuqian Guo, Lianqing Yao, Wenwen Xia, Fei Chen, Yong Li, Chuandi Zhou, Xiaofang Xu

“…Abstract Purpose To examine the association between tear glucose (TG) and the presence and severity of diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM). Methods A cross-sectional study. TG was examined by rapid qualitative test strip in 160 patients. …”
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Implementation of a genotyped African population cohort, with virtual follow-up: A feasibility study in the Western Cape Province, South Africa [version 2; peer review: 2 approved,... by Robert J Wilkinson, Francisco Lakay, Nicki Tiffin, Joel A Dave, Catherine Riou, Peter Raubenheimer, Anna K Coussens, Tsaone Tamuhla, Melissa J Blumenthal, Maleeka Abrahams

“…Background There is limited knowledge regarding African genetic drivers of disease due to prohibitive costs of large-scale genomic research in Africa. Methods We piloted a scalable virtual genotyped cohort in South Africa that was affordable in this resource-limited context, cost-effective, scalable virtual genotyped cohort in South Africa, with participant recruitment using a tiered informed consent model and DNA collection by buccal swab. …”
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Association between exposure to perfluoroalkyl and polyfluoroalkyl substances with estimated glomerular filtration rate: Mediating role of serum albumin by Hua Fang, Huajing Chang, Danjing Chen, Wenxin Qiu, Jiangwang Fang, Yunli Wu, Xian-E. Peng

“…However, the mediating role of albumin in PFAS-induced renal impairment and the identification of sensitive populations remain uninvestigated. Methods: This study included 9328 individuals from NHANES 1999–2018 with data on serum PFAS, creatinine, albumin, and covariates. …”
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GDF15 induces immunosuppression via CD48 on regulatory T cells in hepatocellular carcinoma by Meng Li, Yuan Gao, Wei Zhang, Zhijun Tan, Kuo Zhang, Zhaowei Wang, Lei He, Weina Li, Chuanyang Xu, Jieyu Zhang, Desheng Wang, Kefeng Dou, Ran Zhuang, Boquan Jin, Qiang Hao, Wangqian Zhang, Shuning Wang, Jintao Gu, Lei Shang, Haichuan Su, Yingqi Zhang, Cun Zhang

“…We investigated the selective mechanism exploited by HCC that lead to Treg cells expansion and to find more efficacious immunotherapies.Methods We used matched tumor tissues and blood samples from 150 patients with HCC to identify key factors of Treg cells expansion. …”
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Planetary health education in undergraduate medical education in Germany: results from structured interviews and an online survey within the national PlanetMedEd Project by Fabio Grieco, Sandra Parisi, Anne Simmenroth, Michael Eichinger, Michael Eichinger, Janina Zirkel, Janina Zirkel, Sarah König, Jana Jünger, Jana Jünger, Eva Geck, Eva-Maria Schwienhorst-Stich

“…This study therefore aimed (a) to assess the current implementation of Planetary Health in undergraduate medical education in Germany and (b) to explore its characteristics as a foundation to develop evidence-informed recommendations for mainstreaming Planetary Health Education in medical schools in Germany.MethodsThe study comprised structured interviews followed by an online survey, both targeting all 39 medical schools in Germany. …”
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