Sleep Disorders and Reproductive Health: Mechanisms, Consequences, and Potential Interventions by Magdalena Rosa-Bończak Rosa, Patrycja Marta, Filip Maciej Huzarski, Klaudia Anna Pawełek, Gabriela Monika Ferfecka, Agata Ossolińska, Natalia Morawiecka, Lucyna Stolarska, Oliver Carlton, Weronika Kłosowicz

“…The aim of this study is to analyze the impact of sleep disorders on reproductive health, focusing on the mechanisms, clinical consequences, and potential therapeutic interventions.     Materials and Methods This article is based on an analysis of scientific literature concerning the impact of sleep disturbances on reproductive health, utilizing data from databases such as PubMed, Frontiers, and Google Scholar. …”
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Increasing trend of antimicrobial resistance among methicillin-resistant Staphylococcus aureus strains in Southwest Finland, 2007–2016: An analysis of shifting strain dynamics and... by Jaakko Silvola, Kirsi Gröndahl-Yli-Hannuksela, Tiina Hirvioja, Kaisu Rantakokko-Jalava, Mari Kanerva, Kari Auranen, Harri Marttila, Jenna Junnila, Jaana Vuopio

“…To understand the implications of these changes to the management of MRSA, we sought to analyse the antimicrobial resistance (AMR) trends of MRSA in relation with patient characteristics. Methods: Antimicrobial susceptibility was determined for 10 clinically relevant antimicrobials. …”
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Prevalence of non-alcoholic fatty liver disease in out-patients of the Russian Federation: DIREG 2 study results by V. T. Ivashkin, O. M. Drapkina, I. V. Mayev, A. S. Trukhmanov, D. V. Blinov, L. K. Palgova, V. V. Tsukanov, T. I. Ushakova

“…Primary objective: to estimate the prevalence of NAFLD within the general practitioner’s and gastroenterologist’s patient flow.Materials and methods. The prospective disease registry was carried out as epidemiologic, observational, cross-sectional, multicenter investigation to assess NAFLD prevalence at outpatient practice in the Russian Federation. …”
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Predicting Multi-Scenario Land Use Changes and Soil Erosion in the Huaihe River Basin Based on Coupled PLUS-CSLE Model by GUO Weiling, XU Liuyang, JIA Jiang, GAO Chang, XIA Xiaolin, WANG Bangwen, ZHANG Jingyu, CHEN Lei, CHEN Yingjian

“…[Objective] Understanding the future temporal and spatial evolution of land use and soil erosion in the Huaihe River Basin is of significant importance for rational and coordinated use of land resources, formulating future soil and water conservation strategies, and promoting sustainable development strategies. [Methods] Based on the PLUS model and the Chinese Soil Loss Equation (CSLE), the land use patterns in the Huaihe River Basin under three scenarios—natural development, ecological protection, and rapid development—for the year 2030 were simulated, and the future soil erosion patterns in the basin under these three scenarios were predicted. …”
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Evaluating the effectiveness of integrated traditional Chinese and Western treatment based on symptom grading: a study protocol for a multi-center, randomized controlled trial of p... by Jiaxi Mai, Tingwei Zhou, Tingwei Zhou, Tingwei Zhou, Chen Wang, Chen Wang, Junrong Ye, Junrong Ye, Jiao Chen, Jiao Chen, Jiao Chen, Wen Wang, Wen Wang, Wen Wang, Yuanxin Pan, Yuanxin Pan, Yuanxin Pan, Yanheng Wei, Yanheng Wei, Lexin Yuan, Lexin Yuan, Hang Yang, Hang Yang, Shengwei Wu, Shengwei Wu, Jianxiong Guo, Jianxiong Guo, Jianxiong Guo, Aixiang Xiao, Aixiang Xiao, Aixiang Xiao

“…The proposed study presents a pilot trial to evaluate the effectiveness of interventions at different levels in improving depression status in community populations.MethodsA randomized controlled trial will be conducted in two communities in Guangdong, China, with a follow-up period of 12 weeks. …”
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Exploring patient preferences for intraocular lenses selection in age-related cataract: a discrete choice experiment study by Qiaolin Zhu, Qiaolin Zhu, Qiaolin Zhu, Qianqian Sun, Qianqian Sun, Qianqian Sun, Yujia Huo, Yujia Huo, Yujia Huo, Xiaoling Yang, Xiaoling Yang, Xiaoling Yang, Hehe Huang, Hehe Huang, Hehe Huang, Shanshan Qian, Shanshan Qian, Shanshan Qian, Wenjing Lin, Wentao Yan, Wentao Yan, Wentao Yan

“…IntroductionThis study investigates the preferences of cataract patients in East China regarding intraocular lenses (IOLs).MethodsA Discrete Choice Experiment (DCE) was conducted using a questionnaire that included various IOLs attributes. …”
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Ultrasonographic Assessment of Intima-Media Thickness (IMT), as a Surrogate of Future Atherosclerosis and Cardiac Diseases in Patients with Hashimoto’s Thyroiditis and Concomitant... by Maryam Alaei, Mohamad Ghazanfari Hashemi, Seyedeh Nooshin Miratashi Yazdi, Mohammad Ali Kaviani, Ali Asadifar, Sahand Adib Moradi, Khazar Adibmoradi Langaroudi, Helia Helali, Mina Mahboudi, Aynaz Gerami

“…In this study we aimed to evaluate the changes in sonographic appearance of the carotid artery and its mural thickness in patients with Hashimoto’s thyroiditis and concomitant Celiac disease, as a surrogate marker of atherosclerosis and a predictor of cardiovascular diseases. Materials and Methods: A total of 191 patients including 89 patients with only Hashimoto’s thyroiditis, 11 patients with Hashimoto’s thyroiditis and concomitant Celiac disease, and 91 healthy control subjects underwent ultrasound evaluation of intima-media thickness of carotid artery. …”
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Zooarchaeological investigation of the Hoabinhian exploitation of reptiles and amphibians in Thailand and Cambodia with a focus on the Yellow-headed Tortoise (Indotestudo elongata... by Bochaton, Corentin, Chantasri, Sirikanya, Maneechote, Melada, Claude, Julien, Griggo, Christophe, Naksri, Wilailuck, Forestier, Hubert, Sophady, Heng, Auertrakulvit, Prasit, Bowonsachoti, Jutinach, Zeitoun, Valéry

“…Additionally, we provide a baseline for future zooarchaeological studies and a methodological framework for the detailed analysis of archaeological turtle bones in continental Southeast Asia. …”
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The extent of intestinal involvement is closely related to the severity of IgAV: a risk stratification study based on CT by Yuanqiu Li, Ziman Xiong, Yufan Wang, Yuchen Jiang, Yaqi Shen, Xuemei Hu, Daoyu Hu, Zhen Li

“…Objectives To analyze the differences in clinical manifestations between children and adults with intestinal involvement in IgAV and to identify the specific subtypes requiring particular attention.Methods A systematic review of the HIS system was conducted on patient data from four centers at Tongji Hospital between January 2015 and October 2022. …”
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Phytomedicinal armamentarium: A review of inula racemosa-derived alantolactones and isoalantolactones in anticancer therapy by Joshi Gaurav Santoshrao, Smriti Jamwal, Rakesh Kumar, Ekta Bisht, Bisen Harsh Krishnakumar, Shreya Katoch, R.K. Asrani

“…The review focuses on understanding their mechanisms of action and potential as alternative cancer therapies. Methods: A comprehensive literature search was conducted using databases such as PubMed, Google Scholar, and Web of Science. …”
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Renal transplant recipient and deceased-donor risk profiles at Wits Donald Gordon Medical Centre, Johannesburg, South Africa: A 9-year review by F van der Schyff, M Barnard, B Ströbele, M de Jager, R Britz, P Gaylard, J Loveland

“…To investigate the role of these transplant risk scores in the South African (SA) setting. Methods. A total of 188 adult deceased-donor organ referrals over the 9-year period 1 January 2013 - 31 December 2021 were included. …”
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Impact of pharmacist-prescriber partnerships to track antibiotic prescribing in publicly funded primary care in the Cape Town metropole, South Africa: An implementation study by O Van Hecke, Y Adegoke, M Allwood, K von Pressentin, M Namane, C Butler, M Mendelson, R Coetzee

“…To assess the impact of a pharmacist-prescriber partnership to track antibiotic prescribing in publicly funded primary healthcare clinics in the Cape Town metropole, SA. Methods. We conducted a prospective observational study across five clinics where there was a dispensing pharmacist team. …”
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Assessment of awareness of keratoconus and its relation to eye rubbing among Saudi Arabia population by Nuwayyir Abdullah Alqasimi, Lujain Hatim Aljohani, Renato Ambrósio, Renato Ambrósio, Renato Ambrósio, Renato Ambrósio, Renato Ambrósio, Bader Saad AlQahtani, Bader Saad AlQahtani, Nasser Saleh Al Haydar, Bdour Raja Alanazi, Danah Tariq Alfurayhan, Lina Sami Hussain Saber, Fatemah Saleh Alsalem, Nawaf Abdullah Alqahtani, Jose Manuel Vargas

“…Eye rubbing has been recognized as one of the leading risk factors for KC.ObjectivesThis study aimed to assess the knowledge and awareness about KC and its relation to eye rubbing among the population of the Kingdom of Saudi Arabia.MethodsA cross-sectional study was conducted in 2024 among people residing in different regions of Saudi Arabia. …”
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Microbial dynamics of acute pancreatitis: integrating culture, sequencing, and bile impact on bacterial populations and gaseous metabolites by Agnieszka Chmielarczyk, Edyta Golińska, Anna Tomusiak-Plebanek, Natalia Żeber-Lubecka, Natalia Żeber-Lubecka, Maria Kulecka, Maria Kulecka, Antoni Szczepanik, Katarzyna Jedlińska, Krzysztof Mech, Konrad Szaciłowski, Agata Kuziak, Agata Pietrzyk, Magdalena Strus

“…Additionally, we sought to determine the association between later onset of AP and diverticulitis.MethodsFollowing clinical materials from the patient in the initial phase of AP were collected: rectal swab, colostomy bag contents (in the publication referred to as stoma content/stool) and peripancreatic fluid. …”
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Deciphering the generation of heterogeneity in esophageal squamous cell carcinoma metastasis via single-cell multiomics analysis by Kaiwen Sheng, Jun Chen, Ruitang Xu, Haoqiang Sun, Ran Liu, Yongjie Wang, Wenwen Xu, Jiao Guo, Miao Zhang, Shuai Liu, Juan Lei, Yawen Sun, Yang Jia, Dianhao Guo

“…Examining the chromatin accessibility of ESCC at single-cell level is imperative to understand how it activates oncogenes and contributes to the onset and metastasis of ESCC. Methods We performed single-cell assay for transposase-accessible chromatin sequencing (scATAC-seq) on cancerous and adjacent noncancerous tissues from four ESCC patients who were pathological staged as T1a, T2b, T3b, or T4a, to investigate whether regulatory elements are pivotal in instigating cellular heterogeneity during ESCC metastasis. …”
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Protein tyrosine phosphatase delta is a STAT3-phosphatase and suppressor of metabolic liver disease by Thomas F Baumert, Charlotte Bach, Patrick Pessaux, Catherine Schuster, Frank Jühling, Sarah C Durand, Yujin Hoshida, Fabien Zoulim, Atish Mukherji, Naoto Fujiwara, Marine A Oudot, Armando Andres Roca Suarez, Michel L Tremblay, Barbara Testoni, Joachim Lupberger, Romain Parent, Laurent Mailly, Nassim Dali-Youcef, Emanuele Felli, Maria Saez-Palma, Julien Moehlin, Alessia Virzì, Nicolas Brignon, Eugenie Schaeffer, Romain Martin, Laura Meiss-Heydmann, Zakaria Boulahtouf, Lea Girard, Emma Osswald, Carole Jamey, Daniel Brumaru, Bhuvaneswari Koneru

“…However, the PTPRD-expressing hepatic cell types, signalling pathways responsive to PTPRD and their role in non-viral liver disease are largely unknown.Methods We studied PTPRD expression in single-cell and bulk liver transcriptomic data from mice and humans, and established a Ptprd-deficient mouse model for metabolic dysfunction-associated steatohepatitis (MASH). …”
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The association between TyG index and cardiovascular mortality is modified by antidiabetic or lipid-lowering agent: a prospective cohort study by Changchang Fang, Nanqin Peng, Jiang Cheng, Xiyu Zhang, Wenli Gu, Zicheng Zhu, Xiaoping Yin, Zhiwei Yan, Jing Zhang, Peng Yu, Xiao Liu

“…This study aimed to evaluate whether the association between the TyG index and CVD mortality is influenced by the use of antidiabetic and hypolipidemic agents, given their potential modifying effects on the TyG index. Methods Participants from the National Health and Nutrition Examination Survey (1999–2018) were included in the study. …”
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Inflamed immune phenotype predicts favorable clinical outcomes of immune checkpoint inhibitor therapy across multiple cancer types by Jeanne Shen, Sergio Pereira, Chan-Young Ock, Yung-Jue Bang, Seulki Kim, Sehhoon Park, Se-Hoon Lee, George A Fisher, Young Kwang Chae, Yoon-La Choi, Jin-Haeng Chung, Tony S K Mok, Leeseul Kim, Jun-Eul Hwang, Gahee Park, Sanghoon Song, Seunghwan Shin, Yoojoo Lim, Wonkyung Jung, Heon Song, Hyojin Kim, Taebum Lee, Sukjun Kim, Chang Ho Ahn, Seokhwi Kim, Ben W Dulken, Stephanie Bogdan, Maggie Huang, Chiyoon Oum, Siraj M. Ali

“…Here, we investigate artificial intelligence (AI)-based immune phenotypes capable of predicting ICI clinical outcomes in multiple solid tumor types.Methods Lunit SCOPE IO is a deep learning model which determines the immune phenotype of the tumor microenvironment based on TIL analysis. …”
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Did the resurgence of childhood lower respiratory infections offset the initial benefit of COVID-19-related non-pharmaceutical interventions in children? A time-series analysis by Inès Fafi, Zein Assad, Léa Lenglart, Zaba Valtuille, Florentia Kaguelidou, Camille Aupiais, Aurélie Bourmaud, Alexis Rybak, Stéphane Bechet, Corinne Levy, Robert Cohen, Bruno Frandji, Andreas Werner, François Angoulvant, Romain Basmaci, Naïm Ouldali

“…Whether this recent upsurge overwhelms the initial benefit of NPI remains unknown. Methods We conducted an interrupted time-series analysis based on exhaustive national surveillance systems. …”
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Yiqi Fumai Lyophilized injection protects cardiac contractility in a rat model of heart failure with reduced ejection fraction by modulating SERCA2 by Yongwei Nie, Lu Chen, Yanxin Zhang, Yuqing Yao, Zizhuo Xue, Na Guo, Meixiu Wan, Zhi Li, Chunhua Liu, Dekun Li, Aichun Ju

“…Compensation for the malfunction of these proteins is considered a practical option for restoring heart function. Methods: Coronary artery ligation was used to induce heart failure with reduced ejection fraction (HFrEF) in Sprague-Dawley rats. …”
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