AKT1-Mediated NOTCH1 phosphorylation promotes gastric cancer progression via targeted regulation of IRS-1 transcription by Lingshan Zhou, Yuan Yang, Qian Qiao, Yingying Mi, Yuling Gan, Ya Zheng, Yuping Wang, Min Liu, Yongning Zhou

“…Abstract Purpose This study aimed to investigate that AKT1-Mediated NOTCH1 phosphorylation promotes gastric cancer (GC) progression via targeted regulation of IRS-1 transcription. Methods The study utilized databases such as PhosphositePlus, TRANSFAC, CHEA, GPS 5.0, and TCGA, along with experimental techniques including Western Blot, co-IP, in vitro kinase assay, construction of lentiviral overexpression and silencing vectors, immunoprecipitation, modified proteomics, immunofluorescence, ChIP-PCR, EdU assay, Transwell assay, and scratch assay to investigate the effects of AKT1-induced Notch1 phosphorylation on cell proliferation, invasion and migration in vitro, as well as growth and epithelial-mesenchymal transition (EMT) in vivo. …”
Get full text

El Zika, un Virus Transmitido por Mosquitos by Jorge R. Rey, L. Phil Lounibos, Barry W. Alto, Nathan D. Burkett-Cadena, Cynthia C. Lord, Chelsea T. Smartt, C. Roxanne Rutledge Connelly

“…A history of the virus and its migration are included, along with some details about the virus in the state of Florida and preventative measures people can take to avoid infection. …”
Get full text

HACE1 protects against myocardial ischemia–reperfusion injury via inhibition of mitochondrial fission in mice by Bang-Xia Liu, Juan Zheng, Zhan-Wei Tang, Lei Gao, Meng Wang, Ying Sun, Chen Chen, Heng-Chen Yao

“…However, little is known about the role of HACE1 in the pathogenesis of myocardial I/RI. Methods Male C57BL6 mice with HACE1 knockout (KO) were subjected to 30 min of ischemia via ligation of the left anterior descending artery, followed by 0, 2, 6, or 24 h of reperfusion. …”
Get full text

Bloodstream infections at a tertiary hospital in the Gambia - a one-year retrospective study by Paul Rahden, Ebrima Barrow, Haddy Bah, Sheikh Omar Bittaye, David Nygren, Abdoulie Badjan

“…This study describes causes of bloodstream infections and antimicrobial resistance at a tertiary hospital in The Gambia. Methods This retrospective analysis included all blood cultures performed at the Edward Francis Small Teaching Hospital, Banjul, The Gambia, from September 2022 to August 2023. …”
Get full text

Follicular Occlusion Syndrome — a Possible Option of Follicular-Retension Origin of Pilonidal Sinus by D. D. Shlyk, M. N. Pikuza, Yu. E. Kitsenko, A. S. Pirogova, N. B. Paramonova, R. T. Rzaev, N. P. Teplyuk, P. V. Tsarkov

“…Аim: to analyze and evaluate the clinical and morphological manifestations of pilonidal sinus disease (PSD) as a part of follicular occlusion syndrome (FOS).Materials and methods. In the Clinic of Coloproctology and Minimally Invasive Surgery, 80 patients with PSD underwent surgeries from November 2018 to December 2019: 62 (77.5 %) patients — with primary PSD, 18 (22.5 %) — with recurrence of the disease.Results. …”
Get full text

ENERGY AND ECONOMIC EFFICIENCY OF BIOETHANOL PRODUCTION DEPENDING ON THE QUALITY OF CORN GRAIN by Vitalii Palamarchuk, Roman Lohosha, Vadim Krychkovskyi

“…The elements of the yield structure, including the productivity of maize hybrids, were determined in accordance with established methods. The harvesting and accounting of the crop was conducted manually at each experimental site, followed by weighing and conversion to standard grain moisture. …”
Get full text

Behavioral representations within the endogenous dual attentional pathways during audiovisual integration processing by Zhongtian Guan, Mingli Yan, Miao He, Yubo Liu, Zhixi Zhang, Chunlin Li

“…However, the cognitive strategies and neural mechanisms involved in audiovisual integration under endogenous attentional modulation are unclear, and in particular, the functional relationship between the dorsal and ventral pathways still needs to be thoroughly investigated.MethodsWe design only auditory (A), only visual (V), and audiovisual attention (VA) tasks based on the classical Posner paradigm with spatial, temporal and neutral cues for behavioral indicators, brain activation, and their correlations.ResultsOur results showed significant differences in behavioral performance between tasks, with weaker performance on the dual-channel task than on the single-channel task. …”
Get full text

Utilization, Demand, And Willingness to Pay for Telehealth Services: A Study of Patients in Selected Vietnamese Provinces by Hung Ta, Hoan Van Vu, Thu Xuan Mai, Hieu Thi Minh Nguyen, Toan Thanh Thi Do, Hoat Ngoc Luu

“…This study aimed to describe the utilization, demand, and willingness to pay for Telehealth services in selected provinces in Vietnam. Methods: A cross-sectional survey involving 438 participants from three Vietnamese provinces was conducted between late 2021 and early 2022. …”
Get full text

Higher Levels of Postoperative Mobility and Activity as Measured by the AM-PAC 6 Clicks Instrument Are Associated with Improved Outcomes after Lumbar Fusion by Parimal Rana, Jane C. Brennan, Andrea H. Johnson, Justin J. Turcotte, Chad M. Patton

“…This study aimed to explore the relationship between patient mobility and activity, measured by the Activity Measure for Post-acute Care (AM-PAC) “6-Clicks” assessment and postoperative outcomes in lumbar fusion patients. Methods: A retrospective review of 306 lumbar fusions (105 with 6-Clicks mobility and 289 with 6-Clicks activity scores) was conducted. …”
Get full text

Genomic characterization and molecular predictive biomarkers for chemotherapy in patients with metastatic triple-negative breast cancer treated in a real-world setting by Erik Olsson, Henrik Lindman, Evangelos Digkas, Viktoria Thurfjell, Haidar Mir Ali, Ute Krüger, Anna-Karin Wennstig, Marie Sundqvist, Antonios Valachis

“…Purpose: We aimed to characterize genomic alterations with potential prognostic or predictive significance in patients with metastatic triple-negative breast cancer (mTNBC) treated with chemotherapy in a real-world setting. Patients and methods: Next-generation sequencing with FoundationOne® CDx was conducted primarily on primary tumor tissue from 112 consecutive patients with mTNBC. …”
Get full text

Relationship between caries indexes and obesity in a sample of Puerto Rican adolescents by Lydia M. Lopez del Valle, Mariely Nieves-Plaza, Sona Rivas-Tumanyan, Rosana Hanke-Herrero

“…This study aimed to evaluate the association between caries and obesity in adolescents.MethodsThis was a cross-sectional study of a convenience sample of 187 Puerto Rican adolescents aged 13–19 years, attending, among them, five high schools. …”
Get full text

Elevated fasting serum xylitol levels are associated with a lower risk of incident type 2 diabetes among individuals with prediabetes in the Chinese population by Yicheng Qi, Xiaoyong Li, Yu Liu, Meng Wang, Yiming Wu, Qing Su, Li Qin, Jing Ma

“…Although polyols affect glycometabolism, little is known about the association between fasting serum polyol levels of participants with habitual diet and the risk of prediabetes progressing to type 2 diabetes. Methods In this nested case-control study, 180 participants who developed from prediabetes to type 2 diabetes (progressors), and 180 matched controls (non-progressors) with prediabetes during a 3.5-year follow-up were enrolled. …”
Get full text

Burden assessment of podoconiosis in Wayu Tuka woreda, east Wollega zone, western Ethiopia: a community-based cross-sectional study by Kebede Deribe, Gail Davey, Kenate Bekele, Tsige Amberbir, Geleta Tadele, Abdi Samuel

“…This study was conducted in Wayu Tuka ‘woreda’ (district), western Ethiopia to determine the prevalence of podoconiosis and assess factors associated with acute adenolymphangitis (ALA) episodes.Methods and analysis A two phase, community-based cross-sectional study was conducted between January and March 2015. …”
Get full text

Comparative analysis of viability, proliferation, and mineralization potential of human pulp and osteoblastic cells exposed to different bioceramic endodontic sealers by Marcos Coelho Santiago, Gustavo Henrique de Oliveira Salles, Gustavo Gomes de Lima, Laudimar Alves de Oliveira, Loise Pedrosa Salles

“…Background: The present study aimed to compare the viability, proliferation, and mineralization potential of human dental pulp cells (hDPCs) and osteoblasts cell line (Saos-2) after exposure to AH Plus® Bioceramic (AHP-B), Bio-C® Sealer (BIO-C), NeoMTA Plus® (NEOMTA-P), and MTA-FILLAPEX® endodontic sealers (MTA-F). Methods: All materials were prepared according to the manufacturer's instructions. …”
Get full text

Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis by Ritin Fernandez, Heidi Green, Arti Muley, Prasad Muley

“…Objective: To evaluate effectiveness of thiamine supplementation on glycaemic outcomes in patients with T2DM.Methods Eligibility criteria: Studies that assessed effect of thiamine supplementation in adults with T2DM which measured glycaemic outcomes—HbA1c, fasting blood glucose (FBG) and/or postprandial blood glucose (PPG) were included. …”
Get full text

Clinical efficacy and learning curve of percutaneous endoscopic cervical discectomy for symptomatic cervical spondylotic radiculopathy by Xiao Sun, Lijuan Zhan, Zhongxin Tang, Mingkui Shen, Haijun Ma, Jun Tan

“…Abstract Background This study aimed to evaluate the clinical efficacy and learning curve of percutaneous endoscopic cervical discectomy (PECD) in treating patients with symptomatic cervical spondylotic radiculopathy (CSR). Methods A total of 105 patients with single-segment symptomatic CSR treated between January 2020 and January 2022 were retrospectively analyzed and divided into PECD and ACDF groups based on the surgical approach. …”
Get full text

Hydroxocobalamin for the treatment of vasoplegia after lung transplantation: A case series by Anh Nguyen, MD, PhD, Rima Bouajram, PharmD, Marek Brzezinski, MD, Sahand Hassanipour, David Gordon, Binh Trinh, MD, Tobias Deuse, MD, Aida Venado, MD, Steve Hays, MD, Jonathan Singer, MD, Jasleen Kukreja, MD, MPH

“…We present a series of 3 cases where hydroxocobalamin was used to treat postoperative vasoplegia. Methods: We conducted a single-center, retrospective review of lung transplantation recipients from January 2016 to December 2020. …”
Get full text

The Effect of Volitional Preemptive Abdominal Contraction on Biomechanical Measures During A Front Versus Back Loaded Barbell Squat by Joseph B. McCormick, Alexander S. Drusch, Darragh J. Lynch, Gesine H. Seeber, Katherine F. Wilford, Troy L. Hooper, Brad S. Allen, Dennis G. O’Connell, Maria J. Mena-Iturriaga, Kinyata J. Cooper, Phillip S. Sizer

“… # Study Design Controlled Laboratory Study # Methods Healthy male subjects with the ability to perform a sub-maximal loaded barbell squat lift were recruited. …”
Get full text

Liver Transplantation for Acute Liver Failure due to Mushroom Poisoning by Hayri Canbaz, Attila Bestemir, Sami Akbulut, Sezai Yilmaz, Yusuf Yavuz

“…The aim of this study is to retrospectively evaluate the results of patients who underwent liver transplantation due to mushroom poisoning. Materials and Methods: In this descriptive and observational study, the demographic and clinical data of 26 patients who presented to emergency units due to clinical features of acute hepatic failure secondary to mushroom poisoning between October 2008 and November 2023 and who underwent emergent liver transplantation were retrospectively reviewed. …”
Get full text

A cross-sectional study of the current status of psychological health and its correlation with academic performance in medical students: taking medical students in a medical univer... by Han Chunhong, Han Chunhong, Ding Jingjing, He Huan, Zheng Peiyao, Zhang Xiaona, Yang Xiaowen, Zheng Aiming

“…This study examines the psychological health of medical students in a Chinese university and its impact on academic performance, aiming to inform targeted interventions.Methods2022 undergraduate and postgraduates from an independent medical university in Eastern China were selected to score using the Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7(GAD-7), Insomnia Severity Index (ISI), Perceived Stress Scale (PSS), and Beck Scale for Suicide Ideation(BSSI); and the total grade point averages (GPAs) of 2022 undergraduates in the first and second academic years were determined to analyse the main psychological influencing factors.ResultsThe general survey of 2022 new medical students at admission showed that the various scores of postgraduates were higher than those of undergraduates. …”
Get full text