Adipocyte heterogeneity and tumor infiltration of adipose tissue in patients with metastatic breast cancer by Hava Izci, Gitte Zels, Anirudh Pabba, Marion Maetens, François Richard, Maxim De Schepper, Josephine Van Cauwenberge, Ha-Linh Nguyen, Kristien Borremans, Sophia Leduc, Karen Van Baelen, Sigrid Hatse, Tatjana Geukens, Amena Mahdami, Hans Wildiers, Patrick Neven, Wouter Van Den Bogaert, Giuseppe Floris, Christine Desmedt

“…This study therefore investigates regional variations in adipocyte size and adipose tissue tumor infiltration in patients with metastatic breast cancer. Methods: Within the UPTIDER rapid autopsy program, (NCT04531696), 94 adipose tissue samples from subcutaneous, visceral, retroperitoneal, and mammary depots of 22 patients with metastatic breast cancer were collected and analyzed. …”
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Impact of long-term cyanotoxin exposure on cattle: Biochemical, histological, and oxidative stress assessment by Mounira Bensalem, Amina Amrani, Hadjer Zaidi, Fateh Sedrati, Omar Laouar, Zhi Wang, Hichem Nasri

“…Aligning with the “One Health” framework, the research evaluates the biochemical, histological, and oxidative stress impacts of MCs on livestock as environmental sentinels. Materials and Methods: A herd of 40 cattle (20 exposed and 20 non-exposed) was studied during the summer bloom period of 2019. …”
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Prognostic value of tumor‐infiltrating lymphocytes and PD‐L1 expression in esophageal squamous cell carcinoma by Jie Hu, Takeshi Toyozumi, Kentaro Murakami, Satoshi Endo, Yasunori Matsumoto, Ryota Otsuka, Tadashi Shiraishi, Shinichiro Iida, Hiroki Morishita, Tenshi Makiyama, Yuri Nishioka, Masaya Uesato, Koichi Hayano, Akira Nakano, Hisahiro Matsubara

“…The purpose of this study was to investigate the interactions and clinical significance of PD‐L1 expression and TILs in ESCC. Methods Tissue specimens were collected from 126 patients with ESCC who underwent curative esophagectomy. …”
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Prevalence of Japanese encephalitis in pigs in Mainland China during 2000–2024: a systemic review and meta-analysis by Xue-Tong Liu, Li-Dong Jiang, Yu-Ting Lin, Ran Zhao, Qi Wang, Shu-Ying Zhang, Shu-Ying Zhang, Shu-Ying Zhang, Emad Beshir Ata, Xin Liu, Yuan Wang, Zi-Xuan Liu, Cui Xu, Ying Xiao, Yi-Fan Wang, Xue Leng, Qing-Long Gong, Rui Du, Rui Du, Rui Du

“…This study aimed to analyze the factors contributing to JE occurrence in pigs across China.MethodsA systematic search was done using six databases for the published epidemiological studies on porcine JE, including the Chinese Web of Knowledge (CNKI), Wan Fang Database, ScienceDirect, Web of Science, VIP Chinese Journal Database, and PubMed.ResultsA meta-analysis of 31 studies from 2000 to 2024 found an overall prevalence of 35.2% (95% CI: 25.1–46.1). …”
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Post-treatment of rat aflatoxicosis by camel milk and silymarin by Nahla H. Hassaneen, Shabaan A. Hemeda, Abeer F. El Nahas, Ghadeer M. Albadrani, Muath Q. Al-Ghadi, Zuhair M. Mohammedsaleh, Sabreen E. Fadl, Eman M. El-Diasty, Hader I. Sakr, Hader I. Sakr

“…In addition, camel milk and silymarin reduce the impact of AFB1 on the hematology, serum biochemical markers, histopathology of the liver and testes, and expression of the inflammatory, antioxidant, and male reproductive genes.Methods40 rats were used to evaluate the beneficial effect of silymarin and camel milk against aflatoxin B1 (AFB1) toxicity in rats. …”
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Advancing the understanding of Naegleria fowleri: Global epidemiology, phylogenetic analysis, and strategies to combat a deadly pathogen by Awadh Alanazi, Sonia Younas, Hasan Ejaz, Muharib Alruwaili, Yasir Alruwaili, Bi Bi Zainab Mazhari, Muhammad Atif, Kashaf Junaid

“…This review provides a detailed overview of N. fowleri epidemiology, transmission dynamics, phylogenetic diversity, state-of-the-art diagnostic techniques, therapeutic approaches, and preventive measures. …”
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Antitumor effects of natural killer cells derived from gene-engineered human-induced pluripotent stem cells on hepatocellular carcinoma by Mayuna Nakamura, Yuka Tanaka, Keishi Hakoda, Masahiro Ohira, Tsuyoshi Kobayashi, Kenji Kurachi, Kouichi Tamura, Hideki Ohdan

“…Abstract Mortality and recurrence rates of hepatocellular carcinoma (HCC) remain high despite the use of various treatment methods. Recently, cell-based immunotherapy using natural killer (NK) cells has attracted considerable attention in cancer immunotherapy. …”
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Striking a balance between aesthetics and safety: a comparative study on the maternal and neonatal outcomes of mini-incision cesarean section by ChunLan Yuan, ShiMei He, WenQian Jian, MeiRong He, HuiFang Huang, JianChun Huang, MeiPing He, KaiSun Zhao

“…The aim of this study is to compare the risks and outcomes of mini-incision cesarean sections with those of conventional incision cesarean sections. Methods A total of 99 pregnant women with full-term singleton pregnancies, who delivered at the Second Nanning People's Hospital from January 2024 to September 2024, were enrolled in this study. …”
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Rapid aging of influenza epidemics in China from 2005/06 to 2016/17: A population-based study by Weibo Tang, Hao Lei, Nan Zhang, Yaojing Wang, Shimeng Cai, Shuyi Ji, Lei Yang, Mengya Yang, Can Chen, Shigui Yang, Dayan Wang, Yuelong Shu

“…However, there is limited knowledge regarding the aging of influenza epidemics, which is crucial for estimating the disease burden. Methods: We collected weekly influenza surveillance data from 2005/06 to 2016/17, and quantified the aging of influenza-like illness (ILI) and influenza virus-positive cases in China via the mean age of the influenza cases and the proportion of individuals aged 65 and above among the influenza cases. …”
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Effects of low, moderate, and high-intensity aquatic exercise on joint edema in induced rat knee arthritis by Alline Mardegan Mioto, Daniel Fernando dos Reis, Thiago Alves Garcia, Guilherme Akio Tamura Ozaki, Iara Buriola Trevisan, Rodrigo Metzker Pereira Ribeiro, Robson Chacon Castoldi, José Carlos Silva Camargo Filho

“…Objective: To evaluate the impact of low-, moderate-, and high-intensity physical exercise on induced arthritis. Methods: Twenty 60-day-old rats were divided into 5 groups: Control Group Arthritis (GCA), Control Group Placebo (GCP), Group Low Physical Activity (GL), Group Moderate Physical Activity (GM), and Group Intense Physical Activity (GI). …”
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The effects of maternal health literacy, family functioning and self-efficacy on antepartum depression in pregnant women in China: a moderated mediation model by Ling Zhang, Li Ren, Hongyu Li, Haiyan Qiu, Hong Yang, Xiaolan Shi, Honghui Rong, Chuanfen Zheng, Fengju Li, Ting Luo, Lu Lu, Enyu Lei, Dali Yi, Ji-an Chen

“…Therefore, this study aimed to explore the associations between these factors and whether MHL and SE mediate the relationship between FF and AD. Methods This cross-sectional study included 1392 pregnant women from 6 hospitals in Chongqing, China. …”
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Affective touch enhances low gamma activity during hand proprioceptive perception in children with different neurodevelopmental conditions by Álvaro Sabater-Gárriz, Álvaro Sabater-Gárriz, Álvaro Sabater-Gárriz, Álvaro Sabater-Gárriz, José Antonio Mingorance, José Antonio Mingorance, José Antonio Mingorance, Francesc Mestre-Sansó, Vicent Canals, Yannick Bleyenheuft, Pedro Montoya, Pedro Montoya, Inmaculada Riquelme, Inmaculada Riquelme, Inmaculada Riquelme

“…The modulation of gamma oscillations by different types of tactile stimuli, including affective touch, is not well understood, particularly in children with neurodevelopmental disorders such as cerebral palsy and autism spectrum disorder.AimsThis study aims to explore how affective touch influences gamma oscillatory activity and proprioceptive performance in children with typical development, cerebral palsy and autism spectrum disorders.Methods and proceduresEEG data were recorded from participants during passive wrist mobilizations under three conditions: following an affective touch stimulus, after a non-affective touch stimulus, and with no tactile stimulation. …”
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Preoperative liquid biopsy transcriptomic panel for risk assessment of lymph node metastasis in T1 gastric cancer by Ping’an Ding, Jiaxiang Wu, Haotian Wu, Wenqian Ma, Tongkun Li, Peigang Yang, Honghai Guo, Yuan Tian, Jiaxuan Yang, Limian Er, Renjun Gu, Lilong Zhang, Ning Meng, Xiaolong Li, Zhenjiang Guo, Lingjiao Meng, Qun Zhao

“…Current pathological assessments often misclassify patients, leading to unnecessary radical surgeries. Methods Through analysis of transcriptomic data from public databases and T1 GC tissues, we identified a 4-mRNA panel (SDS, TESMIN, NEB, and GRB14). …”
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The phytohormone abscisic acid enhances remyelination in mouse models of multiple sclerosis by Femke Van Gaever, Femke Van Gaever, Fleur Mingneau, Fleur Mingneau, Sam Vanherle, Sam Vanherle, Yasmine Driege, Yasmine Driege, Mira Haegman, Mira Haegman, Elien Van Wonterghem, Elien Van Wonterghem, Junhua Xie, Junhua Xie, Roosmarijn E. Vandenbroucke, Roosmarijn E. Vandenbroucke, Jerome J. A. Hendriks, Jerome J. A. Hendriks, Rudi Beyaert, Rudi Beyaert, Jens Staal, Jens Staal, Jens Staal

“…ABA, which is abundant in fruits such as figs, apricots and bilberries, is known to cross the blood-brain barrier and has demonstrated neuroprotective effects in conditions like depression and Alzheimer's disease.MethodsIn this study, we investigated whether ABA supplementation enhances remyelination in both ex vivo and in vivo mouse models.ResultsOur results indicated that ABA enhanced remyelination and that this enhanced remyelination is associated with increased lipid droplet load, reduced levels of degraded myelin, and a higher abundance of F4/80+ cells in the demyelinated brain of mice treated with ABA. …”
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Phenylalanine-derived β-lactam TRPM8 antagonists: revisiting configuration and new benzoyl derivatives by Cristina Martín-Escura, Maria Angeles Bonache, Alicia Medina-Peris, Thomas Voets, Antonio Ferrer-Montiel, Asia Fernández-Carvajal, Rosario González-Muñiz

“…Aim: To expand the understanding of the structure-activity relationship within a family of amino acid-derived β-lactam TRPM8 (transient receptor potential melastatin channel, subtype 8) antagonists, this work investigated both the configuration-dependence of potency and selectivity, and explored strategies for increasing total polar surface area (TPSA). Methods: Diastereoisomeric compounds derived from H-Phe-OtBu, and analogues incorporating differently substituted benzoyl groups, were synthesized by stereoselective solution pathways. …”
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A patient-led survey on information and communication needs of patients with metastatic breast cancer in Ireland and Northern Ireland (CTRIAL-IE 23–05) by Siobhan Gaynor, Yvonne O'Meara, Emer Mulvaney, Rachel J. Keogh, Catherine S. Weadick, Fran J. Duane, Ann Mc Brien, Helen Greally, Mary Jane O'Leary, Ieva Teiserskyte, Isabel Beristain, Jacinta Marron, Eibhlin Mulroe, Vicky Donachie, Sarah Mc Loughlin, Seamus O'Reilly

“…Introduction: Although treatment advances have improved survival rates for patients with metastatic breast cancer (MBC), patient expressed needs have not been evaluated in Ireland to date. Methods: A 76 item questionnaire was designed by the lead author and a cohort of 41 other MBC patients in collaboration with a multidisciplinary team. …”
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A comprehensive analysis of the epidemiological and genomic characteristics of global Serratia Marcescens by Wenqin Chen, Zheqian Li, Jie Zheng, Danwei Wang, Shuo Gao, Wanqing Zhou, Han Shen, Yan Zhang, Xiaoli Cao

“…Objective: To analyse the epidemiological and genomic characteristics of S. marcescens at a global scale. Methods: High-quality genomes of S. marcescens were retrieved from NCBI and annotated using Prodigal. …”
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PCR-detection rates of T. pallidum ssp. pallidum in swab samples from the Czech Republic (2004–2022): Combined RPR, IgM, and PCR tests efficiently detect active syphilis by Eliška Vrbová, Petra Pospíšilová, Eliška Dastychová, Martina Kojanová, Miluše Kreidlová, Daniela Vaňousová, Filip Rob, Přemysl Procházka, Alena Krchňáková, Vladimír Vašků, Radim Strnadel, Olga Faustmannová, Monika Dvořáková Heroldová, Ivana Kuklová, Hana Zákoucká, David Šmajs

“…However, parallel testing with these methods was even more effective, i.e., RPR + PCR was 96.1 % effective and RPR + IgM + PCR was 97.8 % effective. …”
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The Treatment Effect of Plantago Major on Lung Cancer Based on the Computed Tomography and Pathological Findings: A Case Report Study by Saade Abdalkareem Jasim, Bashar Mudhaffar Abdullah, Patricio Yánez-Moretta, Wesam R. Kadhum, Yasser Fakri Mustafa, Enas R. Alwaily, Munther Abosoda, Ali Alsalamy, Sada Ghalib Al-Musawi, Alaa A. Omran

“…The treatment effect of PM was assessed and presented based on CT and laboratory examinations for this patient as a first human case study. Materials and Methods: A 64-year-old woman, with gastrointestinal bleeding as well as high Erythrocyte Sedimentation Rate (ESR) and C-Reactive Protein (CRP) levels, was examined by the chest CT scan for suspicious lung cancer. …”
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GNA15 predicts poor outcomes as a novel biomarker related to M2 macrophage infiltration in ovarian cancer by Qin Liu, Qin Liu, Yabing Sun, Yabing Sun, Tao Zhang, Wanrun Lin, Jing Zhang, Huijuan Zhang, Huijuan Zhang, Wenxin Zheng, Hong Xu, Hong Xu, Feng Zhou, Feng Zhou

“…This study aims to establish a novel prognostic signature and identify M2-like TAM-related biomarkers in OC using RNAseq-based transcriptome analysis.MethodsPrognostic M2-like TAM-related genes were identified through univariate Cox regression, consensus clustering, and LASSO regression. …”
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