Bicyclic peptide-enhanced covalent inhibitor of SARS-CoV-2 3CL protease by Qian Wang, Yanhui Wang, Jian Li, Hong Liu, Shiyu Chen

“…Enhance the potency of the discovered bicyclic peptides for potential development into anti-SARS-CoV-2 drugs. Methods: Rational design was employed to discover the initial bicyclic peptide—warhead conjugates. …”
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Effects of Coach’s Verbal Encouragement During Small-Sided Volleyball Games on Specific Physical Fitness and Technical-Tactical Behavior of Youth Athletes by Taufiq Hidayat, Irma Febriyanti, Advendi Kristiyandaru, Suroto, Hari Wisnu, Ahmet Kurtoğlu, Amayra Tannoubi, Joseph Lobo, Baglan Yermakhanov, Jarosław Muracki, Edi Setiawan

“…Purpose: This study aims to investigate the impact of coach’s verbal encouragement small-sided volleyball games (CVESSVG) towards specific physical performance, and technical-tactical behavior among youth athletes. Methods: There were forty youth male volleyball athletes involved in this study, which were allocated in CVESSVG (n = 20), and small-sided game-non coach’s verbal encouragement (SSG-non CVE) (n = 20). …”
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Delphi consensus survey: the opinions of patients living with refractory ulcerative proctitis and the health care professionals who care for them by Philip Smith, Stuart Bloom, Christian Selinger, Ailsa Hart, Christopher Lamb, Anjan Dhar, Helen Steed, Matthew Brookes, Jonathan Macdonald, Ian Arnott, Shellie Radford, Gordon W Moran, Susan Ritchie, Victoria Fletcher, Jonathan Segal, N Sharma, Shahida Din, Daniel Gaya, J Butterworth, S Andrews, P Adams, Deborah Morris, Pearl Avery, Philip Oppong, Mario Guslandi, Maro Kyriacou, Rachel Linger, Madhoor Ramdeen, John Appleton, John Anneh, B Kussel

“…The aim of this study was to establish a consensus on the thoughts and opinions related to refractory proctitis disease burden and best practice for management.Methods A three-round Delphi consensus survey was conducted among patients living with refractory proctitis and the healthcare experts with knowledge on this disease from the UK. …”
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Therapeutic potential of mesenchymal stem cell-derived extracellular vesicles in ischemic stroke: A meta-analysis of preclinical studies by Xiaoming Zhang, Yibing Guo, Kun Fang, Xiangqian Huang, Duo Lan, Mengqi Wang, Lina Jia, Xunming Ji, Ran Meng, Da Zhou

“…This study aims to systematically evaluate the therapeutic effects of mesenchymal stem cell-derived exosomes (MSC-Exos) on IS outcomes in rodent models. Methods: A comprehensive literature search was conducted across multiple databases to identify studies investigating the effects of MSC-Exos on rodent models of IS. …”
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PI3Kδ inhibitor linperlisib combined with gemcitabine and oxaliplatin for relapsed or refractory diffuse large B-cell lymphoma: a multicenter, single-arm phase Ib/II trial by Peng Sun, Hong Cen, Haiyan Yang, Rui Huang, Zhen Cai, Xuekui Gu, Hanying Bao, Zusheng Xu, Zuhong Xu, Zhi-Ming Li

“…Abstract Background This investigation assessed the therapeutic potential of combining linperlisib, a targeted inhibitor of phosphatidylinositol 3-kinase delta (PI3Kδ), with gemcitabine and oxaliplatin (GEMOX) for patients with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL). Methods This was a multicenter, phase Ib/II clinical study conducted across six sites in China, enrolling 39 individuals with histologically confirmed R/R DLBCL. …”
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Real-world outcomes of maintenance therapy post-autologous stem cell transplantation in newly diagnosed multiple myeloma by Ka-Won Kang, Dae Sik Kim, Se Ryeon Lee, Mi Hwa Heo, Hyeon-Seok Eom, Jongheon Jung, Ji Hyun Lee, Sung-Hyun Kim, Youngil Koh, Chang-Ki Min, Seung Shin Lee, Sung-Nam Lim, Ho-Young Yhim, Myung-won Lee, Je-Jung Lee, Sung-Hoon Jung, Soo-Mee Bang, Kihyun Kim, the Korean Multiple Myeloma Working party [KMMWP]

“…Abstract Background In the Republic of Korea, only lenalidomide, bortezomib, ixazomib, and thalidomide monotherapy are available as maintenance therapy post-autologous stem cell transplantation (ASCT). Methods To determine whether maintenance therapy confers a survival benefit in the real world, we compared treatment outcomes according to the use and type of maintenance therapy in patients who underwent ASCT following frontline therapy with the triplet regimen of bortezomib, thalidomide, and dexamethasone for newly diagnosed multiple myeloma in 15 nationwide centers. …”
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Platelet-rich fibrin and silver nano-particles loaded chitosan treatment for post- laminectomy epidural scar adhesions: in vivo rats study model by Samah Fouad, Awad Rizk, Esam Mosbah, Mostafa M. Nabeeh, Walaa Awadin, Ayman S. Elmezayyen, Ekramy Elmorsy, Adel Zaghloul

“…This study aimed to evaluate the use of silver nano-articles (AgNPs) loaded on chitosan (Chi/Ag-NPs) with platelets-rich fibrin (PRF) gel for the reduction of post-laminectomy epidural scar adhesions. Methods A total of 90 male Sprague Dawley rats (255 ± 55gm) were randomized in-to six groups, each group with 15 rats: control group, laminectomy group, PRF group, Chi/Ag-NPs group, combined treatment group (PRF + Chi/Ag-NPs), and a group to prepare PRF. …”
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Trends in breast cancer among elderly women: Development in estrogen and HER2 subtypes in the last ten years by Frederik K. Palshof, Lina S. Mørch, Maj-Britt R. Jensen, Hans H. Storm, Niels Kroman, Tove H.F. Tvedskov

“…We assessed trends in BC incidence of tumor subtypes for women with focus on the elderly. Methods: Changes in BC incidence in women by age from 2012 to 2021 were assessed using data from the Nordic countries. …”
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Self-Reported COVID-19 Vaccine Status and Barriers for Pediatric Emergency Patients and Caregivers by Amanda M. Szarzanowicz, Kendra Fabian, Maya Alexandri, Carly A. Robinson, Sonia Singh, Michael Wallace, Michelle D. Penque, Nan Nan, Changxing Ma, Bradford Z. Reynolds, Bethany W. Harvey, Heidi Suffoletto, E. Brooke Lerner

“…Objective: This study determined if the caregivers of children in the emergency department (ED) have the same COVID-19 vaccination status as the child, the reasons they chose to not vaccinate the child, and self-identified barriers to vaccination to determine if the ED is appropriate for vaccination intervention. Methods: A survey was administered to caregivers of pediatric ED patients at four Children’s Hospitals in: Augusta, GA, Buffalo, NY, Madison, WI, and Sacramento, CA. …”
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Design, theoretical approaches and new framework of pyrazolo[3,4-d]pyrimidine as potent anticancer agents: Efficient synthesis, ADME-T and molecular docking by Peduri Suresh Reddy, Thuraka Sekhar, Pinnu Thriveni, Gandla Mahesh Kumar, Allaka Tejeswara Rao, Mohammad Raish, Tota Giridhar, Gudipati Srinivasulu

“…Novel 1,3,4-thiadiazole-based pyrazolo[3,4-d]pyrimidine derivatives (7a–7 l) were synthesised in this study, and their structures were ascertained utilizing a range of spectroscopic methods, including HREI-MS, IR, and NMR (1H/13C). …”
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SAR Image Simulation for Crater Terrain Using Formation Theory-Based Modeling and Hybrid Ray-Tracing by Ya-Ting Zhou, Yongsheng Zhou, Qiang Yin, Fei Ma, Fan Zhang

“…However, existing simulation methods often overlook crucial factors, including the explosive depth effect in crater morphology modeling and the double-bounce scattering effect in electromagnetic scattering calculations. …”
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Mechanical resistance comparison between interlocking micro-nail and tension band for fractures subject to muscular flexion forces by Alois Foltran Müller, Silvio Henrique de Freitas, Renata Gebara Sampaio Dória, Julia Belotto Guaraná, Fábio de Souza Mendonça, Atanásio Serafim Vidane, Lázaro Manoel de Camargo, Rachel Santos Bueno Carvalho, Antônio Carlos Shimano, Carlos Eduardo Ambrósio, Bruno Watanabe Minto

“…It was proposed in this study to mechanically compare two fixation methods (interlocking micro-nail or tension band) for fractures under muscular tension. …”
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Research trends and hotspots in post-stroke speech rehabilitation: A bibliometric analysis by Nan Huang, Kang Zou, Fang Liu, Zhen Su, Long Chen, Yanbiao Zhong, Yun Luo, Maoyuan Wang, Li Xiao

“…Objective: This study aimed to identify hotspots and trends in post-stroke speech rehabilitation research from 2003 to 2023 to guide future studies. Methods: Articles on post-stroke speech rehabilitation from 2003 to 2023 were retrieved from the Web of Science Core Collection. …”
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COVID-19 Pandemic and IBS. Results of the All-Russian Observational Non-interventional Program to Study the Effectiveness of the Drug Kolofort® in Real Clinical Practice in Patient... by V. T. Ivashkin, R. A. Abdulkhakov, I. G. Bakulin, S. V. Zaitsev, V. I. Luchina, S. N. Mekhtiyev, S. G. Peshekhonov, E. A. Poluektova, T. I. Semenova, S. N. Serikova, G. N. Tarasova, E. A. Trush, Y. P. Uspenskiy, I. B. Khlynov, V. V. Tsukanov, N. P. Chernus

“…Aim: to study the effectiveness and safety of using the drug Kolofort® in outpatients with irritable bowel syndrome (IBS) after a new coronavirus infection.Materials and methods. An observational non-interventional program was conducted in patients with exacerbation of IBS symptoms after a new coronavirus infection. …”
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Early childhood weight trajectory differences in twins, singletons, and gestational-age matched singletons by Anna Booman, Byron A. Foster, Kristin Lyon-Scott, Miguel Marino, Jonathan M. Snowden, Janne Boone-Heinonen

“…In this study, we characterized normative weight trajectories of twins and singletons in a contemporary, diverse cohort. Methods: Data were from the PROMISE study, an electronic health record-based cohort of pregnant people and their children in the US (2005–2021). …”
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PREDICTING THE LEARNING PATH TO LEARNER’S OPTIMUM COMPREHENSION by Ifeanyi Isaiah Achi, Chukwuemeka Odi Agwu, Christopher Chizoba Nnamene, Sylvester C. Aniobi, Ifebude Barnabas C., Kelechi Christian Oketa, Godson Kenechukwu Ezeh, John Otozi Ugah

“…This is due to the present systems' inability to model the learner to determine the best methods for achieving maximum comprehension. Hence, this research paper focuses on deriving an improved mathematical model for predicting the learning path to a learner’s optimum comprehension. …”
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Reconstruction of climatic events from the 16th century in Transylvania: interdisciplinary analysis based on historical sources by Ovidiu Răzvan Gaceu, Tudor Caciora, Ștefan Baias, Cezar Morar, Mihai Dudaș, Marius Stupariu, Maria Maxim

“…IntroductionUnderstanding past climate variability is essential for interpreting current and future climate trends, particularly during defining climate periods for the past two millennia, such as the Little Ice Age, which had significant socio-economic impacts.MethodsThe present study uses an interdisciplinary approach, analyzing written documents such as chronicles, diaries, and official records to extract data related to climate events in the 16th century in Transylvania (on the current territory of Romania). …”
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Bottom-up analysis for carbon emissions from passenger and freight transport sectors in Xi’an: a city-level study using MOVES and LMDI models by Ya’nan Bo, Liyuan Zhang, Jiahao Zhong, Wei Zhong, Pengyue Zhu

“…This study employed a localized MOVES model, integrating high-resolution urban vehicle data, along with a categorical LMDI decomposition model, to conduct a detailed bottom-up analysis of carbon emissions from passenger and freight vehicles in Xi’an. …”
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Randomised feasibility study of an intestinal adsorbent in acute diarrhoea in The Gambia by Elena Markaryan, Matthew Dodd, Stephen Allen, Carol Howell, Angela Allen, Paul Rahden, Abdoulie Fatty, Momodou Lamin Jobarteh, Abdoulwahab Sallah, Ebrahim Jaiteh, Doreen Umoh, Fanta Bass, Radovan Hnatič

“…An intestinal adsorbent may reduce diarrhoea duration and severity.Methods Randomised controlled feasibility trial with two phases: phase 1 (0–4 hours and double-blind) and phase 2 (up to 5 days and open-label). 50 children aged 6–59 months with acute diarrhoea presenting with no or some dehydration to the emergency paediatric unit and outpatient clinic at Edward Francis Small Teaching Hospital, Banjul, The Gambia were randomised to either standard treatment (oral rehydration fluid and zinc) or standard treatment with polymethylsiloxane polyhydrate for up to 5 days.Results Recruitment was completed in 7 months. …”
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Micro-/nanobubble oxygenation irrigation enhances soil phosphorus availability and yield by altering soil bacterial community abundance and core microbial populations by Qingyong Bian, Qingyong Bian, Zhiduo Dong, Yupeng Zhao, Yaozu Feng, Yaozu Feng, Yaozu Feng, Yanbo Fu, Yanbo Fu, Zhiguo Wang, Jingquan Zhu, Liang Ma

“…Therefore, we established two irrigation methods, conventional irrigation (CF) and micro-/nanobubble oxygenation irrigation (MB), to investigate the combined effects on enzyme activity, microbial communities, and soil phosphorus availability in the rhizosphere soil of maize.The results showed that compared to the CF treatment, the MB treatment significantly increased available phosphorus content and alkaline phosphatase activity in maize rhizosphere soil by 21.3% and 15.4%, respectively. …”
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