Gut microbiota dysfunction in Crohn’s disease by Sylvie Buffet-Bataillon, Sylvie Buffet-Bataillon, Gabriela Durão, Isabelle Le Huërou-Luron, Olivier Rué, Olivier Rué, Yann Le Cunff, Vincent Cattoir, Guillaume Bouguen

“…Here, we investigated metagenomic functions using PICRUSt2 during the course of CD to better understand microbiota-related disease mechanisms and provide new insights for novel therapeutic strategies.MethodsWe performed 16S rRNA-based microbial profiling of 567 faecal samples collected from a cohort of 383 CD patients, including 291 remissions (CR), 177 mild-moderate (CM) and 99 severe (CS) disease states. …”
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Closer look at circulating nitric oxide levels and their association with polycystic ovary syndrome: A meta-analytical exploration by Seyed Sobhan Bahreiny, Akram Ahangarpour, Elnaz Harooni, Mahdi Amraei, Mojtaba Aghaei, Reza Mohammadpour Fard

“…Objective: This meta-analysis aims to elucidate the association between NO levels and PCOS, investigate the potential of NO as a biomarker for PCOS diagnosis, and evaluate its clinical significance. Materials and Methods: A systematic review was conducted in several electronic databases, including PubMed, Web of Science, Cochrane Library, Scopus, EMBASE, and Google Scholar, to identify relevant studies published up to January 2024. …”
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A multistage drug delivery approach for colorectal primary tumors and lymph node metastases by Yihang Yuan, Quanjun Lin, Hai-Yi Feng, Yunpeng Zhang, Xing Lai, Mao-Hua Zhu, Jue Wang, Jiangpei Shi, Yanhu Huang, Lele Zhang, Qin Lu, Zeli Yuan, Jonathan F. Lovell, Hong-Zhuan Chen, Peng Sun, Chao Fang

“…Thus, effective non-invasive methods to treat metastatic LNs would be highly desirable. …”
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Degradation and ultrastructural changes of resin-based pit and fissure sealants under simulated chewing conditions by Pimduean Sivavong, Ekamon Mahapoka, Anucharte Srijunbarl, Thawanrat Singthong, Thanchanok Suriyapongprapai, Soranun Chantarangsu, Murali Srinivasan, Thantrira Porntaveetus, Dusit Nantanapiboon

“…This study aimed to assess the abrasive wear of experimental pit and fissure sealants (DIF) compared with the other commercial pit and fissure sealants by measuring surface roughness, volume loss, and ultrastructure after chewing simulation at different time points. Methods Specimens were divided into five groups (n = 10): Clinpro™(CP), Teethmate™ White (TW), Teethmate™ Natural (TN), experimental sealant (DIF), and Filtek™ Supreme Flowable Restorative (FC). …”
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Lack of Tissue Virological Response as a Predictor of Relapse in Chronic Hepatitis D after Completion Bulevirtide Therapy by P. O. Bogomolov, N. A. Shub, N. A. Gasilova, A. A. Belyakova, T. G. Lidzhieva, E. A. Kondrasheva, N. A. Barsukova, M. V. Arapova, E. A. Isaeva, S. V. Koblov, M. V. Kalashnikov, O. S. Kuzymina, A. Yu. Demyanov, A. O. Bueverov, I. V. Maev

“…Aim: to evaluate the significance of a positive polymerase chain reaction result for hepatitis D virus RNA (HDV RNA) in liver biopsy specimens of patients with chronic hepatitis D (CHD) after completion of antiviral therapy (AVT) as a predictor of infection relapse.Materials and methods. The study included 21 patients with CHD who received combined AVT with peginterferon alpha and bulevirtide for 48 weeks, followed by bulevirtide monotherapy for 48–96 weeks, making the total duration of antiviral therapy 96–144 weeks. …”
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The Spatio-temporal Evolution of NDVI in the Three Gorges Reservoir Area Driven by the Synergistic Effect of two Factors over the Past 21 Years by QI Haimei, ZHENG Peilong, WANG Yunqi, WANG Jiani, LI Cheng, ZHANG Xiaoming

“…[Objective] To clarify the spatio-temporal characteristics of vegetation evolution in the Three Gorges Reservoir Area, and to quantitatively analyze the relationships between vegetation and key determinants, including climate, terrain, and human activities. [Methods] Based on Normalized Difference Vegetation Index (NDVI) data, a suite of analytical techniques was employed, including Theil-Sen Median Trend Analysis, the Mann-Kendall Test for significance, Hurst Exponent Analysis, and Geographic Detector Modeling, to investigate the spatio-temporal patterns and driving forces of NDVI within the Three Gorges Reservoir Area from the year 2000 to 2020. …”
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Lightweight AES Design for IoT Applications: Optimizations in FPGA and ASIC With DFA Countermeasure Strategies by Salman Ahmed, Nabihah Ahmad, Nasir Ali Shah, Ghulam E. Mustafa Abro, Ardhi Wijayanto, Abdinasir Hirsi, Abdul Rehman Altaf

“…In addition, the study reviews DFA countermeasures that highlight fault detection methods, error detection levels, protection positions, and associated design overheads such as area, frequency, and throughput penalties, with special consideration for resource-constrained IoT devices. …”
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Phytochemical and pharmacological review of Erica Genus (L.) Ericaceae plants by Francis Adu-Amankwaah, Hleziphi V. Mpundu, Kudakwashe Nyambo, Paula Strauss, Kudzanai Ian Tapfuma, Ndivhuwo Tshililo, Motunrayo Victoria Badejo, Lawrence Mabasa, Vuyo Mavumengwana, Lucinda Baatjies

“…Despite their widespread ethnomedicinal use, a comprehensive review of the pharmacological potential of Erica species is still lacking. Study Design and Methods: This review presents an overview of the phytochemical, ethnomedicinal, pharmacological and toxicological properties of Erica species. …”
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Effects of foliar spraying ABA on ultrastructure and photosynthesis of cotton leaves at bolling stage by CHENG Guo, ZHAO Xiushuai, YIN Zi, WANG Xingpeng, HE Shuai

“…[Objective] The study aims to investigate the mechanism of different concentrations of abscisic acid (ABA) on the photosynthetic effect and ultrastructure of cotton leaves during the bolling stage, and provide a theoretical basis for the regulation of cotton ineffective water loss by ABA in southern Xinjiang. [Methods] Cotton ‘Tahe No. 2’ cultivated in Alar of Xinjiang was sprayed with water (control) and ABA at low concentration (50 μmol/L) and high concentration (100 μmol/L). …”
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Integrating E-cadherin expression levels with TNM staging for enhanced prognostic prediction in colorectal cancer patients by Jae-Ghi Lee, Ilkyu Park, Hannah Lee, Seungyoon Nam, Jisup Kim, Won-Suk Lee, Myunghee Kang, Jung Ho Kim

“…The goal was to establish a more accurate prognostic prediction for colorectal cancer patients by analyzing E-cadherin expression levels alongside TNM staging. Methods The study examined colorectal cancer patients by dividing them into groups based on E-cadherin expression levels. …”
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Single-cell transcriptomes of dissecting the intra-tumoral heterogeneity of breast cancer microenvironment by Peixian Chen, Kaifeng Liang, Xiaofan Mao, Qiuyuan Wu, Zhiyan Chen, Yabin Jin, Kairong Lin, Tiancheng He, Shuqing Yang, Huiqi Huang, Guolin Ye, Juntao Gao, Dan Zhou, Zhihao Zeng

“…Abstract Objective To investigate the mechanism by which heterogeneity in breast cancer developed and acted in single-cell transcriptomes. Methods The composition of breast cancer based on the single-cell transcriptomes of 54,055 high-quality cells from clinical specimens of 4 malignant and 4 non-malignant patients were investigated. …”
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Evaluating knowledge gains from structured sexual and reproductive health education among in-school adolescents in Southeast Nigeria by Chibuike Agu, Chinyere Ojiugo Mbachu, Ifunanya Clara Agu, Godstime Eigbiremolen, Ugenyi Iloabachie, Ozioma Nwankpa, Obinna Onwujekwe

“…This study aimed to assess the difference in SRH knowledge between adolescents in schools that received SRH interventions and those in non-intervention schools in Ebonyi State, Southeast, Nigeria. Methods This was an intervention study that employed an ex-post outcome design. …”
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Length of stay after colorectal surgery in Italy: the gap between “fit for” and “actual” discharge in a prospective cohort of 4529 cases by Lorenzo Pandolfini, Duccio Conti, Piercarlo Ballo, Silvia Rollo, Alessandro Falsetto, Gian Matteo Paroli, Paolo Ciano, Michele Benedetti, Leonardo Antonio Montemurro, Giacomo Ruffo, Massimo Giuseppe Viola, Felice Borghi, Gianandrea Baldazzi, Massimo Basti, Pierluigi Marini, Mariano Fortunato Armellino, Vincenzo Bottino, Giovanni Ciaccio, Alessandro Carrara, Gianluca Guercioni, Marco Scatizzi, Marco Catarci, the Italian ColoRectal Anastomotic Leakage (iCral) study group

“…The aim of this study is to understand the reasons for this difference and its clinical impact on the overall length of stay (LOS). Methods All patients enrolled in the prospective iCral3 study were analyzed regarding any difference and reason between the “fit for discharge” (FFD) and “actual discharge” (AD) dates. …”
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Estimation of evaporation in Andalusian reservoirs: Proposal of an index for the assessment and classification of dams by Santiago García-López, Marcia Salazar-Rojas, Mercedes Vélez-Nicolás, Jorge. M.G.P. Isidoro, Verónica Ruiz-Ortiz

“…New hydrological insights for the region: Data from 76 large dams in Andalusia, including their descriptive characteristics, morphometric details, and hydrological information, were retrieved from institutional sources. …”
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Pulp stones and kidney stones-related gene: An investigation of single nucleotide polymorphisms in the gene encoding parathyroid hormone by Prescila Mota de Oliveira Kublitski, Bruna de Souza Romano, Vania Gomes Moraes, Manoel Damião Sousa-Neto, Lívia Azeredo Alves Antunes, Erika Calvano Küchler, Leonardo Santos Antunes, João Armando Brancher, Edgard Michel-Crosato, Marilisa Carneiro Leão Gabardo

“…Purpose: The aim of this study was to investigate the association between the presence of PS and kidney stones (KS) and single nucleotide polymorphisms (SNPs) in the parathyroid hormone (PTH) gene, which is related to KS. Methods: This cross-sectional study included adults of both sexes, divided into groups: with PS and without PS. …”
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Styloid process phenotype and atheromatous plaque: Radiographic and bone density assessment in parathyroid disease by Adilia Mirela Pereira Lima Cid, Davi de Sá Cavalcante, Marcela Lima Gurgel, Ana Carolina Saraiva, Ana Alicia Sales Ricardo, Lúcio Mitsuo Kurita, Paulo Goberlânio de Barros Silva, Catarina Brasil d’Alva, Ana Rosa Pinto Quidute, Fabio Wildson Gurgel Costa

“…Additionally, it aimed to analyze the association between the bone mineral status of patients with parathyroid diseases and the radiographic findings. Material and methods: A cross-sectional case-control study was conducted with individuals diagnosed with PHPT (n = 25) and post-surgical hypoPT (n = 25). …”
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Managing Liver Cirrhosis: a Multidisciplinary Approach by V. M. Durleshter, S. A. Gabriel, N. V. Korochanskaya, O. V. Kovalevskaya, S. N. Serikova, P. V. Markov, O. A. Usova, D. S. Murashko, V. Yu. Dyn'ko, A. Yu. Bukhtoyarov, M. A. Basenko

“…Analysis of the experience of managing patients with liver cirrhosis (LC) at the Regional Clinical Hospital No. 2 of the Ministry of Health of Krasnodar Krai.Materials and methods. In this retrospective study, we assessed data on routine outpatient monitoring of 832 patients with LC and oesophageal varices by the outpatient and inpatient services of the Regional Clinical Hospital No. 2 during 2009-2019.Results. …”
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Triiodothyronine treatment in mice improves stroke outcome and reduces blood–brain barrier damage by Daniel Ullrich, Dagmar Führer, Heike Heuer, Steffen Mayerl, Steffen Haupeltshofer, Linda-Isabell Schmitt, Markus Leo, Rebecca D Szepanowski, Tim Hagenacker, Markus Schwaninger, Christoph Kleinschnitz, Friederike Langhauser

“…Post-stroke administration of 3,3′,5-triiodo-L-thyronine (T3) has been reported to substantially improve outcomes, but the optimal dosage and time window remain elusive. Methods: Stroke was induced in mice by transient middle cerebral artery occlusion (tMCAO), and T3 was administered at different doses and time points before and after stroke. …”
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Effects of shrinkage, temperature and the degree of connection (N/N f) on the behavior of steel-concrete composite beams by Halima Aouad, Nacer Rahal, Houda Beghdad, Mohamed Sadoun, Abdelaziz Souici, Sara Zatir, Khaled Benmahdi

“…In this work, the partial shear connection at the steel-concrete interface is taken into account according to the degree of connection (N/Nf). Methods: This involves reformulating the model proposed in 2024 by Rahal et al analyzing the behavior of composite steel-concrete beams in full shear connection under the effect of temperature and concrete shrinkage. …”
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Evidence of vancomycin-resistant Staphylococcus aureus, multidrug-resistant S. aureus, and Enterococcus faecium-causing mastitis in Thailand and Cambodia by Sambo Na, Montira Intanon, Anyaphat Srithanasuwan, Wasana Chaisri, Witaya Suriyasathaporn

“…It focuses on detecting methicillin-resistant Staphylococcus aureus, vancomycin-resistant S. aureus (VRSA), and vancomycin-resistant enterococci by identifying the presence of mecA, vanA, and vanB genes in bacterial isolates. Materials and Methods: A total of 65 bacterial isolates (55 S. aureus from Thailand and 10 Enterococcus faecium from Thailand and Cambodia) were analyzed. …”
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