FIXED COMBINATION OF VALSARTAN AND AMLODIPINE: EFFECTS ON THE LEFT VENTRICULAR HYPERTROPHY REGRESSION, ALBUMINURIA REDUCTION AND ENDOTHELIUM FUNCTION IN HYPERTENSIVE PATIENTS WITH METABOLIC SYNDROME by Ye. I. Tarlovskaya, N. S. Maksimchuk, I. Ye. Sapozhnikova, S. V. Malchikova

“…To study effects of fixed combination of valsartan and amlodipine on of left ventricular hypertrophy (LVH) regression, microalbuminuria reduction and endothelium function in hypertensive patients with metabolic syndrome (MS).Materials and methods. 20 hypertensive patients (15 females and 5 males) with metabolic syndrome and a history of previous ineffective antihypertensive therapy were studied. …”
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Muscle Proteome Analysis of Facioscapulohumeral Dystrophy Patients Reveals a Metabolic Rewiring Promoting Oxidative/Reductive Stress Contributing to the Loss of Muscle Function by Manuela Moriggi, Lucia Ruggiero, Enrica Torretta, Dario Zoppi, Beatrice Arosio, Evelyn Ferri, Alessandra Castegna, Chiara Fiorillo, Cecilia Gelfi, Daniele Capitanio

“…In severe cases, we observe pronounced metabolic dysfunction, marked by dysregulated glycolysis, activation of the reductive pentose phosphate pathway (PPP), a shift toward a reductive TCA cycle, suppression of oxidative phosphorylation, and an overproduction of antioxidants that is not matched by an increase in the redox cofactors needed for their function. …”
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Liver fibrosis and markers of endothelial function at metabolic syndrome and early disorders of carbohydrate metabolism by L. V. Chesnokova, I. M. Petrov, Ye. A. Sidorova, I. A. Troshina, Yu. A. Petrova

“…Complex estimation of endothelial function at non-alcoholic fatty liver disease (NAFLD) in association with early disorders of carbohydrate metabolism, in relation to liver fibrosis severity.Material and methods. …”
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Key microbial functional genes and their diversity involved in soil typical reduction processes: A review by FENG Jiayin, ZHU Min, HE Yan

“…Therefore, the key functional genes and their diversity involved in several major reduction processes in soils were reviewed in this paper. …”
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Functional-metabolic activity of neutrophils granulocytes at patients the herpetic infection by B. S. Nagoev, Z. A. Kambachokova

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Diversity and function of soluble heterodisulfide reductases in methane-metabolizing archaea by Xingyu Lyu, Hang Yu, Yahai Lu

“…In this study, we investigated the functional diversity and evolutionary dynamics of HdrA in methane-metabolizing archaea. …”
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Myoglobin expression improves T-cell metabolism and antitumor effector function by Haifeng C Xu, Diran Herebian, Ertan Mayatepek, Dirk Brenner, Aleksandra A Pandyra, Philipp A Lang, Sascha Dietrich, Julia Werner, Georgios Theodorakis, Ichiro Katahira, Mitrajit Ghosh, Michal Gorzkiewicz, Luisa de Sousa Santos, Ann Kathrin Bergmann, Max Anstötz, Anne Busch, Carsten Berndt

“…Accordingly, Mb expression increased effector T-cell function against tumor cells in vitro with concomitant reductions in superoxide levels. …”
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Imidazoline receptor agonists: more than blood pressure reduction? by D. V. Nebieridze, S. V. Nedogoda

“…The review contains original data and international studies’ results demonstrating that selective I1 imidazoline receptor agonists, and, in particular, Albarel®, a new sympatholytic agent, provide not only adequate and longterm blood pressure control, but also other beneficial metabolic and vascular effects. Most important ones are insulin resistance reduction, improvement of endothelial function and elasticity in middle-sized and large vessels. …”
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Amelioration of metabolic disorders by a mushroom-derived polyphenols correlates with the reduction of Ruminococcaceae in gut of DIO mice by Li Sun, Li Bao, Dorji Phurbu, Shanshan Qiao, Shanshan Sun, Yangzom Perma, Hongwei Liu

“…Furthermore, we show that PAE produces taxonomic and predicted functional changes in the gut microbiome of DIO mice. …”
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ACTOVEGIN INFLUENCE ON METABOLIC AND VASOMOTOR FUNCTION OF MICROVASCULAR ENDOTHELIAL OF HUMAN SKIN by A. A. Fedorovich, A. N. Rogoza, E. M. Kanisheva, S. A. Boytsov

“…Microcirculatory oscillations at the frequency of 0.01 Hz reflect both vasomotor and metabolic function of microvascular endothelium. Actovegin improves oxygen and glucose tissue utilization as well as increases nitric oxide production with microvascular smooth muscle tone reduction.…”
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Integrative Strategies for Preventing and Managing Metabolic Syndrome: The Impact of Exercise and Diet on Oxidative Stress Reduction—A Review by Ana Onu, Daniela-Marilena Trofin, Andrei Tutu, Ilie Onu, Anca-Irina Galaction, Dragos-Petrica Sardaru, Dan Trofin, Cristiana Amalia Onita, Daniel-Andrei Iordan, Daniela-Viorelia Matei

“…This review analyzed the effects of different exercise intensities—low, moderate, and high-intensity interval training (HIIT)—on metabolic health, oxidative stress (OS), inflammation, and cardiovascular function. …”
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c-Myc promotes metabolic reprogramming in pulmonary hypertension via the stimulation of glutaminolysis and the reductive tricarboxylic acid cycle by Manivannan Yegambaram, Xutong Sun, Qing Lu, Alejandro Garcia Flores, Marina Zemskova, Jamie Soto, Adam Rauckhorst, Emin Maltepe, Ting Wang, Jeffrey R. Fineman, Stephen M. Black

“…Metabolic flux analysis showed elevated glutaminolysis and enhanced metabolic flux through the reductive tricarboxylic acid (TCA) cycle in pulmonary arterial ECs isolated from an ovine experimental model of PH (PH-PAECs). …”
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Phycospheric Bacteria Alleviate the Stress of Erythromycin on <i>Auxenochlorella pyrenoidosa</i> by Regulating Nitrogen Metabolism by Jiping Li, Ying Wang, Yuan Fang, Xingsheng Lyu, Zixin Zhu, Chenyang Wu, Zijie Xu, Wei Li, Naisen Liu, Chenggong Du, Yan Wang

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Nitric oxide mediates metabolic functions in the bivalve Arctica islandica under hypoxia. by Julia Strahl, Doris Abele

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Effects of metabolic and organ function factors on the efficacy of radioactive iodine therapy for hyperthyroidism by Yue Hu, Shan Liu, Xiaoliang Xiong, Lixing Wang, Yinlong Zhao

“…IntroductionRecent studies suggest that metabolic and organ function indicators could influence radioactive iodine treatment (RAIT) efficacy in hyperthyroid patients, but their relationships with thyroid function remain unclear.ObjectiveThis study aims to explore the impact of these markers on RAIT efficacy and thyroid function.MethodA total of 135 hyperthyroid patients undergoing RAIT were enrolled, with biomarkers collected at baseline and 1, 3, and 6 months posttreatment. …”
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The Effect of Karst Carbonate Rock Dissolution on Nitrogen Metabolism Microorganisms and Their Functions in Paddy Soils by Fengling Liu, Hu Wang, Bing Wang, Xu Mao, Jianbo Cheng, Chengwu Fan, Tengbing He, Tianling Fu

“…The effects of CRD on N-metabolizing microorganisms and functional genes in N metabolism were investigated using metagenomic sequencing technology. …”
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Microbial biodiversity and metabolic functioning in sediments of coastal dune lakes on a remote island by John K. Pearman, Jack Sissons, Joseph Kanyi Kihika, Georgia Thomson-Laing, Susanna A. Wood

“…Investigation of metabolic potential with metagenomics showed that the abundance of genes involved in nitrogen cycling were related to the nitrogen:phosphorus ratio while assimilatory sulfate reduction was correlated with sulfur and organic matter concentrations. …”
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Linalool exhibit antimicrobial ability against Elizabethkingia miricola by disrupting cellular and metabolic functions by Mingwang He, Weiming Zhong, Rongsi Dai, Su Long, Ying Zhou, Tongping Zhang, Boyang Zhou, Tao Tang, Linlin Yang, Sifan Jiang, Wenbin Xiao, YanJiao Fu, Jiajing Guo, Zhipeng Gao

“…Fourthly, metabolome analysis revealed an increase in metabolites related to the glycerophospholipid metabolic pathway and NADP content in E. miricola, which may be a metabolic response to linalool stress. …”
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Selective metabolic regulations by p53 mutant variants in pancreatic cancer by Sabrina Caporali, Alessio Butera, Alessia Ruzza, Carlotta Zampieri, Marina Bantula’, Sandra Scharsich, Anna-Katerina Ückert, Ivana Celardo, Ian U. Kouzel, Luigi Leanza, Andreas Gruber, Joan Montero, Angelo D’Alessandro, Thomas Brunner, Marcel Leist, Ivano Amelio

“…Thus, the two variants selectively control different metabolic pathways in pancreatic cancer cells. Mechanistically, p53R270H induces alterations in the expression of genes associated with oxidative stress and reduction in mitochondrial respiration. …”
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HEP14 treatment improves ovarian function in aged mice through mitophagy enhancement and oxidative stress reduction by Liming Gui, Jiajia Sun, Qin Zhong, Kan Liu, Qili Sun, Yingtong Di, Helen Picton, Bin Tang, Xiaojiang Hao, Changzhong Li

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