Myeloid TGF-β signaling shapes liver macrophage heterogeneity and metabolic liver disease pathogenesis by Ziyi Meng, Xiaoxue Qiu, Zhimin Chen, Yu-tung Lee, Linkang Zhou, You Lu, Tongyu Liu, Siming Li, Benjamin Levi, Katherine A. Gallagher, Jiandie D. Lin

“…However, the mechanisms shaping liver macrophage heterogeneity and function during disease progression remain poorly understood. …”
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Energy imbalance in oPOI ovarian granulosa cells is linked to reduced glucose bioavailability and metabolism by Weronika Marynowicz, Paulina Głód, Dawid Maduzia, Justyna Gogola-Mruk, Anna Ptak

“…Molecular analysis of GCs and CCs involved RT-qPCR and functional assays, including Seahorse metabolic profiling, fluorometric/luminescent enzyme activity tests, and mitochondrial fluorescent staining. …”
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Intestinal Fut2 deficiency exacerbated alcohol‐related liver disease by disrupting nicotinamide metabolism by Liuying Chen, Zhongwei Yin, Luorui Shang, Hang Yuan, Wenkang Gao, Shuhan Wang, Shuyan Wang, Xiaohua Hou, Shenglan Yang, Huikuan Chu

“…This reduction in nicotinic acid synthesis results in decreased NAD+ production in the liver via the Preiss–Handler pathway. …”
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Bifidobacterium animalis BD400 protects from collagen-induced arthritis through histidine metabolism by Yang Yang, Yang Yang, Qing Hong, Qing Hong, Xuehong Zhang, Zhenmin Liu, Zhenmin Liu

“…The expression of intestinal barrier protein was analyzed by qPCR to evaluate the intestinal barrier function. Alterations in gut microbiota and metabolites were assessed by 16S rDNA and non-targeted metabolomics.ResultsThe findings reveal that administering Bifidobacterium animalis BD400 orally led to a significant reduction in arthritis clinical scores and paw swelling thickness in CIA rats. …”
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METTL16 controls airway inflammations in smoking-induced COPD via regulating glutamine metabolism by Xinyu Jia, Shan Liu, Chunan Sun, Manni Zhu, Qi Yuan, Min Wang, Tingting Xu, Zhengxia Wang, Zhongqi Chen, Mao Huang, Ningfei Ji, Mingshun Zhang

“…Mechanistically, METTL16 could regulate lung epithelial mitochondrial function by participating in the reprogramming of glutamine metabolism. …”
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Limosilactobacillus reuteri prevents progression of ankylosing spondylitis in mice by restoring gut microbiota-metabolism homeostasis by Lianjun Yang, Ke You, Kun Wang, Bin Liu, Tao Chen, Zhifei Cui, Dawei Zhang, Zhihai Su, Xiang Liu, Hai Lu

“…Additionally, L. reuteri enhanced intestinal mucosal barrier function, as demonstrated by improved histopathological integrity, reduced intestinal permeability, and restored expression of tight junction proteins ZO-1 and occludin. …”
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Metabolic capabilities are highly conserved among human nasal-associated Corynebacterium species in pangenomic analyses by Tommy H. Tran, Isabel F. Escapa, Ari Q. Roberts, Wei Gao, Abiola C. Obawemimo, Julia A. Segre, Heidi H. Kong, Sean Conlan, Matthew S. Kelly, Katherine P. Lemon

“…Overall, the minimal species and strain variability in metabolic capacity implies coexisting strains might have limited ability to occupy distinct metabolic niches.IMPORTANCEPangenomic analysis with estimation of functional capabilities facilitates our understanding of the full biologic diversity of bacterial species. …”
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Impact of elevated sclerostin levels on bone resorption: unravelling structural changes and mineral metabolism disruption by María Encarnacion Rodríguez-Ortiz, Juan Miguel Díaz-Tocados, Ana Isabel Torralbo, Karen Valdés-Díaz, Antonio Rivas-Domínguez, Fátima Guerrero, Irene Reina-Alfonso, Manuel Naves-Díaz, Cristina Alonso-Montes, Cristian Rodelo-Haad, Mariano Rodríguez, Juan Rafael Muñoz-Castañeda, IMIBIC Nephrology Group

“…Aims: The physiological function of sclerostin remains unknown. Sclerostin is synthesized by osteocytes and operates by inhibiting the Wnt/β-catenin pathway. …”
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The Expanding Role of GLP-1 Receptor Agonists: Advancing Clinical Outcomes in Metabolic and Mental Health by Mohamad Al Qassab, Mohammad Mneimneh, Ahmad Jradi, Bassem Derbas, Dana Dabboussi, Justine Khoury Baini, Nadia Katrib, Nadim Chaarani, Philippe Attieh, Amjad Kanaan, Frederic Harb, Sami Azar, Hilda E. Ghadieh

“…Furthermore, they promote natriuresis and stabilize renal function. Moreover, GLP-1 RAs present significant cardiovascular benefits, including improved myocardial function, reduced atherosclerosis progression, enhanced endothelial health, and decreased major adverse cardiovascular events (MACEs). …”
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Reviews and syntheses: On increasing hypoxia in eastern boundary upwelling systems – zooplankton under metabolic stress by L. Frederick, L. Frederick, M. A. Urbina, M. A. Urbina, R. Escribano, R. Escribano

“…Adjustment of the aerobic respiration under variable oxygen levels deserves special attention since such adaptive responses to endure mild or severe hypoxia may involve trade-offs in energy usage that impact other metabolic functions or energy-demanding processes. …”
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Phanerochaete chrysosporium reduces heavy metal uptake in rice by affecting rhizosphere microbes and root metabolism by Renyan Duan, Yu Zhang, Qian Dai, Li Yang, Hui Yang, Fumin Meng, Wei Hu, Ping Zhang

“…The addition of functional microorganisms is a common approach for remediating farmland contaminated with heavy metals, but the mechanisms underlying their reduction of crop absorption of these metals require further investigation. …”
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Intermittent hypoxia-induced enhancements in corticospinal excitability predict gains in motor learning and metabolic efficiency by Alysha T. Bogard, Thomas G. Hembree, Aviva K. Pollet, Andrew C. Smith, Stephanie C. Ryder, George E. Marzloff, Andrew Q. Tan

“…We recently demonstrated that AIH improves motor adaptation, motor savings, and metabolic efficiency during split-belt walking. Thus, we hypothesized that AIH increases lower limb excitability and that these enhancements would predict the magnitude of motor learning and the corresponding reductions in net metabolic power. …”
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CSF Amyloid-β42 associates with neuropsychiatric and cognitive outcomes via cerebral glucose metabolism by Ali Azargoonjahromi, Hamide Nasiri, for the Alzheimer’s Disease Neuroimaging Initiative#

“…In the MCI group, higher cerebral glucose metabolism was associated with reductions in both neuropsychiatric and depressive symptoms, suggesting that higher glucose metabolism reflect higher activation state of investigated brain regions. …”
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Crosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance by Siyuan Zhang, Haimei Wen, Ying Chen, Jingya Ning, Di Hu, Yujiao Dong, Chenyu Yao, Bo Yuan, Shuanying Yang

“…At the species level, Lachnospiraceae bacterium was enriched after both subcutaneous and intravenous tumors inoculation, whereas levels of Muribaculaceae bacterium Isolate‐110 (HZI), Ligilactobacillus murinus and Bacteroides acidifaciens reduced. Metabolic function analysis showed that the reductive pentose phosphate cycle, urea cycle, ketone body biosynthesis, ectoine biosynthesis, C4‐dicarboxylic acid cycle, isoleucine biosynthesis, inosine 5′‐monophosphate (IMP), and uridine 5′‐monophosphate (UMP) biosynthesis were elevated after tumor inoculation, whereas the cofactor and vitamin biosynthesis were deficient. …”
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Regional variation in cerebral oxygen metabolism during acute severe hypoxia with temporary cognitive impairment by Daehun Kang, Koji Uchida, Clifton R. Haider, Norbert G. Campeau, Myung-Ho In, Erin M. Gray, Joshua D. Trzasko, Kirk M. Welker, Jeffrey L. Gunter, Matt A. Bernstein, Max R. Trenerry, David R. Holmes, III, Michael J. Joyner, Timothy B. Curry, John Huston, III, Yunhong Shu

“…Fractional changes in CBF (δCBF) and BOLD (δBOLD) were combined using a modified Davis model, adjusted for physiological differences between normoxia and acute and severe hypoxia, to calculate the fractional change in cerebral metabolic rate of oxygen (δCMRO2). Group-level z-normalized δCMRO2 maps revealed significant regional heterogeneity, with most pronounced reductions in areas associated with the dorsal and ventral attention networks and executive frontoparietal networks. …”
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Konjac glucomannan as an emerging nutritional strategy for obesity control via gut microbiota and metabolic regulation by Anindita Ghosh, Priyanka Mohol, Sumana Ghosh

“…Conclusion KGM emerges as a promising functional dietary component in regulating obesity and metabolic syndrome, with its effects attributed to both its physicochemical properties and its influences on gut-microbial dynamics. …”
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Transdiagnostic remission of psychiatric comorbidity in post-traumatic stress disorder, ADHD, and binge-eating disorder using ketogenic metabolic therapy: a retrospective case repo... by Erin L. Bellamy, Nicole Laurent

“…Qualitative reports substantiated marked functional gains, including improved occupational engagement and social functioning.ConclusionThis report demonstrates the potential of KMT to achieve comprehensive remission in severe, treatment-resistant psychiatric comorbidities. …”
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Bezafibrate-driven mitochondrial targeting enhances antitumor immunity and prevents lung cancer via CD8+ T cell infiltration and MDSC reduction by Jing Pan, Jiaheng Li, Qi Zhang, Mofei Huang, Yian Wang, Ming You

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Succinate Regulates Endothelial Mitochondrial Function and Barrier Integrity by Reham Atallah, Juergen Gindlhuber, Wolfgang Platzer, Rishi Rajesh, Akos Heinemann

“…An MTS assay 1 h post stimulation with DES suggested reduced metabolic activity in HUVECs. Concurrently, elevated production of ROS, including mitochondrial superoxide, and a reduction in mitochondrial membrane potential were observed. …”
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The discrepant effect of blood glucose on the risk of early and late lung injury: a national cohort study by Lu Wang, Yicheng Zhou, Xiaojuan Jiao, Qin Zhang, Kun Feng, Yunfeng Shen

“…Results The study involved the examination of respiratory symptoms, pulmonary function tests, and mortality analyses encompassing 3714, 3916, and 173 subjects, respectively. …”
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